Researchers discovered a novel class of early replicating fragile sites contributing to genome instability in B cell lymphomas. These sites, uncovered through genome-wide sequencing, overlap with mutations associated with the disease and suggest a major feature of its mutational landscape.
The Pitt team found that targeting Nef, a small HIV protein, could prevent it from replicating and infecting other cells. They discovered a compound called B9 that blocks Nef activity, impairing its function in the viral replication process.
Researchers found that patients view physicians who use decision aids as less capable and may assign them responsibility for negative health outcomes when using CDSSs. To mitigate this, healthcare providers can incorporate decision aids to engage patients and facilitate understanding of diagnoses.
Researchers found a pulsar, PSR B0943+10, that changes its behavior between two extreme states: one dominated by X-ray pulses and the other by highly organized radio pulses. The team used simultaneous observations with the XMM-Newton satellite and two radio telescopes to reveal this unique behavior.
Scientists have found a new dynamic process in liquid crystal cells triggered by strong electric fields. The theory of spatio-temporal chaos explains this effect, which affects the electro-optic switching phenomenon used in devices.
A study of 20 cohort studies found that high fruit and vegetable intake was associated with a lower risk of estrogen receptor-negative (ER-) breast cancer. The results suggest that increasing vegetable consumption may help lower ER- breast cancer risk, which accounts for only 15-20% of breast cancers.
A new concept has emerged to describe the natural world's resources supplied to humans, but its application raises ethical concerns about social equity and responsibilities. The study highlights the need for considering multiple values and interests when analyzing nature's contribution to humanity.
The EU has announced €38 million funding for research into rare diseases, aiming to develop new diagnostics and treatments through global data sharing. Advances in DNA sequencing have brought personalized treatments closer, but scientists now need to collate data to identify genetic causes of diseases.
Researchers discovered a signaling pathway in macrophages that detects escaping bacteria and activates an enzyme to trigger self-destruction, protecting against lethal infections. The caspase-11 detection pathway protects mice from infection with Burkholderia species, including the potentially deadly B. pseudomallei.
Animal studies suggest that type of anesthetic used, number of exposures and age contribute to risk of inflammation, cognitive deficits. Research findings indicate potential safer alternatives for young children.
Researchers identified a compound that blocks the expression of BLM protein, crucial for certain tumors to grow. The compound ML216 has the potential to stop tumor growth and is being explored as a treatment for osteosarcomas and soft tissue sarcomas.
Rachel Somerville's research focuses on creating computer models that simulate galaxy formation and evolution. Her work helps astronomers understand how galaxies first formed and how they continue to evolve in the contemporary universe.
A team of researchers at the University of Washington has discovered an organic ferroelectric molecule with promising properties for memory, sensing, and energy storage. The molecule offers a range of benefits, including lower costs, flexibility, and reduced toxicity.
Researchers found higher uropathogenic E. coli reservoirs in post-menopausal women's bladders compared to pre-menopause, which can lead to UTIs. Estrogen supplementation reduced these reservoirs dramatically, highlighting a potential new approach to prevent or treat UTIs in this population.
Tropical Cyclone Garry continues to intensify due to favorable conditions, with microwave satellite imagery confirming deep convection around its low-level circulation center. The storm is expected to briefly reach cyclone strength before wind shear weakens and dissipates it.
A University of Illinois study shows that retailers must balance the shopping process for consumers and pricing behavior of upstream suppliers through strategic manipulation of store layout. The findings suggest that making certain products convenient to consumers may not be the best retail strategy, as it can influence pricing behavio...
Research reveals mechanism of epigenetic reprogramming and how it may affect gene expression, potentially leading to disease susceptibility in offspring. The study found that some methylation marks can escape reprogramming and be passed on to offspring.
A new web-based teaching tool, Genomics Explorers, has been awarded the Science Prize for Inquiry-Based Instruction. The tool helps students formulate and explore their own research questions using genomic data sets, promoting real research experience and ownership of the process.
Researchers at the US Department of Agriculture have discovered a new method for producing insect-killing fungi, which significantly reduces production costs and increases yields. The liquid culture fermentation process uses less expensive nitrogen sources, making it a more cost-effective alternative to traditional methods.
A landmark study published in Annals of the Rheumatic Diseases found that lupus patients taking immunosuppressive medications do not have a significantly increased risk of developing lymphoma. The study involved nearly 5,000 cancer-free lupus patients and found no clear association between disease activity and lymphoma risk.
Researchers discovered a calcified ovarian teratoma in a Roman-age skeleton, shedding light on the presence of this tumour in antiquity. The tumour contained four anomalous teeth and a small bone fragment, providing valuable information for the study of ancient diseases.
