A new method predicts the time from Alzheimer's disease onset to full-time care, nursing home residence, or death with high specificity. The method uses a complex model based on data gathered from a single patient visit and can predict outcomes such as time to assisted living or incontinence.
A study by Michigan Medicine found that female family physicians are more likely to order the HPV test for low-risk women aged 30-65 compared to their male counterparts. The likelihood of ordering the test also varies among clinics and physician training levels.
Scientists have discovered a molecule called CNFy produced by the bacteria Yersinia pseudotuberculosis, which facilitates the infection process by manipulating the host cells' molecular switches. This allows the bacteria to inject toxins into immune cells more efficiently, leading to inflammation and tissue damage.
A team of researchers has identified a family of enzymes crucial for cancer growth in p53 mutant cells. Targeting these enzymes with novel agents may prevent the growth of p53 mutant cancers, benefiting patients with breast, ovarian, lung, colorectal, and brain tumors. The study suggests that inhibiting Type 2 PIP kinases could shut do...
Researchers have discovered that zebrafish chemicals can differentiate human stem cells into muscle cells in the laboratory, making muscle cell therapy a more realistic clinical possibility. The discovery has the potential to revolutionize treatments for muscular dystrophy and diabetes.
The global prevalence of kidney failure treatment is skyrocketing, with a 165% increase in dialysis treatments over the past two decades. Dialysis therapy has seen significant growth, particularly in countries with universal access, where adjusted prevalence increased by 134%.
A USC study has identified a cellular signaling pathway that converts healthy mesenchymal stem cells in the jaw into tumor cells, leading to benign but potentially harmful tumors. The researchers hope that this understanding can be used to develop target-specific treatments for these tumors.
Researchers identify genes that promote stem cell self-renewal and tissue repair, opening up possibilities for metabolic drugs to enhance regeneration. A network of RNA-binding proteins regulates stem cell function and tissue growth during fetal development.
An international team of researchers urges the development of science needed to manage climate risks and capitalize on unexpected opportunities. Climate preparedness research integrates social and climate science, engineering, and other disciplines.
Research suggests that living through war leads to increased solidarity among members of one's own group, shifting motivations toward greater equality. This effect is most pronounced when the war experience occurs during middle childhood and adolescence, leaving a lasting impact on psychology.
A new study by Professor Terry Sloan and Professor Sir Arnold Wolfendale found that changes in solar activity had a negligible impact on global temperatures. The researchers compared data on cosmic rays entering the atmosphere with global temperature records, concluding that less than 14% of the twentieth century's warming was attribut...
A recent study published in Nutrition found that higher chocolate consumption is associated with lower total and central body fat levels in European adolescents. The researchers controlled for other factors, such as diet and physical activity, to reach this conclusion.
Researchers developed a saliva test for diagnosing acute kidney injury, found Mediterranean diet linked to reduced risk of chronic kidney disease, and explored mindfulness meditation's benefits on blood pressure in patients with kidney disease. Initiating dialysis can cause significant burdens and loss of independence in elderly patients.
A University of Michigan Health System study found that prenatal group visits for expectant Japanese women who discussed childbirth and baby care topics with peers felt less anxious and better prepared. The groups allowed women to connect on a personal level, share experiences, and take control of their pregnancy.
Researchers discovered that the SLC24A5 gene plays a crucial role in skin pigmentation variation among South Asians. The study found evidence of positive selection for this gene in North India but not in South India, highlighting an intriguing interplay between natural selection and demographic history.
Researchers found that Cul4 modifies histone proteins to weaken their interaction with chaperones, leading to genomic instability and tumor formation. The study suggests that cancer cells may have evolved mechanisms to disrupt proper nucleosome assembly, affecting genome stability.
Breast cancer cells with high levels of microsomal glutathione S-transferase-1 (MGST-1) resistant to chemotherapy can be killed using nanoparticles carrying doxorubicin. This approach enhances the effectiveness of drug treatment while minimizing adverse reactions.
Research team develops co-assembly approach to create complex nanostructures with preprogrammed properties. The nanoparticles, resembling caterpillar larva, can be designed with specific functions and stimuli responsiveness.
Allergy expert Dr. David Stukus debunks common myths, including artificial dyes, vaccines, at-home blood tests, dietary restrictions, and pet allergies. He emphasizes the importance of consulting a board-certified allergist for proper evaluation and treatment.
NASA satellites captured high-resolution images of Super-Typhoon Haiyan, revealing a powerful eye and widespread thunderstorms. The storm's maximum sustained winds reached 165kts (190mph) with heavy rain potential due to extremely cold cloud top temperatures.
