Researchers at the Fred Hutchinson Cancer Center have found that removing immune suppressor cells from pancreas tumors triggers a spontaneous anti-tumor immune response, providing hope for future immunotherapy strategies. The study showed that these cells, called granulocyte-myeloid-derived suppressor cells (Gr-MDSCs), actively work ag...
A new study at the University of Liverpool explains how cells adapt to low oxygen environments, potentially controlling cell survival signals. By monitoring protein levels and gene expression, researchers discovered optimal conditions for keeping cells alive, which could lead to cancer treatment advancements.
Scientists discovered that polyphosphate, an ancient chemical present in all living creatures, plays a crucial role in protein folding and can substitute for complex chaperone proteins. This breakthrough could lead to new strategies for treating protein folding diseases like Alzheimer's and Parkinson's.
The TRMM satellite revealed that Tropical Cyclone Guito produced heavy rainfall at a rate of over 50mm per hour in the Mozambique Channel. The satellite data contradicts earlier forecasts predicting landfall, highlighting the importance of accurate weather modeling and monitoring.
A new study from the University of Toronto Scarborough finds that human emotion is felt more intensely under bright light, affecting decision-making. Participants rated stimuli under different lighting conditions, showing a preference for brighter lights to amplify positive and negative emotions.
A new mathematical model developed by Brown University scientists can predict how trees compete for space in the canopy, revealing that incumbent trees dominate 97.9% of a given square meter two years later.
Researchers analyzed UK wind farms and found that turbines produce three-quarters of their original output after 19 years, compared to a third after ten years. The study suggests that wind farms are an effective long-term investment and can help the UK tackle future energy challenges.
Researchers found that a two-way approach can be more effective in reducing health disparities due to social stigma. Interventions at the individual level, such as educational approaches, can be combined with structural changes, like legislative reforms, to achieve better outcomes.
Giant hot flow anomalies can swallow Venus whole due to its magnetic field absence, posing a significant threat to the planet's surface. Observations from European Space Agency's Venus Express reveal frequent and large-scale space weather events at Venus.
A new study by Michigan State University's Michael Colaresi suggests that foreign aid from rival nations can create mistrust among citizens and hinder the establishment of democratic governments after civil wars. Only one country, Algeria, bucked this trend by becoming more democratic in the following decade.
A study by Royal Holloway University found that younger people, men, and childless individuals are more prone to abandoning HIV treatment in South Africa. This can lead to the spread of the disease, putting not only their own lives at risk but also those of others.
Research published in Pediatrics shows that premature babies who hear more adult talk in the NICU have higher language and cognitive scores at 18 months. The study found that every increase in adult word count per hour during the recording period was associated with a two-point increase in the language score.
The SAGE Junior Faculty Professional Development Teaching Award recognizes new teaching professionals in criminal justice and criminology disciplines. The award provides a travel stipend to attend the ACJS Annual Meeting, where winners will engage with top educators, researchers, practitioners, and students.
A new approach allows for the sequencing of hundreds of nuclear genes across members of the Compositae, enabling better-resolution phylogenetic relationships and addressing evolutionary questions about the family. The method, termed target sequence capture, has been successfully tested using 14 species from the sunflower family.
Researchers found that insect distribution is primarily defined by their tolerance to extreme temperatures, not average temperature changes. This knowledge helped model the expected shift in distributions due to climate change, with some species predicted to disappear entirely in a few decades.
A study found that sparing bilateral level IB lymph nodes during radiation therapy for oropharyngeal cancer significantly improved patient-reported xerostomia scores. This reduction also led to lower radiation doses to nearby salivary organs, causing less damage to post-treatment salivary function.
A new study finds that rural primary care physicians are committed to professionalism and quality improvement, contrary to common perceptions. They were more likely to participate in quality improvement activities, discuss costs of care with patients, and report having added Medicaid or uninsured patients to their patient panels.
Researchers at Queen Mary University of London have identified 11 new genetic variants associated with high blood pressure and heart disease. These findings provide valuable insight into the body's regulation of blood pressure, potentially leading to the development of new treatments for hypertension.
A new study identifies a protein essential for relocating cytokinins from roots to shoots, regulating plant growth and development. The research has implications for increasing biomass yield and stress tolerance of plants grown for biofuels or agriculture.
A clinical opinion published in the American Journal of Obstetrics and Gynecology suggests that maternal oxygen supplementation during labor may not benefit the fetus and could be harmful. The authors recommend reserving oxygen for mothers with hypoxia only, pending further research.
