Researchers at the National Cancer Centre Singapore have discovered a crucial link between mutant p53 genes and reduced treatment response in cancer patients. The dominant-negative effect of these mutations inhibits tumor suppressor activity, leading to poor responses or earlier relapse after treatment.
Jeffrey H. Reed, a Chaired Professor of Electrical and Computer Engineering at Virginia Tech, has received the 2012 Forum International Achievement Award for his significant contributions to software-designed radio and cognitive radio.
Scientists will use high-throughput screening to identify novel inhibitors of ASK1, a promising therapeutic target for diseases like rheumatoid arthritis. The grant aims to develop new treatments using compounds from the Scripps compound collection.
Researchers at Northwestern University have developed a new organic solar cell design that maximizes light trapping using a geometric pattern inspired by natural evolution. The design achieved a three-fold increase over the Yablonovitch Limit, a thermodynamic limit for photon trapping in semiconductors.
A systematic review found that yoga has positive effects on mild depression and sleep complaints, as well as improving symptoms associated with schizophrenia and ADHD in patients on medication. The review of over 100 studies highlighted the benefits of yoga for mental health illnesses, except for eating disorders and cognition problems.
Researchers found that an acidic microenvironment can drive cancer cells to spread and propose neutralizing pH as a therapeutic opportunity. Tumors adapt by creating acidic environments through increased glucose metabolism, hampering oxygen delivery and acid elimination.
Researchers found that nearly 3% of pediatric acute kidney injury cases can be directly linked to the use of common nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen. The study identified four young patients who needed dialysis and at least seven who may have suffered permanent kidney damage.
Researchers at BUSM demonstrate that tissues derived from patient-specific induced pluripotent stem (iPS) cells are not rejected when transplanted back into genetically identical recipients. The study finds that differentiated iPS cells can mature into various cell types, including neuronal, hepatocyte, and endothelial cells, without i...
A new patent issued for an experimental compound RTX, which represents a potential new class of drugs to alleviate intractable pain. The method patent covers intrathecal administration of RTX, promising to improve lives of people with severe pain.
A new Notre Dame study examines the dual-use aspect of nanotechnology research, exploring both its benefits and threats. The report discusses the potential for nano-sized particles to breach the blood-brain barrier and deliver targeted medicines, while also posing a serious threat in combat situations.
Researchers investigated the effects of Huanglongbing (HLB) on orange juice produced from diseased trees, finding that HLB symptoms can affect juice quality but not necessarily cause a bitter taste. The study suggests that mixing fruit with and without HLB symptoms could help address commercial operations' problems.
A new study by Wake Forest Baptist researchers found that emotional stress can reduce the effectiveness of prostate cancer therapies and accelerate tumor growth. Stress-induced activation of a cell signaling pathway may lead to a vicious cycle of stress and cancer progression.
A new study reports that non-steroidal anti-inflammatory drugs (NSAIDs) cause acute kidney injury (AKI) in children, with younger patients more seriously affected and at higher risk of chronic kidney disease. The study found that 30% of patients experienced mild chronic kidney damage after recovery from AKI.
The National Institute of Standards and Technology (NIST) has developed a novel chip-scale instrument using carbon nanotubes to measure laser power with high accuracy. The mini-radiometer achieves this by absorbing light over a broad range of wavelengths and converting it to heat, allowing for precise measurements.
Researchers at Temple University Health System have identified a potential target for treating sepsis: the STIM1 protein. By blocking its activity, they halted a cascade of cellular events that lead to out-of-control inflammation and protected lungs from severe damage. The findings may lead to new treatment strategies against sepsis.
Austrian physicist Friedrich Hasenöhrl's work on blackbody radiation in a cavity may have influenced Einstein's famous equation E=mc2. However, the study also reveals that Hasenöhrl arrived at an incorrect energy/mass correlation due to failing to account for mass loss during radiation.
Researchers developed an efficient method to induce human induced pluripotent stem (iPS) cells into intermediate mesoderm, the precursor of kidney cells. The protocol achieved a high success rate of 90% or more and successfully generated renal tubule structures.
Researchers discovered an identical gene mutation in the telomerase gene in all family members with malignant melanoma, leading to overactive telomerase and virtual immortality. The mutation was also found in non-inherited melanomas, suggesting a link between sun exposure and cancer development.
A new study led by Wayne State University will aim to develop methods for better identifying women at increased risk for stroke. The research aims to educate doctors on how to follow recommended guidelines to identify these patients, leading to improved treatment and screening rates.
Researchers at Aalto University have demonstrated improved light absorption and surface passivation on highly absorbing silicon nanostructures using atomic layer coating. This breakthrough advances the development of high-efficiency solar cells, which can potentially increase efficiency to new levels.