A new study finds that 65% of Americans agree clinicians should be involved in explaining DTC genetic test results. This concern is shared by physician groups and medical journals, highlighting the importance of doctor guidance on interpreting genetic risks.
A peptide fragment derived from cow's milk, lactoferricin B25, exhibits potent anticancer capability against human stomach cancer cell cultures. This finding provides support for the potential therapeutic agent for gastric cancer treatment.
A randomized trial found that lowering salt intake reduces excess fluid volume, blood pressure, and protein excretion in the urine of people with CKD. This could lead to a 30% reduction in risk of progressing to end-stage kidney disease.
A new study finds that high temperatures and low rainfall influence trachoma transmission in Africa, with eye-seeking flies more active at higher temperatures and abundant in areas with low rainfall. The World Health Organization aims to eliminate blinding trachoma by 2020, but understanding all factors affecting the disease is crucial.
A recent study led by Ohio State University researchers reveals that the virus that causes cervical cancer can directly damage host DNA and contribute to cancer development. The study used whole-genome sequencing to investigate the relationship between HPV and human genomes in cancers.
Researchers at Rice University discovered that the accumulation of von Willebrand factor (VWF) in heart valve tissues contributes to their progressive hardening with age. As tissues from pig valves are commonly used to make human heart-valve replacements, VWF helps regulate blood clotting in both pigs and humans.
Researchers at University of Copenhagen and University of Edinburgh identified 53 genes that regulate cell adhesion in embryonic stem cells. This new insight will enable scientists to maintain stem cells more effectively and efficiently manipulate adult cells to revert to a stem cell-like stage.
Dartmouth researcher Scott Williams found that a person can have multiple DNA mutations in different parts of their body, resulting in varying genotypes. These discoveries challenge traditional views on human uniqueness and may impact forensic analysis, paternity testing, and genetic screening.
Bariatric surgery can help obese kidney disease patients lose weight, but it comes with a higher risk of complications and mortality. The study found that 61% of patients lost weight after surgery, but experienced 16 adverse events, including two deaths related to surgical complications.
Scientists at Boston Children's Hospital discover that enhancing cell metabolism is key to tissue repair, opening new avenues for regenerative treatments. They found that reactivating the dormant Lin28a gene enhances mitochondrial metabolism, leading to enhanced wound healing and regeneration.
A Swedish study found that birth before 32 weeks is associated with increased risks of retinal detachment in childhood, adolescence and young adult life. The research indicates the need for ophthalmologic follow-up in children and adults born extremely and very prematurely.
Researchers have developed software that can learn from a patient's normal and seizure electrical activity to predict when another seizure may occur. This allows for an early warning system, potentially enabling people with epilepsy to live safer lives by avoiding hazardous situations before a seizure begins.
Researchers discovered that the Lin28a protein enhances tissue repair in adult mice, promoting hair regrowth and repairing damaged ears and digits. This finding opens up potential treatments for adults using drugs to boost wound healing and cellular metabolism.
A new study found that seven in 10 primary care patients with anxiety disorders eventually received adequate medication or psychotherapy, but this took years and was less likely for minorities. The study also showed that people with higher education levels were more likely to receive care.
A recent study published in the Journal of Nutrition Education and Behavior found that three educational sessions on nutrition had a significant impact on the knowledge and behaviors of 118 low-income women. The classes used a holistic approach and experiential learning, covering topics such as shopping, cooking techniques, and food se...
Research finds that war exposure during key periods of life strengthens affinity for one's own group, promoting nation-building or conflict cycles. The study involved participants from war-torn Georgia and Sierra Leone, who showed greater willingness to reduce inequality with partners from their village or school.
A UCSF scientist suggests that complex gene expression mechanisms in humans may have evolved to counter viral infections, rather than for overall organism development. This idea challenges conventional wisdom about the evolution of eukaryotic cells.
A new computational method, LACHESIS, has been developed to quickly assign, order and orient DNA sequencing information along entire chromosomes. This approach can validate chromosomal abnormalities in cancer research and pave the way for low-cost, high-quality genome assemblies.
A study by Georgia Tech researchers found that people in the US and South Korea prefer wearing e-textiles on their wrists and forearms, with minimal acceptance for other locations. Cultural differences play a significant role in perceptions of wearable technology, with Americans focusing on ease of use and South Koreans prioritizing mo...
