Researchers developed an antibody blocking coagulation factor XII, which prevents thrombosis without increasing bleeding risk in clinical settings. This innovation reduces the clotting risk in emergency situations like ECMO treatment and cardiovascular surgery.
A large international study identified an 'invisible-risk' group of adolescents with psychiatric symptoms, despite low risk behaviours being overlooked by parents and teachers. The study found that 13% of adolescents were classified as 'high-risk', while a third group showed similar prevalence of mental health issues.
A large registry study found that up to half of transport accidents involving adult men with ADHD could be avoided if they were taking medication. The results demonstrate a significant decrease in risk of serious transport accidents among men with ADHD who received medication, with a 45% increased risk compared to those without ADHD.
A study published in the EMBO Journal found that cannabis consumption during pregnancy can lead to defective nerve cell development, affecting higher cognitive functions and memory formation. The study identified THC as a key contributor to these developmental deficits.
A new method allows for large-scale generation of high-quality human embryonic stem cells from excess IVF embryos, increasing the supply for potential therapies. This breakthrough method enables production of stem cells without destroying embryos, making it a significant step forward for stem cell research.
A new study from Karolinska Institutet found that the risk of relatives developing multiple sclerosis is lower than previously thought. The study analyzed data from over 28,000 individuals diagnosed with MS in Sweden, revealing a seven-fold increased risk for siblings and a five-fold increased risk for children of MS patients.
Researchers at Karolinska Institutet have identified a new gene, GRHL3, responsible for the most common form of cleft lip and palate syndrome, Van der Woude syndrome. The study found that mutations in GRHL3 may be associated with an increased risk of clefts in non-syndromic cases.
Researchers at Karolinska Institutet have successfully treated two babies in utero with mesenchymal stem cells, a type of connective tissue cell that can form and improve bone tissue. The treatment was administered to babies born with osteogenesis imperfecta, a rare congenital bone disease causing stunted growth and repeated fractures.
A new study published in Blood journal presents a Swedish cancer drug candidate that inhibits tumour growth and prolongs survival in preclinical multiple myeloma models. The substance also kills multiple myeloma cells from cancer patients and overcomes resistance to clinically used drugs.
An international team of researchers at Karolinska Institutet in Sweden have discovered a new mechanism that regulates the way blood vessels grow and connect to each other. The discovery provides essential insights into vascular development and could lead to new opportunities for cancer therapy.
Researchers found that two salamander species have distinct ways of regrowing muscles, with one relying on dedifferentiation and the other on stem cells. This discovery may lead to a better understanding of human muscle regeneration and potentially treat muscular dystrophy.
Swedish researchers have found a way to study glucose regulation by transplanting pancreas cells into the eye, allowing for monitoring of insulin-producing beta-cells and identification of new drug substances. This innovative method could lead to personalized treatment principles and diagnosis of pancreatic problems.
Researchers at Karolinska Institutet have discovered nearly one hundred novel human gene regions that code for proteins, including pseudogenes linked to cancer. The study uses a new proteogenomics method to track down protein-coding genes in the remaining 98.5% of the genome.
Women who have undergone bariatric surgery are at increased risk of premature birth and low birth weight, according to a large registry study. The study suggests that prenatal care should be monitored extra carefully for these women.
Breast cancer cells with high levels of microsomal glutathione S-transferase-1 (MGST-1) resistant to chemotherapy can be killed using nanoparticles carrying doxorubicin. This approach enhances the effectiveness of drug treatment while minimizing adverse reactions.
A Swedish study reveals that many heart failure patients are undertreated, with high mortality rates associated with poor pump capacity, kidney function, blood count, and lack of ACE inhibitors and beta blockers. The study suggests referring these patients to heart failure specialists for evaluation and treatment.
Researchers found that scar tissue formed by stem cells after spinal cord injury helps to prevent further damage and facilitates the survival of damaged nerve cells. The study suggests that more rather than less stem cell scarring could limit the consequences of a spinal cord injury.
Researchers at Karolinska Institutet found that anti-obesity drugs, meal replacements, and a high protein diet can help maintain weight loss. Exercise had no clear effect on weight loss maintenance, while dietary supplements were not associated with reduced rebound gain.
Researchers developed a protocol to optimise preparatory treatment with cytostatics prior to stem cell transplantation for children with chronic granulomatous disease, achieving higher survival rates and minimal adverse reactions. The study involved tailoring doses of fludarabine and busulfan based on blood levels, resulting in a 93% s...
A new study from Karolinska Institutet reveals that administering higher doses of the ADHD drug methylphenidate can be effective in treating individuals with both ADHD and substance dependency. The treatment led to reduced relapse rates, fewer ADHD symptoms, and improved adherence to treatment regimens.
A recent study found no significant increase in serious diseases among HPV-vaccinated girls compared to unvaccinated peers, despite monitoring over 900,000 participants. The researchers also noted that mild adverse reactions such as fever and swelling are common but not considered a concern.
Researchers have discovered that thyroid hormone affects blood vessel constriction, leading to sensitivity to temperature extremes. This knowledge may help future treatment of patients with thyroid disorders who experience temperature-related symptoms.
A team of scientists has developed a synthetic mRNA that induces self-repair and regeneration of the infarcted heart in mice. The study shows that this approach can lead to long-term therapeutic effects, including improved survival following myocardial infarction.
A recent study published in Current Biology found that the brain represents the space near others in the same way it represents the space near itself. This shared representation could help individuals interact more efficiently and understand social cues more intuitively.
Research reveals that maternal mitochondrial DNA can influence an individual's aging process, accelerating it. The findings suggest that inherited genetic mutations from mothers contribute to the aging process and potentially impact brain development.
