A study published in JAMA reveals significant improvement in the survival rate of extremely preterm babies in Sweden, rising from 70% to 77%, while complications decreased, between 2014-2016 and 2004-2007.
Researchers found that IgG antibodies play a crucial role in stabilizing arterial plaques, reducing the risk of rupture and clotting. The study suggests that these antibodies may be a new target for mitigating atherosclerosis and improving cardiovascular health.
A study by researchers at Karolinska Institutet found that very premature babies carry anti-viral antibodies transferred from the mother, suggesting a previously underappreciated source of protection. The analysis also revealed that the protection offered by these antibodies lasts different durations depending on the virus.
Researchers found that oral bacteria are associated with the severity of cystic pancreatic tumours, which can become cancerous. The study suggests that certain oral bacteria may play a role in the development of pancreatic cancer.
Researchers at Karolinska Institutet discovered previously unknown cellular stages of fetal development using gene analysis on individual cells from early mouse embryos. The study revealed a molecular road-map of the events that control cell differentiation, shedding new light on the early development of the embryo.
A study published in Nature reveals that bone growth in mice follows the same principles as cell production in blood and other tissues. The discovery suggests that bone growth may be more dynamic than previously thought, with cells generated from a stem-cell like progenitor cell.
Researchers at Karolinska Institutet have discovered a new skeletal disease linked to an abnormal expression of small RNA molecules. The study reveals that the disease causes skeletal dysplasia, joint pain, and delayed cartilage cell maturation in patients, providing potential diagnostic and therapeutic options.
Nicholas Valerie receives a $50,000 prize for his thesis on NUDT5 and NUDT15 enzymes, demonstrating novel functions in oxidized nucleotide metabolism and their potential as therapeutic targets. The discovery could lead to the development of targeted inhibitors to potentiate cancer therapy.
Researchers found that social threat learning, such as watching a video or receiving oral instructions, can influence decision-making just as strongly as first-hand experience. Participants who learned a certain image was dangerous continued to avoid it, even when it led to more shocks, indicating irrational behavior.
Researchers at Karolinska Institutet have mapped brain networks that control the habenula, a structure linked to feelings of discomfort and aversion. The study suggests a specific pathway that can be modulated using optogenetics, offering hope for developing new treatments for depression and anxiety disorders.
Researchers at Karolinska Institutet develop new approach to targeted cancer treatment using Class Frizzled receptors, potentially effective against rectal and lung cancers. The study reveals molecular details of receptor activation and pathway selection.
A new drug candidate, givosiran, has shown promising results in treating acute porphyria by preventing attacks and reducing hemin need by up to 83%, according to a recent clinical trial. The study's lead author notes that the treatment can effectively prevent acute attacks in seriously afflicted patients with limited options.
Researchers have found a short anti-rejection therapy that can protect transplanted pancreatic islets in diabetic animals, enabling long-term survival and function without the need for life-long immune suppression. This breakthrough could lead to an effective treatment of type 1 diabetes with fewer side effects.
Researchers developed an adaptive treatment strategy to identify patients at risk of treatment failure in Internet-delivered CBT. The study found that adjusting the treatment to accommodate individual needs can significantly improve outcomes for those at high risk.
A study published in Environment International found that PFAS substances, commonly used in consumer products, accumulate in fetal tissue throughout pregnancy. The study also revealed higher levels of these chemicals in male fetuses than female, highlighting the need for further research on their effects.
Researchers found that older cells in MS patients can reform myelin, but new oligodendrocyte generation is severely limited. This suggests treating MS aggressively at an early stage is crucial to prevent further damage.
Researchers at Karolinska Institutet reveal altered mosquito behavior and parasite selection as major obstacles to malaria eradication. The study shows a 96% decline in malaria incidence in Zanzibar, but highlights the need for new strategies to overcome challenges and achieve elimination.
Scientists have developed a precise measuring tool using DNA origami to optimize antibody effectiveness, with distances of approximately 16 nanometres providing the strongest bond. This technology can help better understand the immune response and design more effective antibodies for vaccines and immunotherapy.
Researchers at Karolinska Institutet identified four distinct molecular subtypes of undifferentiated uterine sarcoma, a rare and aggressive cancer, which could lead to improved treatment outcomes. The study also showed that some patients may live longer than initially predicted.
Researchers at Karolinska Institutet analyzed 3.8 million live-born children and found that approximately 1 out of 105 children with severe growth restriction died before age 18, compared to 1 in 202 for moderate growth restriction and 1 in 289 for normal development.
A diet rich in green leafy vegetables, especially those high in inorganic nitrate like spinach and rocket, may prevent liver steatosis. Researchers found that increased nitrate intake reduced fat accumulation in the liver and improved insulin/glucose homeostasis in mice with type 2 diabetes.
Researchers at Karolinska Institutet have devised a new method called Axon-seq to study axons and better understand the pathological development of ALS. The method reveals significant differences in RNA profiles between healthy cells and those with mutated SOD1 genes, which causes ALS.
A large Nordic study found liraglutide reduces the risk of myocardial infarction, stroke, or cardiovascular death among type 2 diabetes patients. The study also showed a lower risk of cardiovascular death and any cause of death with liraglutide treatment.
A new study identifies Frizzled 5 as a promising target for developing drugs against cancer, cardiovascular disease, and fibrosis. The receptor's activation in the cell membrane triggers specific processes within the cell, making it an attractive target for future drug development.
Researchers found that chlorpyrifos had a clear effect on brain development in laboratory animals, even at low doses, which was not reported by the industry-funded study. The study highlights the need for independent academic research to be given a higher status in evaluating chemical safety.
