Articles tagged with Bones
Early-life exposure to PFAS may influence how teens' bones develop during adolescence, leading to lower bone density. The study found that teens with higher PFAS levels had lower forearm bone density, with stronger associations among females.
A team at The University of Osaka has identified a signaling molecule called FGFR3 and a pathway called CREB as key in regulating bone growth. Cells carrying the genetic mutation associated with achondroplasia accumulate in the resting zone and show abnormal behaviors, which included abnormal patterns of division and migration.
Researchers discovered that Apex1 plays a crucial role in initiating and progressing bone healing after injury. The protein is required for activating the master regulatory gene Bmp2, which initiates healing by stimulating periosteal expansion and callus formation.
A new consensus statement provides evidence-based guidance for screening, diagnosis, treatment, and return-to-play protocols for female athletes. The updated report includes a first-of-its-kind adolescent model of the Female Athlete Triad, addressing energy deficiency in growing adolescents.
A Johns Hopkins-led team has created the first map of nerve circuitry in bone, revealing how sensory neurons communicate with bone-building cells to promote healing. The study identifies key protein signals necessary for bone formation and repair.
A prospective multicenter trial validated an improved method for predicting treatment benefits in hormone receptor-positive metastatic breast cancer with bone metastases. Metabolic change assessed by FDG-PET/CT accurately predicted progression-free survival as early as 12 weeks after treatment initiation.
Using GLP-1 receptor agonists may lower the risk of vertebral compression fractures and related surgical interventions in people with type 2 diabetes. The study suggests that these medications have a bone-protective effect, offering benefits for patients.
A new research letter highlights major gaps in how opioid use is tracked among older adults receiving post-acute care under Medicare. Current data sources may overlook most opioid use during critical transition periods, leading to inaccurate understanding of medication use and policy decisions.
Researchers at the University of Tsukuba identified a peptide hormone called Capa that regulates calcium levels in fruit flies. The study found that Capa is secreted by specific neurons and acts on organs similar to vertebrate kidneys to mobilize calcium from stored reserves.
The study found that males have a narrower pelvis, resulting in a more medial starting point for S2AI screws and poorer rod alignment. Researchers aim to tailor treatment to patients' specific anatomy to improve surgical efficiency and outcomes.
Researchers discovered a strong link between our internal circadian clock and the breakdown of old bone tissue. The study found that bone resorption is closely tied to the body's natural rhythm, with implications for maintaining bone integrity and preventing conditions like osteoporosis.
Researchers create a device that prints bone grafts directly onto fractures and defects using a modified glue gun. The tool enables rapid creation of complex implants without pre-fabrication and demonstrates high structural flexibility, anti-inflammatory properties, and natural bone regrowth.
Researchers found signs of osteomyelitis in sauropod fossils from the Cretaceous period, suggesting a fatal bone disease that killed animals quickly. The study identified three previously unknown manifestations of osteomyelitis and provides insights into the environment that favored pathogens.
Scientists at Leipzig University have discovered that the adhesion G protein-coupled receptor GPR133 plays a central role in building and maintaining healthy bone. By mimicking natural activation, a new active substance AP503 can strengthen bones and potentially treat osteoporosis.
Researchers uncovered two myeloid cell populations driving immune dysregulation in polytrauma, highlighting a critical role of TIM cells in immune suppression. The study also identified key genes and communication patterns involved in polytrauma-induced immune responses, providing potential targets for therapeutic intervention.
Researchers developed a novel nanoconfinement strategy to deliver molecular hydrogen for diabetic bone repair. The innovative implant achieves controlled and sustained H2 release, promoting bone regeneration and neural network formation. This technology addresses key limitations of conventional H2 therapy.
Researchers found that disabling mERα signaling in osteoblast lineage cells reduced cortical bone mass and density, leading to weaker bones. This pathway is essential for maintaining bone strength and density, especially in females.
A new survey conducted by Ohio State University Wexner Medical Center found that only 1% of men are concerned about bone density, with cancer and heart disease being top concerns. Men can build back bone density through exercise, nutrition, and lifestyle changes, and early intervention can prevent deadly fractures.
Researchers uncover how RUNX2 regulates cranial base growth by controlling chondrocyte differentiation, proliferation, and organization. The study provides fundamental insights into the complex interplay between RUNX2 and FGFR3, shedding light on novel therapeutic targets for craniofacial defects.
Researchers used a premature aging mouse model to study the effects of age and sex on osteocyte networks and bone structure. Aged PolgA mice showed accelerated skeletal aging, reduced osteocyte connectivity, and increased frailty, with males exhibiting more pronounced changes.
