A systematic review of available evidence suggests that cycling and treadmill workstations are associated with greater short-term physiological changes compared to standing versions. Both types boosted heart rate, energy expenditure, and reduced blood pressure. However, treadmill versions interfered with keyboarding skills.
Scientists have discovered that an antisense RNA can induce the formation of fusion genes in mammalian cells, which may lead to new cancer therapies and biomarkers. The 'cart before the horse' hypothesis is challenged by this finding, revealing a non-coding RNA's role in gene recombination.
Researchers have solved a 20-year riddle of how crucial step in antibiotic biosynthesis occurs, opening way to potentially redesigning antibiotics. The team structurally characterised the peptide bond forming domain in Ebony enzyme, revealing its novel types of condensation domain and its role in regulating neurotransmitters.
A study by Vanderbilt University Medical Center found that freestanding emergency departments (FSEDs) charge significantly more than urgent care centers, even with lower annual patient volumes. FSEDs experienced a decrease in patient volume between 29.5% and 94.8% after converting from urgent care centers.
Researchers have identified midkine as a key driver of inflammation in the heart muscle that can lead to heart failure in patients with myocarditis. The study found that inhibiting midkine reduced neutrophil infiltration and improved heart function.
Researchers at Purdue University have developed a series of drug compounds that have shown promise in treating acute myeloid leukemia (AML), a type of blood cancer that is often lethal. The new compounds work on both common and drug-resistant forms of AML, including those with problematic mutations.
Scientists at CeMM Research Center have developed a method to identify promising drug combinations for chronic lymphocytic leukemia. By combining epigenetic analysis and high-throughput imaging, researchers can predict which drugs are likely to work together effectively, reducing trial-and-error approaches.
Researchers have developed a new optofluidic chip-based test to detect Zika virus, which can identify the stage of infection and guide treatment. The technology has the potential to pinpoint recent infections and predict disease progression.
Researchers in Canada identified seven core principles to improve substance use treatment systems, emphasizing the need for collaboration between sectors and a population-level approach. These principles aim to identify strengths, gaps, and required enhancements in system design.
Researchers found that spectators felt more positive emotions when a referee's decision benefited their team during suspenseful games. The study suggests that advertisers can use individual targeting and tailored branding to create positive associations with sponsored brands.
A new study found that physically active men with a high waist-stature ratio are more likely to develop heart disorders than those with lower ratios. The researchers suggest that the waist-stature ratio is a better predictor of cardiovascular risk than body mass index.
Scientists discover a new family of fungi that threatens the UNESCO-listed Old Cathedral of Coimbra in Portugal. The fungus, Aeminiaceae fam. nov., has been found to cause severe biodeterioration and is considered an endemic species to Iberian Peninsula limestone quarries.
Scientists at Max Planck Florida Institute for Neuroscience create a novel technique called iMT, capable of tracing intricate neural connections with unprecedented sensitivity. This breakthrough could improve our understanding of the brain and uncover novel approaches for diagnosing and treating brain disorders.
Geriatric frequent users are more likely to have multiple chronic conditions and require more resources and medical interventions. The most common conditions among these patients include diabetes, kidney disease, and congestive heart failure.
The inaugural issue of Advanced Photonics showcases significant research across optics and photonics technologies, including light-sheet microscopy and deep learning for digital holography. The journal aims to provide a trusted source of groundbreaking research in optics and optical technologies.
A study by Indiana University found that a moderate level of piracy can have a positive impact on the profits of both manufacturers and retailers, while also enhancing consumer welfare. This 'win-win-win' situation can benefit the overall economy.
Scientists from Australian National University used space technology to predict droughts and increased bushfire risk with unprecedented precision. The team combined satellite data with a computer model simulating the water cycle and plant growth, enabling accurate forecasts of vegetation state up to five months in advance.
Scientists at the University of Pennsylvania have developed a new material called metallic wood that has the strength of titanium but is four to five times lighter. The material's porous structure can be infused with other materials, making it suitable for applications such as plane wings or prosthetic legs that also serve as batteries.
Researchers report that long-lived white cedar trees in northeastern Canada have increased water use efficiency since 1850, likely due to elevated carbon assimilation rates. However, no associated increase in growth rates was observed, suggesting that CO2 stimulation may not lead to increased carbon storage.
Researchers have demonstrated proof-of-principle for an all-photonic quantum repeater, a critical step in long-distance quantum communication. This technology could enable faster and more secure global quantum Internet applications.
