Scientists at Karolinska Institutet have found a new way chromosomes are repaired after damage, contrary to the long-held view that cohesion only occurs during cell division. The discovery shows cohesin reactsivate when DNA breaks, allowing cells to fix damaged sister chromatids.
Researchers at Karolinska Institutet discovered that microRNA molecules, specifically miR-203, are significantly upregulated in psoriasis and may be involved in regulating keratinocytes. This study suggests that microRNA therapies could become more effective than traditional medicines targeting individual proteins.
A new study reveals an alternative distribution mechanism in female sex cells that cause chromosome disorders, leading to infertility and irregular numbers of chromosomes. This fundamental mechanism may help explain the common occurrence of such disorders in females.
Endogenous cannabinoids play a crucial role in establishing nerve cell connections, which may be impaired by maternal cannabis use. This discovery bolsters knowledge of normal brain development and sheds light on potential cognitive deficits in offspring.
A new study from Karolinska Institutet shows naprapathy to be more effective in reducing back and neck pain, with 57% of patients reporting significant improvement after 12 weeks. The therapy combines manual manipulation and muscle treatments, offering a potential alternative to conventional medical advice.
A large cohort study found that using Swedish moist snuff (snus) increases the risk of developing pancreatic cancer by twice the rate of non-users. The study, conducted on almost 300,000 male construction workers, suggests that while the risks are small, snus use can still be a concern for overall health.
The Structural Genomics Consortium has determined the 3D structure of PARP3, a protein of significant relevance to diseases such as cancer, inflammation, and metabolic disorders. The available data can accelerate early-phase drug development projects and contribute to a better understanding of disease mechanisms.
Scientists at Karolinska Institutet have discovered a mechanism controlling how the brain maintains equilibrium in neuronal activity. A rare cell type, Martinotti cell, acts as a safety device by sending inhibitory signals to surrounding pyramid cells when activated excessively.
Scientists at Karolinska Institutet identified a crucial role of Dll4 in blood vessel formation through angiogenesis. The study found that Dll4 signalling determines the number of sprouts and branches formed, which is essential for tissue health and disease prevention.
A new study from Karolinska Institutet found that consuming fizzy drinks and sugary foods significantly increases the risk of developing pancreatic cancer. The study followed almost 80,000 healthy individuals over eight years, discovering that those who drank high-sugar beverages regularly had a 90% higher risk of developing the disease.
Researchers at Karolinska Institutet found that omega-3 fatty acid supplements slowed cognitive decline in a subgroup of patients with very mild Alzheimer's disease, while no effect was seen in those with more advanced disease. The study suggests that omega-3 supplements may be beneficial in halting initial progression of the disease.
A major study from Karolinska Institutet found that eating fatty fish like salmon, sardines, and mackerel at least once a week reduces kidney cancer risk by up to 74% over a decade. The study also highlights the protective effects of omega-3 fatty acids and vitamin D in fatty fish.
Researchers at Karolinska Institutet found that mast cells can contribute to diseases like psoriasis and cancer through a previously unknown activation mechanism. The study suggests that the CD30 protein stimulates mast cell release of proteins regulating inflammatory cell recruitment.
Researchers at Karolinska Institutet in Sweden and Makerere University in Uganda have identified how the malaria parasite conceals itself in the placenta, paving the way for a potential vaccine. The study found that several receptors on the placenta are involved in binding to the parasite, contrary to previous laboratory studies.
A Swedish HIV vaccine trial has shown that over 90% of subjects developed an immune response to HIV after receiving the vaccine, demonstrating a high level of protection against the virus. The study's results are promising and could lead to further clinical trials in Africa.
Research at Karolinska Institutet reveals that human neocortical nerve cells do not regenerate, contradicting previous studies on apes and rodents. The new method uses atmospheric C14 levels to pinpoint cell birth times, showing no cell division took place in the neocortex from infancy to adulthood.
Researchers have created a new genetic model for Parkinson's disease using mice with a deleted TFAM gene, which mimics the human condition. The study shows that dopamine-producing nerve cells in the brain stem degenerate slowly, similar to humans with Parkinson's disease.
