Researchers at Karolinska Institutet and KTH Royal Institute of Technology discovered hydraulic forces aid heart filling. The study suggests reducing atrium size can improve heart function in patients with heart failure.
A Swedish study found that patients registered in the Swedish Heart Failure Registry had a remarkable 35% lower risk of death compared to unregistered patients. This improvement is attributed to better medication and quality care, with registered patients more likely to receive essential heart failure medications.
A new study from Karolinska Institutet shows that short-course preoperative radiotherapy combined with delayed surgery reduces the adverse side-effects of rectal cancer surgery. Patients with delayed surgery develop fewer complications while maintaining equally good oncological outcomes.
A new study from Karolinska Institutet shows that executive cognitive functions in children and young people can be quantified and linked to their performance on the football pitch. The study found strong results for simpler forms of executive function, such as working memory, to be associated with success.
Researchers developed a vaccine that stimulates an antibody targeting pathological tau, discovering its Achilles' heel. The antibody avoids immune reaction towards the body by coupling to a carrier molecule.
Researchers found that individuals lacking the CYP2C19 enzyme have a lower risk of depression and larger hippocampi in adulthood. Increased expression of the enzyme is associated with higher suicidal incidences in depressed patients, suggesting that early life influences may contribute to depression's development.
Researchers develop optical fingerprint to study Salmonella biofilms, providing new tool for understanding mechanisms of biofilm formation. The method is specific and non-toxic, allowing for the detection of biofilm components without harming bacteria.
Researchers from Karolinska Institutet have conducted a study on the impact of sex-discordant blood transfusions on post-cardiac surgery survival. Despite initial findings suggesting a possible increased risk, the new study found no association between these types of transfusions and mortality rates.
Genetic defects in sucrase-isomaltase gene variants are associated with an increased risk of irritable bowel syndrome. The study found that rare mutations were twice more common among IBS cases than healthy controls, and a common variant with reduced enzymatic activity was also linked to increased risk.
Researchers at Karolinska Institutet have measured the absolute numbers of short, non-coding, RNA sequences in individual embryonic stem cells, revealing their precise function. The new method could lead to improved IVF treatments by identifying embryos with the best chance of development.
The bellygenes initiative is a large-scale genetic project studying the genetic makeup of 800,000 Europeans in relation to irritable bowel syndrome. The study aims to reveal pathophysiological pathways that can help explain IBS etiology and inform molecular reclassification of patients.
Researchers discovered that glioblastoma cells inhibit caspase-3 activity in microglia, leading to a tumor-stimulating phenotype. This inhibition causes microglia to stimulate tumor cells instead of attacking them.
Researchers from Karolinska Institutet discovered that pneumococcal bacteria use a human-specific sugar molecule to enhance growth and resistance. This finding sheds light on why pneumococci cause more severe infections in humans than other animals, and could lead to the development of more effective vaccines.
A new study from Karolinska Institutet reveals that the sympathetic nervous system comprises different neurons regulating specific physiological functions. The research found that goose bumps and nipple erection are caused by specialized neurons controlling erectile muscles in these tissues.
A new gene expression analysis method, GlobinLockTM, overcomes technical bias in blood sample analysis caused by erythrocytes, allowing for more effective biomarker identification. The patented assay minimizes reagent and sample material needs, making it a robust tool for biotechnology companies.
A new high-resolution method allows analysis of all RNA molecules and provides spatial information, enabling precise identification of tumor cells and studying gene activity with greater resolution than ever before. This innovation has valuable applications for both preclinical research and cancer diagnostics.
Researchers at Karolinska Institutet identified 12 subclasses of oligodendrocytes and a novel cell distinct from oligodendrocytes residing in blood vessels, uncovering unexpected diversity within the nerve-insulating cells.
Researchers identify epigenomic changes that contribute to the development of type 2 diabetes in obese individuals. These changes are associated with inflammation and trigger insulin resistance, highlighting the importance of epigenetic regulation in metabolic diseases.
Sir Richard Peto, Bob Langer, and Alimuddin Zumla receive Honorary Doctor of Medicine degrees for groundbreaking work in epidemiology, biotechnology, and infectious diseases. Their achievements have transformed the pharmaceutical industry and improved human health worldwide.
A new study from Karolinska Institutet reveals a feedback regulatory system through which dopamine controls its own activity, regulating prolactin levels and potentially mitigating sexual side effects of antipsychotic drugs.
Researchers have made significant discoveries about early human embryo development, finding that genes on the X chromosome are regulated differently in humans than in mice. This new understanding is crucial for the use of embryonic stem cells in regenerative medicine.
A comprehensive report by internationally leading researchers calls for concerted efforts to reduce the burden of dementia. The report advocates for public governmental agencies to form large multinational partnerships with academic centers and pharmaceutical companies to deploy capital resources and share risk.
A Swedish cohort study found that surgeons need to perform at least 15 operations to obtain stable survival results during the first months after oesophagectomy. The learning curve for achieving optimal long-term survival takes 60 operations, highlighting the importance of proper mentorship and training programs.
Researchers developed a nanoparticle technology called Salipro to stabilize membrane proteins in a lipid environment, allowing for high-resolution studies of their structure and function. This enables the discovery of new drugs, therapeutic antibodies, and vaccines targeting these proteins.
Researchers at Karolinska Institutet and University of Oulu identified mechanisms explaining genetic variants' influence on prostate cancer risk. The study reveals widespread deregulation of androgen receptor function, a key player in prostate cancer.
