The Tata Group and IISc are establishing a medical school that will focus on cutting-edge clinical research and medical education in India. The school will offer integrated MD-PhD programs and collaborate with global medical schools to provide students with expertise knowledge and practices.
By reducing the thickness of a commonly-used piezoelectric ceramic material, researchers at Indian Institute of Science (IISc) show that its efficacy can be dramatically increased, resulting in improved strain values. The team discovered that removing oxygen vacancies in lead-free piezoceramics also boosts electrostrain to 1% or higher.
Scientists at Indian Institute of Science have found how diverse neurons across different brain regions work together to control chronic pain in mice. The lateral parabrachial nucleus (LPBN) plays a key role in driving chemotherapy-induced peripheral neuropathy, allowing mice to cope with or suppress pain.
A team of researchers at the Indian Institute of Science (IISc) has developed a machine learning-based approach to predict material properties using limited data. By leveraging transfer learning and multi-property pre-training, they were able to improve model performance and extend its applicability to new materials.
Researchers at Indian Institute of Science discover that viruses like SARS-CoV-2 mimic host proteins to trigger excessive cell death and tissue damage in humans. In contrast, bats show mild symptoms despite harbouring similar viruses, highlighting species-specific responses to viral infections.
Researchers studied ovarian cancer cell migration patterns on soft and stiff surfaces, finding that epithelioid cells are more migratory than mesenchymal cells on stiffer matrices. The study used a novel software toolkit to analyze cell behavior over time, revealing a unique 'slip' movement pattern in epithelioid cells.
A new language called STRONG encodes nanopore shape and structure, enabling machine learning models to predict their properties. This allows for efficient analysis of nanopores and opens up possibilities for gas separation and reducing carbon emissions.
A team of scientists at IISc has devised a way to break down biofilm barriers using an enzyme from the cow’s digestive tract, making bacteria more susceptible to antibiotics. The enzyme successfully broke down biofilms in four strains of Klebsiella pneumoniae and prevented its development altogether.
Scientists have developed a new method for converting crystal to glass using electric current, reducing the need for high-power melt-quench processes. The discovery could transform data storage in devices and unlock wider applications for phase-change memory technology.
Researchers found that the presence of Oecophylla ants at base of mountains drives insect-eating bird diversity to mid-elevations. At lower elevations, bird groups competing with ants reduce in diversity.
The Indian Institute of Science team proposes an on-site alternative using iron nanoparticles that can remediate heavy metals. The S-CMC-nZVI material showed nearly 99% efficiency at Cr6+ removal under different conditions.
Researchers at Indian Institute of Science develop a neuromorphic platform that stores and processes data in 16,500 conductance states, cutting energy consumption by a huge margin. This breakthrough could enable complex AI tasks on personal devices, transforming the development of AI tools.
A glitch in protein synthesis, known as stop codon readthrough, may affect tumour growth and cancer cell proliferation. The study found that preventing this process can lead to increased degradation of target proteins and a delayed cell cycle, resulting in slower tumour growth.
Researchers designed a new supercapacitor that can store more energy through electrochemical phenomena, with increased capacitance when exposed to UV light. The device uses ZnO nanorods and liquid electrolyte, enabling fast-charging capabilities and opening doors for innovative applications in electronics.
A team of scientists from Indian Institute of Science developed a surfactant from cashew nut shell liquid to catalyse industrially relevant reactions in water, leading to 80% higher product yields and replacing expensive catalysts. The study uses micellar catalysis to mimic biological systems.
Researchers develop an artificial fusion protein combining UndB with catalase, creating a whole cell biocatalyst that converts fatty acids to alkenes with high efficiency. The biocatalyst produces pure 1-alkene as a valuable biofuel and can be used to generate a large number of hydrocarbons.
Researchers have designed a novel 3D hydrogel culture system that accurately mimics the mammalian lung environment, allowing for the study of tuberculosis bacteria infection and therapeutics. The system successfully tracks infection progression and demonstrates the efficacy of pyrazinamide in clearing out TB bacteria.
The Indian Institute of Science has fabricated a device to up-convert short infrared light to the visible range, utilizing a non-linear optical mirror stack made of gallium selenide. This innovation has diverse applications in defence and optical communications, including astronomy and chemistry.
Scientists at IISc have found a new series representation for pi that combines specific parameters in a way that rapidly arrives at the exact value of pi. This discovery could lead to practical applications in physics and potentially solve long-standing challenges in representing pi as a combination of mathematical components.
Researchers have identified spermidine as a key molecule that helps Salmonella survive inside macrophages by shielding it from oxidative stress. Targeting spermidine production with an FDA-approved drug, DFMO, may weaken the bacteria's ability to cause infection and improve survival rates in mice.
Scientists have designed a synthetic antigen that can stimulate antibody production against cancer cells. The approach uses a natural protein called serum albumin to carry the antigen, reducing the need for bulky carriers and side effects.
Researchers at IISc developed a novel hydrogel that can remove 95% of polyvinyl chloride and 93% of polypropylene microplastics from water. The hydrogel uses UV light irradiation and has a durable structure, making it suitable for repeated use.
A recent study has identified two distinct viral variants circulating in India, one with a low number of genetic variations and another with a high number of genetic variations. The latter variant is similar to LSDV strains from an outbreak in Russia in 2015, which may have contributed to the severity of the disease.
The Indian Institute of Science has developed new concrete materials using excavated soil, reducing the need for natural sand and minimizing carbon dioxide emissions. The innovative materials show improved compressive strength and reduced waste, offering a scalable solution to the construction sector's environmental challenges.
Researchers propose using coordinated multi-swarm drones to quell forest fires, leveraging AI-enabled fire detection and autonomous decision-making. The approach could lead to more efficient fire suppression and reduced response times.
