Articles tagged with Bones
Patients who discontinue biologic disease-modifying anti-rheumatic drugs (bDMARDs) before orthopaedic surgery are more likely to experience a disease flare following surgery. However, discontinuing bDMARDs does not appear to increase the risk of surgical site infections or delayed wound healing. The review and meta-analysis highlights ...
Researchers have discovered that messenger RNA can be used to regenerate bone at low doses, producing high-quality tissue with no side effects. The new method is superior to existing treatments and may not require repeat doses.
A recent study found that a subset of immune cells within the alveolar bone marrow were activated by the presence of commensal oral microbes, leading to increased osteoclast-mediated bone resorption and bone loss. Reducing the burden of commensal microbes through oral antiseptic rinses can help protect against alveolar bone loss.
The American Roentgen Ray Society recognizes Drs. Nguyen, Beheshtian, Harfouch, and Hashiba for their outstanding research and education contributions to the field of radiology. The awards honor the candidates' scientific merit and potential impact on imaging and allied sciences research.
A team of researchers developed an enhanced version of a modern forensic test to solve a 5000-year-old cold case. The test confirmed the cause of death for a Neolithic man whose remains were found in a mass grave on the coast of Northern Chile, suggesting he died by drowning in shallow saltwater.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism has found that men with high levels of body fat are more likely to have lower bone density and an increased risk of fractures. The researchers analyzed data from over 10,800 people under 60 years old and found a strong positive association b...
A young diplodocid dinosaur with abnormal bony protrusions in its neck bones may have suffered from a fungal respiratory infection similar to aspergillosis. The study provides the first evidence of an avian-style respiratory infection in a non-avian dinosaur.
Researchers developed an optogenetic approach to control parathyroid hormone secretion and prevent secondary hyperparathyroidism-associated bone loss. The method partially attenuated SHPT-associated bone loss in animal models, suggesting its potential as a treatment for hyperparathyroidism-induced bone disease.
Scientists have identified connexin (Cx) 43 hemichannels on the surface of bone cells as a potential new target for medications to treat osteoporosis and other conditions that cause bone loss. The study, published in eLife, reveals how these channels play a crucial role in responding to mechanical stress and building stronger bones.
Researchers found that prunes' phenolic compounds and dietary fiber content may alter gut microbiome, decreasing inflammatory markers and improving bone turnover. Clinical trials showed promising effects of prune consumption on bone health outcomes in postmenopausal women.
A new model using Raman spectroscopy and chemometrics has been developed to accurately determine the post-mortem interval (PMI) in human skeletal remains. This non-destructive technique provides valuable information for forensic medicine and anthropology, improving reliability and accuracy.
A recent study challenges the idea that meat consumption drove major evolutionary changes in humans, suggesting instead that increased research attention may have skewed evidence. The research team analyzed data from nine sites across eastern Africa and found no sustained increase in carnivory after Homo erectus appeared.
Researchers at Rice University and Baylor College of Medicine have created an antibody with an engineered peptide that effectively targets and attacks bone tumors in breast cancer. The study shows the therapeutic efficacy is best when a moderate amount of the drug compound is delivered, offering new hope for treating bone metastases.
An international team led by the University of Ottawa has published findings on the importance of the enzyme GCN5 in maintaining muscle integrity. The study discovered that GCN5 plays a crucial role in boosting the expression of key structural proteins, notably dystrophin.
Fibrodysplasia ossificans progressiva (FOP) may be rooted in impaired and inefficient muscle tissue regeneration, which enables unwanted bone growth. This discovery could lead to new therapies targeting both extra-skeletal bone formation and muscle function.
Regrowing healthy cartilage in damaged joints is a promising approach to treating arthritis. UConn bioengineers successfully regrowed cartilage in a rabbit's knee using piezoelectricity, a phenomenon that also exists in the human body.
A new study reveals that medieval warhorses were bred for success in various functions, including tournaments and long-distance raiding campaigns. The research, published in the International Journal of Osteoarchaeology, found that breeding and training were influenced by biological and cultural factors.
The integration of optical sensing into orthopedic surgical devices has the potential to increase accuracy and improve outcomes in musculoskeletal repair. Researchers explore various types of optical sensing, including spectroscopy and imaging, to address unmet clinical needs in orthopedic surgery.
Researchers have found that blocking mineralocorticoid receptors, a key factor in bone health, may help protect against bone loss and osteoporosis. This new target is thought to be more effective than previously believed logical targets, such as reducing glucocorticoid receptor activity.
