Researchers have identified an enzyme from cow gut that can break down bacterial biofilm components, making them more vulnerable to antibiotics. The enzyme, CRhAB, was found to be effective against two notorious pathogen groups, including Acinetobacter baumannii, which poses a significant threat in healthcare settings.
Researchers at IISc have demonstrated a new way of switching materials between two fundamentally different magnetic states using an electric current. This discovery could pave the way for compact, energy-efficient electronic devices that store information and perform logic operations, with potential applications in quantum computing.
The study reveals how the encephalomyocarditis virus (EMCV) hijacks host ribosomes and translational factors to translate viral genes while blocking host gene translation. Targeting this mechanism could lead to new treatments for EMCV and similar viruses like poliovirus.
Researchers developed a new lightweight cast aluminum alloy that exhibits improved ductility and strength, making it suitable for demanding mechanical and thermal conditions. The alloy's unique nanostructures allow for efficient crack transfer and stress distribution.
Epithelial tissues behave like solids while retaining the disordered structure of liquids. The team developed an active vertex model that incorporated mechanochemical feedback to reproduce experimental signatures of glass dynamics, revealing a link between cellular mechanics, actin organisation, and collective tissue behaviour.
A recent study from the Indian Institute of Science found that self-fertilization is a key trait that helps plants become invasive. The researchers examined 28 species from the daisy family and found that all 11 invasive species could reproduce uniparentally, while most native and non-invasive alien species remained self-incompatible.
Researchers at IISc discovered that low-frequency ultrasound can selectively target and kill oral cancer cells, while leaving healthy tissues unharmed. This approach uses moderate mechanical forces to damage cancer cells beyond their ability to recover, potentially leading to safer treatment strategies for oral cancer.
Researchers have developed smart molecules that can change their physical properties in response to various external stimuli. These materials can form the building blocks for next-generation data storage units, quantum processors, and advanced industrial sensors.
Researchers have successfully synthesized a carbon-free boron alternative to ferrocene, opening up new possibilities for future materials. The new compound has stronger bonding and shows that boron can mimic carbon's ability to form stable rings and complex structures.
Scientists have developed an advanced microscopy technique to visualize critical components of the cell's transcription machinery and proteins that provide structural support to the nucleus. The new technique allows for the visualization of up to 12 biomolecules simultaneously, providing detailed maps of nuclear organization.
Researchers at Indian Institute of Science have devised a method to grow high-quality 2D magnetic materials over centimetre-scale wafers, paving the way for their integration into next-generation electronics. The technique uses Physical Vapour Transport Deposition and enables scalable fabrication with minimal surface roughness.
Researchers at IISc created a method to precisely steer quantum sensors through living cells, overcame challenges like viscous drag and brownian motion. This breakthrough enables real-time measurement of parameters such as local viscosity and temperature inside cells.
A team of scientists at the Indian Institute of Science discovered that disrupting a single gene alters serotonin signaling, leading to swarming behavior in worms. The study suggests that neuromodulatory control of social behavior might be evolutionarily conserved across species.
Researchers at IISc have mapped a neural circuit that links stress to itch. Stress activates specific neurons in the lateral hypothalamic area, which directly regulate itch and reduce scratching behavior. This study provides new insights into the complex relationship between emotional states and sensory perception.
A new study analyzing three decades of research found that animals respond more consistently to lethal humans than non-lethal ones, altering behavior in foraging, vigilance, and movement. Non-lethal human structures can even function as perceived refuges, reducing animal vigilance.
Researchers at IISc have developed a new gate stack that cuts gate leakage by up to 10,000 times, improving threshold stability and reaching high gate breakdown voltages. The advancements enable GaN technology adoption in high-reliability applications.
Researchers found that bacteria exposed to perchlorate produce stronger calcium carbonate crystals, leading to better biocementation skills. The presence of guar gum and nickel chloride enhances the process, paving the way for alternative building strategies on Earth and Mars.
