Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
A recent study found that everyday physical activity does not slow bone loss during menopause, contrary to previous studies suggesting exercise can mitigate age-related bone weakening. Despite this, researchers believe more targeted exercise may help slow hormonal bone loss.
Scientists have identified CD47 as an essential regulator of mesenchymal progenitor cell (MSC) proliferation—cells critical for bone repair. CD47-deficient mice exhibited delayed callus formation and lower bone volume, emphasizing its importance in bone healing.
A study found that mice exposed to microgravity for 37 days experienced significant bone loss, especially in weight-bearing bones. This research may inform human acclimation strategies for spaceflight.
Researchers have identified Naked cuticle homolog 2 (NKD2) as a critical regulator of bone cell differentiation, promoting osteoblast formation while inhibiting adipocyte and osteoclast activity. The study suggests that targeting NKD2 could lead to treatments that prevent bone loss and promote bone formation.
A USC study found proteins and pathways involved in inflammation are associated with changes in bone mineral density (BMD) over time. The research identified potential biomarkers that could serve as early indicators of a person's risk for bone health issues later in life.
Researchers discovered a collection of 27 fossilized bones with shaped into hand tools 1.5 million years ago by early human ancestors. This find suggests that hominins had an advanced understanding of toolmaking, adapting techniques to different materials, indicating greater cognitive skills.
Researchers discovered 27 standardized bone tools over 1.5 million years old in Tanzania's Olduvai Gorge, pushing back known standardization by 500,000 years. The discovery suggests an early ability for planning and knowledge transmission among ancient populations.
A recent study from the University of Gothenburg found that dental implants continue to function well after nearly forty years. The implants, developed by Professor Per-Ingvar Brånemark, have been shown to remain stable and integrate with bone over an extended period.
A new study suggests that early weight bearing on broken ankles is generally safe and can help speed up patient recovery by preventing muscle deconditioning and improving joint range of motion. Healthy patients can typically start bearing weight within three weeks of surgical intervention without experiencing increased complications.
Researchers discovered that FGFR antagonists can effectively rescue impaired bone repair in mouse models of osteochondrodysplasia. The treatments promote chondrocyte differentiation and increase apoptosis rates, enhancing bone formation and mineralization. This breakthrough offers new hope for individuals with skeletal disorders caused...
Researchers at Aston University and the Royal Orthopaedic Hospital are developing an injectable paste using gallium-doped bioglass to treat bone cancer. The substance has anticancer and bone regenerative properties, showing a 99% success rate in eliminating cancerous cells.
A rare case report highlights the association between systemic mastocytosis and severe osteoporosis in a young adult patient, emphasizing the importance of early diagnosis and consideration of SM as an underlying cause. The study aims to raise awareness about this underrecognized condition and its potential impact on bone health.
Researchers at Monash University have developed a zinc alloy that is stronger than permanent steel implants and more durable than biodegradable options. The innovative material could revolutionize orthopaedic care by promoting better healing outcomes and minimizing disruption to surrounding tissues.
Dental implant surgeries require optimal mechanical stress levels for successful bone healing and long-term implant success. Researchers are developing a hybrid biomechanical model using machine learning to provide precise, patient-specific predictions of mechanical stress.
A new study adds weight to the safety and effectiveness of a gene therapy for hypophosphatasia, a rare inherited disorder that causes abnormal bone development. The treatment, AAV8-TNAP-D10, has shown promising results in mice models, with female mice achieving improvements in bone and teeth at lower doses.
Researchers have discovered cut-marked fossil bones from the Grăunceanu site in Romania, dating back to around 1.95 million years ago, indicating early hominin presence in Eurasia 200,000 years earlier than previously thought. The findings provide evidence of tool use by hominins and suggest a more complex history of human evolution.
A research team led by Ohio University's Sabrina Curran has discovered new evidence of early hominin activity in Europe, suggesting that hominins were present on the continent at least 1.95 million years ago. This finding pushes back previous timelines and provides valuable insights into the behavior of early human ancestors.
Researchers identify ferroptosis as a key driver of osteocyte death in melanoma bone metastasis, revealing a promising therapeutic target. Inhibiting the HIF1α-HMOX1 axis shows promise in reducing osteocyte death and preserving bone integrity.
Researchers identify Fam102a as a key regulator of both osteoclast and osteoblast differentiation, leading to enhanced osteoblast formation and bone volume. The study reveals significant protein-protein interactions involving Fam102a and Kpna2, shedding light on the critical molecular interactions involved in bone remodeling.