A study by Marco Sartirana and colleagues found that hospital doctors' ability to become 'hybrid' roles is dependent on effective organizational support. Successful transformations occur when professionals are surrounded by a supportive network, allowing them to legitimize their new management role.
Academics from Northumbria University are continuing their groundbreaking research on liquid droplet behavior. They will investigate ways to control the formation of droplets using electrical voltages, which has never been possible before. This technology could lead to innovative techniques for printing and coatings applications.
Breast cancer cells can shift between two forms of the cell surface molecule CD44, CD44s and CD44v, with different properties and behaviors. Cancer cells expressing mainly CD44s have increased metastatic behavior and resistance to therapy, while those expressing CD44v present increased cell proliferation.
Researchers from NTU and SUTD report an asymmetric reaction using a cationic catalyst, converting racemic substrates to asymmetric products via an S_N2X mechanism. The study also reveals an uncommon chemical interaction, halogen bonding, present between the participating molecules.
A study of people who inject drugs found a significant increase in the risk of infective endocarditis, a serious infection of the heart lining, possibly linked to increasing use of hydromorphone. The risk rose from 13.4 to 35.1 admissions per three months between 2011 and 2015.
Researchers have identified distinct brain patterns that respond differently to learning danger and safety in individuals with varying levels of PTSD symptom severity. The study found that more severely symptomatic veterans exhibited greater corrections in physiological arousal and brain activity when faced with unexpected stimuli.
A new study projects that global well-being will depend more on social factors than economic ones in the next three decades. The researchers used a mathematical approach to project the subjective well-being of the world's population, taking into account dimensions such as freedom, corruption, generosity, and social support.
The updated guidelines now prefer non-vitamin K oral anticoagulants (NOACs) over warfarin for reducing stroke risk in patients with atrial fibrillation. NOACs have been shown to be safer and potentially more effective at preventing blood clots than warfarin, according to new scientific studies.
The SPRINT MIND trial found that intensive lowering of systolic blood pressure did not significantly reduce dementia risk, but had a measurable impact on mild cognitive impairment. The study demonstrated that intensive blood pressure control is safe for the brain and may offer avenues for prevention.
Researchers used machine learning to identify clusters of relationships in medical data that could predict Alzheimer's disease, including cardiovascular health and immune system response. This approach may lead to earlier diagnosis and better prognosis with new blood tests.
Americans with primary care receive more recommended cancer screenings, flu shots, and reported better patient experience compared to those without. Primary care also leads to better overall healthcare access.
A study of over 800 patients with laryngeal cancer found a significant risk of the disease associated with persistent sore throats combined with other symptoms. The research aims to improve early detection and treatment outcomes for cancer patients.
A new study reveals that Anchiornis, one of the earliest known feathered dinosaurs, had feathers with thicker alpha-keratins instead of beta-keratins, lacking necessary biomechanical properties for flight. However, its molecular composition may signify an intermediate stage in the evolution of avian flight feathers.
A clinical trial has shown promise in using stem cells from donors to repair the surface of the eye in patients with limbal stem cell deficiency, a significant cause of sight loss. The trial also sheds light on the causes of sight disorders and offers clues about how eye tissue loss could be repaired.
Researchers have discovered a new class of polymer that can store and exchange electrons, leading to faster charging times for batteries. The organic radical polymers' unique structure allows rapid charge transfer during redox reactions.
The University of Illinois Chicago will continue its role as the Chicago field center for the Hispanic Community Health Study/Study of Latinos, a multi-site study of health issues and risk factors among Hispanic/Latino adults. The new funding will support phase III of the study, which aims to bring back participants for a follow-up exa...
A new study shows that crowdsourcing audience judgments about news source quality can identify and marginalize online misinformation. The study found that both Democrats and Republicans distrust hyperpartisan sites, with low trust ratings across the board.
Dietary inequities in Canada refer to differences in diet quality between people of lower and higher socioeconomic status. Existing nutrition policies are insufficient to address the root causes of poor diets, particularly among those with lower social positions.
Women physician researchers make 7-8% less per year than men, leading to tens of thousands of dollars less in lifetime wealth. Researchers used new models to calculate the impact of salary disparities on accumulated wealth.
A new US study found that prescription opioids are negatively affecting labor force participation and unemployment rates nationwide. The study discovered a strong adverse effect of opioids on labor markets, with a 10% increase in opioid prescriptions per capita leading to a 0.6 percentage point drop in labor force participation rates.
