Researchers have identified a specific cellular mechanism that may help overcome endocrine therapy-resistance in patients with estrogen-positive breast cancers. A novel molecular 'crosstalk' point between estrogen and HER2 signaling pathways has been found to drive tamoxifen resistance, according to new findings.
Climate change, fire suppression, and invasive species are threatening mountain meadows in the Pacific Northwest. These ecosystems, once carpeted with grasses, shrubs, and wildflowers, are declining rapidly, with some areas experiencing a 35% increase in tree occupation over just 57 years.
Sandy's remnants continue to linger over a large area in eastern Canada and the northeastern US, with low-pressure areas stretching from Newfoundland and Labrador west over Quebec, Ottawa, and Toronto. The National Weather Service projects that the low-pressure area will shift offshore by November 6.
Researchers found that individuals who dwell on daily stressors and become increasingly upset are more likely to suffer from chronic health issues. The study suggests that learning how to manage stress is key to maintaining good health.
Researchers found that cannabis users with schizophrenia have higher brain activity and correct answers than those without prior cannabis use. The study suggests that cannabis use can imitate the cognitive weakness leading to schizophrenia in non-psychotic individuals.
A four-year health care project in India's poorest district resulted in a half-fall in infant mortality and a three-quarters reduction in women's death from pregnancy and childbirth complications. Nurse-based clinics expanded access to healthcare, changing attitudes towards patients and leading to increased check-ups and hospital births.
Researchers at the University of Vienna have achieved a world record in entangling twisted light quanta, demonstrating a new method for gyrating photons. This breakthrough could lead to entangling and twisting macroscopic objects in two different directions.
Recent studies suggest that hypertension and diabetes are more prevalent in black versus white donors, but the risk attributable to donation remains unknown. Individuals with prediabetes can safely donate kidneys without increasing their risk of developing diabetes or kidney failure.
The Biophysical Society has recognized five individuals with its 2013 awards for their significant contributions to biophysics and biomedical research. Carol Robinson and Joseph Zasadzinski received awards for their innovative work on mass spectrometry and lipid structures, respectively.
A recent study led by Caltech researchers provides new insights into the process of neural crest cell development. The team discovered that DNA-methyltransferase (DNMT) enzyme acts as a switch to determine which cells will remain part of the central nervous system and which will become neural crest cells.
A large-scale study of over 34,000 individuals has identified 71 new genetic regions linked to inflammatory bowel disease (IBD), increasing the total number of discovered regions to 163. The findings highlight the complex interplay between the immune system and microbial infections in IBD.
Research at CARB has shown that plants use protein receptors to detect modified Nod factors, leading to root nodule development and nitrogen production. Legumes employ a sophisticated detection system to distinguish between pathogenic and beneficial microorganisms.
A promising stem-cell-based approach has been successfully demonstrated in non-human primates, where transplanted spermatogonial stem cells produce functional sperm. Cancer patients who undergo chemotherapy often become infertile due to treatment damage, but preserving and transplanting SSCs may restore fertility.
Scientists at National Jewish Health identified a novel target for treating peanut allergies by inhibiting Pim 1 kinase, which increases in the intestines of allergic mice. Treatment with a small molecule inhibitor reduced allergic symptoms, including diarrhea and histamine levels.
A new test has been found to be more effective and cheaper than traditional cytology testing for women following pre-cervical cancer treatment. The study suggests that using HPV testing as a 'test of cure' can help avoid recurrence of cervical cancer and reduce the burden on healthcare systems.
Research found that church-affiliated teens are more likely to graduate high school and enroll in college, with mentors playing a significant role in their educational success. The study's findings highlight the importance of religious participation and spirituality in achieving higher education attainment.
A Johns Hopkins study found that sticking to a medication regimen reduces debilitating delusions and hallucinations in individuals with schizophrenia. Regular visits to a mental health professional also increase survival rates, suggesting that adhering to treatment plans can improve life expectancy for those affected by the illness.
A study by researchers at the University of Pennsylvania School of Medicine found that apolipoprotein E (apoE) plays a key role in maintaining arterial softness. The protein is associated with the production of collagen and other extracellular matrix proteins, which contribute to cardiovascular disease risk.
Researchers have designed a compound that suppresses symptoms of Huntington's disease in mice by targeting mitochondria, potentially leading to new treatments for neurodegenerative diseases. The synthetic antioxidant XJB-5-131 improves mitochondrial function and enhances neuron survival.
A new computer program has been developed to improve genetic test results for Lynch syndrome, a hereditary predisposition to colon cancer. The program helps assess the risk of colon cancer development by evaluating missense substitutions in mismatch repair genes.