Scientists discovered DDR2 enhances BMP-dependent bone regeneration while mitigating HO risk, offering promising therapeutic opportunities. DDR2 regulates BMP activity, paving the way for safer bone repair interventions.
Researchers uncovered nearly 200 animal remains at Teotihuacán's Moon Pyramid, shedding light on ancient rituals and politics. The discovery highlights the importance of apex predators like golden eagles and jaguars, which were venerated and sacrificed by human communities.
Hebrew SeniorLife has launched a 18-month clinical food trial to test the combination of probiotics and prebiotics for managing bone health in women aged 60. The study, funded by the National Institute on Aging, aims to investigate the underlying mechanisms leading to age-related bone loss.
A new position paper from the International Osteoporosis Foundation and International Federation of Clinical Chemistry proposes a unified nomenclature for bone status indices to enhance diagnostic consistency and clarity. The guidelines offer a comprehensive framework to unify terminology and improve comparability across studies.
Researchers found that biglycan preserves bone structure, while decorin significantly contributes to its mechanical properties. These proteins interact with water to regulate bone's mechanical behavior.
The article highlights the critical role of Fracture Liaison Services (FLS) in combating rising osteoporosis-related fractures. FLS programs have been shown to reduce secondary fracture risk by up to 74% and deliver a return of $10.49 for every $1 invested.
Researchers develop personalized bioceramic grafts through additive manufacturing, offering precise and effective solutions for craniomaxillofacial bone reconstruction. The study highlights the potential of synthetic grafts to degrade in parallel with new bone tissue formation.
Researchers debunked the long-held belief that gut microbes significantly influence age-related bone loss. A study found that bone deterioration occurs independently of the gut microbiome, shifting attention to other biological pathways as potential drivers of osteoporosis.
Researchers at POSTECH developed an innovative injectable adhesive hydrogel that regenerates bone using harmless visible light. The hydrogel addresses limitations of existing treatments by simultaneously achieving cross-linking and mineralization without separate bone grafts or adhesives.
Researchers discover that osteogenic CpG oligodeoxynucleotide iSN40 inhibits osteoclast differentiation and reduces bone resorption. This balanced approach could provide a new treatment option for osteoporosis, an imbalance in bone remodeling characterized by excessive bone resorption.
A QUT-led study found that surgeons are slow to adopt newly developed biomaterials or tissue-engineered solutions for treating bone defects. The researchers surveyed 337 surgeons and 99 scientists, revealing a significant gap between their optimism about future advancements and the slow adoption of these innovations in clinical practice.
Researchers have identified a promising new drug, lomonitinib, targeting treatment-resistant acute myeloid leukemia (AML) with FLT-3 mutation. Additionally, they developed a novel compound to target MALT1 protein in chronic lymphocytic leukemia (CLL), aiming to provide better control of the disease.
Researchers found that megakaryocyte conditioned media from younger mice was more effective at promoting blood vessel growth and improving healing. The study provides a potential approach for developing new therapies to speed up fracture recovery in older individuals, reducing pain and improving mobility.
Researchers have developed a coral-inspired biomimetic material that promotes faster healing and dissolves naturally in the body. The material has been shown to fully repair bone defects within 3-6 months, overcoming limitations of traditional synthetic substitutes.
This special issue of Calcified Tissue International presents a collection of critical reviews and original research articles on osteogenesis imperfecta (OI), covering essential aspects of the condition, including its nosology, genetics, and clinical presentation. The contributions also discuss treatment strategies for both children an...
A global research team has discovered 'natural data loggers' in aquatic species, providing a historical record of the environment. The unique chemical fingerprints left by these organisms can help scientists track water temperatures, pollution levels, and ecosystem health.
Archaeologists have discovered that early North Americans made needles from the bones of fur-bearers, including foxes, hares, and cats, which were likely used to create garments for warmth. The findings provide strong evidence for tailored garment production using bone needles and fur-bearing animal pelts.
A recent study found that levothyroxine use is associated with greater loss of total body bone mass and density, even in participants with normal TSH levels. The research suggests that adults taking levothyroxine should discuss their treatment with their healthcare provider and regularly monitor their thyroid function tests.
Researchers mapped all cells and pathways involved in early skeletal development, shedding light on arthritis and skull growth conditions. The study identifies genetic mutations disrupting soft spots in the skull, potentially leading to congenital conditions.
Researchers develop biocooperative materials by harnessing blood-clotting and peptide self-assembly to repair bones in animal models. The new approach enables the creation of regenerative materials that can be easily assembled, manipulated, and 3D printed while maintaining normal healing functions.