The CAPER-2 mission aims to understand how particles are accelerated in the aurora borealis by studying the interaction between electrons and atmospheric gases. The team hopes to uncover the fundamental physics behind this process, which is crucial for understanding space radiation and astrophysical phenomena.
Research highlights the dangers of unsafe gun storage and calls for pediatricians to counsel families on safe handling practices. The authors advocate for innovative design features and childproofing technologies to reduce firearm-related injuries among young children.
A new study published in Psychological Review reveals that forming good habits depends more on repetition than satisfaction. The research suggests that our brains tend to stick with repeated actions, even if they're no longer rewarding, and opens up a better understanding of conditions like Obsessive Compulsive Disorder.
Researchers discovered a significant rise in infective endocarditis among Ontarians who inject drugs, with hydromorphone prescriptions linked to the increased risk. The study found that reusing injection equipment, common among opioid users, allows for bacterial contamination and increases the chances of heart infection.
A team of researchers has identified a genetic pathway that causes some individuals to develop an abnormal heart rhythm after experiencing a heart attack. They have also discovered a drug candidate that can block this pathway.
A review paper highlights the transformative potential of precision and personalized medicine for cancer treatment. The traditional approach focuses on general treatments, while PPM allows for individualized treatments tailored to specific tissues and gene mutations.
New research shows climate change is shifting how the atmosphere and oceans move heat around the globe, with significant effects on global temperatures. The study found that warming temperatures are driving increased heat transfer in the atmosphere, while reducing it in the ocean.
MU researchers create an artificial intelligence system to quarantine cyberattackers, providing a temporary distraction to allow for a more sophisticated defensive strategy. This approach aims to exploit the psychological aspect of cyberattacks, making attackers believe their efforts are successful.
A new optical microscope system called SIFOM stimulates multiple cells simultaneously using holographic method and monitors cell activity using 3D measurements. The system has potential applications in reconstructing lost nerve pathways, constructing artificial neural networks, and developing food resources.
Researchers found that all Brexit scenarios would reduce fruit and veg intake, with a no-deal Brexit being the most damaging. This led to an estimated 12,400 additional CVD deaths in England between 2021 and 2030.
Pol Besenius will develop fully synthetic vaccines using modular molecular building blocks to overcome stability and shelf life issues. The SUPRAVACC project aims to create immunological protection against bacterial diseases and anti-tumor vaccines.
The University of Warwick has identified the enzyme DGAT1, which controls how much fat is added to particles released by the liver. Inhibiting this enzyme allowed scientists to 'slim down' particles and load them with less fat, reducing the amount of 'bad' cholesterol in the blood.
Scientists from JNCASR and inStem successfully created a synthetic mimic of cytoskeletal networks with structural and temporal programming. The system was developed through reaction-driven controlled growth, enabling precise control over one-dimensional growth and self-repairing features.
A new study identifies key factors involved in cell cycle arrest and illuminates a novel intracellular structure, paving the way for new therapeutic targets to treat kidney fibrosis. The research team found that blocking the formation of TASCCs reduced the severity of kidney fibrotic disease progression in preclinical models.
A study found that the RMET test for mental health understanding is biased against less educated individuals, as well as ethnic and racial minorities. The test relies too heavily on a person's vocabulary, intelligence, and culturally-biased stimuli.
Researchers at Bar-Ilan University have successfully mapped liquids outside coated optical fibers, enabling sensing applications beyond the lab. The use of a polyimide coating overcomes the protective barrier previously hindering sensor performance.
Researchers at George Washington University Cancer Center have engineered a nanoimmunotherapy ensemble to increase the potency of immune checkpoint inhibitors in treating cancer. The goal is to convert 'cold' tumors into 'hot' tumors, which can be more responsive to immunotherapy.
Scientists have discovered a 1.3 km radius body beyond Neptune's orbit, revealing more about the planet formation process. The detection supports models where planetesimals grow slowly into kilometer-sized objects before merging to form planets.
The SU2C Meg Vosburg T-Cell Lymphoma Dream Team is developing CAR-based immunotherapy strategies to target cancerous T cells without harming the immune system. The team aims to find a therapy that can improve outcomes in this patient population and make treatments more available.
A team of researchers has found that diffusion may not be necessary to transport ionic charges inside a hydrated solid-state structure of a battery electrode. This discovery could lead to new design principles for electrodes and potentially improve the energy density and cycle life of high-power batteries.