Researchers at INRS Énergie Matériaux Télécommunications Centre developed a novel nanohybrid structure combining carbon nanotubes and lead sulfide nanoparticles using pulsed laser ablation technique. The new material exhibits strong photoresponse, fast photocurrent response time and spectrally wide photoactivity.
Research finds that supplementing children's diets with fish oil, enrolling them in quality preschool, and engaging them in interactive reading can raise their intelligence. The study also found no evidence to support the idea that early education interventions are more effective than those that begin later.
The international collaboration found that 20-27% of people studied were infected during the first year of circulation, with higher rates in children and lower rates in older adults. The study estimated that up to a quarter of the world's population may have been infected.
Researchers warn that climate change, combined with human-driven factors, could significantly reduce usable groundwater availability for agriculture worldwide. Inadequate monitoring and mismanagement of groundwater usage will exacerbate the issue, compromising global food security.
Researchers at Washington University School of Medicine reprogrammed eye cells to prevent degeneration and allowed mice with retinitis pigmentosa to see. The study aims to develop therapies that can alleviate many forms of visual impairment by modifying existing cells in the eye.
Researchers found that daily antiseptic baths with diluted chlorhexidine gluconate significantly reduced the risk of bloodstream infections in critically ill children. The study involved over 4,000 children and showed a 36% lower risk of infections in those bathed with antiseptic solution.
Researchers at NIST have developed a way to predictably increase or decrease the intensity of quantum dot fluorescence by using DNA templates and controlling distances between gold nanoparticles. This breakthrough enables potential applications in photodetectors, chemical sensors, and nanoscale lasers.
Researchers develop SAPS algorithm to identify significant prognostic gene sets associated with patient survival, overcoming limitations of previous methods. The study found new prognostic signatures in breast and ovarian cancer subtypes, suggesting shared therapeutic targets and potential for improved diagnostics and treatments.
A University of Pittsburgh study demonstrates that content-focused literacy coaching significantly improves student reading comprehension, particularly for low-income English-language learners. The coaching model encourages teachers to facilitate interactive text discussions, leading to better comprehension and retention.
Researchers from MD Anderson Cancer Center found that qigong reduces depressive symptoms and improves quality of life in women undergoing radiotherapy for breast cancer. The study suggests that qigong may prevent a delayed symptom burden and expedite recovery, especially for women with elevated depressive symptoms.
Cyclone Oswald's remnants continue to bring heavy rainfall and gusty winds to eastern Queensland, Australia. The Australian Bureau of Meteorology reports rainfall totals exceeding 700 mm in less than 2 days, leading to rapid river rises.
The article examines the potential consequences of overlapping CaMV 35S promoter regions with viral gene VI in transgenic plants. It discusses the safety implications for foods containing or derived from GM ingredients.
A new study analyzing Greenland ice cores suggests that melting of the Antarctic ice sheet may have contributed more to sea-level rise than the Greenland ice sheet around 100,000 years ago. The research findings indicate a warmer-than-expected climate during the Eemian interglacial period, with surface temperatures about 8 degrees Cels...
A new model called Step and Wait (SAW) predicts technological innovation in six markets, offering a more accurate alternative to outdated models like Moore's Law. The SAW model tracks performance improvements in steps and waits, helping companies invest in the right technologies.
Researchers have discovered a genetic mutation in the NESP4 gene, which disrupts the LINC complex and leads to hearing loss. The study highlights the importance of nuclear positioning for normal hearing.
Researchers have found a way to 'mine' bacterial genomes for new drug leads by exploiting the process of antibiotic resistance. The study, published in the Proceedings of the National Academy of Sciences, reveals that bacteria can produce hundreds of compounds when exposed to antibiotics, many of which are potential secondary metabolites.
Despite concerns about high extinction rates, Griffith University researcher Professor Nigel Stork says the actual number is lower than feared. The study estimates around 5 million species on Earth, with conservation efforts protecting rich biodiversity in key areas.
A UC Irvine study reveals that low-dose exposure to the chemical tributyltin during pregnancy can lead to obesity in offspring and great-grandchildren, affecting gene expression and fat accumulation. The findings suggest permanent effects without subsequent exposure, highlighting the risks of endocrine-disrupting compounds.
A recent study published in Genome Medicine found great diversity in biobanks, with varying organizational structures, specimen types, and purposes. The research emphasizes the need for standardized policies to govern these collections and make samples available for research.
Researchers observed a pulsar that dramatically changes its radio and X-ray emissions, defying existing theories on star emission. The study reveals the pulsar switches between two extreme states, one dominated by X-ray pulses and the other by organized radio pulses.