Researchers at the University of Pennsylvania developed a new medicine to treat patients suffering from homozygous familial hypercholesterolemia, a rare and deadly cholesterol disorder. Lomitapide substantially reduced LDL cholesterol in patients by up to 50% and improved therapeutic goals for some patients.
Researchers identified a family with two of three children affected by CDD, both carrying a rare DGAT1 gene mutation. The study suggests targeting DGAT1 could cause severe diarrheal disorder in individuals with the mutation.
Scientists have discovered how antibiotics work inside tuberculosis bacteria cells using mass spectrometry. The study's findings suggest that current drugs can be improved by modifying their molecules to withstand bacterial degradation, paving the way for more effective treatments.
Researchers used PET scans to visualize the effect of caffeine on brain adenosine receptors for the first time. The study found that up to 50% of A1 adenosine receptors were occupied by caffeine in regular coffee drinkers, suggesting a potential link to neurodegenerative diseases.
A study examines parental behaviors that create anxious children, revealing a link between parents' social anxiety and their offspring's angst. The research identifies specific behaviors, including lack of warmth and criticism, which can increase anxiety in children.
Researchers have created a plentiful supply of glial progenitor cells, which produce myelin, by mastering the chemical symphony that instructs them to divide. This breakthrough could lead to treatments for diseases like multiple sclerosis and cerebral palsy.
A combination of an anti-HER2 drug and an angiogenesis inhibitor significantly improves survival in a mouse model of brain metastatic breast cancer. The treatment extends patient survival by slowing the growth of brain tumors, making it a promising approach for patients with HER2-positive breast cancer who develop brain metastases.
A new study explores the impact of the interleukin-1β gene on brain function alterations associated with schizophrenia. The research found that patients with schizophrenia who were homozygous for the C allele showed reduced prefrontal cortex activation, while healthy volunteers did not differ by genotype.
A Michigan State University-led team is working with Puerto Rican police to improve homicide investigation techniques, aiming to solve more homicides and reduce the murder rate. The goal is to increase clearance rates from 25% to 65% and lower the homicide rate below 20 per 100,000 people.
Researchers found that targeting CD22 protein on lung cancer cells reduces tumor growth and metastasis in mouse models, leading to improved survival rates. The discovery may lead to the development of a novel therapy for non-small cell lung cancer.
Tropical Depression Nilam has covered southern India with its clouds, stretching from Chennai to Kerala, according to NASA's MODIS image. Heavy rainfall is expected over Rayalaseema, Karnataka, and south coastal Andhra Pradesh before the storm dissipates.
Scientists have discovered that a gene switch regulates the expression of genes and promotes cancer development, according to a study published in Science. The study found that removing a specific region containing a genetic variant increased resistance to tumor formation in mice.
A new equine vaccine, Equivac HeV, has been developed to prevent clinical disease caused by Hendra virus in horses. The vaccine, derived from the original work of Christopher C. Broder and Katharine Bossart, is now available for use in Australia.
Researchers at Rensselaer Polytechnic Institute have developed an ultrasensitive method for detecting sugar molecules, known as Glyco-qPCR. This technique enables a more detailed understanding of cellular functions than genetic or proteomic information can provide, and has the potential to revolutionize the study of glycans.
A new study published in PLOS Computational Biology uses a computer model to accurately mimic how the brain processes musical timbre, allowing for better instrument recognition. The researchers found that wind and percussive instruments tend to be most different from each other, with strings and winds being closer together.
A recent study in Neurosurgical Focus highlights the importance of preoperative, intraoperative, and postoperative processes in reducing neurosurgery-related adverse events. The authors propose a national registry for outcome data and monitoring, as well as standardization of specialized equipment and evidence-based guidelines.
Researchers found that TFIIB halts general transcription when DNA damage occurs, enabling cells to prioritize repair and support p53's tumor-suppressing functions. This process allows p53 to bypass the need for TFIIB phosphorylation, activating its target genes vital for DNA damage response.
A computer model reveals that marine bacteria benefit from swimming in turbulent seawater, accessing nutrient-rich zones before they are dispersed. The study finds an optimal swimming speed of about 60 micrometers per second, which confers a feeding advantage but also incurs energy costs.
The Nowgen Schools Genomics Programme provides free, multi-media resources to update the study of modern genetics in schools and colleges. The resources aim to bring cutting-edge research into the classroom, helping teachers and students explore the impact and potential of modern genetics.
Tropical Storm Rosa experienced strong convection pushed southeast of its center due to wind shear. The AIRS instrument captured infrared images showing the strongest thunderstorms in that area had cloud tops as cold as -63F (-52C), leading to heavy rain, weakening Rosa's organization.
