Researchers developed a blood test that accurately diagnoses Alzheimer's disease and measures its progression. The test correlates with the amount of tau aggregates in the brain, distinguishing between early- and late-stage diseases.
A recent study demonstrates gene therapy's potential to restore motor capacity in an ultra-rare disease, Megalencephalic Leukoencephalopathy with Subcortical Cysts (MLC), even after symptom onset. The treatment restored normal protein activity, normalizing physiological brain alterations and reversing motor impairments in treated mice.
The model analyzes host characteristics and virus genetics to predict potential reservoirs for orthopoxviruses, including smallpox and mpox. It identified Southeast Asia, equatorial Africa, and the Amazon as hotspots, overlapping with areas of low vaccination rates.
A study suggests that children were involved in creating prehistoric cave art due to their unique mental and cognitive traits, which allowed them to communicate with entities from the beyond. Children were believed to be liminal beings, bridging the gap between worlds, and delivering messages to non-human entities.
A new study from Intermountain Health shows the gap in heart disease outcomes between men and women is narrowing, with no significant differences by sex from 2015-2019. Women tend to have more comorbidities and stable chest pain, but less severe blockage and revascularization compared to men.
Researchers developed a stem cell-based system to mass-produce high-quality human mitochondria, overcoming a bottleneck in mitochondrial transplantation. The 'mito-condition' culture medium significantly enhances energy output and facilitates cartilage regeneration in osteoarthritis models.
A recent NIH-funded study found that rural adults experience higher rates of heart disease and its risk factors compared to urban counterparts. The study revealed that variables such as poverty, education, and access to healthcare do not explain these differences, with lifestyle risk factors like smoking also playing a lesser role.
Researchers at HKUST have developed an AI-assisted 3D food printing solution that combines printing with infrared cooking to produce safer and more visually appealing food. The system uses graphene heaters to precisely control the cooking process, ensuring shape retention and quality.
A groundbreaking study reveals that autistic children exhibit social attention patterns similar to their typically developing peers during play, with a primary focus on toys rather than faces. This challenges the longstanding assumption that reduced eye contact is a definitive marker of autism.
A new study by Binghamton University researchers suggests that individuals who identify as alt-right tend to be 'system justifiers' driven to maintain the status quo. These individuals believe that traditionalism facilitates order and are drawn to alt-right ideologies as an antidote to perceived or real insecurity.
A Kobe University study found that temperature at the plate interface predicts earthquake type, while a specific plate shape causes a seismic gap. Water released from rock transformation explains slow slip events and tectonic tremors, reducing stress between plates.
The Human Frontier Science Program has awarded fellowships to 50 emerging scientists from 25 nations, fostering life science research and international collaboration. The fellowships focus on cutting-edge projects, including research on memory engrams, coral reefs, and bacterial resistance.
All articles with at least one author based in Africa can now be submitted to the platform and will no longer require funding from a partnering research funder. This expansion aims to increase publication efficiency and improve the experience of African authors, while promoting the rapid sharing and discovery of high-quality research.
A study of 45,202 Norwegian young adults found that using a screen in bed increases the risk of insomnia by 59% and cuts sleep time by 24 minutes. The type of screen activity used does not appear to matter as much as overall screen use in bed, with social media being no more disruptive than other activities.
Hormonal contraceptives initiated immediately after childbirth may increase the risk of developing depression in new mothers. Researchers found that combined oral contraceptives were associated with a higher risk of depression when started earlier postpartum.
The Albert Einstein Jewish Brazilian Hospital launches a project to evaluate the application of quantum computing in developing new drugs and improving disease diagnosis. Researchers aim to use machine learning and quantum optimization algorithms to analyze rainfall data and predict heavy rainfall events.
Researchers have developed a method to remove and destroy per- and polyfluoroalkyl substances (PFAS) from water systems while transforming waste into high-value graphene. The process uses flash joule heating to break down PFAS, producing undetectable amounts of harmful volatile organic fluorides.
Researchers from Prof. Yardena Samuels's lab developed a new approach to cancer treatment by manipulating cancer cells to produce dozens of suspicious proteins, leading to a powerful immune response that destroys human cancer cells and slows tumor growth in mouse models.
A real-world multicenter analysis in China found that allogeneic hematopoietic stem cell transplantation significantly improved clinical outcomes for patients with triple-mutated acute myeloid leukemia. The procedure reduced relapse rates and increased survival probabilities, with most patients achieving complete remission before treat...
The American Thoracic Society's ATS 2025 International Conference will showcase cutting-edge research in pulmonary, critical care, and sleep medicine. The conference will include breaking news from leading experts in the field.
