Researchers successfully used CRISPR gene-editing to correct a defective gene in adult mice, allowing them to survive without treatment. The study offers promising hope for treating genetic disorders, including hemophilia and Huntington's disease.
A new telemedicine program integrating office visits with supplemental phone coaching improves cardiovascular disease risk factors such as fruit and vegetable consumption, physical activity, stress reduction, and medication adherence. Adults who engaged in five or more coaching sessions showed significant improvements.
The LAPLACE-2 study shows evolocumab produces highly significant reductions in LDL cholesterol when added to statins, with 93% of patients achieving an LDL level below 70mg/dL. Evolocumab also reduces non-HDL cholesterol, apolipoprotein B and lipoprotein (a) levels without liver damage or muscle problems.
Researchers analyzed electronic health records to identify individuals at risk of familial hypercholesterolaemia. Only 4.3% of those identified were diagnosed, highlighting the need for improved provider recognition and treatment.
Researchers have developed a thermal interface material that can conduct heat 20 times better than traditional polymers, allowing for reliable operation at temperatures of up to 200 degrees Celsius. The new material could improve thermal management in electronic devices, such as servers and mobile devices.
The AleCardio trial was ended early after patients treated with aleglitazar showed higher rates of heart failure, kidney events, and gastrointestinal bleeding. The study found no cardiovascular benefits despite dual-action on PPAR receptors, leading researchers to consider the class of drug being tested clinically.
The novel inflammation inhibitor darapladib showed no primary-endpoint advantage over placebo in treating chronic coronary heart disease, but suggested benefits for specific coronary artery-related endpoints. Subgroup analysis revealed smokers had a greater decrease in major adverse cardiovascular events.
A UCLA study found that increasing Kir4.1 levels in astrocytes improves walking and prolongs survival in a mouse model of Huntington's disease. The discovery could lead to new drug targets for treating the devastating disorder, which affects one in every 20,000 Americans.
Researchers at MIT analyzed the shells of a sea creature to determine why they are exceptionally tough and optically clear. The shells' unique properties emerge from a specialized nanostructure that allows optical clarity, as well as efficient energy dissipation and localized deformation.
Researchers measured fruit fly food consumption using radioisotope labeling and paired it with the capillary feeder assay to achieve the most accurate measurements. The team's findings provide a best practices guide for nutrition measurement in studies of metabolism and disease.
Researchers have identified two new protein markers, GlycA and GlycB, which are associated with inflammation and cardiovascular disease. Elevated levels of these proteins were found in nearly half of the patients who died or suffered an adverse event during follow-up.
In a phase III study, evolocumab was shown to effectively lower LDL-C levels, with fewer side effects compared to ezetimibe. The results suggest that evolocumab may be a promising alternative for patients who cannot tolerate statins due to intolerable side effects.
A new 6-month follow-up study confirms that early treatment with metoprolol significantly reduces dead heart muscle, hospital readmissions, and cardioverter-defibrillator implantation. The treatment also shows promise for reducing chronic heart failure cases.
A multicenter study found colchicine significantly reduced the rate of disease recurrence, improved symptoms, and hospitalization rates in patients with recurrent pericarditis. The medication was also associated with higher remission rates compared to placebo.
Scientists found a 'continuity field' that smooths out object features, allowing us to perceive stability in the real world. This discovery explains why we often miss subtle changes in movies and everyday life.
A new gel coating has been developed to promote bone growth on implants, allowing for improved integration and reduced rejection. The coating, made from a protein that encourages bone formation, can be released slowly in response to calcium ions, stimulating bone growth on the implant.
A recent study published in JAMA compared two types of heart valve technologies used in transcatheter aortic valve replacement (TAVR) procedures. The researchers found that balloon-expandable valves had a higher rate of device success, with lower rates of complications such as regurgitation and the need for additional surgeries.
The study found that aleglitazar did not decrease the time to cardiovascular death, nonfatal heart attack, or nonfatal stroke among patients with type 2 diabetes. The drug was associated with increased risks of kidney abnormalities, bone fractures, gastrointestinal bleeding, and hypoglycemia.
Researchers have developed new simulations that depict the dynamics of deep Earth, revealing a complex composition of the lowermost part of the mantle. The study suggests that mantle plumes can carry a combination of different materials from several reservoirs, explaining observations of hotspot lavas' chemical complexity.
Patients with uncontrolled high blood pressure treated with renal denervation had low rates of adverse events, including five procedural complications and nine hospitalizations. The procedure also showed significant lowering of office systolic blood pressure by 11.9mmHg at six months.
