Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
Researchers are studying the role of stress hormones and mineralocorticoid receptors in bone health as we age. The goal is to understand how balance between these factors affects our skeletons. By investigating this complex relationship, scientists hope to develop new insights into osteoporosis and other age-related bone disorders.
The research integrated zooarchaeological analysis with rock art depictions, showing a diverse diet and exploitation of various environments. The findings suggest that the artists did not just paint what they ate, but also represented complex mythology and supernatural connections.
A new study reveals that Cutibacterium acnes can persist in biofilms on implants for weeks, invading deep bone networks and causing chronic infections. The bacteria's ability to invade osteocyte lacuno-canalicular networks provides a novel mechanism for treating difficult-to-treat bone infections.
A pilot study by scientists replicates ancient Neanderthal butchering methods to study their diet. The results show that fire-roasted birds are easier to process, with raw birds requiring more effort and resulting in fewer traces on the bones.
A new position paper argues that single race-agnostic FRAX models would unfairly discriminate against Black, Asian, and Hispanic communities. The authors recommend retention of ethnic and race-specific FRAX models for the US with updated data on fracture and death hazards.
A new species of fossil snake, Hibernophis breithaupti, has been discovered in Wyoming, shedding light on the origin and diversification of boas and pythons. The discovery provides important new information on the evolution of small burrowing boas, specifically rubber boas.
A study published in PLOS ONE found cut marks on fossils of a glyptodont, a giant relative of armadillos, that are consistent with known marks made by stone tools. The placement of these marks indicates a butchering sequence targeting areas of dense flesh.
Scientists at the University of Malaga have uncovered a natural quicksand trap in the 'elephant graveyard' of Orce, dated to over 1.4 million years ago. The discovery provides insights into human presence in Western Europe and competition with large carrion hyenas for meat resources.
Early Neolithic groups applied innovative methods to taxonomically identify animal species used in bone artifact production. Deer bones were chosen for projectile tips, while sheep and goats were used for vegetable handling tools.
Scientists have discovered a new hormone, CCN3, that helps maintain bone density and strength in breastfeeding women. In mice, CCN3 increased bone mass and strength, even when estrogen levels were low. The hormone also accelerated bone healing in fracture models, offering hope for treating osteoporosis and other bone conditions.
New research suggests that the plague may have contributed to the population decline of Stone Age farmers in Scandinavia and Northwestern Europe. Analysis of ancient DNA from bones and teeth found that 17% of individuals were infected with the plague, indicating its common presence during the late Stone Age.
Researchers linked impaired blood vessel function with lower bone density and worse bone microstructure, but found no independent causal pathway. The study suggests shared risk factors may be more important in the development of osteoporosis than vascular dysfunction.
Researchers explore the feasibility of deep learning models in segmenting lesions on PET/CT images to improve salvage radiation therapy planning for prostate cancer. The study demonstrates promising potential to reduce inter- and intra-observer variations, leading to more accurate treatment outcomes.
Researchers discovered that inhibiting estrogen receptor alpha in adipocytes can rescue bone loss and promote osteogenesis. This approach has potential as a therapeutic target for treating osteoporosis and preventing bone loss.
A randomized clinical trial found that combining exercise with glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment was the most effective weight loss strategy while preserving bone health. In contrast, GLP-1RA treatment alone reduced bone mineral density at clinically relevant sites.
Researchers explore Extracellular signal-regulated kinase 5 (Erk5) and its unique structures regulating autophosphorylation and transcription. Erk5 is involved in angiogenesis, neurogenesis, energy metabolism, tumor growth, and metastasis, making it a potential target for cancer treatment.
Researchers at UNIGE have identified 2700 genetic enhancers that regulate genes responsible for bone growth, providing insights into adult height and potential causes of bone diseases. The study suggests that variations in these enhancers could explain differences in human size and potentially contribute to developmental pathologies.
Researchers at ETH Zurich create a 3D in vitro model to study brittle bone disease, using healthy cells initially and planning to use cells from patients with the condition. The model successfully emulates bone development, allowing for the discovery of malfunctioning processes and potential treatments.
A study published in the Journal of Archaeological Science: Reports reveals that all members of a Neolithic agropastoral society in Switzerland, including non-locals, had equal access to food resources. The analysis of bone isotopes suggests that this egalitarian society was one of the oldest known in the western part of Switzerland.
A Bronze Age purple dye workshop has been found on the Greek island of Aegina, featuring tools, ceramics, and snail shells that reveal the production process. The site provides insights into Mycenaean culture and trade during the Late Bronze Age.
