The Ellison Medical Foundation has awarded over $1 million to two mid-career scientists, Dr. Charleen T. Chu and Dr. David M. Sabatini, to study the impact of autophagy and mTOR signaling on age-related diseases such as Parkinson's disease.
A new treatment involving AVI-4658 has shown promising results in patients with Duchenne muscular dystrophy (DMD), increasing dystrophin production by skipping exon 51. The treatment was found to be safe and effective, with increased dystrophin expression observed in treated muscles.
Researchers have discovered that the juice of 'cull' watermelons can be efficiently fermented into ethanol, producing approximately 220 L/ha. This process also yields valuable nutrients like lycopene and L-citrulline.
Researchers have discovered a potential therapeutic agent for treating hepatic fibrosis, a scarring condition that impairs liver function and can lead to organ failure. The CCN2 hammerhead ribozyme shows promise in reducing collagen production and cell proliferation, offering new hope for millions affected by liver fibrosis.
Researchers found a way for healthy cells to take charge of cancerous cells by opening up communication channels, stopping them from developing into tumors. The chemicals, known as kinase inhibitors, appear to be relatively non-toxic and can persist even when withdrawn.
Healthcare patient safety interventions face complexity due to diverse populations and technologies. Guidelines from Johns Hopkins experts suggest prioritizing rare but devastating errors over more frequent systemic problems.
Researchers identify a link between high cholesterol and osteoporosis, with the immune system playing a key role in bone loss. The study found that oxidized LDL triggers an immune response, leading to excessive bone damage.
The world's largest fruit bat species, Pteropus vampyrus, is threatened with local extinction due to unsustainable hunting rates in Peninsular Malaysia. International protection is recommended to address the issue.
The Tobacco Atlas estimates that tobacco use kills six million people annually, with two million cancer deaths projected by 2015. The global economy loses $500 billion due to tobacco use, mainly in low- and middle-income countries.
A new study suggests that adolescents who engage in high-risk activities have more adult-like white matter tracts than their peers. This finding challenges the assumption that delayed brain maturation is the cause of impulsive and dangerous decisions during adolescence.
Researchers have identified a new treatment option for patients with ruptured brain aneurysms using stent-assisted coil embolization, which was successful in 72% of cases. The procedure offers an alternative to surgical repair or balloon-assisted embolization, particularly for wide-necked aneurysms.
Researchers found that acute transient hepatocellular injury occurs in patients with cholelithiasis and cholecystitis without evidence of CBD stones, resolving within weeks after surgery. Markers of liver damage are more severe in those with CBD stones or histologically less severe inflammation.
Researchers at UCLA have confirmed the effectiveness of measuring microRNAs in saliva to detect oral squamous cell carcinoma. The study identifies two specific microRNAs, miR-125a and miR-200a, that are present at significantly different levels in the saliva of individuals with oral cancer.
Researchers identified 50 microRNAs in saliva that could help detect oral cancer, including miR-125a and miR-200a. The findings suggest a major step forward in early oral cancer detection.
A study by Risto Moisio and Mariam Beruchashvili finds that Weight Watchers meetings offer a spiritual and therapeutic model for members seeking well-being. The authors conclude that the social function of weekly meetings extends far beyond weight loss, providing a powerful service to its clientele.
Researchers found that ad placement affects consumer perception, with easier-to-read articles leading to more favorable evaluations of ads and products. Placing ads after difficult articles can have negative effects, while ads unrelated to the article may be more positively received.
Despite notable achievements in disease management, South Africa faces a severe HIV and tuberculosis crisis, with 17% of the global burden. The country needs to escalate its public health response to tackle rising drug resistance and improve treatment outcomes.
Researchers at Rhode Island Hospital successfully implemented an alcohol abuse screening and brief intervention model in a community hospital emergency department, achieving positive results. However, the program's sustainability was limited by the lack of additional staff trained to conduct screenings and interventions. The study high...
Scientists investigate Hořava's quantum gravity model, which modifies Lorentz symmetry. The team finds that the modifications only reproduce general relativity on unobservable scales.
Researchers found that Six1 protein is central to tumor development in breast cancer, linked to EMT, stem/progenitor cells, and poor prognosis. Overexpression of Six1 also enhanced ability to metastasize, indicating its role as a key player in aggressive breast cancer.