The Indian Institute of Science team developed a novel technique to fabricate structurally colored films with a liquid gallium metal and polydimethylsiloxane substrate. These films change color in response to mechanical deformation, showing potential applications in smart bandages, movement sensors, and reflective displays.
Two new studies explore the link between attention and eye movements, showing that attention can be lost when objects change suddenly before gaze falls on them. Researchers also found distinct neuronal signatures in primate visual cortex for attention and eye movement signals.
Scientists at Indian Institute of Science have developed a synthetic human antibody that can neutralise a potent neurotoxin produced by highly toxic snakes. The new venom-neutralising antibody was created using an approach adapted from HIV and COVID-19 antibody screening, and shows efficacy nearly 15 times that of conventional antiveno...
A rapid diagnosis protocol using a luminescent paper-based platform has been developed to detect the presence of antibiotic-resistant bacteria. The approach uses a supramolecular hydrogel matrix containing terbium cholate that emits green fluorescence when UV light is shined on it.
Researchers found that ovarian cancer cells spread more easily in tissues that are senescent or aged due to the secretion of a unique extracellular matrix. This matrix attracts cancer cells and allows them to attach and spread faster, potentially leading to worse outcomes in older populations.
Researchers designed a synthetic antigen with high expression levels and stability, offering potential for quick adaptation to new variants. The vaccine candidate triggered strong immune response in animal models and showed enhanced protective efficacy.
Researchers found that logged forests have higher average temperatures and lower humidity, hastening the transition of bird species to higher elevations. Small bird species colonize logged forests better due to temperature tolerance, while larger species remain in primary forests.
Researchers found a single gene involved in iron-sulphur clusters crucial for TB bacterium's persistence. The IscS gene helps regulate the SUF operon, preventing hypervirulence and allowing the bacteria to survive harsh lung conditions.
Researchers at IISc create a novel technique to coat droplets in composite shells containing oil-loving and hydrophobic particles. This method offers flexible shell thickness control over a wide range, enabling the encapsulation of droplets with different sizes.
A new study from Indian Institute of Science finds that certain types of cancer cells respond well to IFN-γ activation, while others don't. The researchers suggest approaches to make non-responsive cancer cells better respond to immunotherapy by targeting their metabolism.
A team of researchers has devised a novel micro heat engine that can produce both high efficiency and high power at maximum efficiency, overcoming the Carnot limit. The study used a tiny gel-like colloidal bead and a laser beam to direct its motion, achieving an efficiency close to 95%.
A team of researchers found that fibroblast cells cultured on substrates with varying degrees of stiffness exhibit changes in cell structure, function, and TGF-β activity, which regulates ECM architecture. This study provides insights into how mechanical forces influence wound healing and tissue development.
Researchers at IISc have developed a novel method to improve pharmacokinetic properties of macrocyclic peptides, which are used in pharmaceutical industries worldwide. By substituting oxygen with sulphur in the backbone of these peptides, they increase resistance to digestive enzymes and lipophilicity, thereby boosting bioavailability.
Scientists at IISc have developed an enzyme mimetic called NanoPtA that can degrade toxic chemicals in industrial wastewater effectively in the presence of sunlight. The nanozyme is highly specific and robust, making it suitable for large-scale industrial use.
The IISc team developed a fully indigenous GaN power switch, comparable to state-of-the-art switches, with a switching time of about 50 nanoseconds. The device's performance is suitable for applications such as power converters for electric vehicles and laptops, as well as wireless communications.
Researchers at Indian Institute of Science create SQ-CARS, a scalable platform for advanced quantum experiments with superconducting transmon qubits, reducing cost and size.
Scientists at IISc have developed hybrid nanoparticles that can kill cancer cells using heat and enable their detection using sound waves. The nanoparticles combine the photothermal and oxidative stress properties of gold and copper sulphide, making them a promising approach for early detection and treatment.
Researchers used DNA-PAINT to study base-stacking interactions in DNA strands, finding that adding one more interaction increases stability by up to 250 times. This information allowed them to design a highly efficient three-armed DNA nanostructure with potential biomedical applications.
Scientists have discovered ancient ocean water trapped in mineral deposits in the Himalayas, providing insights into Earth's past climate and oxygen levels. The deposits suggest that slow-growing cyanobacteria may have triggered a major oxygenation event around 700-500 million years ago.
Researchers at IISc designed a short peptide that targets topoisomerases in disease-causing bacteria, including antibiotic-resistant species. The peptide effectively killed bacterial cells and reduced infection in animal models, providing leads for combination therapy with existing antibiotics.
Researchers at the Indian Institute of Science have discovered picolinic acid's ability to disrupt viral entry into host cells, blocking enveloped viruses like SARS-CoV-2 and influenza A viruses. The compound targets a host-derived component of the virus, causing permanent damage while minimizing effects on the host cell.
Researchers developed super flexible composite semiconductors using inkjet printing, outperforming previous studies with up to 40% polymer addition. The material maintains electronic transport properties while achieving high flexibility and foldability.
The study reveals that the GABA transporter structure is facing the cytosol and bound to a GABA molecule, sodium, and chloride ions. This binding mechanism is crucial for understanding GABA recognition and release into neurons.
A team of researchers at IISc has designed a small molecular fluorogenic probe that can sense Acetylcholinesterase (AChE), an enzyme linked to the progression of Alzheimer's disease. The probe is designed to detect AChE levels in the early stages of the disease, which become imbalanced.
A team from IISc has identified three key factors contributing to the lake's foaming: untreated sewage, surfactants that don't decompose, and heavy rainfall that churns up surfactant-laden sludge. The researchers propose removing accumulated sludge before rains and proper disposal to address this issue.