A prospective study of 1,200 healthy women found that low serum vitamin D levels before diagnosis increased the risk of premenopausal breast cancer. Women with low vitamin D levels had approximately three times the risk of breast cancer as those in the highest vitamin D group.
A recent study suggests that instant online corrections may not effectively dispel false beliefs, particularly among those who already support the falsehood. The study found that real-time corrections were only effective among participants who initially supported electronic health records, while opponents of EHRs discounted the credibi...
A study published in the Canadian Journal of Anesthesia found that hospitals treating patients with anemia before surgery had better outcomes, including reduced blood transfusions, infections, and shorter hospital stays. Early diagnosis and treatment of anemia are crucial to avoid unnecessary transfusions and improve patient care.
Research finds that exposure to certain plastics and hydrocarbons can cause reproductive diseases and obesity in descendants, leading to epigenetic inheritance. The study identifies nearly 200 molecular markers for exposure and disease, paving the way for diagnostic tools and new therapies.
The new $17 million supercomputer will peak at 3.4 petaflops and offer 2.7 petabytes of usable storage, benefiting climate and biological simulations, energy research, and material science applications. Researchers from around the world can apply to use the system, which is expected to accelerate scientific discovery.
A new approach to analyzing repetitive DNA at chromosome ends has revealed potential cancer clues, including a link between telomere length and genetic mutations. The study found that 32% of pediatric solid tumors carried extra DNA for telomeres, compared to brain tumors and leukemia samples.
A new study finds that prostate cancer stigma is a significant barrier to diagnosis and treatment in Ghana, with many men diagnosed at late stages and opting out of therapy. The researchers aim to develop tailored treatment regimens and increase PSA screening rates to improve health outcomes.
The Department of Energy's Pacific Northwest National Laboratory will receive $2.8 million to develop a next-generation adsorption chiller that is smaller, lighter, and operates under extreme temperatures. The system could reduce diesel fuel use by up to 50% and save lives by reducing attacks on American soldiers.
Scientists at Nottingham University are part of a €18m European-wide project using high-tech laser technology to study how drugs interact with cells. They aim to design more effective treatments for chronic illnesses like cancer and asthma by understanding how drug molecules bind and unbind from proteins.
A new study by health economists at the University of York has produced an estimate of the impact on other NHS patients of new and more costly drugs and treatments. The research suggests a refinement of NICE's cost-effectiveness threshold, potentially leading to lower prices for new drugs when value-based pricing is introduced.
A study by Miriam Hospital researchers found that individuals with more willpower lost more weight, were more physically active, and consumed fewer calories from fat. Practicing acts of self-control, such as eating a low-fat diet and working out, can strengthen the 'muscle' of self-control.
NASA's satellite imagery reveals a powerful band of thunderstorms east of Oswald's center, with temperatures as cold as -63 Fahrenheit (-52 Celsius). The low-level circulation center has become well-defined, triggering severe weather warnings for destructive winds and heavy rainfall across parts of Australia.
A new 'scarecrow' gene has been found that controls a unique leaf structure, leading to more efficient photosynthesis. This discovery could lead to new varieties of staple crops with significantly higher yields through genetic engineering.
Research suggests that HIV-like viruses in non-human primates date back to at least 5 million years ago, possibly up to 12 million years ago. The study's findings indicate an evolutionary arms race between viruses and the host immune system, driving selective changes in antiviral genes.
A meta-analysis of large randomised trials found no significant increase in cancer risk among those taking daily folic acid for 5 years or less. The study provides reassurance about the safety of folic acid intake, particularly in countries where fortification is mandatory.
Research by Liliana M. Garces shows that affirmative action bans have a significant impact on the enrollment of students of color in various graduate fields, particularly engineering and natural sciences. The study suggests that institutions must adopt innovative outreach and recruitment practices to reverse underrepresentation trends.
A study published in JNCI Journal of the National Cancer Institute found that median out-of-pocket costs for Canadian breast cancer patients were $1,002, with higher costs among more educated women and those living far from hospitals. Wage losses had a greater impact on family finances than out-of-pocket costs.
Researchers found that snorers have a significantly greater intima-media thickness of the carotid arteries compared to non-snorers. The study suggests that snoring may be an early warning sign for cardiovascular disease, potentially leading to atherosclerosis and other serious health issues.
Researchers found that N. meningitidis adhesion to human microvessels leads to endothelial inflammatory response, clotting, thrombosis, congestion, and vascular leak, resulting in purpuric rash development. The study's findings challenge previous assumptions about the role of circulating bacteria and LPS release in vascular damage.