A team of scientists has identified a potential mechanism for cellular memory, which allows cells to recall the order of transcription factor binding. This discovery sheds light on how cells maintain gene regulation and may have implications for understanding diseases such as cancer.
Researchers at Karolinska Institutet found that CHD5 is essential for stem cells to mature into neurons. In the absence of CHD5, stem cells are unable to silence certain genes and switch on those necessary for neuronal maturation. The study suggests restoring CHD5 in aggressive tumor cells could make them more treatable.
A new mouse model study reveals that interleukin-17 can stabilize atherosclerotic plaques by promoting their stability. This discovery provides crucial information on the role of the immune system in atherosclerosis and may lead to the development of new therapies.
Autophagy, a process where cells consume parts of themselves to clean up damaged organelles and proteins, is controlled by a molecular switch in the cell nucleus. The study found that histone H4 acetylation regulates autophagy-related genes, offering new avenues for disease treatment.
Researchers at Karolinska Institutet developed a breakthrough method called CETSA to measure drug molecules' binding to target proteins. This enables more efficient development of new drugs and potential improvement in cancer treatments.
A new study published in Cell Metabolism suggests that cold exposure can accelerate the growth of atherosclerotic plaque in blood vessels, leading to increased risk of heart disease-related deaths. Brown fat activation has been linked to the formation of unstable plaques that can rupture and cause blockages in the heart and brain.
Researchers at Karolinska Institutet have identified two genetically-defined groups of nerve cells in the spinal cord that control limb alternation at different speeds of locomotion. The study found that these cell populations are essential for normal gait, and their removal disrupts the animals' ability to walk.
A study from Karolinska Institutet found that our imagination can affect how we experience the world, changing our actual perception. The research used illusions to test the impact of mental imagery on sensory perception.
Women with obesity have a higher risk of giving birth to preterm infants, particularly those born extremely preterm. Obesity-related diseases and increased inflammation contribute to this increased risk.
Researchers at Karolinska Institutet have discovered a promising strategy for defeating neuroblastoma by targeting the MYCN protein. The approach involves inhibiting the MYC gene, which leads to the accumulation of fat droplets in cancer cells and ultimately causes cell death or development into harmless neurons.
A new method for manufacturing short, single-stranded DNA molecules has been developed by researchers at Karolinska Institutet and Harvard University. This technique can produce large amounts of DNA copies cheaply using bacteria, improving the quality and scalability of DNA fragment production.
Researchers at Karolinska Institutet discovered that aspirin-triggered resolvin D1 can prevent and treat postoperative cognitive dysfunctions by resolving inflammation. The study found that treatment with a single dose of AT-RvD1 protected the brain from memory dysfunction after surgery.
Researchers at Karolinska Institutet have obtained detailed images of how the transport protein GLUT transports sugars into cells. The study's findings could lead to new strategies to fight cancer cells by blocking fuel pumps that introduce sugars and other nutrients required for cell metabolism.
A study published in PNAS reveals how disrupted cellular energy metabolism contributes to the development of Alzheimer's disease. In early-stage Alzheimer's, amyloid-beta-peptide accumulation disrupts mitochondrial function, leading to over-accumulation of calcium and neuronal death.
Researchers at Karolinska Institutet developed a method to assess tamoxifen's effect on breast cancer, using mammograms. Women showing a 20% reduction in breast density have a 50% reduced risk of dying from breast cancer over 15 years.
A Swedish study published in Neurology suggests a decline in the risk of developing dementia over the past 20 years. The study, which analyzed data from the SNAC-K study on aging and health, found that improvements in cardiovascular disease prevention may have contributed to this decrease.
Researchers at Karolinska Institutet have developed a method to induce the sensation of having a phantom hand in non-amputated individuals. Participants experienced an invisible hand when touched, revealing that multisensory integration can lead to embodiment of empty space.
A groundbreaking study by Mügen Terzioglu and colleagues challenges long-held ideas about the protein MTERF1's importance in mitochondrial transcription and translation. The findings, published in Cell Metabolism, demonstrate that MTERF1 is not as crucial to mitochondrial function as previously thought.
A large-scale research study has identified over 80 genetic 'spelling mistakes' linked to an increased risk of breast, prostate, and ovarian cancers. The study found that these alterations can be described as single nucleotide polymorphisms (SNPs), which are common in the DNA of patients with cancer.
The Horizon Health web portal provides a valuable online resource for journalists and interested citizens, featuring accurate and up-to-date information on health research funded by the EU. The platform aims to improve communication on EU-funded health research projects, mainly towards the media and general public.
A Swedish national registry study found that HPV vaccination before age 14 significantly reduced the incidence of genital warts in girls. The study also revealed socioeconomic disparities in vaccination rates, with higher educated parents more likely to vaccinate their daughters.
Researchers at Karolinska Institutet have identified a gene variant associated with higher production of kynurenic acid, which may explain psychotic features in bipolar disorder. The study suggests that inflammation and stress trigger the production of KYNA, leading to increased levels in patients' brains.
Swedish scientists developed theranostic nanoparticles that can deliver chemotherapy to breast cancer cells while being detectable in MR scanners. The particles are biodegradable and show no toxicity, making them a potential tool against cancer.
A new study from Karolinska Institutet reveals that cortisone increases the risk of acute pancreatitis. Patients treated with cortisone are recommended to avoid alcohol and smoking to minimize the risk. The study found a 70% higher risk of developing acute pancreatitis among those taking cortisone tablet form.
Researchers at Karolinska Institutet have discovered a new pseudogene that regulates the tumour-suppressing PTEN gene, enabling its potential reversal. This finding could lead to more effective cancer treatments by reprogramming cancer cells and preventing resistance.