A new study published in Clinical Infectious Diseases found that vaccinating children against rotavirus indirectly protects unvaccinated adults from severe diarrhea and vomiting. The study suggests pediatric immunization may be more cost-effective than previously thought due to reduced health care costs among adults.
Researchers created an EEG-based computer system that activates optical fibers in the brain to arrest seizure activity and reduce severe 'tonic-clonic' events. The approach shows promise for treating severe manifestations of epilepsy with minimal side effects.
Researchers at BRIC, University of Copenhagen, have found that blocking the enzyme Lysyl Oxidase (LOX) can significantly decrease metastasis in breast cancer models. This breakthrough suggests a new approach to prevent tumour microenvironment scarring and enhance patient outcomes.
Researchers found a 43% increase in autism among mothers with top 20th percentile CRP levels and an 80% increase at the top 10th percentile. The study used a large national birth cohort and adds to evidence of an overactive immune response altering fetal brain development.
A Phase 3 clinical trial shows that tofacitinib preserves joint structure in RA patients with moderate to severe disease, reducing progression of joint erosion and narrowing. The medication is effective in treating RA symptoms and reducing the rate of joint damage, providing new evidence for its treatment.
A new mobile device can perform laboratory-quality HIV testing in just 15 minutes and sync results with patient health records globally. It also detects weakly positive samples missed by existing rapid tests, revolutionizing diagnosis and treatment for people in resource-limited settings.
Scientists have discovered that dung beetles use the Milky Way's gradient of light to ensure they keep rolling their balls in a straight line. The beetles' ability to orient themselves using this method has been proven, giving them an advantage in navigating their environment.
A University of Michigan study reveals how certain genes activate cells that cause rheumatoid arthritis in mice, potentially leading to new treatments for both arthritis and other autoimmune diseases. The discovery challenges long-held theories on the association between HLA genes and autoimmune disorders.
Researchers found pomalidomide provided a minimal or better response for 42% of patients with disease relapsed after treatments. The study demonstrated 'encouraging activity with manageable toxicity', paving the way for phase II studies and potential FDA approval.
A soy-dairy protein blend has been shown to extend the anabolic window and promote muscle growth by stimulating muscle protein synthesis. The study found that consumption of the blend after exercise prolonged amino acid delivery to muscles and extended muscle cell growth signaling.
Researchers at Northwestern University have created an exotic new chemical compound that links two identical tetracationic rings together using a mechanical bond. The compound's stable organic radical properties make it useful for applications in batteries, semiconductors and electronic memory devices.
The new Advanced Metrology Laboratory at NPL will house an estimated 20 laboratories for 40 scientists, focusing on high-precision metrology. This facility will enable cutting-edge research in key nano and quantum metrology programmes, driving growth in the UK's technological development and application.
A synthetic corkscrew peptide has been shown to kill antibiotic-resistant Gram-negative bacteria by dissolving their double-layered membranes. The peptide, KLAKLAKKLAKLAK, was effective against a variety of strains of E. coli, A. baumanii, and P. aeruginosa, including multi-drug resistant strains.
African ball-rolling insects guide themselves along straight paths under starlit skies but lose orientation under overcast conditions. Dung beetles exploit celestial cues like the Milky Way for navigation, suggesting other nocturnal insects might follow suit.
Research reveals glial cells regulate blood vessel development, leading to potential insights into Alzheimer's and hemorrhagic stroke. A chance finding in a mouse study uncovered a previously unknown crosstalk between the nervous system and blood vessels.
Peach trees require specific chilling hours to produce flowers and fruit. Clemson researchers are studying the mechanisms of chilling and heat requirements to help breeders adapt cultivars to warmer winters. The goal is to maintain high fruit-quality traits while breeding for increased heat requirement.
A new feathered dinosaur fossil found in China's Jurassic period pushes back the known origins of birds, which were previously thought to have evolved from theropod dinosaurs around 120-130 million years ago. The discovery provides additional evidence for a more complex evolution of flight.
Researchers developed a grammar-aware password cracker that can bypass security with 10% of dataset cracked exclusively by the team's algorithm. The study highlights the importance of using different parts of speech in passwords, as pronouns are far fewer in number than other words.
A new study found a strong association between childhood abuse and an increased risk of uterine fibroids in adulthood among African-American women. Women who experienced physical or sexual abuse before age 11 had a higher incidence of fibroids, with the risk increasing with severity.
Researchers created a new method to analyze molecular interactions by leveraging hypergraphs to represent complex connections among molecules. The approach resolves limitations of traditional graph-based models, enabling more accurate discovery of interaction patterns.