A study of 28,000 childhood cancer survivors found that exposure to different anthracycline chemotherapies results in variable long-term cardiovascular risk. Specifically, daunorubicin was associated with decreased cardiomyopathy risk compared to doxorubicin, while mitoxantrone appeared to have greater long-term cardiomyopathy risk.
A team of researchers led by Professor Hopi Hoekstra conducted a years-long study on the survival of light- and dark-colored mice in different habitats. The results confirmed the intuition that light-colored mice survive better in light-colored habitats, and also pinpointed a mutation related to survival that affects pigmentation.
Researchers found that ancient asteroid impacts played a crucial role in creating the early evolved crust on Earth, which later gave rise to continents. The impact melts produced layered magmatic intrusions and made the crust more evolutionarily complex.
A University of Southampton study reveals that salmon egg membranes adjust their structure to cope with reduced oxygen levels in rivers. This adaptation enables embryos to incubate successfully. The research found that membrane thickness, porosity, and permeability vary among different salmon populations.
Researchers reveal how stars contribute to the creation of elements, from hydrogen to heavier elements like lawrencium. The study highlights the dynamic nature of the periodic table, which has grown as new elements have been discovered or created in laboratories.
Researchers have found a short anti-rejection therapy that can protect transplanted pancreatic islets in diabetic animals, enabling long-term survival and function without the need for life-long immune suppression. This breakthrough could lead to an effective treatment of type 1 diabetes with fewer side effects.
Researchers at City University of Hong Kong create innovative method to transport micro-droplets using capillary force on slippery surface, enabling detection of E. coli and S. aureus bacteria in biomedical analysis. This technology has potential applications in fog collection, water harvesting, heat exchangers, and other fields.
The Harvard Museum of Natural History announces a new Climate Change exhibit featuring multimedia displays, interactive stations, and real-time ocean monitoring data. The exhibit aims to educate visitors about the global impacts of climate change and provide solutions for reducing fossil fuel emissions.
Researchers at Penn State have identified a complex of proteins crucial for the maturation of the malaria parasite's sexual stage, which is required for transmission to mosquitoes. Disrupting this complex inhibits the parasite's ability to mature and infect mosquitoes, offering a new tool in the fight against malaria.
Researchers identified interleukin 10 receptor (IL-10R) as key player in regulating immune response to parasitic whipworms. The discovery helps understand the signalling mechanism maintaining a balance between host, parasite, and gut bacteria.
A new study reveals that microplastics have been ingested by every marine mammal examined, with synthetic fibers being the primary source. The findings suggest that while the number of particles is relatively low, more research is needed to understand the potential impacts on animal health.
A new study by Cardiff University reveals that aging damages white matter cells, which can affect grey matter in the hippocampus and cognitive function. Researchers found that damage to support cells in white matter may lead to tissue health issues in the hippocampus, a region important for memory and involved in Alzheimer's disease.
Scientists have found that invasive skin cancer molecules reprogram healthy immune cells, allowing the cancer to spread. Researchers discovered that blocking certain chemicals can help prevent the aggressive skin cancer from coming back after treatment.
Scientists developed an electron microscopy technique to directly identify isotopes in amino acids at the nanoscale without damaging the samples. This allows for real-space observation of dynamic chemistry and creates a foundation for scientific discoveries.
A new study in The FASEB Journal reveals that AICAr inhibits cell proliferation and has cytotoxic potential for childhood ALL cells by regulating nucleotide metabolism. The researchers confirm that Acadesine's inhibition of cell proliferation is independent of AMPK activation, but dependent on P53.
Researchers at the University of Minnesota Medical School demonstrate spinal cord stimulation can immediately restore some voluntary movement and autonomic functions years after a paralyzing injury. The study expands inclusion guidelines for epidural stimulation, offering new hope for patients with traumatic spinal cord injury.
A new 3D printer uses light to transform gooey liquids into complex solid objects in a matter of minutes, smoother and more flexible than traditional printers. The technology has the potential to mass-customize products, including prosthetics and eyeglass lenses.
Researchers discovered 27 new molecules with significant therapeutic potential for treating fatty liver disease and obesity by activating the PPAR-delta protein. These molecules are currently undergoing pharmaceutical evaluations and show promise in improving physical endurance and reducing waistlines.
A new method developed by researchers at the University of Luxembourg and others can predict how drug molecules arrange themselves in different energetic conditions, reducing the risk of formulation failures. This approach could help pharmaceutical companies avoid costly development errors and ensure their drugs function properly.
