Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
A team of researchers has discovered a new species of Polynesian sandpiper, the Prosobonia sauli, from fossilized bones found on Henderson Island. The bird is believed to have gone extinct soon after humans arrived on the island, which archaeologists estimate happened no earlier than the eleventh century.
Researchers propose that declining hip fracture rates may be linked to generational differences in lifetime lead exposure, with bone mineral density and risk of fractures decreasing as lead levels decrease. The authors suggest that assessing lead levels in bones removed during hip replacements could help validate this hypothesis.
Researchers analyzed data from the Global Burden of Disease Study 2017 to find a high burden of musculoskeletal disorders across the globe. The team found approximately 1.3 billion prevalent cases and 121,300 deaths due to these conditions.
A large-scale study found that LDCT scans can identify a significant number of adults with low bone mineral density, equating to 49 million and 22.8 million Chinese citizens, respectively. The study revealed an unexpectedly high prevalence of osteoporosis in men, which may impact management strategies.
Researchers have discovered that the iconic Clovis spear-point and other distinctive tools were created by North America's earliest inhabitants for only a brief 300-year period. This finding provides new insights into the origin and demise of the Clovis culture, which once occupied the continent at the end of the last Ice Age.
Researchers found that measures such as grip strength and lean mass are associated with bone density in premenopausal women, particularly those who engage in substantial physical activity. The study also highlights the importance of considering lifestyle factors beyond just body size and age.
A new ceramic artificial bone coating has been developed with improved adhesion strength, enabling robust coating on metal and polymer surfaces. This breakthrough reduces production cost and time for implant procedures, addressing issues such as inflammation and loose implants.
Research published in Thorax finds a clear association between steroid treatment and an increased risk of osteoporosis and fragility fractures. Patients prescribed high doses or multiple courses of steroid tablets were more likely to develop these conditions, highlighting the need for bone protection guidance in asthma management.
A new study from the University of South Australia reveals that children need a specific balance of physical activity, sleep, and sedentary time to optimize their bone health. The ideal combination includes 1.5 hours of moderate-to-vigorous exercise, 10.9 hours of sleep, and careful moderation of sedentary activities.
Researchers developed biocompatible tissue grafts that repaired both bone and cartilage in the temporomandibular joint (TMJ) of pigs. The study showed promising results with intact grafts after 6 months, outperforming existing designs.
Researchers discovered that immobilizing extremities alters the way stem cells interact with their extracellular environment, switching their fate from becoming debilitating bone to benign fat. This finding could help doctors optimize healing in patients with extremity injuries.
A study found that carnivores near people consume over half of their diets from human food sources, disrupting ecosystems. This reliance increases competition among predators, potentially leading to conflicts and detrimental ecological consequences.
A new study reveals that stem cells contribute to the formation of osteophytes, or pathological bone spurs, in arthritis patients. The researchers identified a specific type of stem cell with activity in the Sox9 gene as the major culprit behind this process.
Researchers at Radboud University Medical Center have redefined bone formation, finding that it does not require complex biomolecules in collagen. This breakthrough simplifies the production of bone substitutes and biomaterials.
A new study from Kanazawa University finds that combining antibiotics with antibiotic-laden stem cells effectively treats implant-related bone infections. The researchers used mesenchymal stem cells to deliver ciprofloxacin, which showed strong antimicrobial effects and improved outcomes in animal models of osteomyelitis.
A new study by Nagoya University reveals that narrow-range ultraviolet LED irradiation increases serum vitamin D levels and prevents the loss of bone and muscle mass in aging mice. This safe and stable method could be a promising approach for preventing and treating osteosarcopenia, a condition affecting daily life.
A research team led by Steven Emslie discovered an ancient Adélie penguin colony at Cape Irizar, Antarctica, which has been preserved for thousands of years under the ice. The study found three occupation periods of the cape, with the last one ending around 800 years ago.
A survey of 250 women orthopaedic surgeons found that 68% reported experiencing sexual harassment during their training, with common types including obscene images, unwanted touching, and invitations. Despite efforts to recruit more women and increase leadership positions, the problem persists, emphasizing the need for targeted trainin...
A new material has been developed to transplant bone-forming stem cells into severe bone fractures and speed up the healing process. The bone-like bandage is coated in a protein used for growth and repair, allowing it to enhance the natural ability of bones to heal.
WSU researchers have developed a new approach using soy-based compounds to reduce bone cancer cell viability and promote healthy bone cell growth. The slow release of these compounds from 3D-printed scaffolds showed promise in reducing inflammation and improving overall recovery.