Researchers warn that thinner Arctic sea ice may lead to a tipping point in the AMOC, weakening global ocean circulation and impacting climate in Scandinavia. The Beaufort Gyre, an important feature of the Arctic Ocean, is currently losing large amounts of sea ice due to warmer temperatures.
Recent 'unprecedented' floods are not exceptional if looking further into the past, new research suggests. Geological palaeo-flood records reveal many previous floods exceeded modern peaks, highlighting the need for using these records in flood planning.
Researchers at Cornell University discovered that the FGR protein can induce cell differentiation in leukemia cells similar to retinoic acid treatment. The presence of FGR alone was enough to make these cells mature, producing well-known markers of maturation and expressing inhibitor of the cell cycle p27.
Astronomers have discovered a clear sign of reionization beginning significantly earlier than thought in one of the most distant galaxies detected by James Webb. The galaxy's Lyman alpha light suggests an ionized bubble, a telltale signature of the Universe becoming transparent.
A study estimated that healthcare travel generates approximately 35.7 megatons of CO2e annually in the US, accounting for about 6% of national healthcare-related emissions. The study found that patient travel in rural areas resulted in higher emissions per trip compared to urban areas
The discovery of Lophiostroma leizunia extends the fossil record of stromatoporoid reefs by 20 million years and sheds light on early biomineralization strategies. This ancient sponge, dated to approximately 480 million years ago, was found in Yuan'an, Yichang, South China, and is unique for constructing its skeleton using fluorapatite.
Researchers at UCalgary have discovered a protein called CD2AP that may hold the key to reducing Alzheimer's disease risk. Levels of this protein are lower in patients with AD, and its absence affects memory function, particularly in males. The study suggests a sex-dependent link between vascular system health and brain function.
A team of researchers describes the circumstances of a rare 2019 meteorite fall near Aguas Zarcas in northern Costa Rica, challenging the notion that mudball meteorites are weak. The recovered 27-kilogram meteorite, nicknamed 'Aguas Zarcas,' avoided collisions in space and did not exhibit cracks that weaken many meteorites.
A USC Stem Cell mouse study has identified shared genes involved in regenerating cells in the ear and eye, which could lead to new treatments for hearing and vision loss. The researchers discovered that inhibiting a specific protein, p27Kip1, can encourage regeneration in both organs.
Researchers are developing centrally acting catechol Omethyltransferase (COMT) inhibitors to treat cognitive impairment in certain neuropsychiatric disorders. The Lieber Institute's collaboration with Boehringer Ingelheim is exploring novel treatments for these impairments, which affect millions of people worldwide.
Researchers at Penn State are developing a next-generation synthetic blood substitute called Nano-RBC, which mimics the shape and movement of human red blood cells. The new blood substitute aims to address the shortage of safe blood sources quickly enough for trauma patients, with potential applications in rural or war-torn areas.
Researchers identified a brain signal involved in impaired attentional control from sleep deprivation that could predict worsened athletic performance. Athletes with stronger attention control may be more easily able to overcome the negative effects of lack of sleep and stress on their competitive performances.
Researchers developed a novel ZrO₂/ZrB₂/C nanofiber felt with ultralow thermal conductivity and exceptional electromagnetic wave absorption properties. The material achieved a maximum reflection loss of -54 dB and broad absorption bandwidth of 3.1 GHz, demonstrating excellent microwave absorption capabilities.
Swedish researchers have identified 20 genetic variants associated with an increased risk of atherosclerosis, a leading cause of cardiovascular disease. The study used advanced imaging techniques to examine millions of genetic variants, providing new insights into the disease process and potential ways to prevent it.
A recent study found that the protein tyrosine phosphatase delta (PTPRD) acts as a suppressor of the pro-inflammatory STAT3 pathway in liver cells, regulating lipid and glucose metabolism and protecting peroxisomal function. Reduced PTPRD expression was associated with signs of liver dysfunction and metabolic syndrome in humans.
A large-scale study found that limiting fluid intake in patients with stable heart failure has no health benefits and may even cause increased thirst. Conversely, drinking more fluids without restriction did not lead to any negative outcomes, suggesting that fluid restrictions are unnecessary for these patients.
The BHF PROTECT-TAVI trial found no reduction in stroke rate for patients undergoing TAVR with an embolic protection device. Despite its large sample size, the study showed that cerebral embolic protection devices do not improve outcomes for TAVR patients.
A new approach, Robust Self-training with Label Refinement (RSLR), tackles the challenges of noisy labels in source domains. RSLR uses a Labeling Network to refine pseudo-labels for target samples, improving performance on extensive benchmark datasets.
This study investigates the hepatorenoprotective effects of Lepidium draba L. extracts against cyclophosphamide-induced oxidative injuries in rats. The results show that the extract reduces apoptosis and inflammation, while increasing antioxidant activities.
