A new inherited neurometabolic disorder has been discovered, caused by mutations in the ADK gene. The disease, adenosine kinase deficiency, disrupts the methionine cycle, leading to symptoms such as encephalopathy and abnormal liver function.
Researchers at Karolinska Institutet have found that treating common Cytomegalovirus (CMV) can reduce tumour growth and size. CMV is found in 70-75% of adults and plays a central role in brain tumours, breast cancer, colon cancer, and prostate cancer.
Scientists at Karolinska Institutet found that fat cells in overweight people have a higher capacity for storing fats but a lower capacity for ridding themselves of them. This can lead to an accumulation of triglycerides and cholesterol in the blood, increasing the risk of metabolic diseases.
Researchers monitored two million anonymous mobile phones after Haiti's earthquake and cholera outbreak, providing real-time data on population movements. The method improved humanitarian aid delivery by tracking the migration patterns of people in need of help.
A recent study published in Science has discovered that the majority of scar cells in spinal cord injuries are derived from pericytes, not glial cells. This finding suggests that modulating pericyte activity could potentially stimulate functional recovery after CNS damage.
Scientists at Karolinska Institutet discovered that a gene linked to dyslexia, DCDC2, regulates cilia signaling in brain neurons. This finding presents a possible new neurobiological mechanism for dyslexia and highlights the importance of cilia in cell migration and development.
A Nordic multicentre study found that pelvic organ prolapse surgery using synthetic mesh can restore genital anatomy and provide efficient symptom relief. However, the study also revealed an increased risk of complications with this method compared to traditional surgery.
The study reveals that the brain's amygdala plays a key role in triggering an automatic reaction to unfairness, even when rational thinking suggests otherwise. The findings have significant implications for our understanding of human behavior and decision-making processes.
A team of scientists at Karolinska Institutet has identified a key component in mitochondria's function, which combines with another protein to control ribosome formation and energy production. The discovery sheds light on the regulation mechanisms involved in inherited and age-related diseases.
Researchers at Karolinska Institutet discovered that dopamine controls the formation of new neurons in the adult brain by acting as a switch for stem cells. The study used salamanders, which can recover from Parkinson's-like conditions, to understand how dopamine regulates neural regeneration.
Researchers used carbon dating to determine the age of carotid plaques in humans, finding that plaque formation occurs during a relatively short and late time period in life. The study also found an association between low plaque age, higher insulin levels, and instability.
A study published in PLoS ONE found that simulated acupuncture, also known as placebo, was just as effective as real acupuncture in reducing nausea in cancer patients undergoing radiotherapy. The researchers suggested that the benefits may be due to patient expectations and extra care received during treatment.
Researchers from Karolinska Institutet have discovered that specific inflammatory substances called leukotrienes play a crucial role in the development of aortic stenosis. The study found that anti-inflammatory medication may be a promising new treatment for the disease, which affects millions of people worldwide.
Researchers found caspase enzymes control microglial activation, triggering inflammation and neuronal death in neurodegenerative diseases. Caspase inhibitors showed promise in reducing activated microglia and inflammation in mice.
A Swedish study found that sunlight influences the body's ability to break down medicines, with seasonal variations in drug concentrations closely linked to vitamin D levels. This may lead to increased sensitivity to certain medications, highlighting a new model for understanding individual differences in drug effects.
A new thesis from Karolinska Institutet highlights the importance of parental involvement in preventing adolescent alcohol consumption. Adolescents who exhibit risky behavior at an early age are more likely to develop high consumption patterns and associated health problems. Parents can make a significant difference by strengthening th...
A novel study reveals that a protein complex (Smc5/6) helps release torsional stress during DNA replication, shedding light on heredity dynamics and potential new cancer treatments. The findings may lead to the development of drugs targeting Smc5/6, providing another tool for inhibiting tumour growth.
Researchers have developed a cell therapy that selectively dampens vascular inflammation induced by LDL, showing substantial protective effects against atherosclerosis. The treatment has been shown to reduce the disease process by up to 70 percent in mouse studies.
A new study reveals that free radicals act as signal substances that increase the heart's contractions with the correct force. Persistent stress can lead to chronic levels of free radicals, potentially contributing to heart failure.
Researchers identified heparin as the underlying mechanism that initiates the production of bradykinin, contributing to swelling, anaphylactic, and inflammatory symptoms associated with aberrant mast cell activity. This discovery provides a new strategy for treating allergic diseases by blocking bradykinin or factor XII activity.
Researchers can manipulate the brain's perception of its own body, allowing for new prosthetic limbs and virtual reality experiences. This technology has significant implications for fields like medicine, psychology, and robotics.
Swedish scientist Laura Fratiglioni's research shows that active mental, physical, and social activities can preserve cognitive functions and lower the risk of developing dementia. Factors such as blood pressure, weight, and genetics also play a role in determining an individual's risk.
Karolinska Institutet, a leading medical university in Sweden, has attracted top American researcher Juleen Zierath with its high-quality research environment and competitive ERC grant. She focuses on improving diabetes health through clinical research.
New research from Karolinska Institutet shows that nitrate improves mitochondrial function in humans, consuming less oxygen and producing more ATP per molecule. This finding has significant implications for sports physiology and may also have positive effects on diseases involving mitochondrial dysfunction.
The EurocanPlatform project aims to find more effective ways to prevent, detect and treat cancer. By combining resources and expertise, researchers hope to identify patients at risk for cancer and adapt therapies to individual circumstances.
A Swedish case study reveals how Alzheimer's disease progresses, with high amyloid plaque levels at early stages and declining brain energy. The discovery sheds light on the role of nicotinic receptors and neuroinflammation in the disease, offering new insights for diagnosis and treatment.
