A Phase III clinical trial found no significant improvement in overall survival or progression-free survival with bevacizumab treatment for new glioblastoma patients. Researchers also observed increased symptoms and neurocognitive decline among non-progressing patients treated with bevacizumab.
A UC Riverside study suggests that increasing block-rate water budgets can effectively promote water use efficiency by sending a price signal to customers regarding water scarcity. The study found that average household water use decreased by 15% under the new pricing structure, while overall prices only rose 4%.
Researchers found that smellizing, imagining a product's smell, increases consumers' desire to consume and purchase advertised food products. This effect is strongest when the image of the product can be seen at the same time as the imagined smell.
A clinical trial found that adding bevacizumab to standard glioblastoma treatment did not increase overall survival, but did delay the risk of toxicity. The study also showed a decline in neurocognitive function and quality of life for patients receiving bevacizumab.
A University of Chicago-based team used Beagle, a powerful supercomputer, to analyze genomic data, significantly accelerating speed and accuracy. The findings have immediate medical applications, enabling rapid diagnosis and treatment of genetic diseases.
Environmental scientists warn that synthetic food packaging chemicals can leach into foods and harm human health over the long term. The authors argue that little is known about their impact on chronic conditions like cancer, obesity, and neurological disorders.
Research finds that common honeybee diseases can infect and spread to wild bumblebees, potentially causing decline. The study suggests that managing honeybees is crucial for supporting wild bee populations and reducing the impact of emerging diseases.
A new statistical hierarchical Bayesian model consolidates climate change information from various sources, including observation-based data sets and climate models. The approach provides an ensemble estimate of current and future climate along with a measure of uncertainty.
A new compound called DENAQ has been found to restore light perception in blind mice by conferring sensitivity on ganglion cells. The treatment, which requires only a single injection, shows promise as a potential vision-restoring drug, but further testing is needed for safety and efficacy
Researchers at Harvard University's Wyss Institute have developed a bioprinting method to create intricately patterned 3D tissue constructs with multiple cell types and tiny blood vessels. The breakthrough enables the creation of thicker, functional tissues that can be used for drug testing and potentially replaced damaged human tissue.
Researchers observed that worker ants and broods were extremely resistant to submersion during floods. The ants protected the queen by placing her in the center of the raft, with workers using the brood's buoyancy and their own recovery ability to minimize injury or death.
A chemical leak in Charleston, W.Va., highlights the shortcomings of policies and research on thousands of chemicals. The incident led to 300,000 residents relying on bottled water due to the lack of complete toxicology studies on the leaked chemical, MCHM.
A study by Bowling Green State University researchers suggests a correlation between excessive tanning and mental health symptoms such as OCD and BDD. The findings indicate that prevention messages may not be effective for those with these conditions, highlighting the need for further assessment and treatment.
Researchers at MIT and UConn developed new caching strategies that significantly improved chip performance while reducing energy consumption. The new approaches address the challenges of managing data access and communication between cores, resulting in faster execution times and reduced power usage.
A major study found that lowering blood pressure immediately after a stroke does not reduce the risk of death or major disability. The study included over 4,000 patients and showed no significant differences between groups in mortality or disability rates.
A new Northwestern University study finds that excessive sitting time is a major risk factor for disability in people over 60. Sedentary behavior is almost as strong a risk factor as lack of moderate exercise.
Researchers created computer models using PySB framework to explore biochemical processes driving cancer growth. The models aim to identify what goes wrong in cancer cells' self-destruction signals, potentially leading to novel therapies.
Astronomers using data from NASA's RXTE satellite discovered a dozen cloud events where gas clouds moved across the line of sight, dimming X-ray light produced by supermassive black holes in active galaxies. The study triples previous cloud event counts and provides new insights into the environments around supermassive black holes.
A Kansas State University epidemiologist has found that climate, physical environment, and socio-ecologic conditions contribute to tularemia infections among domestic cats. The study identified newly urbanized areas, residential locations surrounded by grassland, and high-humidity environments as key factors in the disease's prevalence.
The American Heart Association has funded 112 studies at Loyola since 1984, with the latest award bringing the total to $10.6 million. Loyola is recognized as one of the top 50 hospitals nationwide for cardiology and heart surgery.
A study from Queen Mary University of London found that less than 1 in 3 women in England have taken folic acid supplements before pregnancy to prevent neural tube defects. Women from ethnic minority groups and those under 20 were less likely to take the supplements.
