Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
Researchers from the University of Southern Denmark have found evidence of a previously overlooked process in which bone can renew its spongy inner structure (trabecular bone) from within. The finding provides new insight into how the skeleton is maintained, suggesting a potential new mode of bone remodelling.
Researchers analyzed fossil data from 7 human ancestors, finding Australopithecus had strong arms but human-like leg pattern, while early Homo had stronger legs and weaker arms, suggesting a major shift in movement and living habits around 2 million years ago. This finding supports the idea that bipedalism evolved gradually, with early...
A major change in human ancestors' movement took place between 3 million and 1.8 million years ago, combining regular tree-climbing with walking on two legs. Early human ancestors like Australopithecus used trees as much as modern chimpanzees and gorillas do today, but when on the ground, they walked on two legs.
Researchers discovered that β1 integrin and DDR2 form a cooperative collagen-sensing system in skeletal progenitor cells, regulating their migration, proliferation, and differentiation during bone regeneration. Targeting both receptors may provide a more effective strategy for enhancing bone repair in degenerative or injury-related ske...
Researchers found distinct patterns of bone density change after anatomical and reverse total shoulder arthroplasty, with significant declines in bone mineral density over time in patients with osteoporosis. These findings suggest that optimizing osteoporosis treatment and monitoring bone density may improve long-term outcomes after re...
The RadiCaL study, the first randomized trial of a radiopharmaceutical in kidney cancer, found that adding radium-223 to the standard of care does not improve skeletal event-free survival. Patients who received the combination treatment lived a median of 28.3 months, compared with 19.7 months for those who received cabozantinib alone.
A study from Ohio State University found that sooty mangabey monkeys, with feet similar to those of humans, can climb vertical tree trunks with ease. The research suggests that the last common ancestor of humans and chimpanzees could have been a vertical climber, challenging existing theories about foot structure and forest environment...
A study published in PLOS One has confirmed the utility of superworm larvae for cleaning museum specimens. The larvae efficiently remove flesh from skeletons without causing damage, making them an environmentally friendly and safer option than existing methods.
Researchers have digitally preserved the vaquita by scanning a complete skeleton and creating interactive 3D models. The technology enabled the team to capture microscopic skeletal details and make the information accessible to anyone, with the resulting models being made freely available through MorphoSource.
A study presented at ENDO 2026 found semaglutide was associated with a 15% reduction in bone fractures and greater weight loss compared to other anti-obesity medications. The results suggest that semaglutide may have beneficial effects on bone health in people with type 2 diabetes.
A retrospective cohort study found that menopausal hormone therapy significantly reduces the risk of low bone mineral density by 69% compared to non-users. This suggests that hormone therapy could be an effective way to prevent bone loss and lower fracture risks in women after menopause.
Researchers found that zirconia implants trigger an immune-inflammatory niche marked by macrophage involvement and COL6A2/CD44 signaling. In contrast, titanium implants support a regenerative microenvironment with collagenase-1/stromal-derived cell differentiation 1 (SDC1) signaling.
Researchers developed a mineralized DNA hydrogel that coordinates immune regulation and sustained bone regeneration. The material promotes healing-friendly macrophage activity while supporting bone-forming stem cells, accelerating bone repair and improving tissue mineralization.
Researchers discovered that disrupted PTH1R signaling drives abnormal cementum growth and tooth-bone fusion in adult mice, leading to severe dental complications. The study identified the loss of PTH1R signaling as a critical molecular safeguard against excessive cementum formation.
Scientists at Tampere University created a 3D printed ceramic implant material that closely mimics real human bone. The findings advance personalized bone regeneration and may lead to more effective treatments for bone defects.
Researchers identify TGF-β signaling pathway as key regulator of osteoblast quiescence, suggesting its inhibition can aid in reactivation of dormant osteoblasts. Combining TGF-β-blocking antibodies with anti-sclerostin treatment shows promising therapeutic potential for osteoporosis treatment.
A new study reveals the developmental mechanism of bone marrow formation, identifying septoclasts as early organizers followed by LepR-expressing bone marrow stromal cells. These specialized cell populations work together to build the bone marrow environment through a hardwired process supported by RANKL.
Researchers reveal how expansion of bone marrow fat promotes immunosuppressive PD-L1 signaling, leading to enhanced osteoclast activity and accelerated bone loss. Reducing bone marrow fat improves bone structure.
A large multiethnic study identifies genetic factors associated with developmental dysplasia of the hip (DDH) and its progression to osteoarthritis of the hip. Variations in COL11A2, CALN1, and TRPM7 genes were found to be common to both DDH and hip OA.