Researchers have discovered that specific genetic mutations can increase the risk of melanoma by deactivating a gene that protects chromosomes from damage. This finding has significant implications for early detection and treatment strategies.
The study found low rates of narrowing and leakage, with 96.7% of patients without stenosis at six months and 94% at 12 months. The device showed strong short- and mid-term results in patients with certain congenital heart defects.
Researchers at Aarhus University found a correlation between Atlantic Ocean temperature fluctuations and external forces like the Sun's energy cycle and volcanic eruptions since the Little Ice Age. This challenges previous theories of internal variability in ocean circulation, suggesting a complex interaction between mechanisms.
Researchers found a strong link between the AMY1 gene and obesity, with individuals having fewer copies of the gene at higher risk. This discovery highlights the importance of tailoring dietary advice based on an individual's digestive system.
A recent study at Chalmers University of Technology found that greenhouse gas emissions from food production threaten the UN's 2-degree Celsius limit for global warming. Reducing meat and dairy consumption could bring agricultural climate pollution down to safe levels, but broad dietary change can take time.
A groundbreaking study from the University of Exeter reveals a significant discrepancy between observed and modelled precipitation levels in the Northern Hemisphere mid-latitudes. The study suggests that aerosol concentrations in the atmosphere may be underestimating the impact on regional temperature and precipitation changes.
A new study found that cardiac resynchronization therapy with a defibrillator (CRT-D) significantly reduces mortality in mildly symptomatic heart failure patients with left bundle branch block. The five-year survival rate was close to 90% among CRT-D patients.
Researchers identified plasma levels of microRNA 122 and 126 that decline before a person suffers a heart attack, suggesting these markers may help predict imminent risk. The discovery could lead to the development of a blood test to identify people at high risk of having a heart attack.
Women with PVD (vulvar vestibulitis) who regulate their emotions in a satisfactory manner are more fulfilled sexually and relationally. Effective emotional communication can improve pain management and overall quality of life for couples.
A blood test using high-sensitivity cardiac troponin T can accurately predict heart attack risk in patients with chest pain, allowing for targeted admissions and reduced hospital costs. The test's negative predictive value was found to be 99.8 percent for heart attack within 30 days.
A large randomized trial found that renal denervation did not significantly lower systolic blood pressure in patients with severe resistant hypertension. Despite rigorous design and blinding, the treatment failed to meet primary efficacy goals, highlighting the need for further research.
People with celiac disease may have a near two-fold increased risk of coronary artery disease compared to the general population. Researchers found that systemic inflammation and autoimmune processes might influence cardiovascular disease development.
Depression patients showed characteristic path length and node attributes differences compared to healthy controls. An artificial neural network algorithm demonstrated the effectiveness of brain network metrics in machine learning research and clinical diagnosis of depression.
A study found that self-expanding TAVR significantly lowers death rates compared to traditional surgical valve replacement in high-risk patients with severe aortic stenosis. The treatment resulted in lower all-cause mortality and heart attack/stroke-related deaths at one year.
The study found the heart becomes more spherical by 9.4% in microgravity, similar to predicted models, and may benefit certain cardiovascular patients on Earth. The temporary shape change appears after spaceflight, but long-term health effects are unknown.
A large study found that postmenopausal women who consume two or more diet drinks per day are 30% more likely to have a cardiovascular event and 50% more likely to die from related disease. The association persists even after adjusting for other risk factors.
A new study found a 25% jump in heart attacks on Mondays after springing forward and a 21% drop on Tuesdays after falling back. Researchers suggest that the time change may alter the timing of when heart attacks occur, potentially putting vulnerable individuals at greater risk.
Researchers have found a unique genetic pattern in leukemia cells of 22 patients diagnosed with cytogenetically normal acute myelogenous leukemia, which may lead to more targeted therapy and definitive prognosis.
Researchers focus on identifying vulnerable patients, early follow-up, medication, and engagement to lower readmission rates. Studies show that starting ACE inhibitors or ARBs prior to discharge and using risk stratification tools can significantly reduce 30-day readmissions.
A study found that co-culturing dorsal root ganglion neurons with type-2 astrocytes increases neuronal survival rates and process lengths. However, the effect is weaker compared to type-1 astrocytes and oligodendrocyte precursor cells.