Researchers have discovered that actin forms wavefronts around the synapse centre, actively transporting TCR microclusters towards the cell edge. This process rescues TCRs from endocytosis and enables T cells to bind to multiple APCs in succession.
Researchers discovered how the Lsr2 protein in Mycobacterium tuberculosis (Mtb) protects against foreign DNA inserted into its genome. This mechanism involves the protein forming condensates that silence specific regions of Mtb DNA, preventing harm to the bacteria.
A new study found that population bottlenecks can fundamentally reshape how cooperation evolves and persists in complex microbial societies. The researchers discovered that stringent bottlenecks favored fruiting body formation and growth, while relaxed bottlenecks led to an overall increase in competitive fitness.
A team of scientists at IISc has created tiny molecular devices that can be tweaked to perform diverse functions, including behavior as a memory unit, logic gate, selector, analog processor or electronic synapse. The devices' unique chemistry enables adaptability and the ability to store information, compute and adapt in real time.
Physicists discovered connections between Ramanujan's formulae for pi and fundamental physics theories like conformal field theories. The formulas, developed in the early 20th century, yield efficient calculations for phenomena like turbulence and black holes.
A new study found that insectivorous birds in the Eastern Himalayas are declining in survival rates and body mass due to changes in forest microclimates after selective logging. The team suggests conserving primary forests and creating shade covers or supplementing water sources to support vulnerable species.
Researchers have developed a novel pesticide delivery system using Liquid Marbles (LMs) that can enhance droplet deposition on plant surfaces. The LMs, coated with biodegradable hydrophobic particles, follow a unique mode of deposition that increases wettability and reduces waste, up to 50%.
Researchers developed a highly efficient cell-free enzyme system that achieves remarkable increases in catalytic performance, reduces cofactor consumption, and produces high yields of 1-alkenes. The system overcomes challenges of whole-cell biocatalysts by mimicking the biological reaction environment.
Researchers found yeast cells can withstand shock waves and toxic perchlorate salts, simulating Martian conditions. The yeast's ability to produce ribonucleoprotein condensates helps protect against stress, making it a model for astrobiology research and potential life support systems in space.
A new method to recycle PA-66, a type of polymer found in fishing nets and automotive parts, has been developed. The process involves introducing melamine into melted waste, resulting in a nylon material with improved properties that can be reprocessed up to three times.
Researchers have developed a new method to boost energy transfer in magnesium batteries using amorphous materials. The approach uses machine learning to simulate the behavior of ions within these materials, leading to significant improvements in rate of energy transfer.
A new study reveals how Aurora A ensures smooth dissolution of spindle poles during cell division, allowing the genome to be properly encased in new nuclei. The team identified specific regions and amino acids in NuMA that drive its shift between dynamic and solid states.
Researchers at IISc have developed a novel cascaded H-bridge-based multiport DC converter to directly connect to the medium-voltage AC grid, eliminating the need for large and expensive LFTs. This technology offers a 3-5% improvement in energy efficiency and reduces costs, making electric vehicle charging stations environmentally frien...
In graphene, electrons behave like a perfect fluid with electrical properties described by a universal quantum number. Researchers discovered this property in exceptionally clean samples of graphene, observing an inverse relationship between electrical and thermal conductivity.
A new study from the Indian Institute of Science (IISc) reveals that glucose uptake is poorly managed in β-cells from people with Type 2 diabetes, leading to reduced insulin secretion. Restoring proper GLUT trafficking could slow disease progression and personalize therapies, according to the researchers.
A new study reveals that ancient microbes like Asgard archaea may have played a crucial role in the evolution of the cytoskeleton. The researchers discovered two proteins, FtsZ1 and FtsZ2, which behave differently and may represent an intermediate stage in the development of modern cytoskeletal networks.