Researchers found Botox short-term use in low doses does not cause significant bone loss, while higher doses were associated with reduced bone density. Long-term studies are needed to track potential cumulative effects.
Researchers found exposure to warmer temperatures improves bone strength, preventing bone density loss typical of osteoporosis. The gut microbiota plays a crucial role in this phenomenon, adapting to heat by disrupting polyamine synthesis and degradation, which affects osteoblasts and osteoclasts.
A central neural circuit in the forebrain to the hypothalamus mediates chronic stress-induced bone loss via the peripheral sympathetic nervous system. Isolation significantly increases anxiety levels, inducing bone loss in human subjects.
Researchers analyzed fossil bones of Panthasaurus maleriensis, an ancestor of modern amphibians, and found phases of rapid and slow growth depending on the climate. The study provides valuable insight into the prehistoric past, with the Indian site showing evidence of both young and adult animals.
A study found that inhibiting a specific signaling pathway can prevent microgravity-exposed mice from losing muscle and bone mass. The researchers tested this strategy by injecting a decoy receptor into the mice, resulting in similar increases in muscle and bone mass compared to untreated control mice.
Researchers used radiocarbon dating and CT scans to study ancient bones, revealing a Bronze Age tradition of retaining and curating human remains. The findings suggest that Bronze Age people valued the dead in tangible ways, often keeping remains in their homes or displaying them as grave goods.
A new fossil discovery has provided critical evidence for the evolution of the mammalian middle ear, revealing the first unequivocal evidence of the five auditory bones from an extinct group. The findings have narrowed the morphological gap between ancient and modern mammals.
Researchers discovered a new ichnospecies, Karethraichnus zaratan, living on the carapace of an extinct marine turtle during the Late Cretaceous period. The species is believed to be a bivalve that formed symbiotic relationships with its host, revealing new insights into ancient paleoecology and evolution.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism highlights the impact of anorexia nervosa on young women's growth. The research found that girls with anorexia nervosa tend to have stunted growth, which may affect their overall health and well-being.
Three experts, Professor Maria-Luisa Brandi, Dr. Lee Joon-Kiong, and Professor Ego Seeman, have been awarded the IOF President's Award for their contributions to osteoporosis research, education, and public awareness. The award recognizes their efforts to expand the Foundation's programs and outreach in the scientific and policy spheres.
Researchers found that adolescents who engaged in moderate-to-vigorous intensity physical activity had stronger hips at age 25, while time spent in light intensity activity was less clear. The study suggests that supporting young people to remain active could benefit future bone health and prevent osteoporosis.
A team of archaeologists uncovered evidence of the oldest direct cremation in the Middle-East, found in a pyre pit in Beisamoun, Israel, dating back around 9,000 years. The remains indicate a shift away from traditional burial practices towards shorter rituals.
A study published in Advanced Science has revealed that joint implants can release metals into the surrounding bone tissue, leading to osteolysis and premature loosening. The researchers used a unique synchrotron-based X-ray fluorescence imaging setup to determine the concentration and distribution of metallic degradation products.
A study published in The Lancet found that plaster casts are as effective as surgery in healing scaphoid waist fractures in the wrist. Patients who received a plaster cast showed similar outcomes to those who underwent surgery, with no significant difference in pain, function, or complications.
Researchers identified a small protein that mobilizes bone resorbing cells under osteoporotic conditions. Chemical inhibitors targeting this protein show promise in blocking bone resorption without disrupting normal bone turnover.
Researchers find drastic bone and organic matter deterioration since the site's initial excavations in the 1940s, suggesting similar decline may be happening across equivalent sites. The study highlights the urgent need to preserve findings from Ageröd and similar sites due to environmental changes like drainage and pollution.
Researchers at UMass Amherst have identified a key protein component of the Hedgehog signaling pathway as an important player in phenotypic plasticity, allowing cells to sense and respond to environmental inputs. This finding provides insights into how genes and environment interact to shape anatomical traits.
A comprehensive clinical review provides updated guidance on factors affecting peak bone mass, distinguishing low bone mass from proper osteoporosis in young women. The authors outline management and treatment options for premenopausal osteoporosis, including the use of antiresorptive and bone-forming drugs.
A new study analyzing 40 years of Framingham Heart Study data found an association between lowered rates of hip fractures and decreases in smoking and heavy drinking. The study suggests that modifiable lifestyle factors may be beneficial to bone health, along with treatments.
