Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
A new study found that combat-related traumatic injuries can cause localized bone mineral density loss in the hip region, particularly among those who have undergone amputations. The research suggests that this loss is mechanically driven and may be related to altered loading patterns.
A study of skeletal remains from 19th-century England found high incidences of growth delays, vitamin deficiencies, and respiratory disease among child laborers. The analysis suggests low-protein diets and harsh working conditions led to the health consequences.
Increased expression of Musashi 1 on breast cancer cells has significant implications for understanding dormancy and survival in bone marrow. Msi 1 knockdown led to a reduction in cancer stem cells with undetectable PD-L1, suggesting a potential therapeutic target.
A study published in The Journal of Bone & Joint Surgery reports high 10-year implant survival and patient satisfaction rates for robotic-assisted medial knee arthroplasty. The procedure showed excellent outcomes, with over 90% of patients remaining satisfied without revision.
The International Osteoporosis Foundation (IOF) has awarded five young investigators grants for their research on nutritional factors and musculoskeletal health. The winners' projects focus on various aspects of diet, exercise, and bone health, with potential to lead to clinical advances or preventative strategies.
Renowned astronaut Samantha Cristoforetti received the International Osteoporosis Foundation President’s Award for her collaboration on the "Lift Off For Bone Health" public awareness campaign. The campaign reached over three million people, with videos viewed close to two million times.
Professor Bess Dawson-Hughes has been recognized with the 2023 IOF President’s Award for her significant contributions to advancing osteoporosis research and treatment. Her extensive body of work has led to a greater understanding of nutrition's role in age-related bone loss.
Moffitt researchers develop CAR T cells that target prostate cancer biomarker PSCA, killing cancer cells and preserving bone health. Zoledronate treatment enhances antitumor activity with minimal toxicity.
A study analyzing 34,000 people found that lowering sclerostin levels may increase the risk of heart attack, stroke, and type 2 diabetes. The research suggests that strategies to minimize potential impact on heart attack risk are needed.
Scientists discovered that inhibiting microRNA-141-3p can reduce chronic inflammation, muscle loss, and bone degradation in aged mice. By blocking this tiny RNA, researchers found improvements in the spleen's immune response, lower levels of pro-inflammatory proteins, and a more youthful profile in bones and muscles.
Researchers have identified a potential therapeutic target and developed a unique delivery system to treat osteosarcoma, a bone cancer primarily affecting children and adolescents. The novel combination of gene therapy and chemotherapy may improve treatment outcomes and aid in the repair of damaged bones during chemotherapy.
Researchers have made an important human discovery by analyzing the genome of a 3,000-year-old individual found in a cave in Southeast Alaska. The study confirms that some modern Alaska Natives still live almost exactly where their ancestors did over 3,000 years ago.
Researchers have found that the subfornical organ senses circulating parathyroid hormone (PTH) and modulates its peripheral level. PTH then alters bone metabolism and remodeling, highlighting a critical role of the brain-parathyroid-bone axis in maintaining bone homeostasis.
Conclusive evidence of chicken breeding in the Yayoi period of Japan has been discovered at the Karako-Kagi site. The study found that chickens were bred in the area during the middle Yayoi period, around 381-204 BCE, providing clear evidence that breeding occurred on the Japanese archipelago.
A study published in Cell Reports found that rodents exposed to microgravity had altered gut microbiomes, which may contribute to bone loss. The researchers also discovered that certain bacterial species in the gut produced molecules that influenced bone remodeling.
Research highlights devastating impact of war injuries on civilians and soldiers, resulting in complex bone and soft-tissue infections. Doctors describe treating patients with highly complex musculoskeletal infections caused by multidrug-resistant pathogens.
Researchers have identified 145 potential height genes linked to skeletal disorders and growth plate maturation. The study found that genetic changes affecting cartilage cell maturation may strongly influence adult height.
Researchers develop innovative method to analyze ancient bones, making collagen quantifiable and mapping possible. This technique supports the selection of samples for radiocarbon analysis, preserving valuable material and reducing destruction.
Patients with low sodium levels before or after total knee or hip arthroplasty are at increased risk of complications and adverse outcomes. Postoperative hyponatremia was linked to longer hospital stays, higher rates of discharge to rehabilitation centers, and readmission within 90 days.
A research team from Germany, Austria, Canada, and the USA analyzed Troodon eggshells using a new method, revealing that they were produced at temperatures of 42°C and 30°C. The findings suggest that Troodon females laid eggs in communal nests, similar to modern ostriches.