A study on Mauritius kestrels reveals that the birds have adopted a faster reproductive strategy due to habitat loss, allowing them to maintain population numbers despite reduced survival rates as young adults. The researchers warn that human activities can have long-lasting impacts on wild species' life histories.
Researchers at Caltech have shown that bone marrow cells are sensitive to infection-related molecules and respond rapidly. They detect invasion and mount an inflammatory response, producing cytokines that stimulate the differentiation of immune cells.
A new study reveals that Greece's health system is deteriorating due to severe austerity measures, leading to a rise in infectious diseases and mental health issues. The country has experienced significant cuts to its healthcare budget, resulting in reduced access to medical care for many patients.
Researchers at the University of Illinois discovered a method to increase broccoli's anti-cancer properties while prolonging its shelf life. The combined application of methyl jasmonate and 1-methylcyclopropene increased the presence of cancer-fighting agents in broccoli, while reducing ethylene levels that cause decay.
Researchers found a significant decrease in cataract risk among male physicians taking a daily multivitamin supplement, with a 9% lower risk compared to the placebo group. However, the study also found a slight increase in age-related macular degeneration risk among multivitamin users.
A study published in PLOS Genetics reveals that nearly 100 genes may explain the lower cancer incidence rate in patients with central nervous system diseases. Researchers found that specific genes were inversely activated in both diseases, suggesting a protective effect against cancer.
A study found that daily humidification of the mouth and throat region during radiation therapy for head and neck cancer reduced mucositis and hospital stays by nearly 50%. Patients who used humidification spent significantly fewer days in the hospital to manage side effects compared to those who did not.
Researchers discovered a new drug, spironolactone, that inhibits DNA repair mechanisms, making cancer cells more susceptible to chemotherapy. This finding has the potential to enhance cancer treatment protocols and improve patient outcomes.
The University of Chicago Crime Lab has received a $1 million MacArthur Award for Creative and Effective Institutions to study interventions preventing violence. Researchers have found targeted tutoring programs improve school outcomes and reduce violence among high school students.
A new study by Sam Houston State University found that conflicts between work and family life were the most significant issues affecting correctional officers' stress and job satisfaction. The study identified demands from work, incompatibility between work and home roles, and family circumstances as major contributors to job stress.
Researchers at the University of Missouri have successfully treated laboratory mice with a genetic heart defect using a new compound. The study found that the compound reduced the thickness of the mice's heart muscles and improved their cardiac functioning, offering potential hope for treating hypertrophic cardiomyopathy.
Researchers have discovered a method for restoring strength to damaged skeletal muscles in the elderly using stem cell therapy. The treatment involves treating cells outside the body with a drug that prevents protein modification and culturing them on soft biomaterials, allowing aged cells to grow and self-renew.
Studies found that biopsied kidney injuries were modestly associated with delay in organ function, but only for donor kidneys already at high risk. However, there was a large degree of overlap between discarded and transplanted kidneys, suggesting low-quality biopsies may be used to make acceptance decisions.
The Association for Gerontology in Higher Education (AGHE) has honored its newest elected officers, fellows, and awardees for their outstanding contributions to gerontological education. The award recipients include individuals recognized for their leadership, mentorship, and scholarship in the field of aging.
The IPRC Ocean Drift Model has been charting the possible paths of tsunami driftage for nearly 3 years, improving its accuracy by accounting for different shapes and buoyancies. The model predicts the type and timing of material that washes up along windward shores, including oyster buoys, crates, and wood pieces from Japan.
Researchers have created artificial muscles that generate far more force and power than human muscles of the same size, using fibres from fishing lines and sewing threads. These inexpensive muscles can quickly lift weights up to 100 times heavier than humans can, with applications in medical devices, humanoid robots, and prosthetic limbs.
The LUX detector demonstrates its high sensitivity to potential signals in the search for low-mass dark matter particles. The new calibration confirms that no evidence of such particles was found during the detector's initial run.
A team of researchers, including a Western University primatologist, has developed an action plan to conserve Madagascar's 101 lemur species. The plan outlines strategies for 30 priority sites and aims to raise funds for individual projects.
Research by American University found that higher prices for fruits and vegetables are associated with higher BMI in young children. Children from low- and middle-income households tend to buy less healthy foods when prices rise.
Researchers have identified a self-resistance mechanism in Streptomyces platensis bacteria that can bypass antibiotic fatty acid synthesis inhibition. This discovery could lead to the development of new, potent antibiotic drug candidates.