Researchers at SDSC developed software for multi-scale QM/MM simulations, expanding types of simulations that scientists can use to design new drugs and chemicals. The software integrates with AMBER molecular simulation package, reaching a large user base.
A comprehensive review by the American Psychological Association highlights psychologists' expertise in addressing chronic pain. Successful treatment approaches include cognitive behavioral therapy, acceptance and commitment therapy, mindfulness, and hypnosis, which offer more relief than prescription drugs or surgery.
A new high-efficiency cabin air filter (HECA) can reduce ultrafine particle (UFP) exposure by 93% and keep carbon dioxide levels low. Most modern car filters only block 40-60% of UFPs, but the HECA filter's smaller synthetic fibers can capture more particles.
The Italian Society of Nephrology and Springer are joining forces to promote renal diseases research. The new partnership aims to increase the quality and visibility of the Journal of Nephrology.
A new study shows that in vivo endomicroscopy improves the detection of Barrett's esophagus-related neoplasia when used with high-definition white-light endoscopy, reducing unnecessary mucosal biopsies and potentially changing patient care. The approach involves real-time endoscopic diagnosis and imaging-guided therapy.
Researchers have developed a kinetic energy harvester that captures the energy generated by human movements and converts it into electrical energy. The system uses a flexible cantilever to bend with body movements, producing a small but significant voltage that can be stored in a capacitor.
Researchers found that discarding data from subjects with multiple sclerosis who exhibit significant head movement during fMRI may bias sampling away from those with lower cognitive ability. This could lead to skewed results if not addressed by correcting for motion or recruiting a diverse range of participants.
Researchers at Memorial Sloan Kettering Cancer Center reported remarkable results from a clinical study using genetically modified T cells to treat advanced leukemia. The treatment achieved a 88% complete remission rate, exceeding the response rate of salvage chemotherapy alone.
Developers have created a metal oxide shell that increases the stability of nanowire devices, which can detect disease biomarkers and record heart cells. This coating allows nanoelectronic devices to last several months in human body conditions.
Researchers demonstrate low-power photonic devices fabricated using standard chip-making processes, achieving energy efficiencies competitive with electronics. The advancements enable the commercialization of photonic technology, accelerating its adoption in computing and communication applications.
Researchers have identified a genetic alteration in the NF-κB pathway that drives tumor development and provides clues for treating ependymoma, a devastating childhood brain cancer. The study offers new insights into how abnormal proteins can lead to cancer and may aid efforts to understand and intervene against other cancers.
Researchers at Brown University discovered that working memory uses similar brain circuits to those involved in planning motion. They found that the caudate and dorsal anterior premotor cortex contribute to output gating, a crucial process for selecting from working memory. The study's findings provide insight into how the brain effici...
Astronomers have observed huge clouds of gas circling supermassive black holes at the centers of galaxies, revealing a previously unknown phenomenon. These clouds can intermittently dim X-ray sources, providing evidence for their existence and confirming predictions made by recent models.
A University of Illinois study recommends that couples adopt a relationship work ethic that equals or surpasses their professional one, focusing on active listening and quality time. The research found that couples who attended an Intentional Harmony workshop improved significantly in managing work-partner role conflict and reported re...
A collaborative study out of George Washington University found early signs of feeding and swallowing disruption in children with neurodevelopmental disorders, including autism. The research suggests that cranial nerves controlling food intake and swallowing are not developing correctly, leading to mis-coordination.
Joseph C. Glorioso, III, PhD received a Pioneer Award from Human Gene Therapy for his leadership and accomplishments in developing herpes viruses as efficient vectors for delivering therapeutic genes into cells. His research has shown promise for treating complex genetic and acquired diseases, including brain degeneration and cancer.
Substantial reductions in malaria transmission have been achieved across most of Africa, but 57% of the population still live in areas of moderate-to-high transmission intensity. High population growth rates and emerging resistance to insecticides threaten progress.
New research suggests the UK can produce up to 44% of its energy needs from biomass sources like household waste and agricultural residues. The study highlights the potential for biomass resources to contribute significantly to the country's renewable energy targets.
Researchers have developed a biologic drug that prevents the production of HE4 protein, allowing ovarian cancer cells to grow aggressively and resist chemotherapy. The novel biologic has shown promising results in cell and animal models, increasing the potential for improved treatment and survival rates for women with ovarian cancer.