Researchers analyzed a skeleton with a severe knee injury to uncover the complexities of social attitudes towards individuals with disabilities in medieval Europe. The study found that despite negative cultural views, some individuals with disabilities received long-term care and prominent burials.
The USPSTF recommends early, universal screening for syphilis infection during pregnancy to prevent congenital syphilis. Untreated syphilis can cause premature birth, low birth weight, and stillbirth in the fetus.
Researchers found that NFL players are 3.7 times more likely to suffer a tear of the extensor mechanism during a short rest week than a long rest week or resting less than seven days.
Researchers have found that ATF6, a protein activated in macrophages during corticotomy, promotes inflammation and boosts TNFα production to accelerate bone remodeling. The study suggests that targeting the ATF6-TNFα pathway could lead to non-invasive therapies for faster and more efficient orthodontic procedures.
Dr. Elizabeth M. Curtis has been awarded the ESCEO-IOF Pierre Meunier Young Scientist Award for her groundbreaking research on musculoskeletal health and bone disease. Her work focuses on the epidemiology of bone, muscle health, and joint health across the lifespan.
A recent study found that exosomes derived from M2 macrophages can improve bone regeneration by modulating NETs and endothelial cell function. These tiny vesicles deliver miR-93-5p, reducing NETs formation and enhancing blood vessel growth.
Dr Ambrish Mithal, an Indian endocrinologist, has been awarded the prestigious IOF CSA Medal of Achievement for his groundbreaking work in advancing the field of osteoporosis. His pioneering efforts have significantly increased understanding and awareness of osteoporosis globally.
AMMOM has been recognized by the IOF for its significant contributions to osteoporosis awareness and bone health in Mexico. The organization has collaborated extensively with the IOF on various initiatives, including joint scientific meetings and advocacy efforts.
Professor Atsushi Suzuki, Chair of Endocrinology at Fujita Health University School of Medicine, Japan, received the IOF President's Award for his exceptional contributions to IOF. He has shared his expertise as a mentor and engaged member of the Capture the Fracture Governance.
Penghu 1, discovered on the seabed of the Penghu Channel in Taiwan, is revealed to be a Denisovan mandible dating back to 10,000 years ago. The fossil's molecular identification sheds light on the mysterious distribution and appearance of Denisovans in eastern Asia.
A new study from the University of Gothenburg found that titanium micro-particles are consistently present at all examined implants, even those without signs of inflammation. The researchers identified 14 genes that may be affected by these particles, but further research is needed to understand their impact on tissue health.
A systematic review of nearly 6000 runners found that lower energy and fat intakes were strongly associated with a higher risk of injury in female runners. A low-fibre diet also increased the likelihood of bone stress injuries.
Researchers have discovered two distinct pathways of bone regeneration driven by early progenitor cell activation in male and female-derived organoids. The study highlights the importance of a shared set of secreted proteins in the healing process, with potential applications for personalized medicine and noninvasive biomarkers.
A Mediterranean diet combined with physical activity mitigates weight loss–related bone mineral density decline in older adults with metabolic syndrome. This study suggests that lifestyle interventions may be effective in maintaining bone health in this population.
Scientists have discovered that osteocytes undergo structural and functional changes with age, impairing their ability to maintain bone strength. This discovery could lead to new treatments for osteoporosis and age-related bone loss by targeting senescent cells.
A mass mortality event occurred in Triassic Wyoming, where dozens of giant amphibians called metoposaurid temnospondyls died together on an ancient floodplain. The study provides a unique snapshot of a single population and doubles the known number of individuals of the species Buettnererpeton bakeri.
Researchers found clear evidence of air sacs in fossilized alvarezsaurian bones, which may have helped modern birds fly. This discovery provides new insights into the evolution of bird flight and the role of 'hollow bones' in this process.
New research reveals mammals were shifting toward a more ground-based lifestyle several million years before the dinosaurs' mass extinction event. Analyzing small-fossilized bone fragments, scientists found signs of locomotory habit in end of limb bones from marsupial and placental mammals.
Researchers propose a general formula modeling bone adaptation as a function of key loading parameters. The formula provides insights into the relationship between mechanical signals and adaptive bone responses, offering guidance for optimizing exercise regimens and designing medical devices to promote bone health.
A new consensus paper emphasizes the role of bone turnover markers (BTMs) in diagnosing and managing osteoporosis. BTMs, such as procollagen type I N propeptide (PINP) and β-isomerized C-terminal telopeptide of type I collagen (β-CTX-I), are invaluable tools for predicting fracture risk and monitoring treatment adherence.