Researchers at German Cancer Research Center discovered that stem cell genes remain active, allowing for reversible decision-making in becoming a neuron or reverting back to stem cell. Uncontrolled TOR activity can cause brain cancer, highlighting the importance of controlling this signal for future stem cell therapy developments
Scientists have made the first surface gravity measurements on a planet other than Earth using NASA's Curiosity rover on Mars. The rover's accelerometers, used for navigation, were calibrated to measure subtle changes in gravitational acceleration, providing new information about the subsurface of Mars.
A new study estimates that around 4.2 million people die within 30 days of surgery globally, with half of these deaths occurring in low- and middle-income countries. The researchers project that expanding surgical services to address unmet need would add another 1.9 million post-operative deaths annually.
The first 'OSNAP' results show that deep water formation in the Labrador Sea plays a minor role in Atlantic Meridional Overturning Circulation (AMOC) variability. Instead, deep waters moving south through the abyssal basins east of Greenland dominate AMOC variability.
Researchers review novel research hypotheses and approaches to understand the role of environment in Parkinson's disease, particularly before diagnosis. The study suggests targeting specific environmental factors via the nose or gut may help prevent or modify the disease's progression.
A NUS study reveals that crossbreeding between milky storks and their cousins is threatening the species' conservation. The research found that more than half of the stork population in Singapore is genetically influenced by Painted Storks, posing a major threat to the species' survival.
Researchers discovered a correlation between specific genetic variants and the development of psychiatric disorders such as schizophrenia, depression, and autism. The study analyzed DNA samples from nearly all newborn babies in Denmark, finding that these variants are often present in individuals with these conditions.
Exposure to air pollution at school is linked to a higher risk of childhood obesity and overweight. The study found that children exposed to medium or high levels of air pollution had a higher risk of obesity and overweight compared to those with lower exposure.
Researchers at FAU have successfully produced large, stable pieces of graphene with a zigzag edge pattern. This breakthrough enables the control of shape and periphery, which is crucial for investigating electronic properties in detail.
Researchers at University of California San Diego found evidence that p53 stimulates tumor growth by enhancing cancer metabolism, challenging the widely accepted idea that it suppresses cancer. The study suggests that drug therapies designed to enhance p53's function may inadvertently cause opposite effects.
Researchers used mouse models to explain the developmental process behind COPD, finding that immune cells called basophils induce airway degeneration by triggering a cascade of immune responses. The study's findings may lead to therapies targeting basophils or related immune cells to slow down emphysema progression.
Researchers found the immune system plays a crucial role in maintaining healthy intestinal stem cells and preventing bowel cancer by enhancing DNA repair mechanisms. The study discovered that cells of the innate immune system can recognize genotoxic environmental factors, such as glucosinolates, and send signals to epithelial stem cell...
Scientists at MCG are studying a new treatment target for retinal damage, characterized by blood vessel disruption leading to vision loss. They believe the key lies in arginase 1, an enzyme that helps regulate inflammation, which can be either damaging or reparative.
Osaka University researchers developed an algorithm for numerical calculation of EM noise in electric circuits, reducing interference caused by transmission lines. The new method allows for more practical calculations and demonstrates the reduction of EM noise using symmetric 3-line configurations.
A recent study found that 10% of firearm injury survivors will be readmitted to the hospital within 90 days, highlighting a significant burden of morbidity. The researchers also discovered a 30% increased risk of readmission among those with firearm injuries compared to occupant motor vehicle injury patients.
A new study found that higher consumption of fruits and vegetables may be associated with a lower risk of premature death in patients undergoing maintenance hemodialysis. The findings suggest that more studies are needed to fine-tune dietary recommendations for patients with kidney failure.
Researchers used Curiosity's repurposed inertial measurement units to detect subtle variations in gravitational fields, contradicting the theory of a buried rock layer. The study suggests that Mount Sharp formed largely in its current form as a free-standing mound within Gale crater.
Self-driving cars will slow traffic by cruising at low speeds to avoid high downtown parking fees. Cities face challenges regulating autonomous vehicles, which can create havoc if not properly managed. Congestion pricing is proposed as a solution to reduce congestion and pollution.
Molecular vibrations in aspirin cause electron motions visible in real time for the first time through x-ray experiments. Electron distributions shift by 10,000 times larger than atomic displacements, demonstrating hybrid modes in crystal structures.
Cell lines, created from donated tissue samples, require unique considerations when creating research protections due to their value and expertise involved. The new Common Rule may pose unintended consequences for this resource, potentially disrupting scientific progress in cancer research.
Scientists parse animal behavior into digestible chunks using an adaptive model, spotting subtleties that would have otherwise been missed. The study found that complex dynamics can be broken down into simple linear patterns, allowing for the quantification of brain states and movement behaviors in various organisms.