Early-life exposure to PFAS may influence how teens' bones develop during adolescence, leading to lower bone density. The study found that teens with higher PFAS levels had lower forearm bone density, with stronger associations among females.
A team at The University of Osaka has identified a signaling molecule called FGFR3 and a pathway called CREB as key in regulating bone growth. Cells carrying the genetic mutation associated with achondroplasia accumulate in the resting zone and show abnormal behaviors, which included abnormal patterns of division and migration.
Researchers discovered that Apex1 plays a crucial role in initiating and progressing bone healing after injury. The protein is required for activating the master regulatory gene Bmp2, which initiates healing by stimulating periosteal expansion and callus formation.
A new consensus statement provides evidence-based guidance for screening, diagnosis, treatment, and return-to-play protocols for female athletes. The updated report includes a first-of-its-kind adolescent model of the Female Athlete Triad, addressing energy deficiency in growing adolescents.
A Johns Hopkins-led team has created the first map of nerve circuitry in bone, revealing how sensory neurons communicate with bone-building cells to promote healing. The study identifies key protein signals necessary for bone formation and repair.
A prospective multicenter trial validated an improved method for predicting treatment benefits in hormone receptor-positive metastatic breast cancer with bone metastases. Metabolic change assessed by FDG-PET/CT accurately predicted progression-free survival as early as 12 weeks after treatment initiation.
Using GLP-1 receptor agonists may lower the risk of vertebral compression fractures and related surgical interventions in people with type 2 diabetes. The study suggests that these medications have a bone-protective effect, offering benefits for patients.
A new research letter highlights major gaps in how opioid use is tracked among older adults receiving post-acute care under Medicare. Current data sources may overlook most opioid use during critical transition periods, leading to inaccurate understanding of medication use and policy decisions.
Researchers at the University of Tsukuba identified a peptide hormone called Capa that regulates calcium levels in fruit flies. The study found that Capa is secreted by specific neurons and acts on organs similar to vertebrate kidneys to mobilize calcium from stored reserves.
The study found that males have a narrower pelvis, resulting in a more medial starting point for S2AI screws and poorer rod alignment. Researchers aim to tailor treatment to patients' specific anatomy to improve surgical efficiency and outcomes.
Researchers discovered a strong link between our internal circadian clock and the breakdown of old bone tissue. The study found that bone resorption is closely tied to the body's natural rhythm, with implications for maintaining bone integrity and preventing conditions like osteoporosis.
Researchers create a device that prints bone grafts directly onto fractures and defects using a modified glue gun. The tool enables rapid creation of complex implants without pre-fabrication and demonstrates high structural flexibility, anti-inflammatory properties, and natural bone regrowth.
Researchers found signs of osteomyelitis in sauropod fossils from the Cretaceous period, suggesting a fatal bone disease that killed animals quickly. The study identified three previously unknown manifestations of osteomyelitis and provides insights into the environment that favored pathogens.
Scientists at Leipzig University have discovered that the adhesion G protein-coupled receptor GPR133 plays a central role in building and maintaining healthy bone. By mimicking natural activation, a new active substance AP503 can strengthen bones and potentially treat osteoporosis.
Researchers uncovered two myeloid cell populations driving immune dysregulation in polytrauma, highlighting a critical role of TIM cells in immune suppression. The study also identified key genes and communication patterns involved in polytrauma-induced immune responses, providing potential targets for therapeutic intervention.
Researchers developed a novel nanoconfinement strategy to deliver molecular hydrogen for diabetic bone repair. The innovative implant achieves controlled and sustained H2 release, promoting bone regeneration and neural network formation. This technology addresses key limitations of conventional H2 therapy.
Researchers found that disabling mERα signaling in osteoblast lineage cells reduced cortical bone mass and density, leading to weaker bones. This pathway is essential for maintaining bone strength and density, especially in females.
A new survey conducted by Ohio State University Wexner Medical Center found that only 1% of men are concerned about bone density, with cancer and heart disease being top concerns. Men can build back bone density through exercise, nutrition, and lifestyle changes, and early intervention can prevent deadly fractures.
Researchers uncover how RUNX2 regulates cranial base growth by controlling chondrocyte differentiation, proliferation, and organization. The study provides fundamental insights into the complex interplay between RUNX2 and FGFR3, shedding light on novel therapeutic targets for craniofacial defects.
Researchers used a premature aging mouse model to study the effects of age and sex on osteocyte networks and bone structure. Aged PolgA mice showed accelerated skeletal aging, reduced osteocyte connectivity, and increased frailty, with males exhibiting more pronounced changes.
Researchers analyzed a skeleton with a severe knee injury to uncover the complexities of social attitudes towards individuals with disabilities in medieval Europe. The study found that despite negative cultural views, some individuals with disabilities received long-term care and prominent burials.
