The A-PARADDISE consortium aims to develop new drugs against four parasites, including schistosomiasis and malaria, which cause over one million deaths annually. Researchers will use histone-modifying enzymes as a target for new treatments, with the goal of paving the way for clinical trials.
A study of high-achieving young physician-researchers reveals pronounced gender differences in domestic activities among those married with children. Additionally, single-patient trials may help determine statin tolerability, while a US survey reports 2.7 million living with chronic Hep C virus.
Research published in the Journal of Clinical Investigation reveals that DLC1 suppresses breast cancer bone metastasis by inhibiting PTHLH production and regulating TGF-\u00b1 signaling. Clinical samples also show a correlation between reduced DLC1, elevated PTHLH, and bone metastasis.
A study by Michigan State University researchers used rats and vanilla frosting to identify genetic factors contributing to binge eating. The Sprague-Dawley rat strain was found to be prone to binge eating, narrowing the scope of possible genes involved in the disorder.
A new approach to breast reconstruction surgery, known as an enhanced recovery pathway, has been shown to reduce opioid painkiller use in patients by 50% and decrease hospital stays by a day on average. The method includes preoperative analgesics, nonsteroidal anti-inflammatories, and resuming food and walking soon after surgery.
A team of researchers at the University of Pennsylvania has made a groundbreaking discovery about how climbing fibers provide feedback to Purkinje cells, allowing them to detect legitimate error signals amidst random firing. This knowledge will be fundamental to future studies of fine motor control and learning.
Researchers discovered abnormal molecular signaling pathways that promote chronic kidney disease progression, targeting endothelial mitochondrial oxidative stress and glomerular filtration barrier. New therapeutic targets may prevent or reverse disease, providing hope for millions of Americans affected by kidney disease.
A new study by Dana-Farber Cancer Institute and Johns Hopkins University found that an immune system-based therapy called nivolumab can produce lasting remissions in melanoma patients, with some patients remaining alive after two years without treatment. The therapy has been shown to block PD-1, a protein that restrains the immune syst...
A recent study at the University of Eastern Finland found that increasing fatty fish intake can increase large HDL particles in the blood, which protect against cardiovascular diseases. Regular consumption of fish, especially fatty fish like salmon and rainbow trout, may help improve lipid metabolism and reduce cholesterol levels.
Researchers have identified two intermediate steps in water oxidation reactions using an Earth-abundant solid catalyst, cobalt oxide. This discovery provides a better understanding of the individual events in the four-electron cycle and enables the design of improvements to boost efficiency.
A Rice University-led team of researchers found that liver cells up-regulate glycolytic pathway to produce more energy in response to disease, leading to net gain in metabolic output. The study suggests new treatments to delay liver failure by boosting glycolytic energy production.
Researchers found that levels of racial prejudice among white people drop significantly when they live in ethnically mixed communities. Positive contact between people belonging to different ethnic groups leads to more tolerant societies overall.
Researchers aim to create artificial platelets that can stick to injury sites and signal natural platelets to home in on them, offering a potential solution to bleeding disorders. The technology has broad applications in stanching bleeding and detecting diseases.
A yeast model of Alzheimer's disease has identified a drug candidate, clioquinol, that reduces amyloid-β levels by 90% and restores cellular protein-trafficking. The mechanism of action involves chelating copper, which makes Aβ more toxic.
A University of Minnesota study found that using treadmills at work increases physical activity by 7-8% and boosts productivity. Productivity improved as employees adjusted to walking while working, with a substantial increase in overall performance.
Researchers at the University of Michigan have created semi-transparent, colored photovoltaics that can generate electricity while maintaining their color. The cells are 10 times thinner than traditional solar cells and have a nearly 100% quantum efficiency, making them suitable for use indoors and in densely populated cities.
Researchers at UC San Diego discovered that direction-sensing cells in the retina send signals to the cortex, enabling brains to process directional movements. The study has practical implications for understanding and treating disabilities related to motion processing.
Research suggests that having a bedroom television is associated with weight gain in children due to disrupted sleep patterns. On the other hand, a weight-management program combining active gaming resulted in increased physical activity and greater weight loss among overweight and obese children.