Researchers have discovered a unique pattern of neurogenesis in the adult human brain, particularly in the striatum region. New neurons are generated here, which could potentially be useful for developing novel therapies for neurological diseases.
A study comparing post-traumatic stress symptoms among children exposed to disasters and identifying risk factors for resiliency. The article discusses the importance of recognizing similarities and differences in how children and adults react to traumatic events.
New research reveals that supporting cells in the ear can turn into hair cells in newborn mice, leading to potential cell replacement strategies for adults and new treatment approaches for deafness. The study found that blocking the Notch signaling pathway increases the formation of new hair cells from nearby Lgr5-expressing cells.
Elsevier has launched a new journal, TrEAC, which will publish concise and critical overviews of the rapid changes and development in environmental analytical chemistry. The journal aims to enhance understanding of the environment through analysis and detection of new contaminants.
A recent study published in Optometry and Vision Science reveals that nearly 40% of older adults experience color vision abnormalities. The most common type is the blue-yellow error, which can significantly impact daily functioning. Researchers attribute these changes to aging-related eye diseases and lens yellowing.
Researchers have found rare gene variants on chromosome 7 that substantially increase schizophrenia risk, up to 100 out of a 1000 chance. The study also reveals a link between these genes and other disorders such as autism and intellectual development.
Researchers found that patients treated with high-potency statins had a 28% lower risk of death compared to those on simvastatin. Ezetimibe addition showed no improved survival rate, contrary to previous hopes as a potential treatment for heart patients.
Researchers at EPFL have developed bioengineered growth factors that significantly enhance wound healing, bone repair, and new blood vessel formation. The engineered growth factors display improved binding affinity to extracellular matrix proteins, leading to faster tissue closure and granulation tissue production.
Researchers at the Gladstone Institutes have devised a method to reprogram skin cells into cells that closely resemble beating heart cells, exhibiting twitching and contracting patterns. The addition of one genetic factor, Oct4, accelerated the transformation, revealing promising results for pharmaceutical-based therapies.
Two new smartphone applications have been developed to aid in diagnosing epileptic seizures and managing acute stroke care. The epilepsy app was found to be informative in 87% of tested individuals, agreeing with medical diagnoses in 96% of cases.
A new study found that individuals with frailty have lower morning cortisol levels and higher evening levels, associated with reduced grip strength and walking speed. This study suggests a link between disrupted cortisol regulation and loss of muscle mass and strength in frail adults.
A new hypothesis suggests that leprosy has existed for millions of years, with roots dating back to around 10 million years ago. The disease is believed to have evolved from a common ancestor of two known leprosy bacteria, which underwent reductive evolution resulting in a lean genome and loss of free-living ability.
The study found that primary tumor location dictates the risk of disease in the opposite side of the neck, rather than lymph node involvement. No local or regional recurrences were reported, but distant metastasis occurred in 9% of patients.
A recent study has revealed that human and dog brains share dedicated 'voice areas', suggesting a long evolutionary history of this neural mechanism. The research used fMRI scans to compare brain activity between humans and dogs in response to voice and emotional sounds.
The National Cancer Institute (NCI) has rated The Wistar Institute Cancer Center as 'exceptional' and recommended a $14.9 million support grant renewal over five years. This rating highlights the center's commitment to scientific collaboration, research excellence, and translating discoveries into better cancer treatments.
Scientists at The Institute of Cancer Research have discovered that screening for certain genetic mutations in men with a family history of prostate cancer can predict the development of aggressive forms of the disease. The study identified 13 'loss of function' mutations in eight DNA repair genes, which significantly increase the risk...
A novel platform connects engineers in their offices with production locations, enabling real-time video transmission and interactive 3D model views. This approach facilitates remote maintenance by showing operators multiple views of the machine on screen.
A new study aims to identify the causes of oral health problems in HIV-positive patients, including tooth decay, gum disease, and yeast infections. The researchers are analyzing samples from 440 patients to compare their microbiota with uninfected individuals.
A retrospective analysis found that HPV-positive oropharyngeal squamous cell carcinoma patients had a higher overall survival rate than HPV-negative patients after disease progression, with median survival being nearly twice as long. The study also showed improved outcomes for patients who underwent surgery after cancer recurrence.
A study found that feeding cats smaller meals more frequently increased their physical activity, particularly when anticipating meal times. This approach can be a practical solution for pet owners to manage feline obesity and diabetes.