Researchers from the Universities of Bonn and Opole have discovered a fossilized hand with five metacarpal bones in a Late Triassic temnospondyl, Metoposaurus krasiejowensis. This finding is significant because it challenges the long-held assumption that early ancestors of modern frogs and salamanders had only four fingers. The discove...
New research has developed a Lego-inspired scaffolding system using tiny, 3D-printed blocks to promote faster and more efficient healing of broken bones. The study found that growth factor-filled blocks placed near repaired rat bones led to about three times more blood vessel growth than conventional scaffolding material.
A novel genetic measure called gSOS has been developed to assess fracture risk in osteoporosis, which could reduce the need for bone mineral density tests by 37-41%. This cost-effective approach may improve healthcare efficiency and identify individuals at higher risk of diseases like cancer and cardiovascular disease.
A global team of computer scientists developed a novel deep-learning framework to automate precise translation of human motion. The framework can accurately replicate motion retargeting without specifying explicit pairing between varying data sets, enabling the training of stronger models.
Researchers found similarities in dietary patterns between noble families and commoners, despite social differences. They also identified specific trace elements that revealed a person's diet and exposure to certain metals.
A team of archaeologists has discovered the earliest known domestic cat in northern Eurasia, dating back to the late 8th century AD. The well-preserved skeleton revealed that humans cared for the tomcat, suggesting a longer history of human-cat interactions than previously thought.
A recent study published in Communications Biology reveals that osteoblasts use extracellular vesicles to send signaling molecules to immature osteoclasts, triggering their differentiation into mature cells. This process is crucial for bone repair and regeneration after a fracture.
Researchers use advanced X-ray technology to study ancient fish fossils, revealing modern features and challenging previous assumptions about tooth evolution. The findings suggest that the ancestors of modern vertebrates retained a common dental structure, with new teeth added on the inside, contrary to long-held perceptions.
A recent study found that breast feeding during infancy reduces lower limb fracture risk, while maternal smoking increases upper limb fracture risk in young adulthood. Exposures during fetal development and early life have lasting effects on bone health.
Research team found that gut Piezo1 stimulates serotonin production in enterochromaffin cells, regulating gut and bone health. Serotonin is critical for gut function, emotion regulation, and blood pressure control.
Researchers found that a diet dominated by vegetables, cereals, beef, and mutton remained largely unchanged after the Norman Conquest. Only short-term changes were observed, with pork becoming a more popular choice and dairy products used less.
Scientists have identified similarities between ancient New Zealand penguins and Northern Hemisphere plotopterids, suggesting both groups were strong swimmers that used their wings to propel them deep underwater. The study sheds light on how birds evolved to use their wings for swimming instead of flying.
Researchers at Duke University have created a cartilage-mimicking gel that is strong and durable, matching the properties of natural cartilage. The gel has been tested to withstand heavy loads and repeated stress without losing its shape or deteriorating over time.
Forensic investigators can now analyze fragile human remains without excessive handling, thanks to a new 3D printing technique. This approach allows for effective physical fit analysis and demonstrates the potential for improved evidence presentation in court.
Researchers have developed bioactive factors-imprinted scaffold vehicles to promote bone healing by improving the stability and half-life of exogenous biofactors. The vehicles were used in various forms, including rigid bone graft substitutes, soft sponge-like scaffolds, and injectable vehicles, to enhance bone repair.
Researchers at Texas A&M University created superior bone grafts using primitive stem cells, which help create fertile scaffolds needed for bone regeneration. These grafts could reduce inflammation, pain, and the need for revision surgeries, promoting swift and precise bone healing.
Researchers have uncovered a previously unknown substructure in healthy bone tissue using new X-ray techniques, revealing deviations in the orientation of nanocrystals. This discovery has significant implications for understanding bone diseases and developing new biomaterials.
Low physical function and muscle mass after hip fracture increase the risk of accelerated bone deterioration in older patients. Substantial decrements in physical function, muscle strength occur after hip fracture, markedly increasing the risk for subsequent fractures.
Researchers analyzed remains from a 30,000-year-old burial site in France, revealing sorted bones and elaborate cave art. The study provides new insights into complex mortuary dynamics of the Gravettian culture.
Material scientists at Friedrich Schiller University Jena have developed a calcium phosphate cement with added carbon fibers that can seal cracks and promote self-healing. This intrinsic ability could expand the use of bone implants to include load-bearing areas, improving outcomes for patients with fractures or defects.
Researchers from the University of Nottingham found a rare bone in the hearts of wild chimpanzees, measuring only a few millimeters in size. This discovery could help advance the understanding and management of cardiovascular disease in these endangered animals.