A recent survey found that 40% of community pharmacists have dispensed off-label medicines to children in the last month, with only 66% feeling responsible to inform parents. The most common off-label dispensing involves giving drugs to children younger than recommended ages or higher doses.
Five Oregon Health & Science University faculty members have been honored with the 2007 OHSU Faculty Senate Awards. The winners include Michael Danilchik for groundbreaking research on early morphogenesis, William Hersh for developing a respected academic program in biomedical informatics, Carol Christlieb for exceptional service to nu...
A study reveals that hemoglobin levels vary among dialysis patients due to negative feedback control systems and individual sensitivity to ESA treatment. The analysis suggests optimizing treatment systems on a rational basis to reduce variation in hemoglobin values and stabilize dose regimens.
A recent study has found that Bernese Mountain Dogs are more susceptible to Borrelia burgdorferi infection than other breeds. More than half of the dogs tested were infected, with antibodies against B. burgdorferi found in 58% of those studied.
Scientists at McMaster University have made a groundbreaking discovery about human embryonic stem cells, finding they can generate fuel to sustain themselves. This breakthrough has significant implications for future clinical therapy, as it could lead to the development of new treatments for diseases such as Parkinson's and diabetes.
A study by Shinshu University Graduate School of Medicine found that high-intensity interval walking may protect against high blood pressure and decreased muscle strength in older adults. Walking is a legitimate mode of exercise that doesn't require special equipment or membership, according to Dr. James Levine.
Scientists at Fred Hutchinson Cancer Center discovered a modified version of antimycin that selectively kills cancer cells with high levels of survival proteins Bcl-2 and Bcl-xL. The compound's unique mechanism provides a therapeutic window, making it a potential targeted molecular therapy to enhance cancer treatment effectiveness.
Immune cells use filopodia to catch pathogens, with the internal scaffolds growing and shrinking through actin filaments. Researchers tracked the dynamic behavior of these structures for the first time in three dimensions, revealing discrete steps of retraction and a possible molecular mechanism underlying it.
Researchers found that each doubling of a program's scale can reduce costs by around a third, making it a cost-effective strategy to prevent more HIV infections. Larger prevention programs use money more efficiently than smaller ones, with some large programs being ten times more efficient.
Research at Harvard Medical School found that uninsured adults before age 65 require more intensive and costlier care than those with private insurance. This can lead to costly complications and reduced health needs after age 65.
Researchers found that consuming diets with a higher glycemic index increased the risk of developing advanced AMD, with severity linked to dietary glycemic index. The study suggests improving dietary carbohydrate quality through simple alterations may help prevent AMD progression.
A daily pint of milk reduces the risk of metabolic syndrome by 62%, while regular dairy consumption lowers the risk by 56%. The study found that around one in seven men had the syndrome at entry into the study, with those who consumed more dairy produce having a lower risk.
Researchers at St. Jude Children's Research Hospital discovered that treating tumors with bevacizumab first and then administering topotecan therapy after improved tumor blood flow can significantly reduce cancer growth, holding promise for improving treatment for children with neuroblastoma.
A team of UO researchers found that human memory has a four-item limit, varying from person to person, with high IQ individuals able to think about more things at once. The study contradicts the assumption that those who can remember more items have clearer memories.
A twin study published by Monell Chemical Senses Center found that genes account for 53% of the variation in sour taste sensitivity, suggesting a genetic component to individual differences. This discovery may help identify the elusive taste receptor for sourness and inform strategies for promoting healthy eating.
Researchers found that commercially important species take a quarter of a century to recover fully, while ecological equilibrium takes even longer to achieve. Fish recovery rates vary among species due to competition for resources.
A recent study published in BMC Health Services Research found that larger HIV prevention programs in low and middle-income countries can reduce unit costs of prevention services by up to a third. By rapidly scaling up well-run existing programs, the study suggests that more HIV infections may be averted.
Researchers developed a predictive model using Bayesian network modeling to estimate sickle cell disease severity and predict mortality risk. The model identified laboratory markers and clinical events contributing to the risk of death, providing a personalized disease severity score for therapeutic decisions.
A study suggests that taxing high-fat foods in the UK could prevent up to 3,000 heart attack and stroke deaths annually. This approach would increase salt intake instead of reducing it, leading to potential health issues.
The 'Focus: Science and Law' section in Isis explores the intersection of science and law, examining how courts shape scientific theories and practices. Scholars discuss topics such as intellectual property legislation, witness testimony verification, and the commercialization of research.