Researchers discovered that asthma drugs can block cysteinyl-leukotrienes, reducing vessel wall breakdown and dilation. This could lead to the development of new treatments for aortic aneurysms, potentially saving lives and reducing surgical complications.
Researchers at Karolinska Institutet used MRI to measure brain lactic acid levels and found increased levels before other aging symptoms, suggesting a potential indicator of aging and age-related diseases. The study also suggests a link between mitochondrial dysfunction and lactate production in the brain as aging progresses.
The study reveals new insights into how the egg interacts with sperm at fertilization, providing potential clues to infertility and potentially leading to non-hormonal contraceptives. The research was conducted by Luca Jovine's team at Karolinska Institutet and has important implications for human reproductive medicine.
Researchers at Karolinska Institutet have found a potential solution to the blood-brain barrier problem, allowing for the transport of molecules into the brain while preserving basic functions. The discovery, led by Professor Christer Betsholtz, could lead to new therapies for Alzheimer's and stroke.
Researchers at Karolinska Institutet have discovered how stem cells and other cells repair damaged spinal cord tissue in mice. The study identified ependymal cells as a key player in this process, which is crucial for developing therapies for spinal cord injury.
Researchers from Karolinska Institutet are contributing to ESOF 2010 with presentations on topics like neuroscience, intellectual property management, and Parkinson's disease treatment. The university is also organizing workshops and seminars on topics such as entrepreneurship and the future of research.
A new method of antibiotic prophylaxis has been developed to reduce the risk of infection in patients undergoing percutaneous endoscopic gastrostomy (PEG) operations. The routine involves giving a combination of sulfamethoxazole and trimethoprim directly into the PEG-catheter after surgery, resulting in equivalent results with reduced ...
The Wallenberg Institute for Regenerative Medicine (WIRM) at Karolinska Institutet will focus on pioneering research in the blood system and stem-cell therapy, aiming to treat diseases like diabetes, spinal injuries, and neurodegenerative conditions. The grant strengthens the institute's infrastructure with advanced technical equipment...
Researchers at Karolinska Institutet have successfully cultured human embryonic stem cells under chemically controlled conditions without the use of animal substances. This breakthrough enables large quantities of human embryonic stem cells to be produced in a completely defined environment, paving the way for future clinical uses.
A DNA-vaccine targeting DLL4 inhibits the formation of new blood vessels in tumours, leading to reduced tumour growth. The vaccine was shown to be effective in mice with breast cancer, causing a tightly packed network of non-functional blood vessels and poor blood supply.
Researchers at Karolinska Institutet developed a new method for collecting narcotic substances from exhaled breath, which was successful in detecting amphetamine and metamphetamine in all cases of emergency care patients.
A study at Karolinska Institutet found that the dopamine system of healthy, highly creative people is similar to that of people with schizophrenia. High creative skills are also linked to a higher risk of certain mental illnesses. The study suggests a possible mechanism behind creativity and mental health.
The LifeGene project uses Sweden's comprehensive health registries and genetic data to study the origin of disease, exploring interactions between environment, lifestyle, and heredity. The initiative gathers health and lifestyle information from 500,000 Swedes, aiming to improve diagnostics, treatments, and preventative recommendations.
Researchers at Karolinska Institutet have developed a vaccine that can block the immune reaction causing atherosclerosis, reducing disease by 60-70%. The vaccine targets T cells reacting to native LDL particles, reversing previous findings on antioxidants' ineffectiveness against cardiovascular disease.
A team of researchers at Karolinska Institutet has discovered a crucial role for NKT cells in regulating B cell activation and preventing autoimmunity. This finding provides new insights into the mechanisms underlying autoimmune diseases, such as MS and rheumatoid arthritis.
A new study from Karolinska Institutet finds that the limbic striatum, an evolutionarily old part of the brain, is involved in implicit learning of motor sequences. This discovery sheds light on fundamental learning systems shared with primitive vertebrates and has implications for developing treatments for diseases like Parkinson's.
Researchers have discovered that an enzyme found in white blood cells can break down carbon nanotubes into harmless components. This breakthrough finding has significant implications for the future use of carbon nanotubes in medicine, potentially rendering them harmless and reducing toxicity.
Researchers found that a certain form of body fat inflammation is necessary for fat cell turnover in lean, healthy individuals. This challenges the theory that inflammation in adipose tissue only causes insulin resistance and type 2 diabetes.
New research from Karolinska Institutet found that radiotherapy can increase the risk of cardiovascular disease later in life due to sustained inflammation in arteries. The study suggests that post-radiotherapy changes in gene expression may be the cause of this increased risk, which can appear years after treatment.
Researchers at Karolinska Institutet identified the role of VEGF-B protein in regulating fatty acid transport proteins in blood vessel walls, leading to increased fat intake and potential new treatments for metabolic diseases. The study found that blocking VEGF-B signalling may reduce insulin resistance and blood glucose levels.
A clinical trial conducted by researchers from Karolinska Institutet found that eprotirome, a thyroid-hormone-like substance, effectively reduces blood cholesterol levels in patients who have already received statins. The trial showed significant reductions in harmful blood fats, up to 30% lower than those of patients receiving a placebo.
Researchers at Karolinska Institutet have discovered that stem cells can connect with and rescue threatened neurons through direct contact via gap junctions. The findings suggest a new possible treatment approach for brain damage and neurodegenerative diseases.
Researchers at Karolinska Institutet have created a genetically modified mouse that can walk when exposed to blue light. The study provides insight into the neural control of locomotion and has potential implications for treating spinal cord injuries.
Researchers at Karolinska Institutet have identified a new way to block blood vessel formation and halt tumour growth in mice. The discovery focuses on the ALK1 receptor, which is activated by TGF-β proteins that stimulate angiogenesis in tumours.