Researchers found that favorable local climate change led to chronic warfare in ancient Peru, as neighboring regions experienced droughts and migrants put pressure on the agricultural economy. The study suggests that climate change can harm all populations, either directly or indirectly, through destabilization and refugee crises.
A new series of expert reviews explores less common causes of bone loss, including pregnancy-associated osteoporosis and anorexia nervosa-related osteoporosis. The reviews provide comprehensive information on these unusual conditions and their impact on bone health.
Patients with lower levels of sex hormones are more likely to undergo surgery for rotator cuff tears, according to a study published in The Journal of Bone & Joint Surgery. Estrogen deficiency was associated with a 48% higher incidence of rotator cuff repair in women, while testosterone deficiency was linked to an 89% higher rate in men.
A study found that mothers in a 19th century Dutch village had low rates of breastfeeding, likely due to their busy work schedules and easy access to cow's milk. Researchers analyzed the remains of 277 individuals and found little evidence of breastfeeding, surprising given the community's cultural associations with breastfeeding.
Researchers at UCLA found that premenopausal women with low levels of anti-Mullerian hormone are at a higher risk of experiencing significant bone loss within two to three years. The study suggests that measuring AMH levels could help physicians identify women at risk and provide targeted treatment.
A recent study suggests that eating nutrient-rich prunes every day may benefit bone health in postmenopausal women by reducing inflammatory factors. The research found significant reductions in inflammatory markers in prune-eating groups compared to a control group.
Scientists at Texas A¼M University have created water-stable, 2D covalent organic framework nanoparticles that can guide human mesenchymal stem cells to form bone tissue. The new technology has the potential to impact the treatment of bone regeneration and improve drug delivery.
Teréza Hough, CEO of the National Osteoporosis Foundation South Africa, has been awarded the IOF CNS Medal for her outstanding contributions to bone health advocacy. Her work in raising awareness and advancing education among the public and healthcare professionals in South Africa is recognized globally.
Professor René Rizzoli has been recognized for his significant and longstanding contribution to the advancement of osteoporosis research through his work on bone metabolism and mineralization. He is a respected researcher, clinician, and leader in the field of osteoporosis, with a strong focus on prevention and treatment.
The Virtual WCO-IOF-ESCEO 2022 Congress will feature leading experts on osteoporosis, osteoarthritis, and musculoskeletal diseases, with a focus on new clinical research and advances in prevention and patient care. Prestigious awards will also be presented.
Professor Antonio Cherubini has made significant contributions to the field of geriatric medicine and musculoskeletal diseases. He is recognized for his work on aging, bone health, and age-related diseases.
The International Osteoporosis Foundation awarded five young researchers for their groundbreaking work on the role of nutrition in musculoskeletal health. The winners, from Australia, India, and Switzerland, were recognized for their studies on vitamin K1 intake, calcium sources, and dietary inflammatory index.
Researchers create transgenic lettuce that expresses a bone-stimulating hormone, which could help prevent osteopenia in astronauts and resource-limited areas on Earth. The lettuce would need to be consumed daily by astronauts to get a sufficient dose of the hormone.
Researchers at UC Davis have developed genetically modified lettuce producing a drug to protect against bone density loss in microgravity. The transgenic lettuce combines parathyroid hormone with an antibody protein, allowing for stable production and potential self-administration by astronauts.
A new study suggests that mummification in prehistory was more common in Europe than thought, dating back to 8,000 years ago. The researchers found evidence of desiccation and hyperflexion in skeletal remains from the Sado Valley in Portugal.
Chronic liver injury triggers bone loss through the liver-bone axis, characterized by an imbalance of PP2Ac® and LCAT. This study reveals the molecular mechanisms behind HOD disease progression.
Researchers at Osaka University used advanced microscopy to visualize extracellular vesicles secreted by osteoblasts, identifying a subset that limits bone formation and stimulates osteoclast differentiation. This finding could lead to new treatments for bone diseases.
Researchers at RMIT University used high-frequency sound waves to turn stem cells into bone cells, overcoming challenges in mass production and pain associated with extraction. The innovative treatment is faster, simpler, and more efficient than existing methods.
Researchers uncovered bone remains of a first-generation African individual from Senegambia, buried in a Portuguese shell midden 350 years ago. The genetic signature and dietary analysis indicate that he was forcibly translocated to Portugal via the Trans-Atlantic Slave Trade.
Patients who discontinue biologic disease-modifying anti-rheumatic drugs (bDMARDs) before orthopaedic surgery are more likely to experience a disease flare following surgery. However, discontinuing bDMARDs does not appear to increase the risk of surgical site infections or delayed wound healing. The review and meta-analysis highlights ...