Recent advances in robotics enable the creation of prosthetics that mimic natural movement, allowing users to navigate stairs and uneven ground with reduced stress. Studies have shown improved walking speed, decreased energy expenditure, and reduced fall rates compared to passive prostheses.
Researchers discovered how plant cells orient microtubule arrays to bend towards a light source through the action of protein katanin. This process enables plants to grow in response to environmental cues, shedding light on fundamental mechanisms of cell architecture and growth.
Researchers have found that manipulating cyanobacteria's clock genes can increase its production of commercially valuable biomolecules. The study discovered that locking the biological clock into a daytime setting increased the amount of biomolecules produced by up to 700 percent.
Researchers at Johns Hopkins Medicine discovered that exemestane not only inhibits estrogen production but also protects cells from UV radiation, inflammation, and oxidative damage. The drug may have applications beyond breast cancer treatment.
A study analyzing 6 popular food blogs found that vegetarian entrees were lower in calories and saturated fat, while overall recipes were acceptable in calories but excessive in sodium. Nutrition educators and dietitians can work with bloggers to promote healthier recipes online.
The research aims to identify and classify microscopic eukaryote species using new genome sequencing technology, providing a more comprehensive understanding of the vital environmental functions they play. The network will bring together researchers from different fields to study global patterns of biodiversity and ecosystem function.
A multi-center study showed that peripheral prism glasses significantly outperformed sham devices in helping patients with hemianopia avoid obstacles during everyday walking. After six months, 41% of patients continued to wear the real glasses, reporting improved navigation in various environments.
The Infectious Diseases Society of America recommends investing in new diagnostic tests that can identify the bug causing an infection faster and provide results more accurately. These tests would help protect antibiotics and ensure patients receive the best treatment for various infectious diseases.
A study of US nephrologists reveals that hospitalized patients with acute kidney injury (AKI) often do not receive sufficient follow-up care, despite being critically ill. The survey found that only one in five patients seen in clinics for AKI follow-up received reliable transition of care services after hospital discharge.
Biologists at the University of South Carolina have discovered a rare shark species, Sphyrna gilberti, which has a distinct genetic signature and is found only in the Santee and Pee Dee river systems. The discovery highlights the fragility of shark diversity and underscores the importance of studying evolutionary history.
Narrow stripes of dirt and rock beneath massive Antarctic glaciers create friction zones that slow the flow of ice toward the sea. The process is strongly affected by how water infiltrates the space between the ice sheet and the bedrock, researchers found.
Researchers have created an artificial heart that can pump human waste into future robots, powering eco-friendly systems. The device uses shape memory alloys to mimic the human heart's pumping action and is more mechanically simpler than conventional pumps.
A new study published in Psychological Science found that when we perceive someone as trustworthy, their face is perceived as more similar to our own. Researchers used morphing images and bargaining games to test this idea, finding that trust cues can extend beyond social closeness into physical characteristics.
Researchers found that disrupting the circadian clock in mice increases susceptibility to inflammatory disease by controlling the development of key immune cells called interleukin-17-producing CD4+ T helper cells. This discovery could lead to new ways to regulate the immune response and prevent autoimmune diseases.
Researchers at the University of Texas at Arlington are developing a new method to deliver genes that allow expression of light-sensitive proteins, enabling optogenetic stimulation. This technique holds promise for treating neurological disorders and understanding brain function.
The University of Houston will be part of a new Ocean Energy Safety Institute that aims to provide reliable knowledge about critical safety issues. The institute will develop programs of research, technical assistance, and education to support ultra-deep exploration and production.
A new species of Coespeletia has been discovered in the Venezuelan paramos, a high-elevation ecosystem. The species is endemic to the region and is threatened by climate change, emphasizing the need for conservation efforts.
Despite obesity, patients experience improved shoulder function and reduced pain after two years post-surgery, but overall physical function remains unchanged. The study suggests that total shoulder replacement is an effective procedure for pain relief and functional improvement in patients with shoulder arthritis.
Researchers create a new password system, GOTCHA, that incorporates inkblots to protect high-value accounts from stolen passwords. Users describe inkblots with text phrases, making it harder for computers to crack the password.
Levels of bisphenol A (BPA) in dialysis machine components have been found to be toxic to the immune cells circulating in kidney failure patients' blood. Researchers analyzed the effects of BPA on immune cells and found that alternative polymers for dialyzers' components may reduce BPA elution during dialysis.
Researchers at the Gladstone Institutes have identified a unique change in protein structure that guides the production of RNA from DNA. The study sheds light on key aspects of transcription, including polymerase pausing and acetylation, which are crucial for precise transcription and cellular processes.
