Researchers develop adaptive therapy that adjusts drug dose based on tumor response, controlling growth and allowing 60-80% of mice to be weaned off the drug. The treatment approach stabilizes tumors by maintaining a small population of drug-sensitive cells to suppress resistant cell growth.
The study provides information that can be incorporated into clinical assessments for the prevention of cardiac emergencies in basketball players. The analysis reveals that left ventricular cavity sizes in NBA players are larger than in normal adults, but proportional to body size.
Researchers develop new material to collect condensed water droplets using bio-inspired approach combining multiple natural systems. The material harnesses the power of desert beetles' bumps, cactus spines and slippery surfaces to facilitate condensation, promising applications in thermal power plants.
A study published in Scientific Reports found that birds migrating greater distances have more new neurons in brain regions responsible for navigation and spatial orientation. The research team discovered a trend of increasing new neurons in line with migration distance, with different brain regions affected in two species.
A new study reveals that pancreatic cancer is composed of four distinct subtypes, each with its own unique genetic profile and treatment possibilities. These findings have significant implications for diagnosis and treatment, potentially allowing for more accurate prognoses and targeted therapies.
A new study by Simon Fraser University researchers found that differences in working memory capacity correlate with the brain's ability to actively ignore distraction. Individuals with low memory capacity are unable to suppress distractors, leading to attentional deficits.
A UT Dallas study found that student-athletes with lowest GPAs reported viewing themselves as athletes over students, thinking about sports more than academics. Coaches may play a strong role in academic performance, and universities must ensure proper guidance for success.
Researchers found that omega-3 supplementation reduced breast density in postmenopausal women with a body mass index above 29, bordering on obesity. The study suggests that DHA alone may be preferentially protective in these individuals, offering an example of personalized approach to breast cancer prevention.
Scientists have found that ocean acidification is already slowing coral reef growth, with the potential for widespread devastation if left unchecked. Researchers manipulated seawater chemistry in a natural ecosystem to determine the impact of excess CO2 on coral reefs.
The International Terrestrial Reference Frame (ITRF) has been updated by NASA, enabling more detailed studies of global changes in Earth's ocean, ice sheets, land, and atmosphere. Four measurement techniques, including Satellite Laser Ranging and GNSS, contribute to the reference frame.
Researchers at CNIO have developed a gene therapy to repair telomeres, delaying ageing and potentially treating aplastic anaemia. The treatment uses virus-delivered telomerase enzyme to extend telomeres, increasing blood cell production.
Researchers at Ohio State University have engineered new calcium receptors to enhance or preserve heart function in mice without harmful effects. The study shows improved cardiovascular performance and reduced mortality compared to control groups.
Researchers at Dana-Farber Cancer Institute propose securitized consumer healthcare loans to spread the cost of therapies over many years, making them more accessible to patients. This approach aims to generate attractive returns to investors while providing affordable access to life-saving drugs and cures.
A new report from the American Brain Tumor Association reveals that malignant brain tumors are the most common cause of cancer-related deaths in adolescents and young adults aged 15-39. The study, which analyzed data from 2008-2012, also found a shift towards high-grade tumors with increasing age.
A new study demonstrates that pediatric patients with asthma who received their medications in hospital are more likely to avoid emergency department visits. The 'Meds-in-Hand' program, which provides on-site pharmacy delivery, significantly reduced ED visits and improved patient outcomes for discharged children with asthma.
Researchers at the University of Bath created a new laser capable of pulsed and continuous mid-infrared emission between 3.1-3.2 microns, overcoming a major challenge in laser development. The achievement uses silica hollow-core fibers to confine light and gas, enabling efficient interaction and mid-IR emission.
Research found that wastewater treatment plants are a significant source of microplastics in rivers, with particles traveling up to 2 kilometers downstream. The microplastics were home to potentially harmful bacterial communities, highlighting the need for improved filters and treatment processes.
Researchers found that Humboldt penguins' unique feather structure is anti-adhesive and hydrophobic, preventing ice from accumulating. The discovery led to the creation of a nanofiber membrane with similar properties, which could be used in applications like electrical insulation.
A new study found that differences in gene expression patterns in youth can predict longevity. Genes involved in energy production are less active, leading to longer lifespan. Researchers also discovered a potential link between mitochondrial function and longevity.
A novel coordinated care program helped black men who have sex with men adhere to pre-exposure prophylaxis (PrEP), a medication regimen that prevents HIV infection. Nearly 80% of participants agreed to take PrEP, and 70% had protective levels in their plasma at the midpoint.
