Researchers at Dana-Farber Cancer Institute have identified a potential targeted therapy, avapritinib, for pediatric high-grade gliomas. The treatment resulted in tumor reduction and clinical improvement in 3 out of 7 patients with this currently incurable form of brain cancer.
Despite severe sleep deficits, insomniac fruit fly mutants exhibit enhanced memory performance through altered PKA signaling in the mushroom body. This finding suggests a complex relationship between sleep and memory functions.
Researchers challenge traditional view that cool temperate rainforests are fragile ecosystems, finding they depend on disturbance for survival. The study found Antarctic beech trees grew faster and recruited more successfully after higher disturbance levels.
Researchers at Institute for Systems Biology (ISB) have discovered a non-genetic adaptation mechanism that allows melanoma cells to evade BRAF inhibitors within hours. By blocking this early response with a combination therapy approach, the study aims to improve treatment outcomes and prolong the effectiveness of existing treatments.
The Lupus Research Alliance has awarded grants to 11 researchers working on engineered cell therapies for lupus. These studies focus on developing safer and more effective treatments using techniques such as CAR T cells, which involve reprogramming a patient's own immune cells to attack disease-causing cells.
The updated guidelines substantially increased lung cancer screenings overall, but disparities persist among people with limited access to healthcare. Barriers include cost, knowledge, and lack of primary care providers, with mobile units and patient navigators offering potential solutions.
A new study suggests that dividing average daily heart rate by steps taken per day provides a more reliable indicator of cardiovascular fitness. People with elevated DHRPS were twice as likely to have Type 2 diabetes and more than 1.5 times as likely to have high blood pressure compared to those with lower DHRPS.
Researchers identified that conservative tree species, which conserve resources rather than extract them, have a greater potential to fix carbon in biomass under real-world conditions. In favorable climates and fertile soils, acquisitive species grow faster but fix less carbon.
The event will feature major announcements in AI-driven networking, 1.6T advancements, quantum technologies, and next-gen optical innovations. Over 13,500 attendees are expected, with nearly 100 California-based companies participating.
Researchers have developed a method to produce biodegradable plastics called polyhydroxyalkanoates (PHAs) using methane-consuming bacteria. The production rate has been optimized to achieve high PHA yields, resulting in plastics with commercial quality and unique infrared signatures.
Researchers at Northwestern University have identified a previously unobserved function of Exportin-1, a protein that promotes gene transcription and stimulates stronger gene expression. This discovery could aid in the development of new medications to stymie cancer growth without harming healthy cellular function.
Researchers found that humanizing police officers through recruiting materials can increase potential candidates' interest in policing as a career. Exposure to humanizing videos led to increased shared identity with police officers, promoting greater interest in a policing career.
Restricting telehealth prescriptions for opioid use disorder could keep thousands from accessing buprenorphine, a medication that helps people recover from addiction. Researchers found that requiring in-person visits may undo the progress made during the COVID-19 pandemic when telehealth increased access to this life-saving treatment.
Two Indian hospitals, Apollo Hospital in Hyderabad and Aster Hospital in Calicut, have been certified as Comprehensive Stroke Centers by the American Heart Association. These centers meet rigorous standards for stroke care, including advanced imaging and treatment capabilities. This certification is part of the Association's efforts to...
A systematic review of theoretical mechanisms breaking the CEP constraint through contextual differences and pairwise encounter models. These innovations support hundreds of species in natural ecosystems like aquatic environments.
A study found that a topical formulation combining Kalonji (Nigella sativa) and Sirka (vinegar) showed therapeutic potential in treating mild to moderate acne vulgaris. The formulation was compared with a 5% benzoyl peroxide gel, with promising results but limitations such as a small sample size and short duration.
Scientists have captured the first detailed molecular movie of DNA being unzipped at the atomic level, revealing how cells copy their genetic material. The discovery has significant implications for understanding viral and cancer replication.
Researchers have developed a mercury-free method to isolate lithium-6, essential for producing nuclear fusion fuel. The new method uses zeta-vanadium oxide and achieves enrichment rates comparable to the banned COLEX process, paving the way for unlocking nuclear fusion as a sustainable energy source.
Researchers at Schmidt Ocean Institute have discovered vibrant communities of ancient sponges and corals in the wake of recently detached iceberg A-84. This observation sheds new light on the resilience and adaptability of Antarctic ecosystems.
Collagen from natural sources like bovine, porcine, and marine collagen improves skin hydration, elasticity, and appearance. Synthetic collagen variants offer alternative sources with enhanced purity and functionality, used in various cosmetic products.