A new study found that unmarried cancer patients who are separated at diagnosis have poorer survival rates compared to widowed, divorced, and never married patients. The researchers suggest that the stress of separation may compromise an individual's immune system and lead to a greater susceptibility to cancer.
The new initiative will characterize the human immune system under normal conditions and following infection or vaccination, using systems biology approaches. Researchers will analyze human samples from well-characterized cohorts to identify specific patterns of immune molecules that reflect immune system function.
Research published by the American Academy of Neurology links high blood pressure to cognitive impairment in people over 45. The study found that those with high diastolic blood pressure were more likely to experience memory and thinking problems.
The Lancet South Africa series proposes three strategies to address public sector workforce needs, affordable national health insurance, and competent leadership. The authors also discuss the decline in clinical research activity and capacity, as well as health inequities in South Africa, highlighting the need for jobs and cooperation ...
The country's health system faces historical roots of racism, apartheid, and economic inequalities, contributing to poor health outcomes and a high burden of HIV/AIDS. Despite being a middle-income country, South Africa has worse health outcomes than many lower-income countries.
A new analysis reveals that neglected tropical diseases (NTDs) in sub-Saharan Africa cause immense suffering, with helminth infections accounting for approximately 85% of the NTD burden. The study suggests that investing $200-$400 million annually could significantly reduce the burden of these diseases.
A new study published in JNCI finds that training methods for surgeons performing breast cancer sentinel lymph node resection are highly effective. The study evaluated three training methods and found a statistically significant positive association between procedural errors and false-negative rates.
Researchers engineered a chimeric protein that increases cell survival, migration and proliferation to improve liver stem cell engraftment. The protein, TAT-Tpr-Met, was shown to increase the number of hepatic stem cells integrated into the liver of mice.
A study of 7,689 admissions found that early intensive care unit admission significantly reduces mortality in critically ill patients with haematological malignancy. Factors associated with increased risk of death include bone marrow transplantation and severe sepsis.
A new study finds that smokers in rural Indonesia spend 10% of their budget on tobacco, leading to poorer nutrition for their children. Smokers' families prioritize cheaper rice over nutrient-rich meats and vegetables.
A new USC study reveals that prenatal tobacco smoke exposure is associated with detectable changes in DNA methylation patterns, which may impact childhood asthma and cardiovascular disease. Researchers found that children exposed to maternal smoke had lower global methylation levels and higher methylation in certain genes.
Typhoon Vamco boasts an enormous 45-mile-wide eye with cold high thunderstorm cloud temperatures below minus 63 Fahrenheit. The storm is currently in the Northern West Pacific Ocean and will begin changing to an extra-tropical storm, moving into the North Central Pacific Ocean.
The National Institute of Statistical Sciences (NISS) has received funding to develop Bayesian methods for syndromic surveillance using conditionally auto regressive models. The research aims to provide quantified estimates of disease presence, characterize uncertainties, and implement computational methods at a nationwide scale.
A study estimates that implementing basic neonatal care and prevention of mother-to-child transmission could save up to 37,200 children's lives annually in South Africa. The interventions are estimated to cost US$1.5 billion per year, but the authors argue that the costs are affordable and effective implementation is the key gap.
A new study reveals consumers are more persuaded by messages that align with their goals, whether abstract or concrete. The research suggests that fitting the message level of abstraction to a consumer's goals enhances brand evaluations and engages people in tasks beyond product selection.
A study by Russell Belk explores how societal changes impact sharing, highlighting threats like individualization and decline of public education, but also finds healthy models in online communities and forums. Belk suggests promoting sharing through an expanded sense of self and shared ownership.
The American Political Science Association has awarded several notable individuals with prestigious recognition for their contributions to the study and practice of politics. Lawrence O'Toole received the John Gaus Award for a lifetime of scholarship, while Catherine McArdle Kelleher won the Hubert H. Humphrey Award for public service.
A K-State chemist is studying two photosynthetic complexes from a type of bacteria to develop artificial photovoltaic devices that convert sunlight into electricity. The research aims to advance the understanding of structure-function relationship in natural systems.
A new study reveals that popular social networking sites make user personal information available to tracking sites, allowing for direct linking of browsing habits to specific individuals. This can lead to inaccurate profiling and serious consequences for users.
Researchers found that Aurora B kinase helps regulate XIST's chromatin binding by phosphorylating chromatin proteins during mitosis. This study provides insight into X chromosome silencing and may lead to a better understanding of noncoding RNAs and their role in regulating heterochromatin.