Adherence to guideline-recommended care following in-hospital cardiac arrests (IHCA) varies significantly among US hospitals, affecting patient survival. Top-performing hospitals have higher survival rates due to timely and high-quality care.
A study published in JAMA Cardiology found that cardiovascular disease risk prediction models developed with predominantly white populations are effective in black adults. The models were validated using data from the Jackson Heart Study and compared to existing algorithms.
A new study suggests that traditional assessment methods overestimate the vulnerability of salt marshes to sea-level rise. Salt marshes can generally survive higher rates of sea-level rise than predicted by current models, thanks to their ability to grow vertically and migrate landward.
A team of geneticists found that the R2d2 gene distorts cell division, leading to fewer offspring and violating Darwin's principle of natural selection. The discovery has implications for fields like basic biology, agriculture, and human health.
Tropical Cyclone Winston has weakened significantly due to strong vertical wind shear, with strongest storms pushed south of the center. The storm is expected to move south-southwest and weaken further, becoming sub-tropical south of New Caledonia.
Researchers from the University of Exeter are leading a European Commission-funded project to develop strategies for meeting climate change challenges on water, food and energy provision. The SIM4NEXUS project will investigate how policy makers can create sustainable integrated management systems.
Researchers have observed that three years after its explosion, the brightness of a type Ia supernova continues to shine brighter than expected. This finding suggests that the powerful explosions produce an abundance of heavy cobalt, which provides an extra energy boost.
An Ibero-American team has sequenced the Mesoamerican common bean genome, which will aid in improving production and conserving genetic varieties. The discovery has significant implications for agriculture, as it will help identify genes involved in disease resistance, drought tolerance, and seed quality.
Researchers have found that laser ablation creates a temporary opening in the blood-brain barrier, allowing chemotherapy drugs to pass into the brain. This breakthrough raises hopes for longer treatment options and improved patient outcomes.
A new cloud software tool called EucaTool estimates eucalyptus production in Galicia. It allows users to calculate growth and future production by measuring four stand variables.
A team of scientists has confirmed that a 'fast radio burst' originates in the distant universe, using CSIRO radio telescopes and the National Astronomical Observatory's Subaru telescope. The breakthrough allows researchers to weigh the normal matter in the universe, confirming the presence of missing ordinary matter.
Researchers turned skin cells into cancer-hunting stem cells that destroy brain tumors known as glioblastoma, a breakthrough discovery in medical science. The technique increases survival time by 160-220% and has the potential to offer a new and more effective treatment for the disease.
Mathematicians Gino Biondini and Dionyssios Mantzavinos develop a new mathematical model describing wave patterns with small irregularities. Their research shows that many disturbances evolve into single-class wave forms, answering a question scientists have been trying to answer for 50 years.
Researchers found a wild potato with almost seven times as much calcium as usual varieties. Breeding programs can now use molecular markers to identify high-calcium traits, speeding up the breeding process. This discovery aims to improve crop quality and reduce cosmetic issues in potatoes.
Researchers from PLOS ONE discovered three skeletons buried in medieval graves in France that may have belonged to Muslims, with DNA analysis revealing paternal lineage from North Africa. The burials follow Islamic rites and radiocarbon dating suggests the skeletons are from the 7th-9th centuries.
A new study from BSMS shows that computers can detect boredom by monitoring non-instrumental movements. The research has the potential to develop more engaging online tutoring programs and companion robots. By tracking subtle changes in body language, computers can adapt to a user's level of interest.
A high-salt diet has been found to contribute to liver damage in adult mice and embryonic chicks, with excessive sodium leading to cell death and decreased cell proliferation. Vitamin C treatment may partially counteract the negative effects of excess salt.
Research suggests excessive bacterial growth in small intestine may be causing malnutrition and stunting in children living in low-income countries. A study of 103 2-year-old children in Bangladesh found that one in six showed signs of small intestine bacterial overgrowth, which was associated with gut inflammation and stunted growth.
A Johns Hopkins Medicine study found that African children with stunted growth had lower levels of essential amino acids and other protein markers compared to non-stunted children. This challenges the widespread assumption that children in developing countries are receiving adequate protein, highlighting the need for improved diets.
Research suggests that medical students benefit from more hands-on training and responsibility, and assessments of their clinical capabilities need improvement. The study recommends greater emphasis on undergraduate clinical placements and postgraduate supervision to enhance medical education.