A new study found that pregnant women who received preventive oral health care had a lower risk of developing gestational diabetes and hypertensive disorders. The research highlights the importance of integrating oral health education and services into maternal healthcare, particularly in underserved populations.
Researchers developed DeepCeres, a software that uses AI tools to measure 27 structures of the cerebellum with improved precision. This will help in studying neurological pathologies such as ALS, schizophrenia, and Alzheimer's diseases.
The Alliance for Genomic Discovery has completed sequencing 250,000 whole genomes, providing a comprehensive clinical genomic dataset. This data is being leveraged to accelerate drug target discovery and therapeutic research.
The European Lung Cancer Congress 2025 will take place in Paris from March 26-29, featuring renowned experts discussing the latest research on lung cancer prevention, diagnosis, and treatment. The congress will also include award lectures and live streaming of the event.
A study found that women who underwent bilateral oophorectomy were more likely to develop heart failure later in life. The researchers suggest that early menopause may be a contributing factor to this increased risk, and recommend closer cardiovascular monitoring for women contemplating the procedure.
A new USF study identifies several viruses associated with Karenia brevis, the single-celled organism causing red tide. The finding marks an initial step toward exploring viruses as biocontrol agents for red tide blooms.
Compound K exhibits anti-aging properties by enhancing skin barrier function, preventing photoaging, and regulating autophagy. It also protects against mitochondrial dysfunction and promotes tight junctions between keratinocytes.
A large-scale study found that patient pain upon arrival and placement in hallway beds are associated with poorer patient experience in EDs. On the other hand, receiving radiology studies generates more positive experience scores. Understanding these underlying factors can help improve patient outcomes and experiences.
Researchers at Graz University of Technology developed a new understanding of how complex materials like organic semiconductors and MOFs transport thermal energy. They discovered that phonon tunneling plays a crucial role in heat conduction, enabling targeted design of materials with specific thermal properties.
Researchers found that people who later experienced persistent shortness of breath or fatigue had significantly fewer steps per day and a higher resting heart rate before contracting the virus. These findings suggest a link between lower fitness levels and preexisting health conditions in long COVID patients.
Yale scientists have developed a new CRISPR-Cas12a tool that allows simultaneous assessment of genetic interactions on various immunological responses to multiple diseases, including cancer. This enables researchers to study complex genetic interactions and their effects involved in many disorders.
A new study reveals a cell atlas of the endometrium in women with PCOS, showing distinct differences in cellular composition and gene expression. The findings suggest that targeting specific cell types may lead to better treatment options for women with PCOS and related reproductive issues.
A new study from the University of Chicago suggests that patterns of activity in the brain continually reshape memories, even after learning has occurred. Researchers found that behavioral timescale synaptic plasticity (BTSP) is a key driver of this process, explaining the dynamic shifting of place cells in the hippocampus.
Scientists have discovered peptides that bind irreversibly to the transcription factor cJun, permanently blocking its action in cancer cells. The study uses a new screening platform technology and has shown promising results for developing new cancer treatments.
Researchers from RIKEN Center for Emergent Matter Science have discovered a groundbreaking way to control superconductivity by adjusting the twist angle of atomically thin layers. This allows for fine-tuning of the superconducting gap, which is crucial for optimizing Cooper pair behavior and developing high-functionality quantum device...
A new clinical guideline from the American Gastroenterological Association suggests that artificial intelligence-assisted colonoscopy may improve polyp detection rates, but its impact on preventing colorectal cancer remains uncertain. The guideline recommends a cautious approach to widespread adoption, emphasizing the need for further ...
A study published in JCAP has established upper limits on the strength of quantum gravity effects on neutrino oscillations, providing valuable insights into the long-sought theory. The results show no signs of decoherence, a phenomenon that could be a key indicator of quantum gravity's presence.
Antarctic krill exhibit sudden changes in behavior when exposed to the water-borne smell of penguin poo, showing increased speed, turns, and reduced foraging efficiency. This 'zigzagging' is an avoidance reaction that may increase their odds of survival in a swarm.
Researchers found that collective cell movement exhibits robust invariance across diverse systems, including cancer cells and bacteria. This discovery could lead to improved understanding of oncological diseases and tissue engineering, as well as applications in robot navigation and artificial intelligence.
A new study introduces a unified framework to assess the impact of air pollution on ecological health, highlighting rising PM2.5 concentrations in developing countries and declining levels in developed nations. The study provides real-time data to examine the interconnection between air pollution and ecological quality.