A study published in Neurology found an association between low bone density and an increased risk of developing dementia. Researchers analyzed data from 3,651 participants and found that those with the lowest total body bone density were 42% more likely to develop dementia than those with the highest bone density over a 10-year period.
A new forensic science study investigates the decay of infant and juvenile bones, providing insights into decomposition rates and bone degradation. The research helps forensic scientists estimate the time elapsed since remains were at a location and identify suitable bones for DNA sampling.
Researchers developed a new approach to suturing based on the mechanics and spacing of a hitchhiker plant's attachment system, promising to balance forces across sutures and reduce failure rates in surgical procedures. The findings were published in Proceedings of the Royal Society A.
A new coating material developed by Korean researchers facilitates bone regeneration and attracts osteo-progenitor cells, significantly improving the success rate of dental implants. The coating, loaded with BMP-2, prevents non-osteogenic cell invasion and induces high bone differentiation in a short period.
A study found that Spp24 inhibits osteosarcoma tumor cell proliferation, invasiveness, and promotes apoptosis. It achieves this by neutralizing bone morphogenetic protein 2.
Higher body mass index patients undergoing unicompartmental knee replacement (UKR) experience lower revision rates with cementless implants, according to a new study. Cementless fixation is preferred in higher-BMI patients, reducing the risk of revision surgery by up to 40%.
Researchers have identified a new method to predict which sarcoma patients will benefit from a potential new treatment. By inhibiting the plk1 gene, they were able to target and slow down the growth of sarcoma cells. This breakthrough could lead to improved treatment options for sickest sarcoma patients in 5-10 years.
A new drug called CADD522 blocks a gene associated with driving bone cancer's spread, increasing survival rates by 50% in mice implanted with human bone cancer. The breakthrough treatment shows promise in all main bone cancer subtypes and has the potential to save lives and reduce disability.
A study of fossilized bones from Brazilian species found that hollow bones with air sacs enabled dinosaurs and pterosaurs to become larger, as they circulated more oxygen and stayed cooler. This trait evolved independently in different groups, including sauropods, herrerasaurids, and birds.
Researchers found no relationship between growth rate and body size in theropod dinosaurs, with some giants growing slowly and smaller ones rapidly. This study opens the door to future investigations into how animals regulate their growth.
Researchers found that smaller dinosaurs grew rapidly, while larger ones grew slowly, challenging the idea that growth rate determines body size. The study also discovered that changes in growth timing can impact traits such as offspring size and susceptibility to predators.
Researchers at the University of Tokyo found that a specialized wing structure called the propatagium evolved in non-avian dinosaurs, paving the way for modern birds to fly. The discovery, based on statistical analyses of arm joints, helps fill gaps in knowledge about bird flight origins.
Researchers found that strengthening hip abductor muscles can provide effective compensation for weaknesses in knee extensor muscles, leading to improved mobility in people with below-the-knee amputations. The study tested the hypothesis in eight military personnel who had undergone a lower limb amputation and showed promising results.
Scientists used CT scans to analyze unopened expedition crates from the Tendaguru dinosaur site, revealing numerous dinosaur bones, including those of Dysalotosaurus lettowvorbecki. The images also provide a valuable testimony of the historic expedition and colonial context.
A new study from Trinity College Dublin identifies groups most at risk of vitamin D deficiency, including those with dark skin and low intakes. The research highlights the need for better awareness and promotion of adequate vitamin D intake through foods and supplements.
Researchers used MRI scans and texture analysis to differentiate between two types of benign oral bone lesions, ameloblastomas and odontogenic keratocysts. The study found that certain pixel and voxel organizational parameters in the MRI images were statistically significant, enabling more accurate diagnosis and treatment planning.
A University of Gothenburg study found that wheelchair users had significantly lower rates of fractures compared to ambulatory older adults. The study, which included 55,442 wheelchair users in Sweden, showed that wheelchair use was associated with a reduced risk of fractures, particularly osteoporotic and hip fractures.
Researchers highlight potential risk of navicular bone stress injuries in athletes using carbon fiber plate footwear, emphasizing importance of recognition and safe use. The study features five cases of foot pain and subsequent diagnosis in elite track and field athletes and mid-30s competitors.
A new study finds that plasma D-dimer levels have comparable diagnostic accuracy to other commonly used tests for identifying periprosthetic joint infection (PJI), and sometimes outperform the standard tests. The test showed higher sensitivity and specificity in detecting PJI, particularly in certain patient subgroups.
A new study found that long-term voluntary wheel running improved skeletal muscle and bone parameters in female mice, but the effects varied depending on body weight. High body weight was more beneficial for muscle and bone health with aging, especially when combined with exercise.