Researchers identified key mutations in the H5N1 genome that enhance its human adaptive potential. The 2.3.4.4b clade has infected multiple mammalian species and is adapting to humans, posing a concern for increased mortality risk. Surveillance measures are recommended to counter this growing risk.
Researchers have engineered CalBots, magnetic nanobots that can penetrate dentinal tubules and form durable seals, offering lasting relief from sensitivity. The study uses a new class of bioceramic cement to create a regenerative, active nanomaterial with potential implications for future healthcare.
A study found that reward expectation modulates attention in humans, with distinct effects on sensory processing and decision-making. Sensitivity to visual stimuli was linked to sensory attention centers, while decision-making biases were linked to brain regions involved in impulsive decisions.
Researchers at Indian Institute of Science have discovered a long-sought mechanism employed by primitive land plants to regulate plant growth. They found that the non-canonical regulation of the DELLA protein is crucial for promoting growth and development in flowering plants.
Researchers developed an AI-based method to analyze microscope images of corroded metal surfaces, estimating corrosion severity without human input. The technique focuses on two critical indicators: corrosive deposit thickness and porosity, identifying specific pH levels that indicate severe corrosion stages.
Researchers at IISc and Caltech use simulations to map energy landscape for electron movement in PSII, finding D2 branch has higher energy barrier preventing electron transport. The team suggests tweaking components can boost or rewire electron flow across PSII.
A unique luminescent probe using terbium has been developed to detect β-glucuronidase, an enzyme that can aid in liver cancer diagnosis. The sensor's sensitivity and accuracy are comparable to conventional methods but at a lower cost, making it suitable for resource-limited settings.
A novel nanozyme has been developed to prevent excess clotting in conditions like pulmonary thromboembolism and COVID-19. The nanozyme works by controlling reactive oxygen species levels, thereby preventing platelet over-activation and excess clot formation.
Researchers designed a new chiral aminoborane molecule with persistent room-temperature phosphorescence and circularly polarised luminescence, ideal for anti-counterfeiting inks, bioimaging agents, and security tags. The molecule's rigid structure suppresses non-radiative decay, enabling long-lived emission.
Researchers at IISc developed a bacteria-based technique to repair lunar bricks damaged by harsh temperatures and solar winds. The process uses Sporosarcina pasteurii to produce calcium carbonate crystals that fill defects and strengthen the brick.
A recent study from the Indian Institute of Science found that cloud band strength plays a key role in its movement and density of rains during Indian wet spells. The researchers discovered that only strong equatorial cloud bands drive northward propagation, increasing moisture and triggering stronger winds.
Researchers at Indian Institute of Science use polarized light to measure glucose concentration with near clinical accuracy in water, serum solutions and tissue samples. The technique exploits the interaction between glucose molecules and polarized light to create unique sound wave patterns.
A study found that soil bacterial communities show increased antimicrobial resistance due to the presence of a predatory bacterium, Myxococcus xanthus. The researchers suggest that exposure to growth-inhibitory molecules released by M. xanthus leads to the enrichment of resistant isolates.
Researchers at IISc have developed an onsite production strategy for hydrogen peroxide using a zinc-air battery. The process generates H2O2 while degrading toxic dyes, making it a low-cost and highly energy-efficient method. This approach has the potential to be scalable and can be used in various applications.
A recent study by Indian Institute of Science found that tropical lizards, such as rock agamas, prioritize variable food sources over constant ones when hungry. This flexible approach helps them thrive in unpredictable conditions.
A long-term study in the Spiti valley of the Himalayas found that livestock grazing leads to reduced spider populations and increased grasshoppers and disease carriers like ticks and mites. The researchers suggest rewilding native herbivores and improved surveillance to mitigate these changes.
Increasing the spacing between integrin-ECM binding domains on the extracellular matrix can boost the efficiency of ultrasound treatment applied to kill cancer cells. A new study found that this increased spacing triggers myosin forces, pumps more calcium inside, and promotes cell death.