Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
Researchers at University of Virginia Health System have discovered a new treatment target for osteoporosis and bone loss from rheumatoid arthritis. A cellular protein called ELMO1 promotes the activity of osteoclasts, which break down bone, leading to excessive bone degradation.
A recent University at Buffalo study found that patients using proton pump inhibitors (PPIs) for heartburn had smaller probing depths in their gums, indicating less severe gum disease. The researchers suggest that PPIs' side effects may be linked to reduced periodontitis severity.
A subpopulation of mesenchymal stem cells expressing CD73 has been identified as crucial for bone regeneration, displaying enhanced proliferation and differentiation capabilities. This subgroup promotes fracture healing by forming new cartilage and bone cells, contributing to the remodeling process.
Detailed analyses of cremated bone fragments from Tomb of Nestor's Cup uncovered at least three humans with varying life stages, alongside animal remains like goats and dogs. The study sheds new light on funeral practices and ancient Greek culture.
Researchers developed a novel approach to 3D image segmentation, segmenting the gaps between parts instead of contours, to automate tedious tasks. The technique demonstrates promising results in diagnosing TMJ-related issues and has potential applications in other fields.
A new $3 million study will investigate the link between weight loss and bone frailty in diabetics. The research aims to identify metabolomic changes causing increased fracture risk and explore ways to prevent bone loss during intentional weight loss.
A study found that oxcarbazepine, a commonly prescribed anti-seizure medication, is associated with a higher risk of fractures in children with epilepsy. The research team examined the effects of levetiracetam and oxcarbazepine on bone fragility in children between the ages of four and 13.
Researchers found 62 bone tools at Contrebandiers Cave, Morocco, with shaping and use marks indicating they were used for scraping hides to make leather and furs. The discovery highlights the pan-African emergence of complex culture and provides evidence for the earliest clothing in the archaeological record.
The discovery of bone tools in Contrebandiers Cave, Morocco, dating back to 120,000-90,000 years ago, provides strong evidence for the manufacture of clothing during this period. The tools, which showed signs of skinning for furs and pelts, are similar to leather working tools found in other archaeological records.
Aging stem cells in bone marrow lose function due to epigenetic changes that affect bone production. Researchers reverse these changes by adding acetate, rejuvenating the epigenome and improving stem cell activity. This finding holds promise for treating diseases like osteoporosis.
The study found that a specific type of glycosaminoglycan in the scaffold led to greater blood vessel development and immune cell activation. Researchers aim to further understand these interactions to develop biomaterials for bone repair.
A new study suggests that same-day discharge for high-risk patients undergoing hip and knee replacement surgery is safe and feasible. The research found no increase in complications or adverse outcomes with same-day discharge compared to inpatient surgery.
Research shows that large eggs in small hens lead to keel bone fractures, affecting 85% of Danish laying hens. Hens from different production systems also suffer from the issue.
A new study reveals evidence of beer drinking 9,000 years ago in southern China, with ancient pots found at a burial site containing residues consistent with beer fermentation. The discovery suggests that ritualized drinking played a significant role in forging social relationships and cooperation among ancient communities.
A study published in Current Rheumatology Reviews found that rehabilitation exercises significantly improved functional strength and reduced weight in knee osteoarthritis patients. The researchers also noted an increase in exercise adherence among the rehabilitation group compared to the control group.
A Hebrew University study reveals that as worldwide lead production increases, so do rates of lead absorption in people, leading to toxic effects. The research uses ancient human bones to show the close relationship between lead production and human exposure.
The new guideline recommends invasive diagnostic tests but acknowledges their potential infeasibility, instead focusing on clinical improvement to transition to oral therapy. It provides thoughtfully reasoned recommendations based on current evidence to help clinicians identify and manage bone infections.
A recent study published in Journal of Bone and Mineral Research has identified genes and gene pathways that influence the genetic regulation of human height. The research examined genome-wide association studies and assessed the expression of these genetic regions in different layers of the growth plate during childhood.
New research reveals Bronze Age farmers in China prioritized cattle for their diets, utilizing byproducts like millet stalks for feed. This approach differs from other regions, where cows were raised closer to human settlements.
A high-status Bronze Age woman and her twins were found in a Szigetszentmiklós urnfield cemetery, with remains indicating she was 25-35 years old at death. Strontium analysis suggested she was born elsewhere and moved to Hungary between ages 8-13.
A study of 1,741 women and 620 men aged ?65 years found that cognitive decline is linked to accelerated bone loss and a higher risk of fractures in women. The bidirectional relationship between bone loss, cognitive decline, and fracture risk suggests shared underlying factors.