Male giraffes test female sexual receptivity by nudging them to urinate, then inhaling their scent with flehmen. This behavior is crucial for mating and understanding giraffe anatomy supports it.
Scientists at Nagoya University developed an index to estimate a bird's wing use based on coracoid bone strength and body mass. This new tool sheds light on how ancient birds evolved to fly, including the flapping abilities of extinct species.
The Geriatric Fracture Program at Cedars-Sinai Medical Center has been shown to reduce hospital stays by 2.12 days and lower hospital-related costs by $5,316 for patients aged 65 and older. The program's comprehensive care approach, including bone strength assessments and fall prevention strategies, is effective in improving outcomes.
Evans' five-year grant will examine how modularity affects the evolution of complex biological structures and provide a framework for their study. The research could advance our understanding of shape change in other complex structures and have cultural and historical significance.
Researchers have solved an 80-year-old medical mystery that causes kidney damage in children and can be fatal in babies. They discovered a gene mutation is the primary cause, but found that around 10% of patients without the mutation still experience symptoms.
Biomarkers of bone turnover are essential for diagnosing and treating metabolic musculoskeletal diseases. The International Osteoporosis Foundation, IFCC, and ESCEO have collaborated to publish authoritative reviews on the use and interpretation of these biomarkers.
Researchers found that EWS::FLI1 induces Slit2 expression, which activates Robo receptors and enhances Ewing sarcoma growth. Silencing Slit2 strongly inhibited Ewing sarcoma cell growth, providing an opportunity for targeted therapy.
A new study found that approximately three percent of all bone scan patients have markers of cardiac amyloidosis, which can lead to heart failure and increased mortality. The research highlights the importance of early diagnosis and treatment, as well as potential automated detection methods using machine-learning algorithms.
A randomized trial shows that patients undergoing partial knee arthroplasty (UKA) experience faster functional recovery in walking speed and mobility tests compared to those who had total knee arthroplasty (TKA). UKA also resulted in shorter operative times, reduced blood loss, and improved functional outcomes.
Researchers at Helmholtz-Zentrum Berlin discovered that high-energy X-rays can cause damage to bone collagen, even at low irradiation doses. The study used powerful X-ray sources and sensitive detectors to examine the effects on fish and mammalian bone samples.
A team of scientists from TIBI, UIC, and POSTECH has elucidated key points on how cartilage generation is facilitated and alternative bone formation can be avoided. They found optimal conditions for better cartilage regeneration while reducing excessive cartilage formation using human mesenchymal stem cells.
A study found that joint replacement prices are not associated with quality of care, but rather with the type of insurer. The study analyzed publicly available data from 18 hospitals in California and found significant price differences between different payer types.
Researchers developed a customizable, strontium-loaded scaffold that promotes wound healing by stimulating gingival fibroblast activity. The scaffold increased cellular activity of isolated cells while showing minimal toxicity over four days.
Scientists have solved a decades-long puzzle about why ancient tetrapod fossils in Ireland's Jarrow Assemblage had their internal bone structure altered. The team used CT scans and laser ablation to analyze the chemistry of the bones, finding evidence of superheated fluids that cooked and melted the bones.
Researchers at Massachusetts General Hospital have identified a promising oral compound that stimulates bone formation in mice, increasing blood levels of calcium and vitamin D. The compound, SK-124, boosts bone formation and mass without short-term toxicity, offering new hope for preventing and treating osteoporosis.
Researchers from Trinity College Dublin analyzed ancient DNA from two men with multiple osteochondromas, a rare genetic disease, and identified new mutations in the EXT1 gene. This study is the first to discover a new disease mutation in ancient genomic data.
A new study suggests that a transcriptomic technique can help distinguish between infections and non-infectious causes of complications following knee and hip replacement surgery. The technique uses RNA sequencing to determine which genes are expressed and identifies specific immune cell types involved in the response to infection.
A new study found that increasing protein intake by 25g a day and drinking regular cups of tea or coffee can reduce the risk of hip fracture in women by up to 14% and 4%, respectively. The study, which analyzed data from over 26,000 middle-aged women, also discovered that underweight women may experience greater reductions in risk.
A long-term study found that eating more than 100 micrograms of vitamin K1 daily reduced the risk of fractures and hospitalizations by 31-49%. Dark leafy vegetables and one-to-two serves of vegetables are recommended for optimal benefits. Vitamin K1 has been shown to enhance cardiovascular health and promote bone health.
The SpaceX Dragon spacecraft will launch onboard a Falcon 9 rocket with critical research and supplies for the International Space Station. ISS National Laboratory-sponsored projects aim to bring value through space-based research and technology development.