Researchers have identified six promising biomarkers that can detect drug-induced kidney injury earlier than traditional markers, enabling more timely monitoring during drug development. These biomarkers could lead to the development of safer medications and improve patient outcomes.
A recent study reveals that high-mobility group nucleosomal-binding domain 2 (HMGN2) plays a crucial role in glioma progression and serves as a potential biomarker for predicting prognosis. HMGN2 regulates cell cycle progression by binding to histones, enhancing transcriptional activity of proliferation-related genes such as CDC20.
A single-center retrospective study analyzed clinical data, imaging, histopathological manifestations, genetic testing results, and treatment effects in 48 WD patients. The study found age at diagnosis, K-F ring presence, and higher immunoglobulin G levels were associated with cirrhosis risk factors.
A study by Philip Kurian and colleagues reveals a revised upper bound on carbon-based life's computational capacity, connecting it to the universe's information-processing limit. The discovery of quantum superradiance in cytoskeletal filaments enables eukaryotic organisms to process information through tryptophan networks.
Researchers investigated the mechanisms underlying sexual dimorphism in cystinuria and found that mitochondrial Slc3a1 enhances mitochondrial functions by increasing NAD+ uptake. This suggests that restoring mitochondria in renal tubules may improve symptoms, leading to reduced cell death and fibro-inflammation.
Researchers at KIT develop a meta-grating that allows for four times more efficient light control than conventional systems. This technology enables targeted control of light waves, reducing the size and weight of optical systems.
A genetic twin study found that music enjoyment is partly heritable, with distinct genetic pathways influencing different aspects of music pleasure. The researchers discovered that DNA differences contribute to various facets of music enjoyment, such as emotion regulation and musical ability.
A new study found that repeated cold exposure improves autophagic function in young males, enhancing cellular health and increasing cellular cold tolerance. This research provides scientific backing for the potential health benefits of cold water immersion and suggests its potential to prevent diseases and slow down aging.
Khaled Abed Alghani's research reveals five key processes in managing industry platforms: creation, integration, orchestration, navigation, and evolution. Platform-based business models struggle in B2B industries due to complex relationships between businesses.
Scientists have used a cryo-electron microscope to capture detailed images of glutamate molecules interacting with AMPA receptors, revealing the chemical flow that enables learning and thinking in brain cells. The findings could lead to the development of new drugs to treat conditions like epilepsy and intellectual disorders.
New research published in The Journal of Nuclear Medicine explores ways to improve the diagnosis and treatment of metastatic breast cancer using Ga-NeoB PET/CT. Additionally, studies examine the potential of paraaminohippurate to reduce kidney toxicity during radiopharmaceutical therapy.
A recent study found that everyday physical activity does not slow bone loss during menopause, contrary to previous studies suggesting exercise can mitigate age-related bone weakening. Despite this, researchers believe more targeted exercise may help slow hormonal bone loss.
Experts from 22 research institutes evaluate optical technologies in photovoltaics to increase efficiency and enable new applications. Coloured solar modules for facades are identified as a promising innovation.
Researchers at Columbia University School of Engineering and Applied Science have developed a new biologically inspired bottom-up way for 3D electronics to build themselves using DNA. The technique allows for the creation of complex structures with nanoscale precision, which could lead to more powerful and dense electronic devices.
Researchers at Karolinska Institutet have developed a new method to diagnose COPD by analyzing protein levels in nasal lavage. The study found that elevated IL-26 levels can indicate an early phase of the disease, and may lead to new treatment strategies targeting this cytokine.
A study found that intermittent fasting increases sex drive in male mice by lowering serotonin levels, which is linked to tryptophan deficiency. The researchers suggest that similar mechanisms may exist in humans and view fasting as a potential approach for treating low libido.
Juan Gamella's mini-labs provide a flexible test environment for new AI algorithms, allowing researchers to test their performance beyond simulated data. The mini-labs help identify issues early on, enabling targeted improvements to underlying mathematical assumptions and algorithms.
A study by Boston University School of Public Health found that over half of US adults experience some form of discrimination, which can lead to higher chances of depression and/or anxiety. Discrimination-related mental health issues were particularly pronounced among multiracial, White, and Asian populations.
Researchers have created tiny robotic tools that can grip, pull and cut tissue in the brain using external magnetic fields. The tools, which are only a few millimetres in diameter, were tested on a phantom brain and found to make precise cuts with an average width of 0.3-0.4 millimetres.