Researchers used cardiac magnetic resonance imaging to identify patients with mild heart disease who were at high risk of developing more serious heart problems. The study found that these patients had nearly three times the likelihood of experiencing a major cardiac event over time compared to those without a mild heart attack.
The updated 2014 blood pressure guideline significantly affects US adults, with approximately 6 million no longer needing hypertension medication and 13.5 million meeting goal blood pressure levels primarily among older adults and those with diabetes and chronic kidney disease.
Physicians report success in weaning patient off bypass with intra-aortic balloon pump due to reversible left ventricle dysfunction and minimal atherosclerosis. The pump can be an option for patients with mild to moderate aortic insufficiency who don't have severe atherosclerosis.
New studies confirm coronary artery calcium scans as a reliable indicator of long-term heart disease risk, outperforming other tests in low-risk patients. The tests have been shown to detect early signs of plaque accumulation and hardening of the arteries.
A study comparing US and European cholesterol guidelines found substantial differences in statin use recommendations for men and women. The application of these guidelines to a European population resulted in varying proportions of individuals eligible for statins.
A new analysis found that using risk equations can help guide statin therapy for heart disease patients, suggesting they are helpful for clinical decision making. The study also suggests the Pooled Cohort risk equations are valid for informing clinical management decisions.
New relaxed blood pressure guidelines are expected to cut millions from needing hypertension medication. According to the study, the proportion of eligible patients for treatment would decrease from 40.6% to 31.7%, affecting approximately 13.5 million adults.
Researchers have identified key strategies to reduce hospital readmissions for heart failure patients, including starting ACE inhibitors or ARBs prior to discharge, analyzing demographic risk factors, and using automated tools to predict individual risk. These innovative approaches aim to improve patient outcomes and alleviate economic...
Researchers found that statins significantly improve erectile function in men with both high cholesterol and erectile dysfunction. Erectile function scores increased by 24.3% in men taking statins, outperforming lifestyle modifications. The study suggests that statins may help improve blood flow to the penis and reduce symptoms of ED.
A diet rich in fruits and vegetables in early adulthood has been linked to reduced rates of coronary heart disease in middle-aged adults. Young women who ate 8 servings or more per day were 40% less likely to develop calcified plaque in their arteries 20 years later.
A study published in Neural Regeneration Research found that acupuncture at Baihui and Dazhui points can prevent brain cell apoptosis in heroin-addicted rats. This effect is similar to that of methadone, a commonly used drug for treating addiction.
A comprehensive review of bariatric surgery data shows that death rates are reduced by 40% and heart attacks by half compared to non-surgical obese patients. Obesity is a significant health issue worldwide, associated with heart disease, type 2 diabetes, and shorter life expectancy.
Researchers measured p16 levels before, after and a year after chemotherapy to determine its impact on molecular aging. The study found that curative chemotherapy increased molecular age by an equivalent of 15 years in breast cancer patients. This suggests the p16 test may help evaluate treatment effects on long-term health and survival.
Scientists at Harvard T.H. Chan School of Public Health have discovered a technique to accurately determine the amount of nanomaterials interacting with cells and tissues. The Volumetric Centrifugation Method (VCM) enables hazard rankings of engineered nanoparticles, enabling risk assessors to perform accurate assessments.
Research clarifies that ammonia emissions from agricultural exports have a substantial impact on air quality, with the study estimating an annual health cost of $36 billion. The findings suggest that reducing ammonia emissions could lead to significant societal benefits, particularly in the Northeast and Great Lakes region.
A team of University of Missouri researchers completed the genetic history of 134 cattle breeds worldwide, revealing that ancient domesticated African cattle originated in the Fertile Crescent region. This finding proves that cattle were brought to Africa as farmers migrated south and interbred with wild aurochs.
The University of Liverpool will fund 76 PhD students researching areas like financial crashes, nuclear disasters, and environmental crises over eight years. The Centre for Doctoral Training offers a multi-disciplinary approach with industrial partnerships and placements.
A new study found that adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors, including p16INK4a and ARF expression. These age-promoting effects may last for several years after treatment and even be permanent.
A comprehensive analysis of government grants and publications revealed that only a minor fraction of the funding was intended for aging research. Gerontogenes, which increase lifespan when overexpressed or mutated, are involved in stress response pathways that confirm the existence of a genetics-longevity program.
Researchers found that repeated hUCB MNC injections produced greater neuroprotection in mice modeled with MPS III B, preserving hippocampal structure and reducing microglial activation. The treatment also showed promise in modulating anxiety and inflammation.