Aging individuals experience bone loss despite physical activity, highlighting the importance of MSCs in regulating bone mechanoresponse. The new 3D bone marrow analog reveals that trabecular volume affects MSC response to mechanical signals, with higher strains associated with older densities and increased F-actin production
A recent study found that everyday physical activity does not slow bone loss during menopause, contrary to previous studies suggesting exercise can mitigate age-related bone weakening. Despite this, researchers believe more targeted exercise may help slow hormonal bone loss.
Scientists have identified CD47 as an essential regulator of mesenchymal progenitor cell (MSC) proliferation—cells critical for bone repair. CD47-deficient mice exhibited delayed callus formation and lower bone volume, emphasizing its importance in bone healing.
A study found that mice exposed to microgravity for 37 days experienced significant bone loss, especially in weight-bearing bones. This research may inform human acclimation strategies for spaceflight.
Researchers have identified Naked cuticle homolog 2 (NKD2) as a critical regulator of bone cell differentiation, promoting osteoblast formation while inhibiting adipocyte and osteoclast activity. The study suggests that targeting NKD2 could lead to treatments that prevent bone loss and promote bone formation.
A USC study found proteins and pathways involved in inflammation are associated with changes in bone mineral density (BMD) over time. The research identified potential biomarkers that could serve as early indicators of a person's risk for bone health issues later in life.
Researchers discovered a collection of 27 fossilized bones with shaped into hand tools 1.5 million years ago by early human ancestors. This find suggests that hominins had an advanced understanding of toolmaking, adapting techniques to different materials, indicating greater cognitive skills.
Researchers discovered 27 standardized bone tools over 1.5 million years old in Tanzania's Olduvai Gorge, pushing back known standardization by 500,000 years. The discovery suggests an early ability for planning and knowledge transmission among ancient populations.
A recent study from the University of Gothenburg found that dental implants continue to function well after nearly forty years. The implants, developed by Professor Per-Ingvar Brånemark, have been shown to remain stable and integrate with bone over an extended period.
A new study suggests that early weight bearing on broken ankles is generally safe and can help speed up patient recovery by preventing muscle deconditioning and improving joint range of motion. Healthy patients can typically start bearing weight within three weeks of surgical intervention without experiencing increased complications.
Researchers discovered that FGFR antagonists can effectively rescue impaired bone repair in mouse models of osteochondrodysplasia. The treatments promote chondrocyte differentiation and increase apoptosis rates, enhancing bone formation and mineralization. This breakthrough offers new hope for individuals with skeletal disorders caused...
Researchers at Aston University and the Royal Orthopaedic Hospital are developing an injectable paste using gallium-doped bioglass to treat bone cancer. The substance has anticancer and bone regenerative properties, showing a 99% success rate in eliminating cancerous cells.
A rare case report highlights the association between systemic mastocytosis and severe osteoporosis in a young adult patient, emphasizing the importance of early diagnosis and consideration of SM as an underlying cause. The study aims to raise awareness about this underrecognized condition and its potential impact on bone health.
Researchers at Monash University have developed a zinc alloy that is stronger than permanent steel implants and more durable than biodegradable options. The innovative material could revolutionize orthopaedic care by promoting better healing outcomes and minimizing disruption to surrounding tissues.
Dental implant surgeries require optimal mechanical stress levels for successful bone healing and long-term implant success. Researchers are developing a hybrid biomechanical model using machine learning to provide precise, patient-specific predictions of mechanical stress.
A new study adds weight to the safety and effectiveness of a gene therapy for hypophosphatasia, a rare inherited disorder that causes abnormal bone development. The treatment, AAV8-TNAP-D10, has shown promising results in mice models, with female mice achieving improvements in bone and teeth at lower doses.
Researchers have discovered cut-marked fossil bones from the Grăunceanu site in Romania, dating back to around 1.95 million years ago, indicating early hominin presence in Eurasia 200,000 years earlier than previously thought. The findings provide evidence of tool use by hominins and suggest a more complex history of human evolution.
A research team led by Ohio University's Sabrina Curran has discovered new evidence of early hominin activity in Europe, suggesting that hominins were present on the continent at least 1.95 million years ago. This finding pushes back previous timelines and provides valuable insights into the behavior of early human ancestors.
Researchers identify ferroptosis as a key driver of osteocyte death in melanoma bone metastasis, revealing a promising therapeutic target. Inhibiting the HIF1α-HMOX1 axis shows promise in reducing osteocyte death and preserving bone integrity.
Researchers identify Fam102a as a key regulator of both osteoclast and osteoblast differentiation, leading to enhanced osteoblast formation and bone volume. The study reveals significant protein-protein interactions involving Fam102a and Kpna2, shedding light on the critical molecular interactions involved in bone remodeling.