A study published in PNAS reveals that dengue fever transmission is driven by human movement within residential networks. The research found that people visiting friends and relatives in nearby homes were the main driver of rapid transmission. This finding has implications for disease surveillance and control.
The Yale School of Environment's Journal of Industrial Ecology publishes a special issue on Sustainable Urban Systems, focusing on integrated approaches to reduce environmental impact. Research explores global warming, waste management, and phosphorus use in cities worldwide.
Research reveals that recreational fishing and Great Depression-era ditches are causing significant erosion and die-off of cordgrass habitat in Cape Cod salt marshes. The unchecked growth of purple marsh crabs has led to the destruction of this essential ecosystem, threatening the region's ecological balance.
Researchers have found that the human papillomavirus 16 (HPV16) is present in the brains of individuals with a common form of childhood epilepsy. The discovery suggests that the virus may play a role in the development of the condition, and could lead to new therapeutic options related to HPV.
Researchers discovered XPD protein's role in locating damaged DNA, which aids cancer treatment development. The protein works like a scanner that glides along the DNA double helix, marking damaged spots for repair.
Scientists use magnetic levitation to create laboratory techniques for growing tissues virtually identical to those found in people's bodies. Researchers combined four cell types to replicate bronchiole deep inside the lung, creating realistic lung tissue.
A team of researchers has found significant errors in a previously published study claiming to identify awareness in vegetative state patients using bedside EEG technology. The reanalysis questions the validity of the original study's statistical methodology and findings.
Two new mutations have been discovered in the 'dark matter' of the cancer genome, occurring in 71 percent of malignant melanoma tumors. The highly recurrent mutations affect a promoter region adjacent to the TERT gene and may contribute to the development of melanoma.
A study led by Michelle Hindin identified research priorities for adolescent sexual and reproductive health in low- and middle-income countries. The top-ranking research questions suggest that definitions of problems and interventions need improvement, with a shift towards scaling up existing interventions and developing new ones.
Researchers have discovered that cells in every part of a wounded skin patch exert force to pull their neighbors along, coordinating their motions to heal the wound. This new understanding could lead to insights into the process and its long-term implications for healing and cancer research.
A BYU mechanical engineering professor's research reveals that internal waves play a crucial role in predicting weather, leading to frequent forecasting mistakes. By understanding how these waves move energy around, forecasters can develop better linear wave models to improve their predictions.
Researchers in Calgary have launched the world's first gene therapy clinical trial for Fabry disease, a rare inherited enzyme deficiency. The trial aims to transplant stem cells with a working copy of the GLA gene into patients, potentially curing the condition.
The new telescope, with a 100m x 100m collecting area, will scan half of the sky daily and synthesize an image of the sky nearly one billion times per second. The CHIME telescope aims to map a quarter of the observable universe, helping scientists understand the history of the Universe and dark energy's role in its expansion.
A team of researchers at Yale University has identified four new genetic suspects linked to the origins and treatment of meningiomas. The study found that tumors mutated with these genes tend to be located in different areas of the brain, indicating their likelihood of becoming malignant.
The famous Chamber A thermal vacuum testing chamber, upgraded to accommodate the James Webb Space Telescope, will undergo a 90-day test period. The test will confirm the telescope's performance in cold temperatures and include operating system tests.
A study finds that breast milk contains very low levels of tacrolimus, and babies can clear the drug at the same rate whether breast-fed or bottle-fed. Women taking tacrolimus who wish to breast-feed after counseling should not be discouraged from doing so.
A study of nearly 600,000 students found that African-American and Hispanic students tend to work longer hours than non-Hispanic white students but experience less negative effects on their grades. High school students who worked long hours at part-time jobs were more likely to be employed and report working more than 25 hours a week.
Researchers found that a small dose of ractopamine increased muscle mass and feed efficiency in pigs without compromising meat quality. The study confirmed previous findings that 5 mg/kg is an appropriate dose for Brazilian commercial pork production.
A Sun coronal mass ejection occurred on January 23, 2013, at a speed of around 375 miles per second, impacting the magnetosphere. The event caused a space weather phenomenon called a geomagnetic storm, potentially affecting GPS and satellite communications.
The NASA Super-TIGER balloon has shattered the previous record for longest flight by a balloon of its size, reaching 46 days in flight. The balloon is carrying the Super Trans-Iron Galactic Element Recorder (Super-TIGER) experiment to measure rare heavy elements among high-energy cosmic rays.