A recent study found that a subset of immune cells within the alveolar bone marrow were activated by the presence of commensal oral microbes, leading to increased osteoclast-mediated bone resorption and bone loss. Reducing the burden of commensal microbes through oral antiseptic rinses can help protect against alveolar bone loss.
Researchers have discovered that messenger RNA can be used to regenerate bone at low doses, producing high-quality tissue with no side effects. The new method is superior to existing treatments and may not require repeat doses.
The American Roentgen Ray Society recognizes Drs. Nguyen, Beheshtian, Harfouch, and Hashiba for their outstanding research and education contributions to the field of radiology. The awards honor the candidates' scientific merit and potential impact on imaging and allied sciences research.
A team of researchers developed an enhanced version of a modern forensic test to solve a 5000-year-old cold case. The test confirmed the cause of death for a Neolithic man whose remains were found in a mass grave on the coast of Northern Chile, suggesting he died by drowning in shallow saltwater.
A young diplodocid dinosaur with abnormal bony protrusions in its neck bones may have suffered from a fungal respiratory infection similar to aspergillosis. The study provides the first evidence of an avian-style respiratory infection in a non-avian dinosaur.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism has found that men with high levels of body fat are more likely to have lower bone density and an increased risk of fractures. The researchers analyzed data from over 10,800 people under 60 years old and found a strong positive association b...
Researchers developed an optogenetic approach to control parathyroid hormone secretion and prevent secondary hyperparathyroidism-associated bone loss. The method partially attenuated SHPT-associated bone loss in animal models, suggesting its potential as a treatment for hyperparathyroidism-induced bone disease.
Researchers found that prunes' phenolic compounds and dietary fiber content may alter gut microbiome, decreasing inflammatory markers and improving bone turnover. Clinical trials showed promising effects of prune consumption on bone health outcomes in postmenopausal women.
Scientists have identified connexin (Cx) 43 hemichannels on the surface of bone cells as a potential new target for medications to treat osteoporosis and other conditions that cause bone loss. The study, published in eLife, reveals how these channels play a crucial role in responding to mechanical stress and building stronger bones.
A new model using Raman spectroscopy and chemometrics has been developed to accurately determine the post-mortem interval (PMI) in human skeletal remains. This non-destructive technique provides valuable information for forensic medicine and anthropology, improving reliability and accuracy.
Researchers at Rice University and Baylor College of Medicine have created an antibody with an engineered peptide that effectively targets and attacks bone tumors in breast cancer. The study shows the therapeutic efficacy is best when a moderate amount of the drug compound is delivered, offering new hope for treating bone metastases.
A recent study challenges the idea that meat consumption drove major evolutionary changes in humans, suggesting instead that increased research attention may have skewed evidence. The research team analyzed data from nine sites across eastern Africa and found no sustained increase in carnivory after Homo erectus appeared.
An international team led by the University of Ottawa has published findings on the importance of the enzyme GCN5 in maintaining muscle integrity. The study discovered that GCN5 plays a crucial role in boosting the expression of key structural proteins, notably dystrophin.
Fibrodysplasia ossificans progressiva (FOP) may be rooted in impaired and inefficient muscle tissue regeneration, which enables unwanted bone growth. This discovery could lead to new therapies targeting both extra-skeletal bone formation and muscle function.
Regrowing healthy cartilage in damaged joints is a promising approach to treating arthritis. UConn bioengineers successfully regrowed cartilage in a rabbit's knee using piezoelectricity, a phenomenon that also exists in the human body.
A new study reveals that medieval warhorses were bred for success in various functions, including tournaments and long-distance raiding campaigns. The research, published in the International Journal of Osteoarchaeology, found that breeding and training were influenced by biological and cultural factors.
The integration of optical sensing into orthopedic surgical devices has the potential to increase accuracy and improve outcomes in musculoskeletal repair. Researchers explore various types of optical sensing, including spectroscopy and imaging, to address unmet clinical needs in orthopedic surgery.
Researchers have found that blocking mineralocorticoid receptors, a key factor in bone health, may help protect against bone loss and osteoporosis. This new target is thought to be more effective than previously believed logical targets, such as reducing glucocorticoid receptor activity.
Researchers at INRS have developed a bioactive coating that mimics bone tissue using chitosan, collagen, and copper-doped phosphate glass. The coating promotes healing and reduces the risk of rejection, paving the way for improved orthopaedic implant success.
A groundbreaking study reveals early humans preferred to hunt the largest available animals to provide the greatest quantities of food. Over 1.5 million years, humans repeatedly overhunted large animals to extinction, and then shifted to smaller animals, improving their hunting technologies.