The USPSTF recommends early, universal screening for syphilis infection during pregnancy to prevent congenital syphilis. Untreated syphilis can cause premature birth, low birth weight, and stillbirth in the fetus.
Researchers found that NFL players are 3.7 times more likely to suffer a tear of the extensor mechanism during a short rest week than a long rest week or resting less than seven days.
Researchers have found that ATF6, a protein activated in macrophages during corticotomy, promotes inflammation and boosts TNFα production to accelerate bone remodeling. The study suggests that targeting the ATF6-TNFα pathway could lead to non-invasive therapies for faster and more efficient orthodontic procedures.
Dr. Elizabeth M. Curtis has been awarded the ESCEO-IOF Pierre Meunier Young Scientist Award for her groundbreaking research on musculoskeletal health and bone disease. Her work focuses on the epidemiology of bone, muscle health, and joint health across the lifespan.
A recent study found that exosomes derived from M2 macrophages can improve bone regeneration by modulating NETs and endothelial cell function. These tiny vesicles deliver miR-93-5p, reducing NETs formation and enhancing blood vessel growth.
Professor Atsushi Suzuki, Chair of Endocrinology at Fujita Health University School of Medicine, Japan, received the IOF President's Award for his exceptional contributions to IOF. He has shared his expertise as a mentor and engaged member of the Capture the Fracture Governance.
Dr Ambrish Mithal, an Indian endocrinologist, has been awarded the prestigious IOF CSA Medal of Achievement for his groundbreaking work in advancing the field of osteoporosis. His pioneering efforts have significantly increased understanding and awareness of osteoporosis globally.
AMMOM has been recognized by the IOF for its significant contributions to osteoporosis awareness and bone health in Mexico. The organization has collaborated extensively with the IOF on various initiatives, including joint scientific meetings and advocacy efforts.
Penghu 1, discovered on the seabed of the Penghu Channel in Taiwan, is revealed to be a Denisovan mandible dating back to 10,000 years ago. The fossil's molecular identification sheds light on the mysterious distribution and appearance of Denisovans in eastern Asia.
A new study from the University of Gothenburg found that titanium micro-particles are consistently present at all examined implants, even those without signs of inflammation. The researchers identified 14 genes that may be affected by these particles, but further research is needed to understand their impact on tissue health.
A systematic review of nearly 6000 runners found that lower energy and fat intakes were strongly associated with a higher risk of injury in female runners. A low-fibre diet also increased the likelihood of bone stress injuries.
Researchers have discovered two distinct pathways of bone regeneration driven by early progenitor cell activation in male and female-derived organoids. The study highlights the importance of a shared set of secreted proteins in the healing process, with potential applications for personalized medicine and noninvasive biomarkers.
A Mediterranean diet combined with physical activity mitigates weight loss–related bone mineral density decline in older adults with metabolic syndrome. This study suggests that lifestyle interventions may be effective in maintaining bone health in this population.
Scientists have discovered that osteocytes undergo structural and functional changes with age, impairing their ability to maintain bone strength. This discovery could lead to new treatments for osteoporosis and age-related bone loss by targeting senescent cells.
A mass mortality event occurred in Triassic Wyoming, where dozens of giant amphibians called metoposaurid temnospondyls died together on an ancient floodplain. The study provides a unique snapshot of a single population and doubles the known number of individuals of the species Buettnererpeton bakeri.
Researchers found clear evidence of air sacs in fossilized alvarezsaurian bones, which may have helped modern birds fly. This discovery provides new insights into the evolution of bird flight and the role of 'hollow bones' in this process.
New research reveals mammals were shifting toward a more ground-based lifestyle several million years before the dinosaurs' mass extinction event. Analyzing small-fossilized bone fragments, scientists found signs of locomotory habit in end of limb bones from marsupial and placental mammals.
Aging individuals experience bone loss despite physical activity, highlighting the importance of MSCs in regulating bone mechanoresponse. The new 3D bone marrow analog reveals that trabecular volume affects MSC response to mechanical signals, with higher strains associated with older densities and increased F-actin production
Researchers propose a general formula modeling bone adaptation as a function of key loading parameters. The formula provides insights into the relationship between mechanical signals and adaptive bone responses, offering guidance for optimizing exercise regimens and designing medical devices to promote bone health.
A new consensus paper emphasizes the role of bone turnover markers (BTMs) in diagnosing and managing osteoporosis. BTMs, such as procollagen type I N propeptide (PINP) and β-isomerized C-terminal telopeptide of type I collagen (β-CTX-I), are invaluable tools for predicting fracture risk and monitoring treatment adherence.