Research found that healthy individuals with difficulties regulating emotions exhibit smaller volume in orbitofrontal cortex, a region also affected in people with borderline and antisocial personality disorders. The study suggests a continuum in emotional regulation ability, with extreme variants leading to psychiatric diagnoses.
Hereditary angioedema type III is caused by a mutated blood protein factor XII that leads to excessive bradykinin production and vessel leakage. Researchers have identified a natural inhibitor that can block the mutated protein, providing hope for a new treatment.
Researchers found that bone marrow-derived cells can develop into fat cells, with BMI playing a significant role. The study suggests potential new therapies for metabolic diseases and obesity-related conditions.
A study published in the Journal of Clinical Investigation found that microRNA-132 plays a critical role in regulating the transition from inflammation to proliferation during wound healing. The researchers identified miR-132 as a therapeutic target for promoting healing and developing new treatments for chronic skin wounds.
Scientists at Karolinska Institutet have created an organic bioelectronic device that can receive chemical signals and relay them to human cells, mimicking the function of a human nerve cell. This innovation has the potential to improve treatments for neurological disorders by bypassing damaged nerve cells.
Researchers at Karolinska Institutet have discovered a new link between male infertility and autoimmune prostatic inflammation. The study found that the immune system reacts to a protein called transglutaminase 4 in men with autoimmune polyendocrine syndrome type 1, leading to reduced fertility.
Researchers at Karolinska Institutet found that cardiopulmonary resuscitation performed before ambulance arrival increases survival rate by over two-fold. A new SMS Lifesavers system has also caused a 30% increase in CPR, highlighting the effectiveness of mobile technology in emergency response.
A new study published in Cell found that human heart muscle cells are primarily formed during childhood, with only 40% replaced throughout a person's life. This discovery suggests it may be possible to stimulate the rebuilding of lost heart tissue through therapeutic strategies.
Researchers at Karolinska Institutet found that people can be conditioned to associate images with specific pain responses without conscious awareness. This study suggests that unconscious learning may have a significant impact on higher cognitive processes, including pain perception.
Researchers at Karolinska Institutet have discovered how cancer cells can infiltrate the lymphatic system by mimicking immune cells. This finding may lead to the development of new treatments targeting metastasis via the lymphatic system.
Researchers identified a gene variant outside the huntingtin gene that affects disease onset timing. The variant delays symptoms when on the normal protein copy, while accelerating them on the mutated protein copy.
Researchers at Karolinska Institutet create perceptual illusion of having an invisible body, reducing social anxiety responses. The study demonstrates the 'invisible hand illusion' can be extended to an entire invisible body, affecting brain processing of social cues.
A nationwide study in Sweden found that men convicted of sex crimes are more likely to have relatives who also commit similar offenses due to genetic factors. The study suggests a substantial family risk increase and may inform preventive treatment strategies.
A new study provides experimental evidence that a drug inhibiting the EphB-signaling pathway effectively suppresses intestinal tumor development. The study suggests that this knowledge may lead to novel treatments for colorectal cancer patients.
Two studies show that midwives can safely treat failed abortions and miscarriages in rural districts of Uganda, and that home pregnancy tests can replace clinical follow-up examinations. These findings may lead to new international recommendations for medical abortion treatment.
A new study by Karolinska Institutet researchers found that the language used to switch genes on and off has remained conserved across millions of years of evolution. The differences between species reside in the content and length of these instructions, with specific transcription factors recognizing unique DNA words.
Researchers from Karolinska Institutet identified the key role of RIFIN protein in protecting blood type O individuals from severe malaria. The protein binds strongly to A blood cells but weakly to O, explaining why O individuals are less susceptible to the disease.
Pregnant women after bariatric surgery are at higher risk for complications like preterm birth and small babies, but lower risk of gestational diabetes. Maternal health services should provide extra care to these women.
Scientists at Karolinska Institutet have created a detailed map of cortical cell types and the genes active within them using single-cell sequencing. They identified 47 different kinds of cells, including hitherto unknown types, which can help shed more light on diseases like multiple sclerosis.
Researchers at Karolinska Institutet found that eltoprazine significantly reduced Parkinson's disease patients' dyskinesia while maintaining anti-Parkinsonian effects. The treatment was well-tolerated and shows promise as a new therapeutic principle for treating L-dopa-induced dyskinesia.
A new study reveals that long-term endurance training affects thousands of DNA methylation sites and genes associated with improved muscle function and health. The research also found epigenetic differences between male and female skeletal muscle, which may lead to gender-specific therapies in the future.
Researchers at Karolinska Institutet have found no causal link between antibiotics and childhood asthma, contradicting previous studies. The study of half a million children suggests that respiratory infections may increase the risk of asthma, regardless of antibiotic treatment.
A new study shows that gut microbiota can influence the integrity of the blood-brain barrier, which protects the brain from harmful substances. The findings suggest that alterations to our indigenous microbiota may have far-reaching consequences for the blood-brain barrier function throughout life.
A recent study published in PNAS shows that young capillary vessels can rejuvenate aged pancreatic islets, suggesting a new way to treat age-dependent dysregulation of blood glucose levels. By replacing the islet vasculature with young capillaries, glucose homeostasis was fully restored.
A Swedish registry study suggests that beta blockers can improve survival in patients with HFPEF, which affects women more often than men and is characterized by an impaired ability to relax and fill with blood. The treatment difference persisted even after adjusting for various factors.
Scientists at Karolinska Institutet have discovered a key role for the signal molecule TGF-beta in regulating brain stem cells' development potential. By understanding this mechanism, researchers hope to develop new treatments for neurodegenerative diseases.