Researchers have discovered that genes expressed in the nasal passages can serve as accurate proxies for those expressed deeper in the lungs. This breakthrough allows for less invasive and more affordable genetic profiling of asthmatic patients, potentially leading to improved treatment options and better understanding of the disease.
Researchers developed a new method to create ultrathin capacitors with significantly higher capacitance density than commercially available products. This breakthrough could enable the use of printed circuit boards and memory storage devices in next-gen electronics.
Research reveals stick insects have developed a way to generate massive friction when walking upright through a hierarchy of grip with the slightest pressure, allowing them to grip but not stick. The insect's hairy friction pads employ three main tricks to increase contact area under pressure, creating a scale or hierarchy of grip.
A team of researchers from the University of California, Riverside has demonstrated a new type of holographic memory device that uses spin waves to store data. The device has unprecedented data storage capacity and processing capabilities, making it potentially revolutionary for electronic devices.
Oxygen production by cyanobacteria may have initiated 3 billion years ago, with dynamic concentrations rising and falling over billions of years. This new understanding sheds light on the balance between photosynthesis and consumption, impacting life on Earth.
Huntington's disease is caused by an expansion in the polyglutamine tract of a protein called Huntingtin, leading to its misfolding and aggregation. Researchers have discovered that transient intermediate species called oligomers play a key role in neurotoxicity, rather than fibrillar aggregates. Modulating these oligomers through mole...
A team of researchers has identified a giant gas cloud in the Milky Way galaxy, shaped like a long filament and about 50,000 times the mass of our sun. The discovery was made using the High Elevation Antarctic Terahertz telescope, which detects atomic carbon and is located at Ridge A in Antarctica.
Peru's Manu National Park has been recorded with 287 species of reptiles and amphibians, surpassing the previous record in Yasuní National Park. The park's high species diversity is attributed to its large area and steep topographic variation, despite being only 0.01 percent of the planet's land area.
During strong El Niño events, tropical western Pacific sees a sudden drop in sea level, causing prolonged droughts in Samoa and triggering tropical cyclones near Tahiti. Computer climate models predict that these drops could become seasons ahead, helping island communities prepare for the next event.
Chronic musculoskeletal pain affects an estimated 100 million Americans, with low back pain and degenerative joint processes being common causes. Non-steroidal anti-inflammatory drugs (NSAIDs) are not effective in many chronic pain scenarios, but antidepressants and anticonvulsants can provide remarkable relief.
Researchers at UNH found that by age 25, most people have made the most important memories of their lives, with a 'reminiscence bump' between ages 17 and 24. This period is characterized by an over-representation of positive and negative memories.
Researchers at Simon Fraser University have discovered that non-coding RNAs are perturbed in cancerous human cells, allowing for early detection of breast and lung cancers. The study's findings suggest that these molecules can be used to classify patients into subgroups with different survival outcomes.
Articles explore geological processes such as erosion, deposition, and sedimentation, shedding light on catastrophic outburst floods and sediment routing systems. New findings from the Eocene Escanilla Formation and the Ohanapecosh Formation provide insights into facies architecture and sediment grain size variation.
A survey of Malagasy fishing villages found that most fishers support gear restrictions but are less supportive of protected areas and species restrictions. The study suggests an implementation approach prioritizing widely accepted restrictions to increase compliance with current and future fisheries regulations.
Researchers found a massive asteroid around PSR J0738-4042, which is being pounded by asteroids and could form planets. The asteroid's mass is about a billion tonnes, and its formation is linked to the star's intense radiation.
The NuSTAR mission has produced the first map of high-energy X-ray emissions from a supernova remnant, revealing details about the core explosion and its effects on the surrounding gas and dust. The observations provide new insights into the fundamental physics of nuclear explosions and their role in creating life's essential elements.
A Stanford study analyzing over 4,500 trauma cases found that insured patients are more likely to be admitted to non-trauma centers and receive worse care. This is because hospitals may admit insured patients to generate revenue, despite the risk of sub-optimal care.
Researchers found that counties with a history of favoring entrepreneurship and fostering economic self-dependence tend to predict higher self-employment growth rates in the future. The availability of capital matters minimally to self-employment growth, except in small rural counties near metro areas.
The duckweed genome reveals its potential as a biofuel source, with the smallest known plant genome containing fewer than 20,000 protein-encoding genes. This reduced gene count leads to unique characteristics such as neoteny and arrested development.
Researchers found that jazz musicians' brains use syntax to process music, similar to how spoken language is processed in the brain. This study sheds light on the complex relationship between music and language.