A Swedish registry study found that IBD patients with multiple close relatives having colorectal cancer are significantly more likely to develop the disease. The study suggests that future cancer screening guidelines should consider the number of cancer cases in a patient's family.
A study found that SGLT2 inhibitors increase the risk of ketoacidosis in patients with type 2 diabetes who have high blood glucose, low body weight, or a history of ketoacidosis. The risk persists throughout treatment duration, highlighting the need for better support for high-risk patients.
A new study from Karolinska Institutet suggests that breast cancer classification may overlook important biological differences between patients that could affect treatment decisions. Women with tumours having low to moderate levels of estrogen receptors have poorer survival rates, highlighting the importance of precise classification.
Two new studies from Karolinska Institutet suggest that inflammation and genetic factors may contribute to cluster headache, a rare neurological disorder characterized by severe headache attacks. The studies also found that exposure to substances in tobacco smoke may interact with biological mechanisms in the condition.
A hospital-based intervention combining training, quality improvement, and leadership support has been shown to reduce stillbirths and newborn deaths in sub-Saharan Africa. The study, published in Nature Medicine, found a 22% decrease in early perinatal death and a 19% reduction in oxygen-deprivation-related complications among newborns.
Researchers found that active participation in colorectal cancer screening was associated with a 43% lower risk of dying from the disease, compared to just a 26% lower risk for those invited to screening. This study highlights the importance of taking part in colorectal cancer screening to save lives.
A study from Karolinska Institutet found that older adults with longer meal intervals accumulated chronic diseases more rapidly than those with shorter intervals. The association was strongest among people aged 78 years and older, and was linked to faster accumulation of cardiovascular and neuropsychiatric diseases.
Researchers at Karolinska Institutet discovered that gut bacteria convert dietary nitrate and iron into protective molecules, such as dinitrosyl iron complexes, which may improve cardiovascular and metabolic health markers. These findings suggest a previously unknown mechanism by which a specific diet and gut bacteria can promote health.
Researchers developed Pasta, a tool estimating cell biological age from gene activity, identifying substances influencing aging and potential treatments. The tool was tested on 17,000 tissue samples and validated in laboratory experiments, revealing genes linked to DNA damage and cellular stress.
A study from Karolinska Institutet found that people treated with modern NOAC blood-thinning medicines experienced a slower rate of cognitive decline compared to those receiving warfarin or no anticoagulant treatment. This was associated with lower risk of other health problems, including death, stroke, and fractures.
A new oral drug AC01 has been shown to improve heart function and be well-tolerated in patients with chronic heart failure. The study found no serious side effects and suggested potential clinical benefits, warranting further investigation.
A pilot study found that immunotherapy can stimulate egg maturation in women with autoimmune POI, leading to healthy births in three out of ten cases. The treatment involves rituximab, an approved drug for autoimmune conditions and cancers, which suppresses the autoimmune process and activates the remaining egg reserve.
A new blood test, Stockholm3, detected significantly more aggressive prostate cancers than the PSA test without increasing unnecessary follow-ups. The study shows that Stockholm3 identifies 90% of aggressive cancer cases, compared to 74% for PSA.
Fathers who take longer periods of parental leave, up to 14-40 weeks, are less likely to develop depressive symptoms than those with shorter leave. This is because sustained time at home helps build a closer connection with their child and establishes everyday routines.
Systematic reviews and meta-analyses rely on complete data, but many studies lack underlying data. This can lead to unreliable results and assumptions that are difficult to verify. Researchers argue for clearer data sharing requirements to strengthen trust in research and reduce the risk of erroneous conclusions.
A new study from Karolinska Institutet found that neutrophils, a type of white blood cell, can dampen the effect of immunotherapy in cancer treatment. When neutrophils were absent, several immunotherapies became more effective, leading to increased T-cell activation and tumor shrinkage.
A new study by Karolinska Institutet shows that daily smartphone-based heart rhythm monitoring can reduce same-day cardioversion cancellations by 94.7% and save significant healthcare resources. The method, called CORAI, uses photoplethysmography to measure small changes in blood flow, allowing for accurate heart rhythm assessment.
A recent study by Karolinska Institutet researchers found that semantic knowledge plays a vital role in human innovation, enabling individuals to create new connections between objects and ideas. The study showed that groups with access to both semantic knowledge and social learning produced more unique innovations than those with only...
A single dose of psilocybin provided rapid relief from depressive symptoms within a few days, with effects persisting for over three months. The treatment showed a significant advantage over SSRIs, with an average reduction of 9.7 points on the MADRS scale.
Researchers treated 75 children with peanut allergies using slow up-dosing and low maintenance dosing. After three years, 82% of the treatment group could eat at least 3.5 peanuts without an allergic reaction.
A new study from Karolinska Institutet shows that low doses of endoxifen reduce breast density to the same extent as tamoxifen without causing severe side effects. The results suggest a lower dose may be sufficient for therapeutic effect while being better tolerated.
A new study from Karolinska Institutet found that small abnormalities in blood sugar, lipids, and inflammation years before pregnancy are associated with an increased risk of high blood pressure during pregnancy and pre-eclampsia. The findings may contribute to earlier risk assessment and preventive measures.
A new vaccine strategy has generated antibodies capable of neutralising highly divergent HIV variants in an animal model. The study provides new insights into how the immune system can be guided towards a particularly protected part of the virus, which is important for developing an effective HIV vaccine.
A Swedish study of siblings found that adopted children who grew up in more favourable family environments had lower risks of mental health issues, criminality, and social problems. These benefits extended to the next generation, with adopted children's offspring displaying higher functioning and lower risks.
A new study finds that blood protein levels change markedly over the course of a lifetime, rendering adult reference values inadequate for children and adolescents. Gender differences also emerge, particularly after puberty.