A Cornell study found evidence of recent human adaptation, with 101 regions of the human genome showing strong selection signs. These include genes related to skin pigmentation, muscle attachment, and immune system function.
Food crops like corn, lettuce, and potato take up antibiotics from soils treated with manure containing the antibiotic Sulfamethazine. This raises concerns about the potential for contamination of the human food supply, particularly among vulnerable populations like young children who may experience allergic reactions.
Researchers found Ago2 necessary for normal blood cell development, but its role is independent of slicer activity. Ago2 regulates miRNA biogenesis in blood cells through translational control.
A study published in JAMA Network found that antibiotic treatment after a first urinary tract infection (UTI) in children may not reduce the risk of recurrent UTIs, but increases the risk of resistant infections. The study identified risk factors for recurrent UTI and estimated the effectiveness of antimicrobials in preventing recurrence.
A new study by Brandeis University recommends routine screening in primary care for mental health and substance abuse problems. This can help identify more people with behavioral health conditions, leading to earlier treatment.
Researchers at Biodesign Institute have received nearly $9 million in grants to develop a preventive vaccine against breast cancer. The team aims to identify common signatures across various breast tumors using genomics, proteomics, and immunology.
A new study identifies adiponectin as a long-term regulator of energy homeostasis, boosting appetite and slowing energy expenditure in the brain during periods of starvation. Adiponctein helps preserve adequate fat reserves by acting as a starvation signal.
A new special issue of Integrative Cancer Therapies Journal presents research on milk thistle's liver-protective effects and its potential as an anticancer agent. The studies suggest that silymarin, the active compound in milk thistle, can preserve liver function and provide clinical benefits for cancer patients.
A study published in the Journal of the National Cancer Institute found that nearly 80% of Kaposi sarcoma tumors arose independently from multiple cells. This challenges the traditional understanding of cancer origins, suggesting that Kaposi sarcoma is not a true metastatic cancer.
Researchers measured the effect of hepatitis B on patients' quality of life, creating a new tool to better assess overall well-being. The study found that psychosocial impact affected many patients more than physical symptoms, underscoring the need for clinicians to consider social and psychological factors in treatment.
Researchers developed a new drug delivery method using ultrasound to target cancer tumors, releasing chemotherapy drugs from nanobubbles. They found this approach was more effective at blocking tumor growth than other nanoparticle delivery methods. Vitamin D levels were also associated with reduced colon cancer risk in a separate study.
The NSF has chosen Homestake as the site for a multipurpose deep underground science and engineering laboratory. The facility will host a comprehensive suite of experiments across various fields of science, including low background physics and particle physics.
A meta-analysis of 29 studies found that incretin-based therapy improves glycemia, particularly postprandial glycemia, and has a favorable or neutral effect on weight. However, glucagon-like peptide 1 analogues are associated with gastrointestinal adverse effects, while DPP4 inhibitors have an increased risk of infection.
Preliminary research suggests that hydroxychloroquine reduces the risk of developing type 2 diabetes in patients with rheumatoid arthritis. The study found a 38% lower risk among those taking hydroxychloroquine, which increased to 77% for longer-term users.
A study by University of Missouri-Columbia researchers reveals a shift in the communication discipline towards more women authors and collaborative research. The study found that articles by female authors outnumbered those by men around 2000 and that single-authored articles have decreased significantly since the 1960s.
A study found a significant association between the Western-style 'meat-sweet' diet and an increased risk of breast cancer among postmenopausal Chinese women, particularly those with estrogen receptor-positive tumors. The research suggests that low consumption of this dietary pattern may protect against breast cancer.
A new model of early evolution directly connects population fitness to protein properties, resolving a key molecular evolution mystery. The study finds that survival depends on the stability of the least stable proteins, leading to an uneven distribution of fold and gene family sizes.
A combination of calcium and vitamin D found in milk may offer protection against type 2 diabetes, with a 15% lower risk among individuals consuming the most dairy. Additionally, magnesium intake from milk products may also reduce type 2 diabetes risk by 15%.
A new study found that measuring retinol-binding protein 4 (RBP4) levels in blood can indicate the amount of visceral fat surrounding abdominal organs. Elevated RBP4 concentrations are linked to insulin resistance, type 2 diabetes, and heart disease risk.
Researchers discovered a genetically engineered herpes simplex virus reduces smooth muscle cell proliferation and restores endothelial layer in arteries following angioplasty. This study provides an important step towards treating vascular disease with genetically engineered viruses.
