Articles tagged with Bones
A new study adds weight to the safety and effectiveness of a gene therapy for hypophosphatasia, a rare inherited disorder that causes abnormal bone development. The treatment, AAV8-TNAP-D10, has shown promising results in mice models, with female mice achieving improvements in bone and teeth at lower doses.
Researchers have discovered cut-marked fossil bones from the Grăunceanu site in Romania, dating back to around 1.95 million years ago, indicating early hominin presence in Eurasia 200,000 years earlier than previously thought. The findings provide evidence of tool use by hominins and suggest a more complex history of human evolution.
A research team led by Ohio University's Sabrina Curran has discovered new evidence of early hominin activity in Europe, suggesting that hominins were present on the continent at least 1.95 million years ago. This finding pushes back previous timelines and provides valuable insights into the behavior of early human ancestors.
Researchers identify ferroptosis as a key driver of osteocyte death in melanoma bone metastasis, revealing a promising therapeutic target. Inhibiting the HIF1α-HMOX1 axis shows promise in reducing osteocyte death and preserving bone integrity.
Researchers identify Fam102a as a key regulator of both osteoclast and osteoblast differentiation, leading to enhanced osteoblast formation and bone volume. The study reveals significant protein-protein interactions involving Fam102a and Kpna2, shedding light on the critical molecular interactions involved in bone remodeling.
Scientists discovered DDR2 enhances BMP-dependent bone regeneration while mitigating HO risk, offering promising therapeutic opportunities. DDR2 regulates BMP activity, paving the way for safer bone repair interventions.
Researchers uncovered nearly 200 animal remains at Teotihuacán's Moon Pyramid, shedding light on ancient rituals and politics. The discovery highlights the importance of apex predators like golden eagles and jaguars, which were venerated and sacrificed by human communities.
Researchers found that biglycan preserves bone structure, while decorin significantly contributes to its mechanical properties. These proteins interact with water to regulate bone's mechanical behavior.
Hebrew SeniorLife has launched a 18-month clinical food trial to test the combination of probiotics and prebiotics for managing bone health in women aged 60. The study, funded by the National Institute on Aging, aims to investigate the underlying mechanisms leading to age-related bone loss.
A new position paper from the International Osteoporosis Foundation and International Federation of Clinical Chemistry proposes a unified nomenclature for bone status indices to enhance diagnostic consistency and clarity. The guidelines offer a comprehensive framework to unify terminology and improve comparability across studies.
The article highlights the critical role of Fracture Liaison Services (FLS) in combating rising osteoporosis-related fractures. FLS programs have been shown to reduce secondary fracture risk by up to 74% and deliver a return of $10.49 for every $1 invested.
Researchers develop personalized bioceramic grafts through additive manufacturing, offering precise and effective solutions for craniomaxillofacial bone reconstruction. The study highlights the potential of synthetic grafts to degrade in parallel with new bone tissue formation.
Researchers debunked the long-held belief that gut microbes significantly influence age-related bone loss. A study found that bone deterioration occurs independently of the gut microbiome, shifting attention to other biological pathways as potential drivers of osteoporosis.
Researchers at POSTECH developed an innovative injectable adhesive hydrogel that regenerates bone using harmless visible light. The hydrogel addresses limitations of existing treatments by simultaneously achieving cross-linking and mineralization without separate bone grafts or adhesives.
Researchers discover that osteogenic CpG oligodeoxynucleotide iSN40 inhibits osteoclast differentiation and reduces bone resorption. This balanced approach could provide a new treatment option for osteoporosis, an imbalance in bone remodeling characterized by excessive bone resorption.
A QUT-led study found that surgeons are slow to adopt newly developed biomaterials or tissue-engineered solutions for treating bone defects. The researchers surveyed 337 surgeons and 99 scientists, revealing a significant gap between their optimism about future advancements and the slow adoption of these innovations in clinical practice.
Researchers have identified a promising new drug, lomonitinib, targeting treatment-resistant acute myeloid leukemia (AML) with FLT-3 mutation. Additionally, they developed a novel compound to target MALT1 protein in chronic lymphocytic leukemia (CLL), aiming to provide better control of the disease.
Researchers have developed a coral-inspired biomimetic material that promotes faster healing and dissolves naturally in the body. The material has been shown to fully repair bone defects within 3-6 months, overcoming limitations of traditional synthetic substitutes.
Researchers found that megakaryocyte conditioned media from younger mice was more effective at promoting blood vessel growth and improving healing. The study provides a potential approach for developing new therapies to speed up fracture recovery in older individuals, reducing pain and improving mobility.