A Swedish study found no correlation between growing up with hypoallergenic breeds and a lower risk of asthma in children. However, female dogs were associated with a 16% lower asthma risk, while living with two or more dogs reduced the risk by 21%.
A multidisciplinary team of researchers from Karolinska Institutet in Sweden has developed a new anti-inflammatory drug molecule that inhibits inflammation by targeting a protein involved in the repair of oxygen damage to DNA. The discovery could lead to new treatments for inflammatory diseases such as sepsis, COPD, and severe asthma.
Researchers at Karolinska Institutet discovered that oligodendrocytes, cells responsible for myelin production, may play a significant role in MS development. This finding could lead to new therapies targeting areas beyond the immune system.
Researchers found that pneumolysin can interact with a special receptor in immune cells, triggering an anti-inflammatory response. This allows the bacteria to hide from further attack and grow, eventually giving rise to pneumonia. The study's findings may lead to new strategies for tackling pneumococcal infections.
Breast cancer cells can become invasive by changing their identity through a process called epithelial-mesenchymal transition (EMT). A newly identified protein, CXADR, plays a crucial role in this process. Reintroducing CXADR into breast cancer cells can change their behavior and repress invasive properties.
A new type of protein complex has been discovered in human cells, which attaches to its surroundings and plays a key role in cell division. This discovery challenges current knowledge of cell division and may provide answers to an unanswered question about how cells remain attached to the matrix during division.
Researchers at Karolinska Institutet discovered high levels of antiphospholipid antibodies in patients who suffered a heart attack without any autoimmune conditions. The study involved 800 patients and found that 11% had elevated IgG antibody levels, which is associated with blood clots.
Children with inflammatory bowel disease have a higher mortality rate compared to peers without the condition, particularly if diagnosed before age 18. Careful monitoring is crucial for individuals diagnosed in childhood, especially those with ulcerative colitis and primary sclerosing cholangitis.
Researchers found that immunotherapy is effective in treating metastatic melanoma in individuals with CDKN2A mutations, with nearly two-thirds of patients responding to treatment. The study suggests that tumours with CDKN2A mutations have a larger number of mutations, making them easier to recognise by the immune system.
Researchers at Karolinska Institutet found that high-risk HPV-positive tumours had a significantly higher five-year relative survival rate of 74% compared to hrHPV-negative tumours at 54%. The presence of high-risk HPV was also associated with earlier detection and improved socioeconomic status.
Researchers at Karolinska Institutet have discovered a new way in which nerve cells control movement by dynamically adjusting neurotransmitter production. This finding opens up new avenues for treating diseases such as myasthenia gravis and spinal muscular atrophy.
An observational study by researchers at Karolinska Institutet in Sweden found that bariatric surgery is associated with fewer complications during childbirth, including reduced risk of post-term delivery or uterine inertia. The study compared deliveries in women who had undergone weight loss after bariatric surgery to those who did not.
Researchers at Karolinska Institutet identified four types of neurons in the peripheral auditory system, three of which are new to science. The study shows that these neurons play a crucial role in decoding sonic intensity and may lead to new therapies for hearing disorders.
The PROFORMA project aims to strengthen national infrastructures for drugs safety monitoring in four East African countries. The five-year project, funded by EUR 6 million, includes training at Master's and postgraduate level and exchange of knowledge between researchers and experts.
A new study published in Molecular Psychiatry reveals that patients with ADHD and emotional instability disorders exhibit similar brain changes, particularly in the frontal lobe. The findings suggest a broader treatment approach for both conditions, potentially benefiting individuals with ADHD who also experience emotional problems.
A study published in the European Heart Journal reveals that microvascular dysfunction is a prevalent underlying disease mechanism in patients with heart failure and preserved ejection fraction. The research highlights the importance of identifying patients at risk and developing targeted therapies to improve outcomes.
A new study published in Circulation found that oxygen therapy for patients with suspected heart attacks does not reduce the risk of developing heart failure or dying. The study, conducted at 35 Swedish hospitals, involved over 6,600 patients and showed no significant difference in survival rates or complications.
Effective medical treatment and surgery prevent esophageal cancer in people with severe heartburn. The study used health data from 1964 to 2014 and found a significant decrease in cancer risk after treatment.
Researchers from Karolinska Institutet have discovered that a baby's immune system undergoes dramatic changes within the first few weeks of life, adapting to its new environment. This phenomenon was made possible by using advanced techniques of immune cell analysis.
A study by Karolinska Institutet found a clear correlation between elevated blood glucose levels in mothers and the risk of heart defects in their babies. Pregnant women with type 1 diabetes are at a higher risk, especially those with high blood glucose levels during early pregnancy.
Researchers at Karolinska Institutet discovered a built-in molecular brake on human cell division that ensures two complete copies of DNA before cell division, preventing DNA damage and cancer. This process restricts growth to prevent lethal diseases like cancer.
A new mechanism has been identified that triggers multiple sclerosis disease through epigenetic regulation, with a protective variant reducing the risk. The study found that people with the major risk variant HLA-DRB1*15:01 have increased expression of the HLA-DRB1 gene, increasing the risk for MS.
A large study of over 10,000 pregnant women found no increased risk of stillbirth associated with fluconazole use. The results contradict earlier animal data suggesting a potential link between the drug and fetal death.
A new study found that CRISPR-Cas9 gene editing can activate the p53 protein, which reduces the efficiency of gene editing but also contributes to cancer cell growth. Researchers recommend further studies to improve safety for CRISPR-based therapies.
A new study from Karolinska Institutet found that patients diagnosed with high-sensitivity troponin test had a lower risk of future heart attacks, with no difference in mortality one year after the heart attack. The test also led to more coronary angiography and balloon angioplasty procedures.