Researchers at INRS have developed a bioactive coating that mimics bone tissue using chitosan, collagen, and copper-doped phosphate glass. The coating promotes healing and reduces the risk of rejection, paving the way for improved orthopaedic implant success.
A groundbreaking study reveals early humans preferred to hunt the largest available animals to provide the greatest quantities of food. Over 1.5 million years, humans repeatedly overhunted large animals to extinction, and then shifted to smaller animals, improving their hunting technologies.
Researchers used PET scans to quantify antibiotic levels in orthopaedic implants, discovering rifampin penetration is only about 14% as much as previously believed. A higher dose of rifampin achieved higher bacterial killing and fewer antibiotic-resistant strains, suggesting a shorter treatment regimen may be effective.
A new study found that COVID-19 lowered expenses for orthopaedic surgery residency applicants due to the elimination of in-person interviews and away rotations. The median total expenses decreased from $7,250 in 2020 to $2,250 in 2021, with significant savings seen in interview and away rotation costs.
New research on the world's largest pterosaur, Quetzalcoatlus, reveals that it likely leaped into the air before lifting off, using its wings to generate lift. The study, published by the Society of Vertebrate Paleontology, is the most comprehensive on the species yet and provides new insights into its flight mechanics.
A prospective study found that MRI outperformed conventional tests and FDG PET/CT for various staging endpoints in SCLC. Whole-body MRI and FDG PET/MRI were more accurate than FDG PET/CT for assessing local invasion extent.
A study by University of Copenhagen researchers reveals that thousands of tigers are bred on farms and used to produce illegal traditional medicines. Buyers in Vietnam prefer wild tigers' bones over farmed ones due to perceived potency, while also seeking high tiger bone content.
A randomized-controlled clinical trial found that eating prunes daily reduces biomarkers of bone breakdown and improves bone geometry in healthy men aged 50-79. The study adds to existing research on the beneficial effects of prunes on bone health, particularly for men.
A team of researchers has extracted and analyzed ancient proteins and DNA from nearly 4,000 bone fragments at Denisova Cave, yielding five human bones with intact biomolecules, dating back to 200,000 years ago. The findings provide robust insights into the first occupants of the cave and their archaeological signature.
A study by Tokyo University of Science researchers identifies a novel regulatory axis targeting dendritic cell activity, suppressing autoimmune disease symptoms and bone loss. They discovered DCIR binds to glycoproteins on macrophages and osteoclasts, reducing inflammation and immune responses.
UArizona researchers created osseosurface electronics, a wireless device that grows to the surface of bone to monitor health and healing. The thin structure allows for accurate measurements over long periods, enabling personalized orthopedic care.
A new study found that preadolescent endurance runners who experience weight loss, have a history of bone stress injury, or follow a vegetarian diet are more likely to use dietary supplements. The study discovered that supplement use was associated with lower food intake and energy deficiency.
Recent clinical and experimental data suggest that vascular calcification and bone loss share common pathophysiological mechanisms. The International Osteoporosis Foundation's new review elucidates the key associations between the two disorders.
Convolutional neural networks trained to identify abnormalities on upper extremity radiographs are susceptible to a ubiquitous confounding image feature: radiograph labels. Covering these labels increases accuracy, while using them alone leads to decreased performance.
Research suggests that obesity triggers inflammation, leading to an increase in myeloid-derived suppressor cells, which break down bone tissue. This can result in gum disease and tooth loss. The study found a significant link between high-fat diets and increased osteoclasts and alveolar bone destruction.
A new genus and species of iguanodontian dinosaur, Brighstoneus simmondsi, has been discovered on the Isle of Wight. The herbivorous dinosaur is estimated to be around 8 meters in length and weigh 900kg.
Researchers found that blocking nerve growth factor can prevent heterotopic ossification, a challenging condition where bone abnormally grows in soft tissue during healing. The study suggests that pain-relief drugs currently being tested could also protect against this condition.
A new study from the University of Eastern Finland found that postmenopausal women experience a significant decrease in bone mineral density, but at a lower rate than previously assumed. Women who received hormone replacement therapy and those with weight gain during follow-up showed minimal bone loss.
A new study suggests that human presence on the Falkland Islands dates back to around 3450 B.C.E., with evidence of fire activity and stone projectile points consistent with Indigenous South American technology. The research indicates that people likely visited the islands for short-term stays, leaving few cultural materials behind.
Researchers found that as icebergs melted, vegetation became scarce, making it difficult for the giant animals to survive. The team analyzed ancient environmental DNA and sequenced plant remains to draw globally significant conclusions.
