Researchers at Karolinska Institutet identify polyphosphate as a key player in the formation of blood clots and inflammation. The study suggests that phosphatases can break down polyphosphate, preventing both conditions.
A team of researchers at Karolinska Institutet has discovered a gene module underlying atherosclerosis development by analyzing total gene activity in organs relevant to coronary artery disease. The findings suggest that targeting the migration of white blood cells may help reduce the risk of adverse clinical effects.
Researchers found raised levels of interleukin-1beta in the spinal fluid of recent-onset schizophrenia patients, indicating activated brain immune defense systems. This discovery offers new potential treatments for the condition, potentially interrupting its course at an early stage.
Researchers at Karolinska Institutet have identified a paradoxical protein that stimulates stem cell division but prevents cancer growth. The study suggests a potential new treatment using the drug imatinib to prevent colon cancer in high-risk patients.
Researchers at Karolinska Institutet have discovered a mechanism that controls the brain's ability to create lasting memories. The study found that signalling via the nogo receptor 1 plays a key part in this process, enabling the conversion of short-term memories into long-term ones.
A new study published in Pediatrics reveals that children born with low birth weight are at a higher risk of developing asthma later in life. The study, which analyzed data from 10,918 twins, suggests that impaired fetal growth affects lung development and contributes to the development of asthma.
The Lennart Nilsson Award recognizes Carolyn Porco and Babak A. Tafreshi for their stunning images of Saturn and the night sky, inspiring new generations of astronomers and photographers. Their work showcases the beauty of the universe, from the rings of Saturn to the stars in remote locations.
Researchers at Karolinska Institutet found epigenetic DNA mutations in muscles of diabetics that reduce expression of PGC-1α gene. This could explain how environmental factors influence disease development.
Researchers at Karolinska Institutet discovered unstable proteins cause premature ageing by impairing cell respiration. Changes in mtDNA introduce errors into mitochondrial proteins, leading to their instability and breakdown.
Researchers at Karolinska Institutet have developed an electrically conducting plastic delivery electrode that releases specific neurotransmitters to activate neighboring brain cells, enabling precise control of neural signals. This technology has the potential to treat various neurological conditions, including hearing loss, epilepsy,...
Researchers at Karolinska Institutet are making rapid progress in stem cell therapy, with a first-in-human study initiated for Parkinson's disease. The study uses the drug product sNN0031, which has shown long-lasting recovery and new cell formation in animal models. Additionally, a treatment for ALS entered clinical trials last year.
Researchers found no significant increase in violent crime among people with schizophrenia, contrary to previous assumptions. The study suggests that substance abuse co-occurring with schizophrenia is a key factor contributing to violence.
A new study by Karolinska Institutet shows that extra support encourages more women to cycle to and from work, increasing daily physical activity levels. The intervention group achieved a larger proportion of cycling two kilometres or more per day than the control group.
Researchers at Karolinska Institutet discovered tufted bacteria can attach to premature babies' skin, causing infection. The bacteria's unique hair-like structures facilitate adhesion, while LL37 antimicrobial peptide helps inhibit growth.
Scientists at Karolinska Institutet have developed a simple blood test that provides accurate results, helping to ensure patients receive the right treatment. The rapid diagnostic tests (RDT) are being used in low-income countries to improve healthcare outcomes and combat malaria.
Researchers at Karolinska Institutet have discovered a new function for a protein essential to mitochondrial protein synthesis, which plays a key part in cell respiration. Without this protein, mitochondria cannot produce proteins and cellular respiration is impaired.
The study reveals a mechanism in the brain's neuronal network that restricts working memory capacity to two to seven items, with frontal lobes regulating parietal lobe memory capacity. The 'model brain' computations were confirmed using fMRI experiments and suggest improved working memory through increased frontal lobe activation.
Researchers at Karolinska Institutet identified a new gene, Wrap53, that regulates p53 activity. The study reveals that damage to Wrap53 can indirectly cause cancer, making it a potential target for future therapies.
Researchers at Karolinska Institutet found that mice exposed to low temperatures develop more blood vessels in adipose tissue, leading to faster fat metabolism. This discovery offers new therapeutic avenues for obesity and metabolic diseases.
Scientists at Karolinska Institutet have successfully induced people with an amputated arm to experience a prosthetic rubber hand as belonging to their own body. This illusion was achieved by tricking the brain into thinking sensory input was coming from the prosthetic hand.
Researchers at Karolinska Institutet have determined the first 3D structure of ZP3, a protein essential for fertilization in mammals. The findings provide insights into the molecular architecture of animal egg coats and may lead to the development of novel contraceptives.
A Swedish study suggests that a fast food diet rich in fat and cholesterol may be a potential risk factor for Alzheimer's disease. Researchers found that mice fed such a diet developed preliminary stages of the disease, which may indicate a contributory role of dietary factors in its development.
A study from Karolinska Institutet reveals that bad cholesterol inhibits the breakdown of peripheral fat in cells. The discovery opens up new theories for the association between blood lipids and metabolic syndrome.
A new Swedish study found that adjusting clocks to summer time increases the risk of myocardial infarction in the following week by about five percent. The readjustment back to winter time on the last Sunday in October reduces the risk, albeit to a lesser extent, due to the extra hour's sleep.
Scientists at Karolinska Institutet discovered skin stem cells can divide actively and transport themselves through skin tissue, contradicting previous assumptions. The study's findings also suggest a link between hedgehog signaling and the development of basal cell carcinoma, the most common form of skin cancer.