Researchers have discovered a link between cognitive decline and faster bone loss in women, increasing future fracture risk. Cognitive decline over five years was associated with a 1.7-fold increase in fracture risk in subsequent 10 years.
Researchers developed a miniature 3D bone-like tissue model to investigate the effects of anti-androgen therapies on prostate cancer bone tumours. The study found that traditional therapy had limited effect, with interactions between cancer cells and the bone microenvironment significantly impacting disease progress.
Alvarezsaur dinosaurs reduced in size from turkey-sized to chicken-sized around 95 million years ago when they transitioned to an ant-based diet. Their bodies also underwent significant changes, including modified claws and a shift from flesh-eating to termite consumption.
A study published in Scientific Reports reveals that harpy eagles rely on specific prey in canopy forests and starve when these areas are heavily deforested. As a result, breeding pairs may decline by up to 3,256 since 1985, emphasizing the need for forest conservation.
Researchers at University of Arizona Health Sciences found that cancer cells become more aggressive when exposed to tissue stiffening, leading to changes that persist over time. The 'mechanical conditioning' score can quantify these cellular changes and predict patients at high risk for bone metastasis.
Two new articles explore the spatially variable exhumation of the central Appalachian Mountains and constraints on the paleoelevation history of Colombia's Eastern Cordillera. The studies use thermochronology and palynological records to reconstruct ancient tectonic events.
Researchers propose a triple-cycle heat treatment system to improve the microstructure and performance of 3D printed titanium-molybdenum alloy human implants, achieving better biocompatibility and mechanical properties matching human bones. This method enables more widespread use of 3D printed implants in the biomedical field.
A research team from the University of Alaska Fairbanks and Florida State University has found evidence that nearly all types of Arctic dinosaurs reproduced in the region and likely remained there year-round. The discovery contradicts previous hypotheses that the animals migrated to lower latitudes for the winter, suggesting they were ...
Researchers have developed an antibody conjugate called BonTarg that delivers drugs to bone tumors and inhibits metastasis. The combination of a breast cancer drug with a bone-targeting antibody was found to significantly enhance the concentration of the antibody at tumor sites, and inhibit secondary metastasis from infected organs.
A new study reveals that a hormone in fat cells inside bone marrow helps regulate bone and fat production. The findings suggest potential new approaches to treating conditions like osteoporosis.
Researchers found that eating 50 grams of prunes daily for six months improved CVD risk biomarkers, raised 'good' cholesterol, and lowered inflammation. The study suggests that prunes may be a promising addition to the diet to reduce CVD risk and inflammation.
A new study from the University of York suggests that Iron Age people kept everyday items like spoons and grinding stones as emotional reminders of deceased loved ones. This practice is replicated in societies across the globe today, revealing the raw emotional power that mundane objects can acquire at certain times and places.
A Curtin University-led study of ancient bones on Kangaroo Island has provided new insights into the island's past fauna and potential species reintroduction. The research identified 33 species, including extinct ones, and shed light on the impact of European arrival on biodiversity.
A research team from the University of Göttingen has observed a direct interaction between microtubules and intermediate filaments, leading to stabilisation and extended lifespan. This interaction is important for understanding cellular processes and may have implications for diseased cells.
A new international guidance on HR-pQCT provides an overview of current clinical applications and future directions in adults. The technology holds promise for fracture risk prediction, monitoring anti-osteoporosis therapy response, and assessing metabolic bone disorders.
Researchers at the University of Chicago have discovered how cells can remember and respond to environmental pressure by adjusting their protein structures. The team found that an optimal concentration of cross-linkers allows proteins to strengthen under stress, enabling the material to 'remember' past experiences.
Researchers at UVA School of Medicine have identified 19 new genes linked to bone mineral density, providing insights into osteoporosis. The study's novel approach uses laboratory mice to overcome human study limitations.
A study published in Atherosclerosis has found that the build-up of calcium in major blood vessels is linked to a 39% higher risk of serious falls in older women. The research used bone density scans to identify abdominal aortic calcification, which can be detected early on, and may help health professionals to prevent future falls.
Researchers found that middle-aged men with cerebral palsy are up to 5.6 times more likely to suffer fractures than men without the disorder. The study also revealed that critical periods of bone health vary across the lifespan for individuals with cerebral palsy, particularly affecting females and males at different times.
The journal honors the authors of its 10 most oft-cited 2019 papers with certificates of publishing excellence. The papers cover various topics in bone and musculoskeletal research, including muscle function, osteoporosis, and Paget's disease.