The study of 686 Finnish women found that postmenopausal bone loss is approximately 10% over a 25-year period. Taking hormone replacement therapy and gaining weight during follow-up were linked to lower postmenopausal bone loss rates.
A randomised controlled trial found that increasing daily milk, yoghurt, and cheese intake reduced the risk of all fractures by 33%, hip fractures by 46%, and falls by 11% among older adults in residential care. This approach has widespread implications for fracture prevention as a public health measure.
Researchers at University of Virginia Health System have discovered a new treatment target for osteoporosis and bone loss from rheumatoid arthritis. A cellular protein called ELMO1 promotes the activity of osteoclasts, which break down bone, leading to excessive bone degradation.
A recent University at Buffalo study found that patients using proton pump inhibitors (PPIs) for heartburn had smaller probing depths in their gums, indicating less severe gum disease. The researchers suggest that PPIs' side effects may be linked to reduced periodontitis severity.
A subpopulation of mesenchymal stem cells expressing CD73 has been identified as crucial for bone regeneration, displaying enhanced proliferation and differentiation capabilities. This subgroup promotes fracture healing by forming new cartilage and bone cells, contributing to the remodeling process.
Detailed analyses of cremated bone fragments from Tomb of Nestor's Cup uncovered at least three humans with varying life stages, alongside animal remains like goats and dogs. The study sheds new light on funeral practices and ancient Greek culture.
Researchers developed a novel approach to 3D image segmentation, segmenting the gaps between parts instead of contours, to automate tedious tasks. The technique demonstrates promising results in diagnosing TMJ-related issues and has potential applications in other fields.
A new $3 million study will investigate the link between weight loss and bone frailty in diabetics. The research aims to identify metabolomic changes causing increased fracture risk and explore ways to prevent bone loss during intentional weight loss.
A study found that oxcarbazepine, a commonly prescribed anti-seizure medication, is associated with a higher risk of fractures in children with epilepsy. The research team examined the effects of levetiracetam and oxcarbazepine on bone fragility in children between the ages of four and 13.
The discovery of bone tools in Contrebandiers Cave, Morocco, dating back to 120,000-90,000 years ago, provides strong evidence for the manufacture of clothing during this period. The tools, which showed signs of skinning for furs and pelts, are similar to leather working tools found in other archaeological records.
Researchers found 62 bone tools at Contrebandiers Cave, Morocco, with shaping and use marks indicating they were used for scraping hides to make leather and furs. The discovery highlights the pan-African emergence of complex culture and provides evidence for the earliest clothing in the archaeological record.
Aging stem cells in bone marrow lose function due to epigenetic changes that affect bone production. Researchers reverse these changes by adding acetate, rejuvenating the epigenome and improving stem cell activity. This finding holds promise for treating diseases like osteoporosis.
The study found that a specific type of glycosaminoglycan in the scaffold led to greater blood vessel development and immune cell activation. Researchers aim to further understand these interactions to develop biomaterials for bone repair.
A new study suggests that same-day discharge for high-risk patients undergoing hip and knee replacement surgery is safe and feasible. The research found no increase in complications or adverse outcomes with same-day discharge compared to inpatient surgery.
Research shows that large eggs in small hens lead to keel bone fractures, affecting 85% of Danish laying hens. Hens from different production systems also suffer from the issue.
A new study reveals evidence of beer drinking 9,000 years ago in southern China, with ancient pots found at a burial site containing residues consistent with beer fermentation. The discovery suggests that ritualized drinking played a significant role in forging social relationships and cooperation among ancient communities.
A study published in Current Rheumatology Reviews found that rehabilitation exercises significantly improved functional strength and reduced weight in knee osteoarthritis patients. The researchers also noted an increase in exercise adherence among the rehabilitation group compared to the control group.
A Hebrew University study reveals that as worldwide lead production increases, so do rates of lead absorption in people, leading to toxic effects. The research uses ancient human bones to show the close relationship between lead production and human exposure.
The new guideline recommends invasive diagnostic tests but acknowledges their potential infeasibility, instead focusing on clinical improvement to transition to oral therapy. It provides thoughtfully reasoned recommendations based on current evidence to help clinicians identify and manage bone infections.
New research reveals Bronze Age farmers in China prioritized cattle for their diets, utilizing byproducts like millet stalks for feed. This approach differs from other regions, where cows were raised closer to human settlements.
A recent study published in Journal of Bone and Mineral Research has identified genes and gene pathways that influence the genetic regulation of human height. The research examined genome-wide association studies and assessed the expression of these genetic regions in different layers of the growth plate during childhood.