Researchers are developing stem cell-based transplant technology to recreate complex tissues and organs, with successful trials in trachea, oesophagus and lung transplantation. Experimental attempts also show promise for brain regeneration and treatment of acute refractory lung failure.
Researchers at Karolinska Institutet discovered that a deficiency in the endoglin protein weakens tumor blood vessels, allowing cancer cells to spread more easily. This finding suggests that strengthening blood vessel protective function may prevent cancer spread.
A large population-based study of men found that those taking vitamin C supplements are twice as likely to develop kidney stones as non-supplement users. The risk increased with the frequency of supplement use. Conversely, multivitamin use was not associated with an increased risk of kidney stones.
Researchers at Karolinska Institutet have identified the DNA sequences that bind to over 400 proteins controlling gene expression, representing half of all human transcription factors. This discovery provides a valuable resource for furthering our understanding of the human genome and its role in disease development.
Researchers found a human gene associated with the presence of Prevotella bacteria in the gut, which could have implications for treating diseases like Crohn's. The study suggests that genetic variations may influence the makeup of the gut microbiota.
A large-scale Swedish study has found that oesophageal cancer patients who undergo surgery by high-volume surgeons have a significantly lower long-term mortality rate. The study's main finding is that centralization to fewer surgeons results in better survival after esophageal cancer surgery.
Researchers at Karolinska Institutet have identified two molecules that stimulate liver X receptors in the midbrain, promoting the production of new dopamine-producing neurons. These findings may lead to the development of regenerative medicine treatments for Parkinson's disease.
Scientists have identified a new type of nerve cell in the brain that regulates heart rhythm and blood pressure. The discovery may lead to new ways of treating cardiovascular diseases.
Scientists have discovered a new antibiotic principle that selectively blocks the thioredoxin system in bacterial cells, making certain bacteria vulnerable to inhibition. This mechanism could potentially treat conditions like stomach ulcers, TB, and MRSA, providing a new solution for combating antibiotic-resistant infections.
A new study published in BMJ Open found that high-dose vitamin D supplementation reduced symptoms of respiratory tract infection by almost a quarter and antibiotic use by nearly half in patients with frequent infections. However, the treatment had no significant impact on otherwise healthy individuals.
A study of over 15,000 teenagers and young adults found that the risk of attempted suicide is highest within two years after a parent's inpatient care due to mental disorders or suicide attempt. The risk is particularly high for teenagers and declines with age.
Studies have shown that the autonomic nervous system plays a crucial role in regulating insulin secretion from beta cells in the pancreas. Researchers at Karolinska Institutet successfully grafted beta cells into mice eyes to study their function, revealing how the autonomic nervous system influences blood glucose levels.
Researchers at Karolinska Institutet have discovered how the Toxoplasma parasite enters the brain and manipulates host behavior by hijacking neurotransmitters. The study found that infected dendritic cells secrete GABA, a substance linked to anxiety and depression.
Researchers at Karolinska Institutet have discovered that glucagon stimulates its own synthesis, activating a self-reinforcing cycle of hormone production. This finding has significant implications for understanding the regulation of hormone secretion and may hold the key to studying defects in diabetes.
A study suggests that linagliptin, a commercialized diabetes drug, can stimulate neuroprotection and largely reduce brain damage following stroke. This could lead to better prognosis for type 2 diabetic patients after a stroke.
A Swedish study found commonly used heart failure and high blood pressure medications can benefit patients with a rare type of heart failure. The use of ACE-inhibitors or angiotensin receptor blockers lowered mortality rates by 10% in HFPEF patients.
A new study published in Circulation reveals that the arginase enzyme may play a key role in the development of cardiovascular disease in patients with type II diabetes. Inhibiting this enzyme improves blood vessel function in diabetics with angina, but has no effect on healthy individuals or those without angina.
Scientists at Karolinska Institutet have found that IGF-1 blockers are only partially effective because they stimulate the MEK channel, allowing cancer cells to survive. Researchers propose a combination therapy using MEK inhibitors and IGF-1 blockers to overcome this issue
A recent study of over 25,000 individuals with ADHD found that criminal behavior dropped sharply during periods of medication use. The study showed a significant 32% risk reduction for medicated individuals compared to those not taking medication.
A new study from Karolinska Institutet in Sweden suggests that digital X-ray radiogrammetry (DXR) used on standard hand radiographs can help identify patients at higher risk of hip fracture. DXR is a technique comparable to more costly methods and may be used preventively to identify people at risk for osteoporosis.
Scientists have discovered that a gene switch regulates the expression of genes and promotes cancer development, according to a study published in Science. The study found that removing a specific region containing a genetic variant increased resistance to tumor formation in mice.
Researchers found that people in creative professions are treated more often for mental illness than the general population, particularly for schizophrenia. Creative fields were also associated with higher rates of bipolar disorder, depression, anxiety syndrome, substance abuse, and suicidal behavior.
Researchers found a link between prolonged QRS wave and increased mortality in heart failure. A new type of pacemaker could be effective for treating this condition, which is often overlooked.
Research from Karolinska Institutet found a significant association between difficulty chewing hard food and cognitive impairment, including dementia. The study of 557 people aged 77 or older suggests that maintaining good chewing ability may be crucial for brain health.
Scientists at Karolinska Institutet have discovered that the hairs in the inner ear not only move sideways but also change in length when stimulated by sound waves. This finding provides new fundamental knowledge about the mechanisms of hearing and may help develop a new treatment for impaired hearing.