Researchers have identified a new genetic syndrome characterized by severe allergy, immune deficiency, autoimmunity, and motor neurocognitive impairment. The syndrome is caused by mutations in the PGM3 gene, leading to underactive protein production and glycosylation defects.
University of Cincinnati researchers have made a breakthrough in boosting the efficiency of polymer solar cells by adding graphene nanoflakes, increasing performance threefold. The new method aims to make solar-powered panels lighter, less expensive and more flexible.
Resistance to pesticides has increased in nearly a thousand pest species, including insects, weeds, and fungi. Entomologists updated definitions for key terms related to resistance to facilitate understanding and management of the issue.
Researchers at Cold Spring Harbor Laboratory demonstrate a way to observe the activity of inhibitory neurons linking sense of smell with memory and cognition in awake mice. These granule cells provide feedback to alter sensory interpretation based on past experiences.
Scientists at Stanford University have developed a new, potentially clean catalyst that can convert hydrogen and carbon dioxide into methanol with fewer side-products. The nickel-gallium catalyst offers promise for low-cost, low-pressure methanol production using renewable energy sources.
Scientists at UC San Diego School of Medicine have made a breakthrough discovery on the fate determination of T lymphocytes during an infection. They found that individual cells can make decisions about whether to become effector or memory cells almost immediately after exposure to a pathogen, suggesting that this process could be cruc...
Children who outgrow one type of food allergy may develop another, more severe type to the same food. Eosinophilic esophagitis (EoE) can cause swelling and inflammation in the esophagus, leading to symptoms like weight loss and swallowing difficulties.
A study of 1,125 domestic violence victims found that those whose partners were arrested were 64% more likely to die early compared to those who received a warning. Employed black victims suffered the worst effects, with mortality rates over four times higher than those whose partner received a warning.
Current flood losses in Europe are likely to double by 2050, with socioeconomic growth accounting for two-thirds of the increased risk. Climate change is also expected to contribute to this increase, as changing rainfall patterns affect river flow and flood frequency.
A study by McGill University researchers shows that climate change has led to a decrease in ocean salinity, creating a freshwater lid that prevents mixing with warm waters underneath. This has resulted in the suppression of naturally rare events like the Antarctic polynya and contributed to the shrinking of Antarctic Bottom Water.
A scientific team discovered how the immune system makes a powerful antibody that blocks HIV infection of cells by targeting a site on the virus called V1V2. The new findings point toward a potentially more effective vaccine that would generate V1V2-directed HIV neutralizing antibodies.
ICFO researchers develop plasmonic nano-tweezers that trap and manipulate nano-scale objects without mechanical contact, enabling 3D displacement. This technique has potential applications in medicine and nanotechnology.
Columbia researchers have developed a novel method to image small biomolecules, such as drugs and nucleic acids, in living cells without disturbing their functions. By using stimulated Raman scattering microscopy with alkyne tags, they can obtain high detection specificity and sensitivity.
Researchers at NUS created a highly sensitive fluorescence probe to detect Monoamine Oxidase B (MAO-B) activity, which is elevated in patients with Parkinson's disease. The probe can monitor the progression of the disease and has potential as a biomarker.
An international team has identified genetic mutations that reduce the risk of type 2 diabetes by 65% in people with risk factors. These mutations may lead to the development of a new therapeutic strategy for preventing and treating the disease.
A new sensor can measure antibiotic levels in blood with high sensitivity, enabling individualized treatment and reducing potential toxic effects. This development has the potential to improve clinical regimes and combination therapies.
Scientists from Queen Mary University of London developed a novel method to quantify plant tolerance to high light intensity. The study found that plants grown without quick responses to high light had reduced capacity to protect themselves from damage.
Researchers investigated the break-up of supercontinent Gondwana, finding that a nearly orthogonal West African rift was stopped by an opposing Equatorial Atlantic rift, preventing the formation of a Saharan Atlantic Ocean. This study highlights the importance of rift orientation and extension direction in shaping Africa's margin.
Researchers have developed a new laboratory screening technique to find novel treatments for pediatric neuroblastoma. MicroRNAs play an important role in regulating cell development and differentiation, revealing promising targets for new therapies.