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Science News for June 17, 2015


On the road to needle-free medicine

Alternative drug-delivery systems are being explored to overcome syringe injection drawbacks, including ointments, dissolvable tablets and micro-needle skin patches. Several promising results have been shown in animal testing, but widespread adoption will require changing the mindset of pharmaceutical companies and regulators.

SourceAmerican Chemical Society·JournalChemical & Engineering News·DateJun 17, 2015

Identified the epigenetic basis of CVID through the study of identic twins

Researchers identified epigenetic alterations in CVID patients by comparing monozygotic twins. They found higher DNA methylation levels and impaired DNA demethylation in immunodeficient B cells, leading to reduced antibody production and altered cell maturation. These findings provide new insights into the diagnosis and treatment of CVID.

SourceIDIBELL-Bellvitge Biomedical Research Institute·JournalNature Communications·DateJun 17, 2015

A new look at surface chemistry

A new analytical method using high-resolution scanning electron microscopy (HRSEM) has resolved the unique atomic structure at the surface of a material for the first time. This breakthrough enables direct information on both surface and bulk atoms, improving understanding of critical reactions such as catalysis and corrosion.

SourceDOE/Lawrence Berkeley National Laboratory·JournalNature Communications·DateJun 17, 2015

Mold unlocks new route to biofuels

Researchers at the University of Manchester have identified the mechanism and structure of enzymes that produce hydrocarbons from yeast moulds. This discovery provides a new route to producing alpha-olefins, a key intermediate in various industrial applications.

SourceUniversity of Manchester·JournalNature·DateJun 17, 2015

The Lancet: Patients with complications after major surgery more likely to survive if readmitted to the same hospital

A national study involving over 9 million Medicare patients found that patients rehospitalized with complications after major surgery are 26% more likely to survive if they return to the hospital where they had their operation. The researchers suggest maintaining continuity of care when readmissions occur is a key predictor of survival.

SourceThe Lancet·JournalThe Lancet·DateJun 17, 2015

NIH-funded researchers identify new genetic immune disorder

Researchers have identified a new genetic immune disorder, DOCK2 deficiency, which causes debilitating infections and combined immunodeficiency in children. Early screening for the disease can prevent life-threatening infections, and understanding its role may inform the study of more common immune system disorders.

SourceNIH/National Institute of Allergy and Infectious Diseases·JournalNew England Journal of Medicine·DateJun 17, 2015

Fructose powers a vicious circle

Researchers discover fructose's role in heart failure, finding it efficiently converts to fat and stimulates glycolysis. Fructose also activates HIF, leading to increased KHK-C production and a vicious cycle of growth and damage.

SourceETH Zurich·JournalNature·DateJun 17, 2015

How much do consumers know about new sunscreen labels?

A study surveyed patients about their knowledge of new sunscreen labels and found that most understood protection against sunburns but struggled with broad-spectrum protection. Fewer than half correctly identified terminology indicating skin cancer protection, leading to calls for improved labeling clarity.

SourceJAMA Network·JournalJAMA Dermatology·DateJun 17, 2015

Value of nonprofit hospital tax exemption nearly doubled over 9 years, reaching $24.6 billion in 2011

The study found that nonprofit hospitals spent only a small fraction of their 'charity care and community benefit' on efforts aimed at improving the health of the communities they serve. In 2011, hospitals allocated less than 1% of total spending towards community health improvement.

Nightingales show off their fathering skills through song

Research published in BMC Evolutionary Biology found that male nightingales' songs contain specific features, such as repeated song sequences and varied song types, which signal their ability to care for offspring. These song features are linked to greater paternal efforts, including more frequent feeding and defense of the nest.

SourceBMC (BioMed Central)·JournalBMC Evolutionary Biology·DateJun 17, 2015

Aperiodic crystals and beyond

The article explores aperiodic crystals and their implications on our understanding of crystalline order. Recent research has shown that the current definition of crystals, based on point-like diffraction, may need revision as new materials with non-trivial point components in their diffraction are discovered.

SourceInternational Union of Crystallography·JournalActa Crystallographica Section B·DateJun 17, 2015

Lower heart rate variability turns women off

A new study published in Applied Psychophysiology and Biofeedback found a significant link between lower heart rate variability and sexual dysfunction in women. Women with below-average heart rate variability were more likely to report sexual arousal problems and overall sexual difficulties.

SourceSpringer·JournalApplied Psychophysiology and Biofeedback·DateJun 17, 2015

New mechanism for male infertility discovered

Researchers at Karolinska Institutet have discovered a new link between male infertility and autoimmune prostatic inflammation. The study found that the immune system reacts to a protein called transglutaminase 4 in men with autoimmune polyendocrine syndrome type 1, leading to reduced fertility.

SourceKarolinska Institutet·JournalScience Translational Medicine·DateJun 17, 2015

Men get ahead by chatting before negotiations

A study published in Basic and Applied Social Psychology found that men who engage in small talk before negotiations tend to receive more favorable outcomes. In contrast, women who make small talk are perceived less favorably and do not experience the same benefits.

SourceAmerican University·JournalBasic and Applied Social Psychology·DateJun 17, 2015

Isolation and characterization of human hepatocytes and non-parenchymal liver cells

Scientists have developed a method for isolating primary human hepatocytes and different non-parenchymal cell fractions from the same donor tissue. The isolation process involves a two-step EDTA/collagenase perfusion technique followed by Percoll density gradient centrifugation, adherence separation, and magnetic activated cell sorting.

SourceSociety for Experimental Biology and Medicine·JournalExperimental Biology and Medicine·DateJun 17, 2015

Sunscreen confusion may burn shoppers

A Northwestern Medicine study found that many people are confused by sunscreen terminology, with only 43% understanding SPF values and 7% knowing how to protect against early skin aging. This confusion can lead to inadequate protection against sunburns and premature skin aging.

SourceNorthwestern University·JournalJAMA Dermatology·DateJun 17, 2015

Massachusetts General Hospital physicians write of their experiences in Nepal earthquake relief

Two MGH physicians, Renee Salas and Annekathryn Goodman, share their experiences in Nepal earthquake relief, highlighting the challenges of wilderness medicine in remote environments. The teams worked together to provide emergency care and support, while also addressing emotional devastation inflicted on villagers.

SourceMassachusetts General Hospital·JournalNew England Journal of Medicine·DateJun 17, 2015

Restoring natural immunity against cancers

Researchers at Institut Pasteur successfully inhibit enzyme DPP4 to increase T lymphocyte infiltration into tumors, leading to efficient cancer cell destruction. This innovative treatment combines with existing immunotherapies to eradicate tumors in mice.

SourceInstitut Pasteur·JournalNature Immunology·DateJun 17, 2015