A study from Tufts University found that cardiovascular disease hospitalization rates rose precipitously after Hurricane Katrina's landfall, lasting more than a month. The increase was higher among the older black population compared to the older white population.
A Lancet study found that statin therapy reduced the risk of a major vascular event by about a quarter for each millimole per litre reduction in LDL cholesterol, even in older people. Statins also did not increase the risk of deaths from non-cardiovascular disease or cancer at any age.
Researchers discovered a global pattern of extreme rainfall teleconnections linked to jetstreams, which could enhance weather forecasting and damage mitigation. The study's findings have practical relevance for improving predictions of extreme rainfall events.
Researchers at Brown University have discovered that graphene crinkles can be used to assemble molecules into linear arrays, known as 'molecular zippers'. This phenomenon enables easier manipulation and study of molecules, which could have applications in studying biomolecules like DNA and RNA.
A study at Vanderbilt University Medical Center found that African-American patients with blood type B can receive blood type A2 kidneys with similar outcomes. This new option has improved access to transplants for minority patients, increasing the number of available organs and reducing disparities in wait times.
A new prenatal genetic testing approach has been shown to improve the diagnosis of fetal anomalies, identifying a significant cause in nearly half of affected pregnancies. The technique, known as whole exome sequencing, offers a valuable addition to standard prenatal tests, providing clear diagnoses and easing parental fears.
A new method of growing stem cells has been discovered using the tropoelastin protein, which could lead to significant cost savings in treatment options. This breakthrough discovery, published in PNAS, uses a cost-effective approach to encourage the growth and recruitment of mesenchymal stem cells.
A new study published in Cell suggests that targeting immune cells called natural killer cells may help clear out damaged axons and promote healthy regrowth, potentially decreasing chronic neuropathic pain. The findings could lead to a greater understanding of the mechanisms behind neuropathic pain and improve treatment options.
MXenes' conductivity increases as intercalants and termination species are eliminated, making them suitable for applications like energy storage and wearable tech. Researchers developed a new electron microscopy technique to measure surface chemistry in real-time, paving the way for termination engineering.
Scientists at Helmholtz Munich found a transcription factor called Tbx3 that plays a pivotal role in maintaining energy and sugar metabolism. Its absence leads to an identity crisis of satiety neurons, resulting in obesity.
Researchers at the University of Exeter have discovered endangered hammerhead and dogfish species being sold as food in UK chip shops, highlighting a need for more accurate labelling. The study also found that consumers may unknowingly purchase threatened shark species, posing health risks and contributing to declining shark populations.
A recent study found that warmer sea-surface temperatures in the Gulf of Maine are a key predictor of cold-stunning events among juvenile Kemp's ridley sea turtles. The number of cold-stunned turtles is increasing at an alarming rate, with over 2,300 predicted by 2031.
Researchers used scavenger study to find evidence of wildlife diversity in Chernobyl Exclusion Zone. The team observed 10 mammal and five bird species using fish carcasses as bait.
Researchers have restored muscle stem cell function in animal models of Duchenne muscular dystrophy, leading to efficient muscle regeneration and preventing progressive loss of muscle strength. The study's findings suggest a new treatment approach may be effective in addressing this complex disease.
Researchers developed a compact, environmentally stable laser with an ultra-narrow linewidth of 20 hertz, suitable for improving GPS accuracy and detecting gravitational waves. The laser's stability is maintained through self-referencing temperature sensing, allowing precise correction signals to be applied.
A new Cornell study reveals that serotonin neurons play a crucial role in the brain's ability to make appropriate decisions during emergency situations. In high-threat situations, stimulating these neurons elicits escape attempts, while in lower threat environments, they cause pausing.
A study published in Nature Communications found that the Great Dying, a massive extinction event 252 million years ago, likely targeted plant life before animal species. The research team discovered high concentrations of nickel in Australian sediment, which may have been released from Siberian volcanoes and poisoned plant life.
Researchers in Japan developed an integrated system combining photovoltaic power generation and rechargeable batteries to produce hydrogen at a globally competitive cost. The system can adjust the amount of battery charge/discharge and electrolysis hydrogen production in relation to solar power generated, enabling the production of hyd...
A study by National Research University Higher School of Economics found that educated migrants contribute to the convergence of wages across Russian regions. Migrants with secondary or vocational education levels have a significant impact on increasing regional wages, while higher-education migrants have little effect.
Researchers created a lab model of a blood vessel to study angiogenesis, revealing how the molecule EGFL7 influences blood vessel sprouting and integrity. The study suggests EGFL7 as a potential therapeutic target for diseases like retinopathy and cancer.