Researchers at Max Planck Institute for Evolutionary Biology find gene eud-1 that determines wide-mouthed predators and narrow-mouthed bacteria eaters, providing insight into phenotypic plasticity. The discovery sheds light on how organisms adapt to changing environments and challenges current understanding of evolutionary adaptations.
A recent study from the University of Manchester found that tumor oxygen levels impact treatment response. By analyzing gene expression, researchers can predict which patients will benefit from hypoxia-reducing agents before radiotherapy.
The researchers aim to design efficient and cost-effective bimetallic catalysts for clean hydrogen fuel production. The team will develop new mathematical tools to quantify uncertainty and sensitivity in these complex systems.
Researchers found that grandiose narcissism in US presidents is linked to high ratings for public persuasiveness and crisis management, as well as impeachment resolutions. Lyndon B. Johnson scored highest on markers of grandiose narcissism, followed by Theodore Roosevelt.
Researchers will examine conversion to generic tacrolimus in transplant patients to assess its safety and efficacy. The studies aim to address concerns about the use of generic tacrolimus formulations in transplant recipients and provide objective data for clinicians.
Researchers emphasize the need for better engagement between scientists and stakeholders in addressing climate-related issues such as sea level rise, severe storms, and declining snowpack. A comprehensive approach to research is proposed to develop effective measures for establishing adaptation science.
Researchers at OHSU's Vollum Institute published two papers on neurotransmission in Nature, revealing a detailed view of the structural biology of the dopamine transporter. This breakthrough could lead to the development of better antidepressants with few or no side effects.
Researchers at Duke University designed a power-harvesting device that efficiently captures microwave signals and converts them into electrical current. The device has an energy conversion rate of 37%, comparable to solar cells.
Researchers found that in 25 US TV markets, nearly 1/4 of popular youth programs exceeded the industry's voluntary standards for alcohol ad exposure. This could lead to a one-third drop in total youth exposure if ads were eliminated. Exposure to alcohol marketing increases underage drinking and health risks.
Hospital admission during pregnancy significantly increases the risk of serious blood clots (venous thromboembolism), with a particularly high rate among women aged 35 and over. Women hospitalized for three or more days also face an increased risk.
UMMS researchers used advanced techniques to study the 3D structure of mitotic chromosomes, resolving a century-old debate. They found that chromosomes assemble into linearly organized, compressed chromatin loops during the metaphase stage of cell division.
Primary care physicians who took an online training course about skin cancer detection significantly improved their skill to properly diagnose and manage benign and malignant lesions. The enhanced skill level led to a reduction in unnecessary referrals to dermatology specialists.
A new study published in Experimental Physiology found that women exhibit greater shortness of breath when exercising compared to men. The study suggests that this disparity is caused by a stronger electrical activation of the respiratory muscles, specifically the diaphragm, needed to compensate for smaller lungs and airways.
A recent study by Vandenberg et al. found that bisphenol A (BPA) has significant effects on humans at incredibly low doses, often ten to forty times lower than previous toxicology studies. This new understanding of BPA's impact on human health and wildlife highlights the need for stricter regulations.
Researchers find Amazon deforestation could reduce rain and snowfall in the western US, resulting in water and food shortages. A study suggests a 50% reduction in Sierra Nevada snowpack could occur if the Amazon is stripped bare.
Astronomers have observed an asteroid, P/2013 P5, spouting six comet-like tails of dust, defying the typical appearance of asteroids. The unusual tail structures change dramatically in just 13 days, sparking debate over their origin and suggesting a possible rotational breakup.
Researchers at the University of Oulu, Finland, and the Helmholtz Center Berlin have shed light on the structure of thiolase, an enzyme crucial for lipid metabolism in parasites. By blocking the active site, lipid-like substances can be developed to inhibit parasitic metabolism.
Researchers at Johns Hopkins Medicine found that the mammalian target of rapamycin (mTOR) pathway is active in many difficult-to-treat pediatric brain tumors, offering a potential new target for treatment. Blocking this pathway with an experimental drug reduced tumor growth by up to 73% in laboratory studies.
A new study found that consuming more vegetable protein is associated with a 14% lower risk of death in kidney disease patients. The study, which analyzed data from 1,104 CKD patients, suggests that increasing vegetable protein intake may help prolong survival among those with chronic kidney disease.
Researchers discovered that fish use a counterintuitive fin arrangement to increase both stability and maneuverability. By analyzing slow-motion videos and mathematical models, the team found that the opposing forces generated by the fin movements create stabilizing forces while improving velocity change.