Research from the UK Biobank and the Genetic Factors for Osteoporosis consortium found that heavier birth weight is associated with a higher risk of bone fracture and osteoporosis. The study suggests that genes affecting birth weight may also influence an individual's risk of developing osteoporosis as they age.
A preclinical study supports AAV8-TNAP-D10 as a single-dose treatment for hypophosphatasia, extending the life span of mice with minimal side effects. The therapy may provide an alternative to current medication injections, benefiting patients with severe skeletal and dental abnormalities.
Regular strength and impact-type training decreases or prevents age-related bone loss, according to a new study at the University of Jyväskylä. High-intensity training preserves trabecular bone density and cross-sectional geometry, supporting its benefits for bone health.
Researchers developed an immunomodulatory approach using custom-made polymer microspheres to deliver magnesium ions directly into compromised bone. This accelerated bone regeneration rates by encouraging the immune system and skeletal system to work in tandem.
Researchers from Iowa State University discovered radiocarbon dates on rabbit and deer bones that suggest human occupation of the Coxcatlan Cave in Mexico may be up to 20,000 years older than previously thought. The findings could challenge the long-standing theory of human arrival in the Americas via the Bering Land Bridge.
The researchers developed a biomaterial made from discarded bullfrog skin and fish scales that acts as a scaffold for bone-forming cells to multiply, leading to the formation of new bone. The biomaterial has shown low risk of triggering an inflammatory response and could be used to assist with bone growth around surgical implants.
Patients undergoing total hip arthroplasty (THA) show significant improvements in pain, function, and quality of life, as well as improved walking gait biomechanics. However, daily physical activity levels remain largely unchanged, with most patients engaging in only light physical activity.
The Jebel Sahaba cemetery, 13 millennia old, was initially thought to be a testament to prehistoric warfare. However, recent analysis reveals a succession of violent episodes, likely exacerbated by climate change. The study found that individuals bore injuries from projectiles and repeated episodes of violence over their lifetimes.
A new study finds that 25-hydroxyvitamin D3 is an effective treatment for vitamin D deficiency in patients with fat malabsorption syndromes, including gastric bypass surgery and obesity. This water-soluble form of vitamin D3 is better absorbed in these patients and does not get diluted by body fat.
Researchers analyzed 12,000-year-old fish bones from three-spine sticklebacks to study the evolutionary process. They found that genetic variants enabling adaptation to freshwater existed in ocean populations thousands of years ago.
Researchers at Tel Aviv University have developed an active molecule (SNV) that can significantly suppress both inflammation and bone destruction around dental and orthopedic implants. The new technology has the potential to help people with implant failures, gum recession, or loose teeth due to periodontal disease.
A new bone shape measure, SBL, has been identified by researchers using AI to determine the severity of knee osteoarthritis. The study found that SBL values were consistently different from knees without joint space narrowing and associated with greater pain and disability.
Disparities in access to orthopaedic care via telemedicine were found to persist, particularly for Hispanic and Asian patients, as well as those with Medicaid coverage, compared to white patients, English speakers, and commercial insurance holders.
Researchers analyze soldiers' isotopes to determine geographical origin, finding 3 Breton soldiers and 28 French soldiers. The study provides unique insights into alliances and recruitment strategies in wars.
Researchers have mapped the genetic profile of osteocytes, a type of bone cell that controls skeleton growth and decay. The study identifies novel genes associated with rare and common skeletal diseases, paving the way for new treatments and improved diagnosis.
The International Osteoporosis Foundation has published a new Executive Summary outlining key guidance for managing osteoporosis in hematologic stem cell transplant recipients. The summary provides expert recommendations for monitoring, evaluation, and treatment of bone loss in HSCT patients, including a helpful management algorithm.
Researchers found that corals' ability to grow calcium carbonate skeletons evolved between 308 and 265 million years ago, with necessary proteins present in their soft-bodied ancestors. The team identified genes responsible for transporting calcium and removing protons, as well as an acid-rich protein involved in skeleton building.
Researchers developed natural polymer coatings that significantly improved metal electrochemical corrosion properties and allowed for cell attachment while disallowing bacterial attachment. These coatings can be modified to possess multifunctionality, opening a new era of applications in bone tissue engineering.
A new study based on research at a unique fossil site in Utah finds that tyrannosaurs were likely gregarious animals, with evidence suggesting they died together during a seasonal flooding event. The discovery sheds light on the behavior of these fearsome predators and challenges long-held assumptions about their solitary hunting habits.