A new biomarker database, Space Omics and Medical Atlas (SOMA), has been developed to improve astronaut health, but its findings may also be useful for people on Earth with limited mobility or bedridden conditions. The database provides insights into short and long-term health impacts of spaceflight.
A new study combines bisphosphonates, commonly used for osteoporosis, with azole antifungals to treat fungal infections. The combination effectively targets dermatophytes and prevents resistance development.
Researchers from Tel Aviv University discovered 400,000-year-old stone tools, Quina scrapers, used to butcher and process smaller game like fallow deer. The unique tools were made of non-local flint, likely sourced from the Mountains of Samaria, a calving area for the deer.
Researchers at Texas A&M University have discovered a new technique for tissue regeneration using mineral-based nanomaterials inspired by ancient medical practices. The approach aims to induce natural bone formation, reducing the need for invasive procedures and long-term medication, and promoting improved quality of life.
Dr. Melissa Grunlan's team creates regenerative osteochondral plugs, a potential off-the-shelf device to treat OCDs and avoid total knee replacement surgery. The technology offers an alternative to autografting or total knee replacement, providing immediate support for joint function and potentially reducing post-operative complications.
Researchers used novel biomolecular methods to analyze fossil bone fragments at the Smithsonian Museum, revealing excellent preservation of collagen proteins that can provide a molecular barcode for identification. The study provides new insights into the mysterious disappearance of North America's large mammals 50,000 years ago.
Wake Forest University School of Medicine has received a $1.5 million grant to study bone microarchitecture in patients following bariatric surgery. The researchers will use high-resolution peripheral quantitative computed tomography (HR-pQCT) imaging to assess bone loss and muscle changes after weight-loss surgery.
A 6-centimeter-wide fossil of a large cat species, Homotherium, was discovered on the Texas coast. The fossil provided key evidence for the cat's expansion across habitats in Africa, Eurasia, and the Americas.
Researchers discover novel suppressive role of Ctdnep1 in osteoclast differentiation and bone resorption, suggesting potential therapeutic targets for treating excessive bone loss. The study reveals that Ctdnep1 functions as a brake on osteoclast cell differentiation.
A new Cornell University study suggests that smaller bird skeletons evolve more freely due to reduced stress on their bones. This allows for greater variability in wing proportions among small bird species.
Early hunter-gatherers in central Chile regularly visited Tagua Tagua Lake between 12,440-12,550 years old to hunt ancient elephants and process other local resources. The discovery of the fossil remains of a gomphothere at the site provides insights into the subsistence strategies of early humans during the Late Pleistocene.
Researchers at the University of Birmingham have identified PEPITEM, a naturally occurring peptide, as a promising new therapy for osteoporosis and other bone disorders. The study found that PEPITEM enhances bone mineralisation, formation, and strength, and reverses bone loss in animal models.
A new COVID-related syndrome, MDA5-autoimmunity and Interstitial Pneumonitis Contemporaneous with COVID-19 (MIP-C), has been identified in patients with severe lung scarring and autoimmune diseases. The syndrome was discovered through a retrospective observational study by UC San Diego researchers and UK colleagues.
Scientists have found an effective treatment for spitting cobra snakebites by blocking one of the major dermonecrosis-causing toxins with varespladib. The study suggests that this repurposed drug can prevent tissue damage and may become a valuable treatment against black-necked and red spitting cobra venoms.
The 5-year TAF treatment efficacy was high and similar to that of 3-year TDF followed by 2-year TAF in Chinese chronic hepatitis B patients. Favorable effects on bone and renal parameters were sustained with TAF treatment alone and were observed following the switch from TDF to TAF.
Researchers developed a new treatment method using plasma irradiation to speed up bone healing. The study found that displaced fractures exhibited stronger unions than nonirradiated ones, with strength increased by 3.5 times.
The International Osteoporosis Foundation has presented the prestigious IOF President’s Award to Professor Peter Ebeling AO in recognition of his longstanding contributions to advancing the work of the IOF. He is an internationally renowned expert in bone health, with a total of over 536 peer-reviewed publications and a h-index of 93.
A unique collaboration between archaeologists and MeatEater highlights the prevalence of equifinality, where distinct processes can lead to the same outcome. The experiment tested Clovis stone tools' efficiency in processing a bison, offering insights into early human technologies.
Fossilized bone fragments from Western and Central Europe have been identified as belonging to gigantic ichthyosaurs due to their unique microstructure. The discovery sheds new light on an ongoing debate among paleontologists, suggesting that these massive sea creatures could have reached lengths similar to the modern blue whale.
Long-term treatment with methylene blue (MB) and mitoquinone (MitoQ) did not alter age-related bone loss in mice. Antioxidant interventions are insufficient to inhibit skeletal aging, suggesting alternative approaches may be needed.