Researchers are racing to understand and mitigate the degradation of major river deltas worldwide, primarily caused by human activities such as damming, groundwater extraction, and agriculture. The study highlights that more than two-thirds of the world's 33 major deltas are sinking at an alarming rate.
A new practical manual provides guidance on combining euthanasia with organ donation after death, addressing medical and logistical aspects within Dutch law. The manual aims to educate healthcare professionals about this real option, enabling them to follow proper steps.
A team of scientists from Singapore and France has revealed the underlying mechanism for the formation and growth of epithelial tubes. They found that the shape and size of these tubes are governed by mechanical forces arising from cell interaction with the extracellular matrix, influencing lumen morphology and elongation direction.
A study of 399 participants found an association between higher mindfulness scores and healthier glucose levels. The researchers identified obesity risk and sense of control as potential mediators of this link, with mindful individuals being less likely to be obese and more likely to believe they can change their lives.
Research reveals FASD impacts on children's behavior, including internalizing (anxiety, withdrawal) and externalizing (aggression, delinquency) problems, as well as social skills, thought processing, and attention issues.
A study by Aarhus University explores what happens to sibling relationships when parents get divorced and find new partners. The research reveals that children have different experiences depending on whether they live in multiple homes or traditional families.
A study in Swaziland found that implementing Option B+ greatly increased the number of women initiating antiretroviral therapy and improved ART coverage among pregnant women. However, retention in care postpartum was low and no better under Option B+ than previous approaches.
The study confirms 13,000 previously mapped SNPs and newly maps 2,190 unique SNPs to improve drought tolerance, greenbug and wheat curl mite resistance. The research aims to develop high-yielding wheat varieties with improved resilience to stressors across different climates.
Researchers found that physical activity among children is lower in autumn and winter compared to spring and summer. The study highlights the need for increased active opportunities during the colder months to support children's health and development.
Two investigational vaccines against Ebola virus disease induced an immune response among 1,000 participants in the Phase 2 PREVAIL I trial. The cAd3-EBOZ and rVSV-ZEBOV vaccines were well-tolerated and elicited measurable and demonstrable antibodies, respectively.
A new study published in Nature Communications demonstrates that the fear of large carnivores can have cascading effects on the food chain and restore ecosystems. The researchers found that instilling fear in raccoons reduced their time spent feeding and reversed their impacts on their prey, leading to a healthier ecosystem.
A study found that kindergarten general knowledge is the strongest predictor of first-grade and third-grade science achievement. Children's science achievement gaps persist from third to eighth grade, with low-income and minority students facing larger gaps.
A new therapeutic pathway has been discovered to keep cancer cells dormant, offering hope for treating osteosarcoma and potentially other cancers. Researchers found three microRNAs that can inhibit the growth of cancer cells, allowing them to remain asymptomatic and manageable.
The current global coral bleaching event, started in 2014, could extend into 2017 due to record ocean temperatures caused by El Niño. Corals are stressed when expelling symbiotic algae, leading to erosion and destruction of fish habitats.
The composite material emits light and heat when exposed to specific wavelengths of radiation and can be customized to have specific mechanical characteristics. It holds promise for biomedical imaging, drug delivery, and therapeutic treatments.
Researchers have identified a powerful drug, SOM0226 (tolcapone), that can significantly improve the pharmacological treatment of familial transthyretin amyloidosis (ATTR). Tolcapone has been shown to inhibit the aggregation of amyloid fibers by TTR and stabilize the protein structure, slowing down disease progression.
A recent study found that parents' attempts to regulate their emotional expressions can detract from their well-being and high-quality parent-child bonds. Parents reported feeling less authentic and experiencing lower emotional well-being when suppressing negative emotions and amplifying positive emotions during childcare. The study su...
Researchers at the University of Southampton found that copper can destroy MRSA bacteria by damaging their DNA and respiration, making it difficult for them to survive. This discovery explains why touch surfaces made from solid antimicrobial copper are effective in reducing the spread of infections.
Researchers found that high CO2 concentrations in the soil change community dynamics, leading to less efficient food web processes. This study provides insights into the environmental risks of subterranean CO2 storage.
Researchers at University of British Columbia found that human-induced introduction of new species can cause 'reverse speciation', where two similar species merge into one hybrid species. This shift has significant consequences for the ecosystem, altering ecological roles and impacting biodiversity.