This study analyzed changes in bacterial and fungal communities in the rhizosphere soil around GG2 treated with glyphosate, revealing temporary effects on diversity and richness. The integration of transgenic genes had no impact on microbial diversity, while seasonal changes and soil indices such as pH and organic matter significantly ...
Researchers propose GLDH as a more liver-specific biomarker for detecting liver injury, offering greater specificity than current ALT and AST tests. The test performed similarly to ALT for detecting liver injury but was not impacted by associated muscle injury.
Researchers from Emory University are using the International Space Station to study cardiac cells and accelerate the development of cell-based regenerative therapies. The team's findings have led to multiple peer-reviewed publications and could significantly advance methods to produce cardiac cells for heart disease treatment.
Researchers discovered that lipid accumulation promotes immune suppression and therapy resistance in triple negative breast cancer. Blocking Omega-6 fatty acid intake reversed treatment resistance. Disrupting lipid droplet formation also resensitized tumors to chemotherapy and immunotherapy.
The FAPESP Investigator Grant for International Researchers aims to recruit top talent globally to boost São Paulo's scientific and technological leadership. The call is open to researchers living abroad for at least 2 years, with a focus on leadership capacity and research potential.
Researchers develop a powerful model to study TDP-43 pathology, which accumulates in the cytoplasm and depletes from the nucleus, leading to neuronal death. The 'seeded' protein aggregates recapitulate key features of ALS and frontotemporal dementia.
The study aims to enhance tactile displays for the Metaverse, reducing power supply size and enabling wearability. The developed system uses a small 12V boost power supply, multi-channel piezoelectric IC, and software for controlling haptic sensation in multiple gradations.
Researchers explore spatio-temporal patterns of traditional and e-hailing taxis in Xiamen, China, identifying regional mobility patterns. The study reveals differences in spatial behavior between the two types of taxis, with implications for urban transport planning.
Researchers at Ohio State University have discovered a more efficient way to produce methanol from carbon dioxide, a cleaner alternative fuel. The new process uses a dual catalyst system, resulting in a 66% increase in efficiency and paving the way for sustainable technologies.
Researchers have confirmed a neurobiochemical link between dopamine and cognitive flexibility through PET imaging, showing increased dopamine production with cognitively demanding tasks. This finding may lead to the development of more precise treatment strategies for neurological and psychiatric disorders.
A new class of zwitterionic phospholipids, DOPE-Cx, enhances the functional delivery of mRNA via lipid nanoparticles, overcoming endosomal escape and improving mRNA expression. This breakthrough paves the way for advanced therapeutic applications, including mRNA vaccines, cancer treatment, and protein replacement therapy.
A team of physicists at Rice University has made a breakthrough in understanding the behavior of strange metals by leveraging quantum information theory. Electron entanglement peaks at a critical transition point, shedding new light on the exotic properties of these materials.
The University of Texas at Arlington expert discusses the state's largest outbreak in 30 years, with fewer people getting vaccinated contributing to its spread. The MMR vaccine is 97% effective against measles and has been proven safe despite misconceptions about its safety.
A recent study by the CNIO Melanoma Group has discovered a mechanism by which melanomas evade immune system surveillance. The research found that melanoma cells secrete Midkine, a protein that reduces dendritic cell numbers and reprograms their function to promote tumour development.
The Endocrine Society expresses concern over the administration's plan to reorganize HHS, slashing federal funding and staff, which will hinder medical discoveries and approve new treatments. The society warns that politicization of scientific grants will harm millions of people needing medical care for endocrine conditions.
The University of Malaga will coordinate an international consortium, 'X-SeeO2', aiming to hasten the use of cements as carbon dioxide sinks. The €4 million project aims to reduce CO2 emissions and promote the circular economy by upcycling waste.
The peer review process in biomedical journals is expected to undergo a significant transformation with the integration of artificial intelligence (AI) by 2025. AI will assist editors in making decisions on which articles to send out for external peer review, potentially increasing efficiency and effectiveness.
Young and midcareer scientists in the US face potential cuts to government funding, but can leverage this time to explore new possibilities and opportunities for innovation. The article provides guidance on navigating a successful bioscience career amidst anticipated funding cuts.
Two molecular control factors, GPATCH1 and DHX35, ensure accurate splicing by recognizing and rejecting defective pre-mRNAs. This process prevents the production of incorrectly synthesized proteins.
Researchers at HKUST established a pre-OPN OTI model to investigate functional axonal rewiring following CNS injury. They found that intrinsically photosensitive RGCs mediate functional recovery, and proposed a dual-intervention strategy to enhance regeneration efficiency
Researchers have studied the mechanism of action of bioactive compounds from papaya, passion fruit, and medicinal plant extracts. Modified pectins extracted from these plants show potential as supplements or food ingredients to boost biological activity against colon cancer and gut microbiota.