Research at the University of Gothenburg reveals a link between maternal protein intake during pregnancy and the formation of facial bone structures in offspring. The study found that a particular signaling pathway, mTOR, plays a crucial role in shaping the face.
Researchers at Tel Aviv University developed a novel therapeutic strategy using existing medications to inhibit bone metastasis in breast cancer patients. The combination of drugs improved survival rates and reduced bone metastases in animal models and human tissue samples.
A Finnish study reveals that bone-strengthening physical activity levels decrease during adolescence, especially among the least fit youth. Regular exercise during childhood and adolescence is essential for maintaining strong bones and preventing osteoporosis later in life.
A researcher at Ohio State University resolves historical inconsistencies in the name of a popular fossil, confirming that Thomas Jefferson named the genus correctly. The correct name helps ensure accurate documentation of the history of life on Earth and its implications for science.
Researchers found that chlorogenic acid enhances osteoblast proliferation and differentiation, while inhibiting RANKL-induced osteoclastogenesis. Administration of chlorogenic acid antagonizes ovariectomized-induced bone loss in rats.
Scientists have created a new approach for treating tendon-bone injuries by combining manganese silicate nanoparticles with cells to create an immunomodulatory scaffold. This innovation promotes integrated regeneration and functional recovery in patients, offering a promising solution for improving life quality.
A new study refutes previous research suggesting Spinosaurus was an aquatic pursuit predator, highlighting methodological flaws and low accuracy of phylogenetic flexible discriminant analysis. The researchers provide guidelines for future studies to use with caution when applying this methodology to limited datasets.
Researchers at NJIT's Newark College of Engineering and College of Science and Liberal Arts receive $265K in grants from the New Jersey Health Foundation to develop biodegradable materials, enhance bone regeneration, and create air filters for viral removal. The projects focus on addressing environmental impact and promoting healthcare...
A new study found that the link between paternal age and rare congenital disorders is more complex than previously thought. Researchers discovered that while older fathers are more likely to have children with certain bone and heart malformations, some genetic mutations associated with these conditions do not increase with paternal age.
Researchers found that USP1 inhibits cdc42, increases EWS-FLI1 transcriptional output, and simulates Ewing sarcoma growth. A pharmacological inhibitor of USP1 activated cdc42 and inhibited Ewing sarcoma growth.
Researchers created complex 3D structures that mimic bone microstructure using laser 3D printing and an alternate soaking process. The method supports the creation of bone grafts or artificial bone marrow, offering a potential solution to treating leukemia, lymphoma, and immune diseases.
Researchers from Tokyo University of Science identify Cpeb4 protein's crucial role in mRNA splicing and osteoclast differentiation, shedding light on bone disease mechanisms. The study's findings may lead to new diagnostic techniques and treatments for conditions like osteoporosis.
A KAIST research team has developed a biomimetic scaffold that generates electrical signals to promote bone tissue growth, providing a new method for utilizing the unique osteogenic abilities of hydroxyapatite. The flexible and free-standing scaffold demonstrated remarkable potential for promoting bone regeneration in rats.
Researchers at Rice University have discovered a promising new immunological pathway to treat stubborn bone tumors in breast cancer patients. The glyco-immune checkpoint axis, involving protein Siglec-15, plays a crucial role in hiding bone tumors from the immune system.
Stacyann Bailey studies how cancer treatment affects bones, hoping to prevent fractures and improve patient outcomes. Up to 50% of patients with metastatic bone disease develop fractures due to treatment, making her work crucial for their quality of life.
A recent study found that high-intensity impacts during everyday physical activity can help preserve bone density and structural properties in older adults. Moderate and high-impact activities, such as brisk walking or stair climbing, were associated with better preservation of bone mineral density compared to lower-intensity activities.
Researchers from MD Anderson Cancer Center reported a case of a patient with an exceptional response to pazopanib treatment for over 5 years. The study shows that pazopanib prevents or delays the progression of additional metastasis in EWSR1-NFATC2 positive sarcomas. Further studies are warranted.
A pair of proteins YAP and TAZ have been identified as conductors of bone development in the womb. They help direct blood vessel integration into cartilage, a vital aspect of bone development, and may provide insight into genetic diseases such as osteogenesis imperfecta.
Researchers found a clear dose-response relationship between long-term topical corticosteroid use and elevated risks of osteoporosis and major osteoporotic fractures. Women under 50 had higher risks compared to men and other age groups, emphasizing the importance of careful treatment.
Researchers found that Arctic seals' unique nasal structures allow them to conserve 94% of water during breathing, giving them an evolutionary advantage in the Arctic. The study's findings suggest that similar adaptations could be beneficial for other species in diverse environments.