A Northwestern Medicine study using stem cells has shown promise in improving organ transplant outcomes by enabling patients to stop taking anti-rejection medicines. The research, which began in 2009, uses specially engineered stem cells to make the recipient's immune system recognize the new kidney as its own.
Astronomers using the Hubble Space Telescope have observed a unique asteroid with six comet-like tails, challenging current understanding of asteroids and comets. The asteroid's rotation rate may have caused its surface to fly apart, ejecting dust into space.
A recent study by Johannes Gutenberg University Mainz found that the Hartz IV reform had no significant impact on reducing unemployment in Germany. However, earlier reforms such as Hartz I to Hartz III were more effective in lowering unemployment rates.
Researchers at the University of Iowa have created a bio patch that can regrow bone by delivering DNA instructions to cells. The patch successfully regenerated bone in test animals and stimulated new growth in human bone marrow stromal cells. This breakthrough technology has potential uses in dentistry, including rebuilding bone for de...
Research reveals that family naming trends in the US follow regional patterns, with people in states emphasizing honor more likely to use patronyms. Matronymns are rare and do not predict any statewide variables. The study highlights gender differences in naming traditions.
Astronomers have discovered an unusual asteroid with six comet-like tails, which change dramatically over just 13 days. The object's rotation rate may be causing its surface to fly apart, ejecting dust in episodic eruptions.
Experts warn that a Syria polio outbreak could spread to Europe if vaccination coverage is low, particularly in Bosnia, Ukraine, and Austria. High hygiene standards and large refugee populations are key to preventing transmission.
A recent clinical trial found that calcium and vitamin D supplementation improves bone density in patients with epilepsy who take chronic antiepileptic drugs. The results suggest that risedronate may help prevent new vertebral fractures when combined with these supplements.
The NSF has awarded six projects to 12 institutions, including international collaborations, to understand Arctic sustainability. The projects focus on environmental change, governance, and community resilience, with a goal of informing policy and mitigation strategies.
Researchers at UT Southwestern have found that a cholesterol metabolite called 27-hydroxycholesterol promotes tumor growth in estrogen-receptor positive breast cancers. The discovery may explain why endocrine-based therapies are often unsuccessful, providing a new target for therapy.
A study published by UC researchers found that patients with acute kidney injury (AKI) before starting dialysis are 1.5 times more likely to die in their first year compared to those without AKI. This discovery may help improve dialysis outcomes and quality of life for millions of patients.
A large prospective study found that consuming tree nuts was inversely associated with the risk of pancreatic cancer. Women who consumed two or more servings of nuts per week had a significantly reduced risk compared to those who did not.
University of Illinois researchers suggest a partnership between farmers and scientists to develop effective practices for reducing nitrogen and phosphorus losses from agricultural fields. The goal is to find widespread regional acceptance and reduce the size of the hypoxic zone in the Gulf of Mexico.
The changes to Canada's fisheries legislation have removed habitat protection for most fish species, according to a study by University of Calgary and Dalhousie University fisheries biologists. The removal of habitat protection is inconsistent with ecosystem-based management and has been described as politically motivated.
Researchers will investigate how flowers use scent to attract pollinators and predators, driving the evolution of diverse plant species. The five-year project aims to understand the dynamics among plants, mutualists, and enemies to conserve biodiversity.
A minimally invasive endoscopic procedure to remove superficial, early stage esophageal cancer is as effective as surgery that takes out and rebuilds the esophagus, according to a Mayo Clinic study. The research found that patients treated by endoscopy had similar overall survival times compared to surgery.
A new study analyzes injuries to children under 7 years old born to teenage parents, revealing a significant risk of falls and ingested objects. The study emphasizes the need for injury prevention programs focusing on home safety and parental supervision skills to mitigate these risks.
Researchers at Boston Children's Hospital successfully grew human muscle cells in a dish using a combination of compounds identified through a rapid culture system. They also boosted muscle mass and reversed disease in a mouse model of Duchenne muscular dystrophy, paving the way for potential clinical trials.
Research suggests hyper-connected neurons may cause social symptoms in autistic children, leading to potential new treatment strategies and early detection methods. The study found a link between brain connectivity and severity of social impairment in individuals with autism.
Researchers discovered that a protein called HDAC5 plays a crucial role in triggering the regrowth of damaged nerve cells. By activating HDAC5, scientists hope to develop treatments that enhance axon regrowth and potentially restore sensation in nerve injuries.