Small regional live music venue operators are experiencing stress and burnout due to challenges with audience access and fairly paying performing artists. The study highlights the impact of rising public liability costs, rent, and energy prices on venues' bottom line. Solutions include localised approaches, music feedback forums, and d...
A new study introduces Greylag Goose Optimization (GGO) algorithm, combining it with a seven-level inverter to enhance MPPT and reduce THD, ensuring stable and high-quality power supply for agricultural machinery.
Scientists at the University of South Australia have developed a phospholipid complex to improve cannabidiol's effectiveness in treating epilepsy, multiple sclerosis, and other neurodegenerative diseases. The new formula increases cannabidiol's solubility by up to six times and improves its absorption in the gastrointestinal tract.
A team led by Dr. Marcus Botacin is creating a large language model (LLM) to automatically identify malware and write rules to defend against it. The LLM will use signatures to complement human analysts' skills, identifying malware faster and more accurately.
The new DESI results show that the impact of dark energy may be weakening over time, suggesting a fundamental shift in how we think about dark energy. The collaboration's findings are consistent with other measurements, including supernovae and the light left over from the dawn of the universe.
Researchers studied the musky rat-kangaroo's movement patterns, observing a unique 'bound' gait that differs from other marsupials. The findings suggest a potential pathway to the evolution of bipedal hopping in kangaroos, with future studies informed by fossil discoveries.
A clinical trial shows that removing amyloid plaques from the brain can delay Alzheimer's symptoms, supporting the amyloid hypothesis. The treatment reduced the risk of developing dementia in people destined to develop early-onset Alzheimer's disease.
Research led by a UCL academic found that people who share more meals with others are more likely to report higher levels of life satisfaction and wellbeing. The study analyzed data from over 150,000 respondents in 142 countries and found that meal sharing is as strong an indicator of life satisfaction as income.
Researchers at UCL identified key brain regions involved in remembering words, finding shrinkage in the front and side of the brain linked to difficulty recalling words. Detailed MRI scans showed a dispersion network for creating and storing word memories, crucial for understanding epilepsy conditions.
Researchers developed a microfluidic device to alleviate limitations of conventional blood-filtering machines used in treating hyperleukocytosis in children. The new device separates blood cells by size without platelet loss or adverse effects, enabling safe leukapheresis procedures.
Dr. Owen Witte has been awarded the 12th annual Harrington Prize for Innovation in Medicine for his groundbreaking work on leukemia, lymphoma, and other cancers. His discoveries have led to life-saving therapies like Gleevec and ibrutinib, transforming cancer treatment.
Scientists have developed a new gene replacement therapy in mice that alleviated symptoms without side effects, offering long-term recovery for patients. The therapy targets the SCN1A gene, which plays a crucial role in regulating brain activity, and shows promising results in treating Dravet syndrome.
A study found that delirium prevalence at SNF admission decreased from 4.3% to 2.5% between 2014 and 2019, with a significant reduction in persistent delirium among female, frail, and dementia subgroups.
A new study reveals that dance can facilitate emotional expression and foster social bonds, creating a powerful buffer against stress. By incorporating dance into weekly routines, individuals can enhance their resilience and improve overall wellbeing.
A new study found that doctors and patients agree on the urgency level of emergency department visits only about 38% to 57% of the time. Researchers explored concordance between discharge diagnoses and reasons for visit, finding that nearly 40% of visits are not medical emergencies.
A new gamified mobile health app, More Stamina, has been shown to effectively manage MS-related fatigue by helping users track their daily activities and energy expenditure. The study found that the app facilitated conversations between MS patients and their families, improving understanding and support.
Crew-9 astronauts conducted research on protein crystallization studies and a new drug for Alzheimer's, dementia, and Parkinson's. They also supported student-led experiments, contributing to the next generation of explorers.
Researchers at Oregon State University have developed uniquely shaped, fast-heating nanoparticles that can effectively treat ovarian tumors. The nanoparticles exhibit exceptional heating efficiency when exposed to an alternating magnetic field, raising temperatures by 3.73 degrees Celsius per second.
A recent study suggests that long COVID-19 cases can result in significant annual costs of $5,084 to $11,646, primarily due to productivity losses and direct medical expenses. The estimated total cost for current long COVID cases in the US is between $2.01 billion and $6.56 billion annually.
Researchers at St. Jude Children's Research Hospital found that removing the 'signal jammer' protein VDAC2 can improve how tumors respond to immunotherapy. This breakthrough could lead to new ways to enhance immunotherapies and make them more effective in treating resistant cancers.