Identification of factors that influence breast cancer metastasis to bone
One of the more serious and frequent complications of advanced breast cancer is bone metastasis, which is exacerbated by TGF-β signaling; however, it is not clear how TGF-β production is regulated prior to and during metastasis. In this issue of the Journal of Clinical Investigation , Guohong Hu and colleagues at the Shanghai Institutes for Biological Sciences evaluated murine models of invasive breast cancer and determined that cancer cells lacking the putative tumor suppressor DLC1 have a greater propensity toward infiltrating bone, while overexpression of DLC1 inhibited bone colonization. DLC1 knockdown increased TGF-β signaling, resulting in elevated levels of parathyroid hormone-like hormone (PTHLH) and increased metastasis, and pharmacological inhibition of PTHLH production prevented spread to bone. Furthermore, evaluation of clinical breast tumor samples revealed a correlation between reduced DLC1 , elevated PTHLH , and bone metastasis.
TITLE: DLC1-dependent parathyroid hormone–like hormone inhibition suppresses breast cancer bone metastasis
AUTHOR CONTACT: Guohong Hu
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, , CHN
Phone: 86-21-63844516; E-mail: ghhu@sibs.ac.cn
View this article at: http://www.jci.org/articles/view/71812
CELL BIOLOGY
TITLE: Assembly of the cochlear gap junction macromolecular complex requires connexin 26
AUTHOR CONTACT: Kazusaku Kamiya
Juntendo University Faculty of Medicine, Tokyo, JPN
Phone: +81-3-5802-1229; Fax; E-mail: kkamiya@juntendo.ac.jp
View this article at: http://www.jci.org/articles/view/67621
TITLE: Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis
AUTHOR CONTACT: Paul Trainor
Stowers Institute for Medical Research, Kansas City, MO, USA
Phone: 816-926-4414; E-mail: pat@stowers.org
View this article at: http://www.jci.org/articles/view/72688
ONCOLOGY
TITLE: SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome
AUTHOR CONTACT: Guido Marcucci
The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
Phone: 614-366-2261; E-mail: guido.marcucci@osumc.edu
View this article at: http://www.jci.org/articles/view/70921
TITLE: SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas
AUTHOR CONTACT: Adam Bass
Dana Farber Cancer Institute, Boston, MA, USA
Phone: 6176322477; E-mail: Adam_Bass@dfci.harvard.edu
View this article at: http://www.jci.org/articles/view/71545
NEPHROLOGY
TITLE: Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis
AUTHOR CONTACT: Erwin Bottinger
Icahn School of Medicine at Mount Sinai, New York, NY, USA
Phone: 212.241.0800; Fax: 212.849.2643 ; E-mail: erwin.bottinger@mssm.edu
View this article at: http://www.jci.org/articles/view/71195
NEUROSCIENCE
TITLE: Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy
AUTHOR CONTACT: Thomas Gillingwater
University of Edinburgh, Edinburgh, UNK, GBR
Phone: +44 131 6503724; E-mail: T.Gillingwater@ed.ac.uk
View this article at: http://www.jci.org/articles/view/71318
PULMONOLOGY
TITLE: Fibrotic extracellular matrix activates a pro-fibrotic positive feedback loop
AUTHOR CONTACT: Matthew Parker
University of Minnesota, Minneapolis, USA
Phone: 612-205-2514; E-mail: park0523@umn.edu
View this article at: http://www.jci.org/articles/view/71386
Journal of Clinical Investigation