Scientists at Karolinska Institutet have created a new method to produce insulin-producing cells from human stem cells, effectively regulating blood sugar levels in laboratory tests and reversing diabetes in mice. The optimized production process yields more mature and purer cells, demonstrating their potential for future treatments.
A new study finds that people with long COVID are at a higher risk of developing cardiovascular diseases, including cardiac arrhythmias and coronary artery disease. The study shows that women with long COVID have twice the risk of receiving a cardiovascular diagnosis compared to women without the condition.
A collaboration between Karolinska Institutet and Karolinska University Hospital has integrated whole genome sequencing into routine diagnostic investigations for rare diseases. This approach has enabled the diagnosis of a genetic cause in 23% of patients, with diagnoses involving variants in over 1,500 different genes.
Researchers at Karolinska Institutet have mapped immune gene variation across multiple global populations, identifying common genetic variants that affect antibody production. The findings may contribute to understanding infection susceptibility and inform vaccine design.
A new study published in Journal of the American College of Cardiology found that digital CBT significantly reduced cardiac-related anxiety and improved patients' quality of life and physical function after a heart attack. The treatment showed stable benefits up to one year after completion.
A new study published in JAMA Pediatrics finds that children with obesity but without metabolic complications still face a significantly increased risk of developing type 2 diabetes, high blood pressure, and abnormal blood lipid levels later in life. Treatment can greatly benefit these children, reducing the risk of future diseases.
A new study published in JAMA Network Open reveals that fathers' mental health declines over time after the birth of their child, with increased risk of anxiety and substance abuse diagnoses returning to pre-pregnancy levels. However, depression and stress-related disorders continue to rise by over 30% one year after childbirth.
The study compares remaining life expectancy at age 75 for women and men in Sweden and Japan, finding that older Japanese individuals generally have lower mortality than Swedes. However, this difference is primarily observed among those receiving some form of elder care, with Japanese women expected to spend more years in elder care.
A new study from Karolinska Institutet found that older people with a genetic risk of Alzheimer's disease who consume relatively large amounts of meat have a lower risk of cognitive decline and dementia. The study also shows that the type of meat is important, with a lower proportion of processed meat associated with a lower risk of de...
A large cohort study found that people using anticholinergic medications, commonly prescribed for urinary incontinence and anxiety, have a higher risk of developing cardiovascular disease. The cumulative use of these drugs was associated with an increased risk of heart failure and arrhythmias.
A study published in European Heart Journal found that nearly half of hospitalised heart failure patients are readmitted within a year, with the risk of death also remaining high. Patients with severely reduced heart function face the highest risk, highlighting the need for careful follow-up and tailored care.
Daily exercise and protein-rich drinks showed significant health benefits for people with dementia. Participants improved physical ability and required less care time in dementia wards compared to control groups. The study suggests that improved function can affect the amount of support needed.
A new study published in Gastroenterology has investigated the link between ulcerative proctitis and rectal cancer, revealing no increased risk in patients with isolated proctitis. The study followed nearly 16,000 people with ulcerative proctitis for over ten years, finding a low incidence of rectal cancer and precancerous lesions.
Researchers at Karolinska Institutet created the first activity-based maps of the prefrontal cortex, revealing a hierarchy of information flow rather than tissue structure. This challenges traditional definitions of brain regions and has major implications for understanding brain organisation overall.
A Swedish study published in JAMA Neurology found that prolonged air pollution exposure is associated with a higher risk of developing motor neuron disease, including ALS. Long-term exposure to even low levels of air pollutants was linked to faster disease progression and increased mortality rates.
A new blood test has identified a protein signature linked to cancer in patients with non-specific symptoms. The test distinguishes cancer from other conditions with high precision and can help prioritize patients for further diagnostics.
Researchers have identified a new method to predict asthma exacerbations with a high degree of accuracy, analyzing data from three large asthma cohorts. The study found that the ratio between sphingolipids and steroids was the most powerful predictor of future health.
Researchers have developed a web-based tool to identify people at risk of developing chronic kidney disease through subtle abnormalities in kidney function. The study shows that individuals with an eGFR below the 25th percentile had a markedly higher risk of developing kidney failure.
Research reveals that fat located near the colon contains an unusually high number of inflammatory fat cells and immune cells, suggesting a unique function in communicating with the immune system in the gut region. This tissue may be an adaptation to the gut microbiome and could contribute to amplifying or sustaining inflammation.
A new study from Karolinska Institutet reveals the Epstein-Barr virus can damage the brain and contribute to multiple sclerosis through molecular mimicry. The researchers found that cross-reactive T cells are significantly more common in people with MS, and targeting these cells may lead to new treatments.
Research from Karolinska Institutet found that alpha frequency determines body ownership by modulating temporal integration of bodily signals. Faster frequencies led to higher temporal resolution, while slower frequencies caused broader timing differences.
A new study from Karolinska Institutet reveals that long-term type 2 diabetes can cause red blood cells to become directly harmful to blood vessels. The researchers found that microRNA-210 plays a crucial role in this process, and its levels in red blood cells may serve as a biomarker for early detection of cardiovascular complications.
A new study from Karolinska Institutet identified seven blood biomarkers that predict the risk and progression of multimorbidity in older adults. These biomarkers reflect biological processes such as metabolism, inflammation, and neurodegeneration.
Researchers discovered that microglia's TGF-beta signaling acts as a brake, preventing nerve fibre damage in ageing spinal cords. This protective mechanism may contribute to the development of certain neurological diseases.
A new study published in JAMA Oncology found that the HPV vaccine can protect against severe precancerous lesions of the vulva and vagina. Vaccination before the age of 17 offers the strongest protection, with a 55% lower risk compared to unvaccinated women.