A team of researchers has identified 30 patients with previously undiagnosed conditions, linking them to rare mutations in the FLVCR1 gene. The study reveals a range of severe developmental disorders, including anemia and bone malformations, which share similarities with mice lacking the Flvcr1 gene and Diamond-Blackfan anemia.
New research led by the University of Southampton found that vitamin D supplements during pregnancy increase children's bone mineral density in mid-childhood. Children born to mothers who received extra vitamin D supplementation had stronger bones and were less likely to break them.
Researchers develop novel Ta-based implants with improved biocompatibility and osseointegration properties, enabling better bone growth and stability. The designs optimize mechanical and biological requirements for optimal clinical results.
A study of human skeletal remains from the Tudor warship Mary Rose reveals that handedness may influence clavicle bone chemistry as people age. The analysis found increased mineral content and decreased protein content in right clavicles compared to left, suggesting repeated stress on the right side during activities like sailing.
Research investigates effect of calcium sulfate aspect ratios and chitosan addition methods on interface properties of calcium sulfate/chitosan composite bone cement. Short rod calcium sulfate displays better interface adhesion, setting time, compressive strength, and biocompatibility.
Researchers at Osaka Metropolitan University have found that plasma irradiation can enhance tendon-to-bone junction repair, leading to faster healing rates and stronger repairs. The study used rabbit models to test the effects of plasma on rotator cuff injuries, showing promising results.
The Endocrine Society's new statement highlights research gaps on opioids' effects on the endocrine system, which can lead to conditions like male hypogonadism and secondary adrenal insufficiency. Clinicians need to monitor patients using opioids for signs of these health consequences.
A new clinical model developed by researchers at Uppsala University accurately predicts the risk of hip fractures in the elderly. The model identifies patients at high risk without requiring bone density measurements, allowing for earlier preventive treatment.
A new study found that people with severe mental illness are more likely to experience fragility fractures than the general population. The researchers analyzed GP records of over 440,000 people between 2000 and 2018 and found a significant association between severe mental illness and fragility fractures.
A team of researchers discovered a protein that blocks bone-forming cells by preventing them from maturing. The study found that the protein CLEC14A reduces bone formation, while its absence leads to increased mineralized bone tissue.
Researchers from UNH's Forensic Anthropology Lab worked with town officials to investigate and document the remains, which showed signs of hardship and health issues. The reburial ceremony marked a rare opportunity for closure and respect for the individuals buried in hasty unmarked graves.
Researchers from USC and Caltech develop a new method to study hematopoietic stem and progenitor cells within the bone marrow without extracting them. This breakthrough could inform efforts to optimize bone marrow transplantation and provide insights into various health conditions, including cancer and heart disease.
A recent study published in Knee Surgery, Sports Traumatology, Arthroscopy found that children who undergo surgery for discoid lateral meniscus are at higher risk of developing further knee injuries with age. Younger patients were particularly prone to relapse after surgery.
A new study published in PNAS suggests that delivering microparticles containing CCL2 directly to the gums can inhibit bone loss and speed up bone repair in a mouse model of periodontal disease. The therapy modulates the immune response, shifting macrophages from inflammatory M1 type to anti-inflammatory M2 type.
Researchers at Aston University have created a potential treatment for bone cancer using gallium-doped bioactive glasses, which has shown a 99% success rate in killing osteosarcoma cells. The therapy also promotes early stages of bone formation and regenerates diseased bones.
A novel PEEK-based implant material, sPEEK/BP/E7, has been developed to promote bone growth and possess potent antibacterial capabilities. The material exhibits enhanced cytocompatibility and osteogenicity in vitro, outperforming traditional samples.
Researchers found that molecular interactions shield peptide bonds from water, allowing collagen to stay intact in ancient bones. This discovery could lead to the design of long-lived materials.
Researchers found an atomic-level interaction in collagen that defends it from water molecules, preventing hydrolysis and allowing it to survive for millions of years. This discovery provides evidence that the peptide bonds in collagen are resistant to breakage by water, contradicting previous expectations.
Researchers created a mouse model to study relative energy deficiency in sport (REDs), revealing the syndrome impacts the entire body and affects males and females differently. REDs leads to hormonal and reproductive issues, insomnia and fatigue, bone weakness and injury, and anxiety and depression.
A new study found that bone fracture rates in older women differ dramatically by race, with White women having the highest risk. Hispanic women had a lower risk of 10%, while Asian-American women experienced varying fracture rates depending on their ethnicity. The study highlights the need to better understand factors behind these diff...
A large clinical food trial will be conducted to test the effects of a combination of probiotics and prebiotics on bone health in women aged 60 years and above. The study aims to develop potentially safe and inexpensive dietary interventions for osteopenia and osteoporosis.