Researchers developed a new optical imaging technique that uses tissue-penetrating laser light to analyze ultra-thin collagen fibers in breast tumor tissue samples. The study found that women with denser fiber patterns were more likely to need lymph node biopsy and removal, reducing the risk of unnecessary surgeries.
Researchers have created the world's first family tree linking every known bird species and found that they are accelerating their rate of evolution. The study reveals that birds' speciation rate is increasing, not declining, with no drop-off in tropical regions.
Recent studies claiming to use brain scans for autism diagnosis are flawed and unreliable. Researchers need to conduct large-scale multicenter studies to understand the biological basis of autism.
Scientists from UNH's Space Science Center will develop a cutting-edge radiation detector to measure and calculate absorbed dose in matter and tissue resulting from exposure to indirect and direct ionizing radiation. The project aims to aid in understanding the hazards posed by space radiation and protect astronauts on extended missions.
A team of researchers at the University of Pittsburgh School of Medicine has successfully restored fertility in male primates who became sterile due to cancer drug side effects. The study involved transplanting spermatogonial stem cells into testes, resulting in functional sperm that fertilized eggs and produced early embryos.
A recent study by George Bizer and colleagues found that negatively framed political attitudes are stronger than positively framed attitudes, particularly when people process the messages deeply. This effect is strengthened when people think more deeply about the issues involved.
A new study by MIT and Northwestern economists reveals that kinship networks are crucial for accessing credit, smoothing consumption, and financing large investments. The research suggests that indirect access to banks is as effective as a direct connection, highlighting the importance of social safety nets in reducing financial vulner...
The Initiative for Maximizing Student Development at SDSU is expanding its program with a $2.8M NIH grant, providing opportunities for 30 students in biomedical and behavioral sciences. The program offers top-notch guidance, research, and advancement opportunities to diverse students.
A recent Johns Hopkins study found that repeated surgeries to remove glioblastomas, the most aggressive brain tumors, can increase median survival time from 14 months to 26.6 months. This may be due to increased efficacy of radiation and chemotherapy with each successive surgery.
A new study uses blood testing to predict cathepsin activity, enzymes accelerating diseases like atherosclerosis and cancer. The technique achieved high predictability, ranging from 90 to 95 percent, and may help develop personalized treatments for tissue-destructive diseases.
Researchers are using computational models and digital tools to build a clearer picture of disease mechanisms, aid in diagnosis, and test therapies. These advancements have the potential to predict patient risk and develop more effective treatments.
Using data from NASA's Fermi Gamma-ray Space Telescope, scientists measured the most accurate amount of starlight in the universe and determined the extragalactic background light (EBL), also known as cosmic fog. The EBL is a fossil radiation field created by ancient starlight that continues to travel through the universe.
Researchers found that adding fruits and vegetables can reduce metabolic acidosis and preserve kidney function in CKD patients. Poor dietary habits and poverty are also linked to an increased risk of kidney disease, highlighting the need for targeted interventions to address disparities in care.
Researchers at Boston University developed a novel technique to produce human induced pluripotent stem cells (iPSCs) from peripheral blood, offering an ethical alternative to embryonic stem cells. The method has been published in JoVE and provides a valuable resource for studying rare genetic disorders.
Researchers discovered that fruit fly larvae with simple eyes can assemble complex images using rapid head scanning, challenging traditional views on vision. The study suggests the brain plays a crucial role in processing visual input, enabling organisms to recognize details and patterns despite limited visual acuity.
The National Center for Atmospheric Research is launching a three-year, international study to analyze the effects of smoke from traditional cooking methods on human health. The researchers will combine sensors with computer models to examine links between air pollutants and diseases such as meningitis in northern Ghana.
Benaroya Research Institute (BRI) has received a $100,000 grant from the Bill & Melinda Gates Foundation to develop rapid malaria vaccines using synthetic minigene libraries. This innovative approach aims to identify protective target antigens in a fraction of the time required by conventional technologies.
Researchers at George Mason University are conducting three trials to target breast cancer using a malarial drug called chloroquine. The trials aim to prevent the development of breast cancer in its early stages, reducing the risk of invasive cancer.
New research examines how social groups work, including in-group conformity and prejudice reduction strategies. Studies find that oxytocin stimulates in-group conformity and a small dose of negativity can reduce prejudice toward stigmatized groups.
FOXSI will study nanoflares on the sun using a state-of-the-art x-ray telescope that focuses incoming x-rays. The mission aims to understand energy transfer and coronal heating by observing how these small flares impact the sun's atmosphere.