A comprehensive genomic and epigenomic analysis of ICE syndrome has identified key genes and epigenetic changes associated with the disorder. The study found significant associations between genetic variants and copy number losses in specific genes, as well as promoter hypomethylation leading to epithelioid hyperplasia.
Research reveals that organic fertilizers alter organic acids in the soil, modifying bacterial communities harboring pqqC and phoD genes. This leads to improved phosphorus solubilization and enhanced phosphorus utilization by plants.
A study analyzing nearly 270,000 seed plant species reveals environmental conditions, particularly climate, play a significant role in shaping global plant distributions. Physical barriers have a smaller effect on ancient plant groups that have had longer periods to disperse widely.
A recent study published in Science Advances found that oral contraceptive use in women is associated with changes in steroid hormone levels, while smoking in men is linked to altered levels of nearly every steroid hormone measured. The study also discovered a link between decreased androgens and various diseases in aging men.
Researchers have discovered that some fish, known as blue runners, hide behind sandbar sharks to launch high-speed attacks on smaller fish. The shadowing behavior improves their chances of success and may protect them from predators and conserve energy.
Göttingen research team develops infomorphic neurons that learn independently and self-organize among neighboring neurons. This allows the smallest unit in the network to control its own learning, enabling novel machine learning approaches and a deeper understanding of brain function.
A team of engineers has created a new hydrogel that rapidly switches between soft and hard states, making it ideal for real-time applications such as impact-resistant wearables or soft robots. The 'instant armor' hydrogel achieves this with a high-entropy design that allows rapid recovery in just 28 seconds.
A new project aims to analyze the hidden mechanisms of energy transition models, determining which narrative patterns are included and finding ways to make them more transparent and inclusive. By simulating future energy systems in real-world labs, researchers hope to remove uncertainties and mistrust surrounding the energy transition.
A team of researchers from the University of Pennsylvania School of Veterinary Medicine has made a groundbreaking discovery about the immune system's response to the latent stage of Toxoplasma gondii. The study found that certain T cells can target neurons containing cysts, promoting parasite control. However, this process also poses a...
A new study reveals that two dam failures and flawed risk assessment amplified the Derna Flood, which was nearly twentyfold more destructive than expected. The research highlights the urgent need for improved flood mitigation strategies, especially in dryland regions.
The PathActMarker R package infers pathway activity from gene expression data, allowing researchers to quantify dysregulation at the individual sample level. It provides eight state-of-the-art tools for pathway activity inference and analysis.
Researchers developed a 3D-printed hydrogel from cow meniscus tissue, customized to individual patient needs, offering a more precise solution for meniscus repairs. The treatment aims to outperform current methods, which often result in poor healing.
Researchers found that inhibiting S1pr3 reduces pulmonary fibrosis by reducing M2 macrophage polarization. S1pr3 inhibitors were also effective in ameliorating fibrosis in mice, suggesting a potential therapeutic strategy for humans.
William Murphy, a genomicist at Texas A&M University, was named the 2025 SEC Professor of the Year. He studies genome structure, function and evolution to understand genetic basis of species traits and diseases.
A professor is conducting a study to increase forest farming in Appalachia, with the goal of creating a sustainable economy for the region. The project aims to develop the workforce and formalize businesses to ensure efficient supply chains.
Researchers found that methanogens are modular hubs in microbial hierarchical webs, influencing soil organic matter and nutrient availability. The study highlights the importance of understanding microbial ecology in wetland ecosystems for conservation and sustainable development.
Researchers at University of Pittsburgh developed a new treatment approach for anthrax by reactivating the ERK pathway with a combination of growth factors. This method shows promise for treating the disease beyond its typical point of no return, offering hope for patients diagnosed late in the illness.
Researchers found that placing smartphones out of reach doesn't reduce distraction, as people shift attention to laptops. The study suggests that device usage is driven by habits and routines developed with devices, not the devices themselves.
The Ottoman Empire's recognition of diverse religions was a means to monitor and control non-Muslim populations. Research by Osaka Metropolitan University Associate Professor Masayuki Ueno found that this 'tolerance' was actually a form of control, utilizing public presence of religious diversity to conduct surveillance.
A UniSA-led study is trialing medication safety rounds in aged care homes to identify and address potential problems with medication use. The project aims to reduce medication-induced harm and improve residents' health and wellbeing through pharmacist-led safety rounds, adapting an existing palliative care need rounds model.