Researchers used PET scans to quantify antibiotic levels in orthopaedic implants, discovering rifampin penetration is only about 14% as much as previously believed. A higher dose of rifampin achieved higher bacterial killing and fewer antibiotic-resistant strains, suggesting a shorter treatment regimen may be effective.
A new study found that COVID-19 lowered expenses for orthopaedic surgery residency applicants due to the elimination of in-person interviews and away rotations. The median total expenses decreased from $7,250 in 2020 to $2,250 in 2021, with significant savings seen in interview and away rotation costs.
A prospective study found that MRI outperformed conventional tests and FDG PET/CT for various staging endpoints in SCLC. Whole-body MRI and FDG PET/MRI were more accurate than FDG PET/CT for assessing local invasion extent.
New research on the world's largest pterosaur, Quetzalcoatlus, reveals that it likely leaped into the air before lifting off, using its wings to generate lift. The study, published by the Society of Vertebrate Paleontology, is the most comprehensive on the species yet and provides new insights into its flight mechanics.
A study by University of Copenhagen researchers reveals that thousands of tigers are bred on farms and used to produce illegal traditional medicines. Buyers in Vietnam prefer wild tigers' bones over farmed ones due to perceived potency, while also seeking high tiger bone content.
A randomized-controlled clinical trial found that eating prunes daily reduces biomarkers of bone breakdown and improves bone geometry in healthy men aged 50-79. The study adds to existing research on the beneficial effects of prunes on bone health, particularly for men.
A team of researchers has extracted and analyzed ancient proteins and DNA from nearly 4,000 bone fragments at Denisova Cave, yielding five human bones with intact biomolecules, dating back to 200,000 years ago. The findings provide robust insights into the first occupants of the cave and their archaeological signature.
A study by Tokyo University of Science researchers identifies a novel regulatory axis targeting dendritic cell activity, suppressing autoimmune disease symptoms and bone loss. They discovered DCIR binds to glycoproteins on macrophages and osteoclasts, reducing inflammation and immune responses.
UArizona researchers created osseosurface electronics, a wireless device that grows to the surface of bone to monitor health and healing. The thin structure allows for accurate measurements over long periods, enabling personalized orthopedic care.
A new study found that preadolescent endurance runners who experience weight loss, have a history of bone stress injury, or follow a vegetarian diet are more likely to use dietary supplements. The study discovered that supplement use was associated with lower food intake and energy deficiency.
SourceElsevier·JournalJournal of the Academy of Nutrition and Dietetics·TypeData/statistical analysis·DateNov 17, 2021
Recent clinical and experimental data suggest that vascular calcification and bone loss share common pathophysiological mechanisms. The International Osteoporosis Foundation's new review elucidates the key associations between the two disorders.
Convolutional neural networks trained to identify abnormalities on upper extremity radiographs are susceptible to a ubiquitous confounding image feature: radiograph labels. Covering these labels increases accuracy, while using them alone leads to decreased performance.
Research suggests that obesity triggers inflammation, leading to an increase in myeloid-derived suppressor cells, which break down bone tissue. This can result in gum disease and tooth loss. The study found a significant link between high-fat diets and increased osteoclasts and alveolar bone destruction.
A new genus and species of iguanodontian dinosaur, Brighstoneus simmondsi, has been discovered on the Isle of Wight. The herbivorous dinosaur is estimated to be around 8 meters in length and weigh 900kg.
Researchers found that blocking nerve growth factor can prevent heterotopic ossification, a challenging condition where bone abnormally grows in soft tissue during healing. The study suggests that pain-relief drugs currently being tested could also protect against this condition.
A new study suggests that human presence on the Falkland Islands dates back to around 3450 B.C.E., with evidence of fire activity and stone projectile points consistent with Indigenous South American technology. The research indicates that people likely visited the islands for short-term stays, leaving few cultural materials behind.
A new study from the University of Eastern Finland found that postmenopausal women experience a significant decrease in bone mineral density, but at a lower rate than previously assumed. Women who received hormone replacement therapy and those with weight gain during follow-up showed minimal bone loss.
A randomised controlled trial found that increasing daily milk, yoghurt, and cheese intake reduced the risk of all fractures by 33%, hip fractures by 46%, and falls by 11% among older adults in residential care. This approach has widespread implications for fracture prevention as a public health measure.
Researchers found that as icebergs melted, vegetation became scarce, making it difficult for the giant animals to survive. The team analyzed ancient environmental DNA and sequenced plant remains to draw globally significant conclusions.
The study of 686 Finnish women found that postmenopausal bone loss is approximately 10% over a 25-year period. Taking hormone replacement therapy and gaining weight during follow-up were linked to lower postmenopausal bone loss rates.