Researchers have introduced a novel method called E2URec to address the need for LLM-based recommenders to forget specific user data while maintaining performance. The approach significantly reduces computational cost and time associated with unlearning.
Ligustroside reduces intracellular tyrosinase activity and melanin content by suppressing the MAPK and PKA/CREB signaling pathways. It also downregulates critical melanogenic markers like MITF, tyrosinase, and TRPs.
This population-based study found that 0.5% had carotid artery stenosis, while 44.4% had carotid plaque among 194,878 adults in China. Risk factors for both conditions included hypertension, diabetes mellitus, stroke, and smoking.
A large randomized controlled trial found no significant difference in health status between patients with restricted and unrestricted fluid intake. Despite this, patients on fluid restriction reported more thirst and had lower overall health scores at baseline compared to those with liberal fluid intake.
A minimally invasive procedure using a clip to repair the tricuspid valve significantly reduced symptom severity and decreased recurrent hospitalization for heart failure. The study found a 28% reduction in hospitalizations at two years, with improved safety and effectiveness compared to medical therapy alone.
A new study has found that clopidogrel outperforms aspirin monotherapy in reducing heart attack rates without increasing bleeding risk in high-risk patients following percutaneous coronary intervention (PCI). Researchers observed a significant reduction in ischemic endpoints, primarily driven by a decrease in heart attacks.
A new study found that survival rates for athletes suffering sudden cardiac arrest vary significantly by race, with 57% of Black athletes and 54% of other race athletes dying between 2014-2023. Improved emergency preparedness likely played a role in increased survival rates.
Research by the Max Planck Institute reveals how nematodes can shift to 100% predatory behaviour over 101 generations in response to dietary changes. The study highlights the role of multi-generational genetic memory and microRNA involvement in shaping evolutionary adaptations.
A study found that intravenous iron supplementation resulted in a 20% lower risk of cardiovascular death or first heart failure hospitalization, as well as improved symptoms and quality of life. The benefits were most pronounced in the first year after treatment, suggesting a meaningful association between iron dosage and outcomes.
Patients who received nurse-led follow-up care had a 30% lower rate of cardiovascular death, non-fatal heart attacks, or strokes at five years compared to those receiving standard care. This was achieved through improved lifestyle habits and medication adherence.
Early IABP use did not improve 60-day survival or transition patients to long-term treatment compared to standard medical care. The trial found that the device offered no additional benefit, leading to its early termination.
Patients with severe triple-vessel heart disease showed no significant difference in outcomes between CABG and PCI at five years. The FAME-3 trial enrolled 1,500 patients with triple-vessel disease and found that both procedures performed similarly well, considering recent advances in surgical and minimally invasive techniques.
Researchers have developed a new solver, PBCounter, that can efficiently count weighted models on pseudo-Boolean (PB) formulas. The algorithm uses dynamic programming and Algebraic Decision Diagrams to solve the problem. Experiments show that PBCounter outperforms existing solvers on CNF formulas.
A study found that pulse oximeter readings underestimated blood oxygen levels in patients with dark skin pigment, but also showed a positive bias in 20% of observations. The results suggest that future devices could be designed to indicate uncertainty and improve accuracy across different skin pigmentation categories
A novel AI-powered imaging technique, AngioFFR, has been shown to be comparable to conventional FFR assessment in evaluating patients for PCI. The study found that patients treated with AngioFFR-guided PCI had similar clinical outcomes as those treated with IVUS-guided PCI.
A new transcatheter valve has shown high survival rates and improved quality of life in patients with aortic regurgitation. The trial found an overall mortality rate of 8.1% at one year, meeting non-inferiority to open heart surgery outcomes.
Researchers developed a conformal programmable metasurface that generates Orbital Angular Momentum (OAM) waves at millimeter-wave frequencies without external spatial excitation. The design mitigates feed leakage radiation and realizes low-profile configuration, enabling next-generation wireless communication and space-based applications.
A new mobile integrated health program delivered in-home visits from paramedic teams to people with heart failure did not significantly reduce hospital readmissions or improve health status compared to standard follow-up phone calls. However, the study found that women and younger patients may benefit more from this intervention.
Patients with low surgical risk undergoing transcatheter (TAVR) or surgical aortic valve replacement (SAVR) show comparable death, stroke, and reintervention rates at five years. The study found that TAVR is as effective as surgery in improving symptoms, functional class, and overall quality of life.
Researchers found that banks referred for violations are significantly more likely to engage in risk-heavy strategies and speculative lending. Stronger boards with larger and more independent membership can dampen the negative impact of misconduct.
A new report calls for the integration of play into children's healthcare, highlighting its benefits in reducing stress, anxiety, and improving psychological health. The study synthesizes evidence from over 120 studies and suggests that embedding play in healthcare settings could improve long-term outcomes for children.