A new study found that neurosurgical treatment of severe anxiety disorders can be effective in relieving symptoms, but also carries a significant risk of side-effects such as apathy and epilepsy. The study monitored 51 patients for up to 23 years after undergoing capsulotomy, a procedure that involves severing nerve fibers in the brain.
New research from Karolinska Institutet reveals the role of substances like cytokines and leukotriene B4 in inflammation and arteriosclerosis. The study identifies three enzymes that contribute to the formation of LTB4, a powerful chemotactic substance that reinforces inflammation.
COPD and asthma are major economic burdens on Swedish society, with annual costs totaling SEK 9.1 billion and SEK 3.7 billion respectively. These lung diseases significantly degrade quality of life, especially severe cases of COPD and asthma.
Researchers have discovered a protein complex called Smc5/6 that plays a crucial role in repairing damaged DNA and untangling chromosomes before cell division. The complex is involved in two distinct pathways, one for repair and the other for untangling, and its function has significant implications for understanding genetic stability.
Researchers have identified a signal transduction process regulating stem-cell division, which could lead to drugs stimulating endogenous cell production. The discovery may help treat conditions such as stroke and Parkinson's by promoting the formation of new nerve cells.
Researchers discovered that an endogenous peptide called LL-37 plays a critical role in preventing urinary tract infections. Boosting LL-37 levels may provide a new way to prevent UTIs and offer a defense against the infection.
Researchers at Karolinska Institutet have identified a short peptide molecule that can vaccinate and protect against the spread of tumours from different tissues, including melanoma, colon cancer, lymphoma, and fibrosarcoma. The study points towards new possible ways of developing a treatment for advanced tumour diseases.
Two genes, Lmx1a and Msx1, play a critical role in forming cerebral dopamine cells. This discovery can be used to control the formation of dopamine-producing cells from stem cells in a highly effective manner, representing an important step towards a stem-cell-based treatment for Parkinson's Disease.
A study by Karolinska Institutet found that alcohol consumption significantly increases the risk of violent behavior, with a 13.2-fold higher risk within 24 hours. Use of certain medications, such as benzodiazepines and antidepressants, was associated with a decreased risk of violence.
Researchers identify 64 genes used to separate breast cancer patients with good and poor prognoses. The technique of DNA microarray analysis could help predict patient response to adjuvant therapy, avoiding unnecessary treatments.
A new study from Karolinska Institutet found an inverse relationship between the birth weight of a baby and the risk of cardiovascular diseases among fathers, suggesting genetic factors may be at play. The study also revealed that mothers of babies with low birth weights are more likely to develop cardiovascular disease.
Multiple short exposures to wet work can cause more dermatitis than single long exposures, emphasizing the need for preventive measures. Reducing frequent and intense exposure of hands to water, detergents, and soaps is crucial in preventing hand eczema.
A six-week cycling study found that regular exercise activates hundreds of genes in young, healthy men, some linked to diabetes and cardiovascular disease. The study also showed that individuals who improved their performance most activated more genes in the muscles, a phenomenon not previously seen.
Research suggests that moderate drinking enhances new nerve cell formation in adult brains, which may contribute to long-term effects of alcohol on the brain. The study's findings have sparked interest in understanding the role of these new cells in cerebral activity and their potential link to addiction.
Researchers have discovered two new experimental drugs that target peroxisome proliferators-activated delta receptors (PFAARä) in muscle cells, increasing glucose absorption and boosting energy production. The findings offer a potential alternative to insulin therapy for patients with Type 2 diabetes.
A new study published in Epidemiology found no correlation between prenatal ultrasound exposure and reduced intellectual capacity. Researchers analyzed data from approximately 180,000 boys born in the 1970s, revealing small differences that could be attributed to other factors.
Researchers identified a gene variant that increases the risk of rheumatism, MS, and myocardial infarction by 20-40%. The discovery may lead to more reliable diagnostics and better treatments for patients.