Researchers found that prenatal cocaine exposure in zebrafish altered neuronal development and acutely dysregulated the expression of circadian genes, including melatonin. Circadian factors may provide new therapeutic strategies to counteract developmental effects of prenatal cocaine exposure.
Researchers found that 90% of monitored newscasts included at least one instance of stealth advertising, with an average of 2.5 individual slots per newscast. The study aimed to gauge the extent of material with commercializing effects on newscasts and viewers.
A new study found that patients treated with HCQ were less likely to develop diabetes, and those who did were more likely to manage their disease without medications. The medication may also be suitable for people at high risk of developing diabetes as a preventive therapy.
A Yale University study published in Archives of Internal Medicine found that top-ranked hospitals may not necessarily provide better care for heart attack patients. The research compared death rates among patients treated at both ranked and non-ranked hospitals, revealing a surprising disparity between the two groups.
Postmenopausal Asian women who consume a meat-sweet Western diet are at higher risk of developing breast cancer compared to those on a vegetable-soy diet, according to the study. The researchers found that high intake of the meat-sweet pattern increased estrogen-receptor-positive breast cancer among overweight postmenopausal women.
Researchers suggest golf course habitats can be improved by creating diverse pond types that mimic natural wetlands, reducing chemical runoff and insect predators. Drying ponds in the fall also benefits amphibians by eliminating bullfrog tadpoles that outcompete other species.
Researchers at Carnegie Mellon University have developed two systems that use web images to enhance edited photos. Photo Clip Art uses labeled images from LabelMe as clip art, while Scene Completion draws upon millions of photos from Flickr to fill in holes. These systems enable users to achieve realistic results with minimal skills.
The FDA review found no strong association between eating tomatoes and decreased cancer risk, but some limited evidence for associations with prostate, ovarian, gastric, and pancreatic cancers. The agency allowed qualified health claims for these four cancers, citing very limited and preliminary scientific research.
A new study has identified a key genetic function involved in wing formation in fruit flies, providing insight into the internal laws regulating embryo development. The research uses mathematical modeling to simulate biological systems and confirms the stability of this gene network across evolution.
A study by Elizabeth J. Susman found that kids who prefer evenings are more likely to exhibit antisocial behavior, rule-breaking, and attention problems. Earlier puberty is linked to more antisocial behavior in boys and relational aggression in girls.
The study found that vaginal bacterial communities differ greatly among women, with at least eight distinct types, each unique to a specific racial group. Understanding these differences is crucial for developing effective treatments and preventing infections, including those caused by HIV.
Gro Amdam, an assistant professor at Arizona State University, has been awarded the "Outstanding Young Investigator" award from the Research Council of Norway for $1.6 million over four years to support her research on honeybees.
A new Illinois-based study has found that Miscanthus is more productive than switchgrass in terms of biomass production, with Miscanthus gaining 33% more carbon and having a greater leaf area. This research has implications for the development of sustainable bioenergy crops.
Three QUT researchers, including Dr Joanne Voisey, have received Smart State Fellowships to develop a genetic test for schizophrenia diagnosis and a polymer bandage for treating burn-related scars. Dr Martens will work on purifying water using nano-technology.
Researchers found that simple, low-literacy interventions increased discussions about prostate cancer and led to more men receiving screening tests. These findings suggest that empowering patients through patient interventions can effectively promote discussion of prostate cancer.
The study found that 75 percent of US adults will be overweight by 2015, with minority groups and those from lower socioeconomic backgrounds facing the greatest disparities. The research highlights the need for targeted interventions to address the growing obesity crisis in the United States.
Researchers at Dana-Farber Cancer Institute have identified a gene and protein known as PRDM16 that controls the production of brown fat, a type of adipose tissue that generates heat and counters obesity. The study suggests that turning up this switch in humans could be a new strategy for treating overweight and obesity.
The March of Dimes reports that nearly 90% of US babies are screened for life-threatening disorders, up from 38% in 2005. However, 500,000 babies remain uninsured, highlighting the need for federal guidelines and increased funding to support states' newborn screening programs.
Researchers successfully formed a single chemical bond on a single molecule, then broke it without disturbing adjacent atoms. They created a molecular-sized electronic switch with reversibility achieved.
Researchers at Carnegie Mellon University and Harvard University found that perceived neediness, rather than race, drives charitable giving to Hurricane Katrina victims. Within subgroups of whites, racial bias affects giving to blacks, while non-identifying whites give more to blacks.