This special issue of Calcified Tissue International presents a collection of critical reviews and original research articles on osteogenesis imperfecta (OI), covering essential aspects of the condition, including its nosology, genetics, and clinical presentation. The contributions also discuss treatment strategies for both children an...
Archaeologists have discovered that early North Americans made needles from the bones of fur-bearers, including foxes, hares, and cats, which were likely used to create garments for warmth. The findings provide strong evidence for tailored garment production using bone needles and fur-bearing animal pelts.
A global research team has discovered 'natural data loggers' in aquatic species, providing a historical record of the environment. The unique chemical fingerprints left by these organisms can help scientists track water temperatures, pollution levels, and ecosystem health.
A recent study found that levothyroxine use is associated with greater loss of total body bone mass and density, even in participants with normal TSH levels. The research suggests that adults taking levothyroxine should discuss their treatment with their healthcare provider and regularly monitor their thyroid function tests.
Researchers mapped all cells and pathways involved in early skeletal development, shedding light on arthritis and skull growth conditions. The study identifies genetic mutations disrupting soft spots in the skull, potentially leading to congenital conditions.
Researchers develop biocooperative materials by harnessing blood-clotting and peptide self-assembly to repair bones in animal models. The new approach enables the creation of regenerative materials that can be easily assembled, manipulated, and 3D printed while maintaining normal healing functions.
A team of researchers has identified 30 patients with previously undiagnosed conditions, linking them to rare mutations in the FLVCR1 gene. The study reveals a range of severe developmental disorders, including anemia and bone malformations, which share similarities with mice lacking the Flvcr1 gene and Diamond-Blackfan anemia.
New research led by the University of Southampton found that vitamin D supplements during pregnancy increase children's bone mineral density in mid-childhood. Children born to mothers who received extra vitamin D supplementation had stronger bones and were less likely to break them.
Researchers develop novel Ta-based implants with improved biocompatibility and osseointegration properties, enabling better bone growth and stability. The designs optimize mechanical and biological requirements for optimal clinical results.
A study of human skeletal remains from the Tudor warship Mary Rose reveals that handedness may influence clavicle bone chemistry as people age. The analysis found increased mineral content and decreased protein content in right clavicles compared to left, suggesting repeated stress on the right side during activities like sailing.
Research investigates effect of calcium sulfate aspect ratios and chitosan addition methods on interface properties of calcium sulfate/chitosan composite bone cement. Short rod calcium sulfate displays better interface adhesion, setting time, compressive strength, and biocompatibility.
Researchers at Osaka Metropolitan University have found that plasma irradiation can enhance tendon-to-bone junction repair, leading to faster healing rates and stronger repairs. The study used rabbit models to test the effects of plasma on rotator cuff injuries, showing promising results.
The Endocrine Society's new statement highlights research gaps on opioids' effects on the endocrine system, which can lead to conditions like male hypogonadism and secondary adrenal insufficiency. Clinicians need to monitor patients using opioids for signs of these health consequences.
A new study found that people with severe mental illness are more likely to experience fragility fractures than the general population. The researchers analyzed GP records of over 440,000 people between 2000 and 2018 and found a significant association between severe mental illness and fragility fractures.
A new clinical model developed by researchers at Uppsala University accurately predicts the risk of hip fractures in the elderly. The model identifies patients at high risk without requiring bone density measurements, allowing for earlier preventive treatment.
A team of researchers discovered a protein that blocks bone-forming cells by preventing them from maturing. The study found that the protein CLEC14A reduces bone formation, while its absence leads to increased mineralized bone tissue.
Researchers from UNH's Forensic Anthropology Lab worked with town officials to investigate and document the remains, which showed signs of hardship and health issues. The reburial ceremony marked a rare opportunity for closure and respect for the individuals buried in hasty unmarked graves.
A recent study published in Knee Surgery, Sports Traumatology, Arthroscopy found that children who undergo surgery for discoid lateral meniscus are at higher risk of developing further knee injuries with age. Younger patients were particularly prone to relapse after surgery.
Researchers from USC and Caltech develop a new method to study hematopoietic stem and progenitor cells within the bone marrow without extracting them. This breakthrough could inform efforts to optimize bone marrow transplantation and provide insights into various health conditions, including cancer and heart disease.
A new study published in PNAS suggests that delivering microparticles containing CCL2 directly to the gums can inhibit bone loss and speed up bone repair in a mouse model of periodontal disease. The therapy modulates the immune response, shifting macrophages from inflammatory M1 type to anti-inflammatory M2 type.