Researchers at Karolinska Institutet have made a major breakthrough in type II diabetes treatment by inhibiting VEGF-B. The study shows that VEGF-B inhibition can prevent and treat insulin resistance, which is related to the storage of fat in muscles, blood vessels, and heart.
A Swedish commercial weight loss program called Itrim was evaluated for its effectiveness, and researchers found that participants lost an average of 11 kg after one year. The program, which includes three different diets and group sessions, showed promising results with the most rigorous diet resulting in the greatest weight loss.
Researchers tested APR-246 on 22 patients with advanced blood or prostate cancer, finding indications that the substance restored p53 gene function and triggered cancer cell apoptosis. In two patients, tumor regression was observed, suggesting potential clinical benefits.
Scientists at Karolinska Institutet developed a new technique using under-twisted DNA origami to deliver cancer drugs, such as doxorubicin, directly to tumor cells while minimizing harm to surrounding healthy tissue. This approach allows for slower release of the drug, enabling more effective treatment at lower concentrations.
Researchers at Karolinska Institutet in Sweden have discovered that sorafenib can effectively treat multiple myeloma by inducing cell death in human myeloma cell lines. The study found that the drug also prevented or delayed disease progression in live mice, supporting its use as a treatment for this blood cancer.
Researchers at Karolinska Institutet used mobile data to predict population movements after a disaster, improving aid delivery accuracy. By analyzing patterns in anonymous user locations before and after the 2010 Haiti earthquake, they were able to accurately forecast people's whereabouts with 85% probability.
Researchers at Karolinska Institutet report positive effects of an active vaccine, CAD106, against Alzheimer's disease. The study found that 80% of patients developed protective antibodies without side effects.
Researchers found that the human olfactory bulb, a brain structure processing sensory input from the nose, lacks new neuron generation like other mammals. This discovery may explain why humans have a poorer sense of smell compared to other animals.
A study of 2,588 Finnish schizophrenic patients found that antidepressive treatment reduced mortality risk by 43%, whereas bensodiazepine use increased the risk of early death and suicide by 91%. The researchers also found no association between taking multiple antipsychotics and increased mortality.
Researchers at Karolinska Institutet have made a significant breakthrough in understanding the stratum corneum, the outermost layer of human skin. By determining its molecular structure and function at a detailed level, they aim to develop new methods for drug delivery via the skin.
A new study from Karolinska Institutet suggests that measuring executive functions can predict a player's success in soccer. The researchers found a correlation between high scores in cognitive tests and better performance on the pitch, supporting the idea that game intelligence is not just innate but can be developed.
A new study from Karolinska Institutet in Sweden found that cancer patients are at a significantly increased risk of suicide and cardiovascular death during the first week following a diagnosis. The risk decreases rapidly over time but is most pronounced for those with poor-prognosis cancers.
A new study from Karolinska Institutet found that patients who suffered serious post-operative complications after esophageal cancer surgery had more symptoms of breathlessness, fatigue and eating problems, with impairments lasting for five years. Patients require long-term monitoring to identify and target any problems quickly.
A new study by Karolinska Institutet researchers found that DNA methylation levels in white blood cells are lower in patients with schizophrenia and related to age of disease onset and treatment response. The discovery may lead to the development of a simple test to diagnose schizophrenia.
Researchers at Karolinska Institutet discovered that D-serine improves memory in 'depressed' rats by increasing brain plasticity. This finding suggests a potential treatment approach for depression, targeting the support cells' functionality.
Researchers at Karolinska Institutet discovered that pridopidine binds to the sigma-1 receptor, a previously unknown mechanism of action. This finding could lead to new treatments for schizophrenia, Parkinsonian tremors, and neurodegenerative diseases.
A Swedish register study reveals that children born to certain immigrant groups have an increased risk of developing autism with intellectual disability. The study suggests that environmental factors may contribute to the development of autism, particularly for children whose mothers migrated just before or during pregnancy.
A team at Karolinska Institutet has generated a map of the effects of small molecules on PARP1 and other proteins, which may explain putative side effects and contribute to new cancer therapies. The study's results provide unique insights into specificity and cross-reactivity of PARP inhibitors.
A new study reveals that palliative care is more nuanced than expected, incorporating aspects like bodily care, contact, environment, and rituals. Researchers found three key areas often overlooked in palliative care: bodily care and contact, secure and aesthetic environments, and death-related rituals.
The Stichting af Jochnick Foundation is funding research into the fundamental causes of diabetes at Karolinska Institutet, aiming to develop more effective treatments for the disease. The project will use unique methods to study insulin regulation in living organisms and identify new targets for drugs.
Patients with low levels of anti-PC in connection with acute coronary syndromes are at a greater risk of complications and premature death. Inhibiting inflammation and cell death may have a protective effect on cardiovascular disease.
Most patients who survive oesophageal cancer surgery recover an average quality of life, but one in six experience significant deterioration. Hospitals must improve identification and follow-up for these patients to prevent persistently low quality of life.
Researchers at Karolinska Institutet found that blood proteins EPO and PDGF-BB contribute to cancer tumour development and proliferation. The study suggests a potential therapeutic approach by targeting both proteins.
Researchers at Karolinska Institutet have discovered a new player in the body's defense against cancer, VCP/p97 complex. This complex plays a crucial role in regulating the recruitment of tumor suppressor protein 53BP1 to damaged DNA.
A new method for counting molecules has been developed by researchers at Karolinska Institutet, allowing for the accurate measurement of RNA and DNA molecules in cells. This breakthrough enables the counting of absolute numbers of molecules, rather than just relative differences between samples.