Scientists have identified three previously unknown subgroups of innate lymphoid cells (ILCs), a group of immune cells crucial for maintaining the barrier function of mucosa. This discovery was made possible by single-cell RNA sequencing, which allowed researchers to analyze gene expression across thousands of genes.
Long-term use of liraglutide can lead to a gradual exhaustion of insulin-producing beta cells, reducing their secretion of insulin. This study using humanized mice suggests the need for caution when prescribing long-term GLP-1 analogues.
Researchers at Karolinska Institutet have determined the 3D structure of Juno, a mammalian egg protein essential for triggering gamete fusion. The study reveals that changes in Juno's shape alter its ability to bind with sperm protein Izumo1, bringing scientists closer to understanding fertilization.
Scientists at Karolinska Institutet have identified a cell type in the brain's frontal lobes that is integral to attention. Parvalbumin-expressing neurons were found to reflect animals' level of attention, with high activity associated with attentive states and low activity with inattentive states.
Researchers at Karolinska Institutet have discovered a new role for motor neurons in influencing rhythmic movements. Motor neurons directly control the recruitment of upstream excitatory interneurons via gap junctions, indicating they are not passive recipients of signals from interneuronal circuits.
A Swedish-Ugandan study has shown that sterilized mosquito nets can replace costly surgical meshes in inguinal hernia repairs without compromising patient safety or treatment efficacy. The study involved over 300 adult males from rural Uganda and found no significant differences between groups.
A new study by researchers at Karolinska Institutet found that extremely premature babies who later develop autism show distinct brain differences as early as the neonatal period. The study suggests that environmental factors can play a key role in the development of autism.
Researchers at Karolinska Institutet identified a gene variant linked to psychotic symptoms and cognitive impairment in people with bipolar disorder. The study found that the gene variant affects levels of specific proteins in the brain, which may lead to new targeted drug development.
A new study from Karolinska Institutet found a significant link between maternal polycystic ovarian syndrome (PCOS) and autism spectrum disorders (ASD) in children. The study, which analyzed data from over 24,000 ASD cases and 200,000 controls, suggests that exposure to sex hormones early in life may play a role in the development of ASD.
Researchers at Karolinska Institutet have successfully engineered new diaphragm tissue in rats using stem cells and 3D scaffolds, which can regrow with the same complex mechanical properties as natural diaphragm muscle. The technique offers hope for a cure for congenital diaphragm malformations and possible future heart muscle repairs.
A team of scientists identified a population of 'stop cells' in the brainstem that enable mice to halt their locomotion. These cells depress neuronal networks involved in generating locomotor rhythm, allowing animals to make graceful stops. The findings may provide insights into how locomotion is affected in diseases like Parkinson's.
A Swedish registry study found that mechanical heart valve prosthesis has superior long-term survival rates compared to biological valve prosthesis, particularly for relatively young patients. The risk of stroke was similar for both types of prostheses, but patients with biological valves were more likely to require re-operation.
A new blood test for prostate cancer significantly improves detection of aggressive cancer, reducing false positives and unnecessary biopsies. The STHLM3 test analyzes protein markers, genetic data, and clinical information to detect cancers in men with low PSA values.
A recent study from Karolinska Institutet shows that the human genome's 'grammar' is more complex than even intricate spoken languages. The findings contribute to understanding how genetic differences affect disease risk and pave the way for cracking the genetic code controlling gene expression.
A new study from Karolinska Institutet shows that the mouse heart generates a substantial number of muscle cells early in life, as does the human heart. After the neonatal period, the generation of new heart muscle cells stops and the heart growth mainly occurs by size increase of muscle cells.
Researchers found that three minutes of high-intensity exercise changes how muscle cells manage calcium, leading to improved endurance. Antioxidants may undermine this effect by removing the breakdown of calcium channels.
Researchers at Karolinska Institutet identified a hormonal mechanism explaining why women with PCOS are more likely to develop mental health issues. The study found that excessive testosterone exposure during fetal development can lead to anxiety-like behavior in both male and female offspring.
A large registry study of almost 50,000 patients in Sweden found that transfusion with stored blood does not influence patient outcomes after heart surgery. The study provides firm reassurance that current blood storage practices are safe.
A new registry study by Karolinska Institutet found a strong correlation between household disposable income and long-term survival after cardiac surgery. The study included 100,000 patients and showed that those with higher incomes had significantly lower mortality rates, even after adjusting for other risk factors.
Researchers at Karolinska Institutet have found that OSU6162 can reduce craving for alcohol in people with alcohol dependence, normalizing dopamine levels in brain reward system. Thorough clinical studies are needed to confirm efficacy.
Researchers at Karolinska Institutet have discovered a mechanism that explains how insulin-producing cells can be both insulin-resistant and insulin-sensitive at the same time. The study identifies a key factor, PI3K-C2α, that causes a switch in signaling pathways, leading to beta cell proliferation.
Scientists from Karolinska Institutet have identified 32 genes that are switched on within two days of fertilization, marking a significant breakthrough in understanding early embryonic development. The study's findings also reveal the importance of 'junk DNA' in regulating gene expression.
Scientists at Karolinska Institutet have discovered that mutations in the KCC2 gene cause severe early infant epilepsy by disrupting chloride ion regulation. This imbalance leads to uncontrolled brain signals, resulting in epilepsy symptoms.
Daily changes in nuclear positioning of circadian genes regulate their activity with a 24-hour period. Researchers identified two proteins PARP1 and CTCF that bring genes to the periphery, promoting silent state.
Researchers found that tumour pericytes manipulate the tumour environment to help cancer cells escape immune surveillance. Increasing pericyte numbers could potentially decrease IL-6 expression and improve cytotoxic T-cell activity.