Researchers at Karolinska Institutet discovered that human brains have a higher rate of oligodendrocyte maintenance and can modulate myelin production, enabling faster adaptation and learning. This finding has significant implications for understanding neurological diseases such as MS.
A new study published in Nature Communications reveals that cilia on pancreatic beta cells are covered with insulin receptors, and altered ciliary function is associated with type 2 diabetes. The research found that ciliary defects impaired insulin release, leading to elevated blood glucose levels in mice.
Researchers found that exercise training induces changes in skeletal muscle that prevent the accumulation of a substance called kynurenine, which is associated with depressive behavior. In contrast, genetically modified mice with well-trained muscle characteristics showed no depressive symptoms despite being exposed to stress.
Researchers at Karolinska Institutet found that age-dependent reduction of mitochondrial function in beta cells leads to reduced insulin release. Impaired calcium ion dynamics is the molecular mechanism underlying this process.
A meta-analysis of 112,000 participants found that childhood trauma significantly increases the risk of obesity in adulthood. The study revealed a 34% higher risk among adults who experienced abuse as children, with physical and emotional abuse leading to increased risks of 28% and 36% respectively.
Researchers at Karolinska Institutet find that the striatum integrates sensory input from touch, vision, and sound to guide movements. The study provides insight into the brain's processing of external input and its role in motor function and disease.
Researchers used DNA origami to test theories about cell signaling, finding that distance between ephrin molecules affects EphA2 receptor activity in breast cancer cells. This study developed a method for controlled environment cell communication research, which may lead to new approaches to pharmaceuticals.
A Swedish study using national patient registers found no link between ADHD drug treatment and increased risk of suicide attempts or suicide. Instead, researchers suggest that ADHD medications may have a protective effect against suicidal behaviors.
A new study reveals that parasympathetic neurons originate from immature glial cells in mouse embryos, forming a previously unknown developmental pathway. This discovery may lead to new medical treatments for congenital disorders of the nervous system.
Researchers at Karolinska Institutet identified the EBF1 gene driving unhealthy adipose tissue development, associated with increased risk of insulin resistance and type 2 diabetes. The study found that individuals with large fat cells had lower EBF1 expression, altered lipid mobilization, and insulin resistance.
Researchers at Karolinska Institutet successfully transplanted a regenerated esophagus into rats, showing regeneration of nerves, muscles, epithelial cells and blood vessels. The breakthrough could improve survival and quality of life for patients with oesophageal disorders.
Researchers at Karolinska Institutet have identified a new way of treating cancer by inhibiting the MTH1 enzyme, which cancer cells require for survival. This approach differs from previous treatments that target specific genetic defects and offers a potential breakthrough in fighting the disease.
A nationwide study in Sweden found that single men are more likely to die of cutaneous malignant melanoma. The researchers discovered that this applies to men of all ages, regardless of education level or residence. Early detection is crucial for survival, as skin cancer can be cured if treated early enough.
Researchers at Karolinska Institutet have discovered a new mechanism to kill glioblastoma cells using Vacquinol-1, which causes uncontrolled vacuolization leading to cell explosion and necrosis. This approach may lead to new cancer treatments, potentially working for other cancer diseases.
Studies show that when participants experience an 'out-of-body' illusion, their memories are fragmented and stored improperly. The research suggests a close relationship between body experience and memory, with implications for understanding psychiatric conditions such as PTSD and schizophrenia.
Researchers from Karolinska Institutet found that the MYC gene promotes neural cell differentiation rather than proliferation in intact neural tissue. This discovery may lead to new approaches for treating spinal cord injuries and promoting nerve cell growth.
Researchers at Karolinska Institutet have successfully produced a molecule that blocks LTA4 hydrolase from producing LTB4, while maintaining the inactivation of Pro-Gly-Pro. This could lead to new hopes for treating chronic obstructive pulmonary disease (COPD) and various types of inflammatory skin diseases.
Researchers found that early but not advanced forms of atherosclerotic plaques in mice regress when 'bad' cholesterol is lowered. The study suggests that preventative cholesterol-lowering treatment could prevent more advanced plaque development and reduce the risk of stroke or heart attack.
Researchers at Karolinska Institutet have identified a biological circadian clock in the cochlea that controls how well hearing damage heals. The discovery may lead to new treatment methods for hearing loss affecting up to 15% of the population.
Researchers at Karolinska Institutet have identified a new drug candidate, VLX600, that selectively kills dormant cancer cells in solid tumors by starving them. The drug works by inhibiting mitochondrial respiration, causing the cells to die from starvation. A clinical study is planned to take place this year.
Researchers at Karolinska Institutet found that a subtle epigenetic change facilitates structural changes of the centromere prior to cell division, ensuring proper chromosome distribution. This mechanism is highly similar in human cells and yeast cells, suggesting its key role in preventing incorrect chromosome numbers.
Research from Karolinska Institutet reveals lower levels of resolution-regulating molecules in Alzheimer's patients' brains and cerebrospinal fluid, correlating with reduced cognitive function. The study suggests stimulating inflammation resolution may prevent neuronal death and improve memory functions.
A new study from Karolinska Institutet found that acidic tumor pH counteracts chloroquine's ability to inhibit autophagy in cancer cells. The results may explain the lack of efficacy of chloroquine in clinical studies, particularly in tumors with low oxygen and acidic pH.
A Swedish register study found that receiving three doses of HPV vaccine significantly reduces the incidence of genital warts compared to two doses. The study, published in JAMA, suggests that a three-dose regimen may be more effective in preventing genital warts than previously thought.