Researchers at Karolinska Institutet have found that thrombolysis can be safely administered up to four and a half hours after an ischemic stroke, without significantly increasing the risk of hemorrhage complications or death. This extends the time window for treatment, potentially benefiting more patients.
A new study by Karolinska Institutet found that immigrant women from different countries have varying risks of developing cervical cancer. Women from east Africa had a significantly lower risk, while those from Norway and Denmark had a higher risk.
A Swedish study found that living with a spouse or partner in midlife reduces the risk of developing dementia, including Alzheimer's disease. The study showed that people living alone ran twice the risk and widows/widowers faced the greatest risk of developing dementia.
Research at Karolinska Institutet found that people with schizophrenia have an increased number of unusual chromosomal changes, particularly structural changes that can alter gene function. These changes, known as copy number variants, may contribute to the development of the disorder.
Researchers have identified low levels of naturally occurring antibodies as an increased risk factor for cardiovascular disease, particularly stroke in men. This breakthrough finding suggests that anti-PC antibodies play a crucial role in the development of cardiovascular disease.
A study of over 7,600 Swedish twins found that genetic factors and the individual's unique environment play a significant role in determining their choice of sexual partner. The results suggest that familial and public attitudes have a minimal impact on this decision.
Researchers found a previously unknown cooperation between pancreatic beta cells and alpha cells, crucial for glucose balance. The discovery may lead to better blood sugar regulation in diabetes patients by targeting the glucagon/glutamate pathway.
A study from Karolinska Institutet found that golfers have a lower death rate than non-golfers, with a 5-year increase in life expectancy. Golfing, especially with a low handicap, has beneficial health effects.
A new study from Karolinska Institutet found that men who exercise regularly are less likely to die from cancer than those who don't. The researchers discovered a 33% increased survival rate among men who walked or cycled for at least 30 minutes a day, with more extensive physical activity leading to a 16% lower incidence of cancer.
Scientists at Karolinska Institutet have developed a new, cheaper DNA-sequence method that can map disease genes in large patient groups, leading to quicker breakthroughs for new treatments.
A Swedish study found that female sex offenders are more likely to suffer from mental illness or drug abuse than male perpetrators. The research compared 93 convicted women with over 20,000 normal women and 13,000 women convicted of non-sexual crimes.
Researchers at Karolinska Institutet have identified a receptor called ALK7 as crucial in regulating body fat deposition and insulin release from beta-cells. Removing the ALK7 receptor improves insulin release and decreases fat accumulation, suggesting potential new therapies for diabetes and obesity.
A gluten-free vegan diet has been shown to lower blood levels of oxidized LDL-cholesterol and increase anti-PC antibodies, providing atheroprotective effects. This study suggests that diet can impact the immune system and reduce disease incidence.
Researchers at Karolinska Institutet have discovered a network of genes that lower blood cholesterol levels and prevent the development of atherosclerotic plaques. The findings suggest that targeting these genes could be an effective way to combat atherosclerosis, the main cause of myocardial infarction and stroke.
A study discovered a 'fat-burning' gene that plays a crucial role in insulin sensitivity. When this gene is impaired, it can lead to increased risk of obesity and worsening diabetes.
American cancer researcher Professor Robert A Weinberg has been awarded the new Swedish science prize, which recognizes his pioneering discoveries in basal tumour biology and tumour suppressant genes. He will give lectures at Karolinska Institutet and forge links with researchers to advance cancer research.
Researchers have identified a new gene test that can identify men with a higher risk of developing prostate cancer. The study found that men carrying a combination of known risk genes are four to five times more likely to develop the disease, providing a potential breakthrough in early detection and treatment.
A new report by Karolinska Institutet and KTH identifies untapped potential for enterprise and new jobs in the medtech field. The report recommends closer collaboration between academia, healthcare, and industry to achieve industrial growth.
Researchers at Karolinska Institutet found that hysterectomy significantly increases the risk of urinary incontinence, with the highest likelihood noted within five years of the removal of the uterus. Women who had a hysterectomy before menopause or after multiple deliveries were particularly at risk.
Felice Frankel, a renowned scientific imagist, has been awarded the 2007 Lennart Nilsson Award for her exceptional work in creating crystal-clear scientific illustrations. Her photographs reveal previously invisible aspects of the world and have captivated the attention of scientists and the general public alike.
The study identified specific parts of PfEMP1 that are likely to bond more strongly with receptors in blood vessels, producing a stronger adhesive effect. These protein parts are common in parasites causing severe malaria, and their identification could lead to the development of a vaccine to prevent the disease.
An international team of researchers has identified three new genes associated with rheumatoid arthritis, including TRAF-C5 and STAT4. The study analyzed the genomes of over 1,500 patients and 1,850 controls, revealing a broader understanding of the disease's genetic mechanisms.
Scientists have discovered a new mechanism by which insulin-secreting cells regulate KATP channels, allowing for timely energy supply and storage of blood sugar. This discovery sheds light on how the human body maintains normal blood glucose levels and prevents diabetes.
Scientists identify MTERF3 as a mitochondrial factor that inhibits mtDNA expression and slows down cellular energy production. This discovery may lead to new ways of treating diseases related to impaired mitochondrial function.
Researchers at Karolinska Institutet have elucidated the crystal structure of LTC4 synthase, a major influence on asthma development. The study enables the development of new therapeutics by tailoring molecules to block the enzyme's active sites.