Heat waves pose a significant threat to older adults and individuals with chronic diseases, who are more susceptible to heat-related illnesses due to impaired thermoregulation. Air conditioning and working fans can reduce the risk of mortality by up to 80% and 30%, respectively.
Researchers found that women and men use hesitant language when discussing topics that don't align with their gender, but also exhibit similar patterns of tentativeness in neutral topics. This challenges the notion of innate gender differences in communication style.
Researchers found that presenting risk as natural frequencies and using bar charts helped participants make decisions consistent with their values. The studies also showed that different data presentations can be more persuasive, regardless of the participant's values. Healthcare providers should strive to maintain objectivity while re...
Researchers at Cold Spring Harbor Laboratory have developed a sensitive and accurate way of identifying gene copy number variations (CNVs) using new DNA sequencing technologies. This method allows for the detection of small structural variants that were previously overlooked by current methods.
A Tel Aviv University researcher suggests that tears signal vulnerability and attachment, making interpersonal relationships stronger. Crying is not just a symptom of pain or stress, but an evolution-based mechanism to bring people closer together.
A large cohort study suggests that mild glucose intolerance in pregnancy may be an early indicator of women at increased risk of heart disease. Women with subclinical blood vessel changes during pregnancy are more likely to develop type 2 diabetes and vascular disease.
A University of Wisconsin-Madison team successfully grew multiple types of retina cells from two types of stem cells, suggesting a potential future in repairing damaged retinas. The discovery will also lead to laboratory models for studying genetically linked eye conditions and screening new drugs.
A new prognostic marker for human breast cancer has been identified, with elevated GLI1 protein levels associated with poor overall survival. The study found a positive correlation between GLI1 expression and tumor stage, lymph node status, and unfavorable prognosis.
The Faidherbia acacia tree has the potential to revolutionize African farming by providing a free source of organic nitrogen, increasing crop yields, and improving soil health. Its unique growth habit and adaptability to various climates make it an ideal solution for reversing soil degradation and supporting farmers' livelihoods.
Idaho researchers have been awarded a three-year grant to explore novel approaches to gene therapies by targeting specific sections of chromosomes with locked nucleic acids. The team aims to improve targeting and show its impact on genes, potentially leading to new treatments for genetic diseases.
Researchers at Heidelberg University Hospital discovered that mice with thick blood formed larger but more stable plaques, reducing the risk of vascular obstruction. However, long-term use of anticoagulants reversed these advantages, highlighting the need for caution when prescribing these medications.
The Eli and Edythe Broad Foundation has renewed its three-year grant to support high school students in gastroenterology research careers through the AGA Foundation's Student Research Fellowship Awards program. The program provides funding for students to conduct research under the supervision of an approved preceptor.
A new study published in Obesity and Weight Management explores the link between obesity and erectile dysfunction, finding that excess weight increases the risk of ED due to atherosclerosis-related hypertension and hormonal changes. Research shows that weight loss and increased physical activity can improve symptoms.
A new study found that consuming sugar-free beverages with low-calorie sweeteners leads to greater dietary restraint, a key factor in successful weight maintenance. Researchers concluded that artificially sweetened beverages may be an important weight control strategy among individuals who have achieved or maintained weight loss.
Researchers at the University of Illinois Chicago are developing an educational comic book to teach AIDS patients about food safety, highlighting risks such as listeria and toxoplasmosis. The study aims to improve awareness and reduce life-threatening infections among AIDS patients.
A study found that amateur designers have lower self-evaluations of their products when compared to professionals. However, consumers enjoy intentionally competing against professionals, leading to more favorable self-evaluations when informed of contests beforehand.
A genomic study has identified a plausible cause of colony collapse disorder in honey bees. The research found that the loss of ribosomal function, caused by viral infections and other stressors, contributes to the mysterious disappearance of American honey bees.
A Kansas State University study found that employees who are engaged in their work experience better moods and more satisfaction at home. The researchers tracked 67 extension agents over two weeks to determine the relationship between daily work engagement and work-to-family facilitation.
Research finds that higher levels of testosterone in women are associated with a greater appetite for risk, leading to more risk-prone career choices. In contrast, men with similar testosterone levels exhibit lower risk aversion.
Researchers at Texas A&M University discovered that male bats use distinguishable syllables and phrases as love songs to attract females. The study found that the sounds are made in a specific pattern to form a song, with organized sequences within each phrase, and are used by males during mating.