Researchers at Aston University have created a potential treatment for bone cancer using gallium-doped bioactive glasses, which has shown a 99% success rate in killing osteosarcoma cells. The therapy also promotes early stages of bone formation and regenerates diseased bones.
A novel PEEK-based implant material, sPEEK/BP/E7, has been developed to promote bone growth and possess potent antibacterial capabilities. The material exhibits enhanced cytocompatibility and osteogenicity in vitro, outperforming traditional samples.
Researchers found that molecular interactions shield peptide bonds from water, allowing collagen to stay intact in ancient bones. This discovery could lead to the design of long-lived materials.
Researchers found an atomic-level interaction in collagen that defends it from water molecules, preventing hydrolysis and allowing it to survive for millions of years. This discovery provides evidence that the peptide bonds in collagen are resistant to breakage by water, contradicting previous expectations.
Researchers created a mouse model to study relative energy deficiency in sport (REDs), revealing the syndrome impacts the entire body and affects males and females differently. REDs leads to hormonal and reproductive issues, insomnia and fatigue, bone weakness and injury, and anxiety and depression.
A new study found that bone fracture rates in older women differ dramatically by race, with White women having the highest risk. Hispanic women had a lower risk of 10%, while Asian-American women experienced varying fracture rates depending on their ethnicity. The study highlights the need to better understand factors behind these diff...
A large clinical food trial will be conducted to test the effects of a combination of probiotics and prebiotics on bone health in women aged 60 years and above. The study aims to develop potentially safe and inexpensive dietary interventions for osteopenia and osteoporosis.
Researchers are studying the role of stress hormones and mineralocorticoid receptors in bone health as we age. The goal is to understand how balance between these factors affects our skeletons. By investigating this complex relationship, scientists hope to develop new insights into osteoporosis and other age-related bone disorders.
The research integrated zooarchaeological analysis with rock art depictions, showing a diverse diet and exploitation of various environments. The findings suggest that the artists did not just paint what they ate, but also represented complex mythology and supernatural connections.
A pilot study by scientists replicates ancient Neanderthal butchering methods to study their diet. The results show that fire-roasted birds are easier to process, with raw birds requiring more effort and resulting in fewer traces on the bones.
A new study reveals that Cutibacterium acnes can persist in biofilms on implants for weeks, invading deep bone networks and causing chronic infections. The bacteria's ability to invade osteocyte lacuno-canalicular networks provides a novel mechanism for treating difficult-to-treat bone infections.
A new position paper argues that single race-agnostic FRAX models would unfairly discriminate against Black, Asian, and Hispanic communities. The authors recommend retention of ethnic and race-specific FRAX models for the US with updated data on fracture and death hazards.
A new species of fossil snake, Hibernophis breithaupti, has been discovered in Wyoming, shedding light on the origin and diversification of boas and pythons. The discovery provides important new information on the evolution of small burrowing boas, specifically rubber boas.
A study published in PLOS ONE found cut marks on fossils of a glyptodont, a giant relative of armadillos, that are consistent with known marks made by stone tools. The placement of these marks indicates a butchering sequence targeting areas of dense flesh.
Early Neolithic groups applied innovative methods to taxonomically identify animal species used in bone artifact production. Deer bones were chosen for projectile tips, while sheep and goats were used for vegetable handling tools.
Scientists at the University of Malaga have uncovered a natural quicksand trap in the 'elephant graveyard' of Orce, dated to over 1.4 million years ago. The discovery provides insights into human presence in Western Europe and competition with large carrion hyenas for meat resources.
Scientists have discovered a new hormone, CCN3, that helps maintain bone density and strength in breastfeeding women. In mice, CCN3 increased bone mass and strength, even when estrogen levels were low. The hormone also accelerated bone healing in fracture models, offering hope for treating osteoporosis and other bone conditions.
New research suggests that the plague may have contributed to the population decline of Stone Age farmers in Scandinavia and Northwestern Europe. Analysis of ancient DNA from bones and teeth found that 17% of individuals were infected with the plague, indicating its common presence during the late Stone Age.
Researchers linked impaired blood vessel function with lower bone density and worse bone microstructure, but found no independent causal pathway. The study suggests shared risk factors may be more important in the development of osteoporosis than vascular dysfunction.
Researchers explore the feasibility of deep learning models in segmenting lesions on PET/CT images to improve salvage radiation therapy planning for prostate cancer. The study demonstrates promising potential to reduce inter- and intra-observer variations, leading to more accurate treatment outcomes.
Researchers discovered that inhibiting estrogen receptor alpha in adipocytes can rescue bone loss and promote osteogenesis. This approach has potential as a therapeutic target for treating osteoporosis and preventing bone loss.