Researchers developed a way to track rare diseases like DMD and FA using motion capture technology and AI. The approach identifies clear movement patterns, predicts future disease progression, and increases the efficiency of clinical trials.
Researchers found that selective serotonin reuptake inhibitors (SSRIs) affect reinforcement learning, leading to reduced sensitivity to rewards and emotional dullness. The study provides new insights into the mechanisms behind this common side effect.
The Australian black swan's genetic makeup makes it highly susceptible to viral illnesses like avian flu. Without common immune genes found in other waterfowl, the species is at risk of decimation if HPAI enters its native habitat.
Researchers from the University of Science and Technology of China revealed the point defect mechanism in antimony selenosulfide, leading to improved photovoltaic performance. The study used O-DLTS to detect defects driven by temperature and showed the formation and evolution of point defects through annealing.
Researchers successfully conducted the first Fermi-scale single-particle double-slit experiment using an unstable ρ0 meson in a high-energy heavy-ion collision. The study demonstrates wave-particle duality, where the meson's decay products exhibit interference patterns indicative of quantum entanglement.
Researchers from Bar-Ilan University have re-examined data on jet velocities and discovered that lower initial jet speed can explain perpetual emission, filling the gap between velocities. This finding changes the paradigm and proves that jets are formed in nature at all speeds.
A study by researchers from the University of Tsukuba found that ELOVL6 deficiency increases ceramide levels, leading to enhanced airway inflammation and reduced treatment efficacy in patients with severe asthma. Modulating lipid composition may provide a novel approach for treating resistant asthma.
Researchers have developed a van der Waals crystal featuring monolayer-like excitonic behavior in bulk form, leading to a verified weak interlayer electronic coupling. The crystal enables a spontaneous parametric down-conversion process, resulting in a detection of one photon heralding the presence of another.
Researchers from the University of Tsukuba found that web-based interventions are effective in promoting weight loss in people with overweight and obesity. The most effective components include social support, self-monitoring, behavioral goal setting, and personalized information.
Researchers developed a novel, calibration-free, and reconstruction-free imaging technique that directly obtains a clear image from a single shot of speckle images. The method uses real-time video imaging to build a three-dimensional image, taking slices through the speckles.
Scientists from Tokyo Metropolitan University have developed a new electrode material for deep-ultraviolet light-emitting diode applications, combining excellent electrical conductivity with unprecedented transparency. The new electrodes promise to impact industry by enabling more efficient and compact light sources for sterilization p...
A new study identifies how bacteria in deep-sea hydrothermal vents survive and thrive in the presence of toxic metals like copper and cadmium. Bacteria use transporter proteins to pump out these metals, but also employ more complex strategies, such as flagella formation and granule growth, to detoxify cadmium.
A combination of two novel immunotherapy drugs has shown promising clinical activity in treating patients with refractory metastatic colorectal cancer. The study found that 23% of patients had a tumor reduction, and the disease control rate was 76%. The treatment was well-tolerated, but adverse events were common.
Researchers used density functional theory to investigate the mechanical properties of superionic ice XVIII, which is thought to make up a large part of Neptune and Uranus. The study found that dislocations in the crystal lattice produce shear, leading to macroscopic deformations and potentially influencing the planets' magnetic fields.
Despite relaxed regulations, buprenorphine overdose deaths remained low and often involved multiple substances. The study suggests that expanded access to treatment for opioid use disorder is crucial to reducing overdose rates.
A new study reveals that vertebrate species involved in the live wildlife trade exhibit distinctive life history traits, including large numbers of offspring across long reproductive lifespans. This profile is likely financially advantageous for trades involving captive breeding, but also increases the risk of species becoming problema...
Researchers at the University of Reading are working on a £2 million project to increase UK-grown faba beans in bread, improving nutritional quality and sustainability. The 'Raising the Pulse' project aims to encourage farmers to switch wheat-producing land to faba bean for human consumption.
Researchers identified geographic, racial and ethnic, socioeconomic, and clinical characteristics as key contributors to the elevated suicide risk among cancer patients. Timely symptom management and targeted psychosocial interventions are crucial for preventing suicide in individuals diagnosed with cancer.
A study by the University of Tsukuba found that Siebold's beech populations on Okushiri Island have high genetic diversity, suggesting they may have persisted there since before the last glacial maximum. This challenges the assumption that island populations are less genetically diverse due to geographical isolation.
Researchers from the STAR Collaboration have observed a global spin alignment signal in heavy-ion collisions, showing a preference for one state over two in phi mesons. The surprising pattern cannot be explained by conventional mechanisms and is linked to local fluctuations in the strong force within the quark-gluon plasma.
Researchers discovered that female and male mouse hearts react uniformly at first to noradrenaline but exhibit differences in recovery time, affecting electrical activity. These findings may contribute to arrhythmia susceptibility between men and women, offering new insights into sex-based responses to stress hormones.
A Phase 3 clinical trial has shown that a four-drug chemotherapy regimen significantly increases overall survival and progression-free survival in patients with stage 4 pancreatic ductal adenocarcinoma. The study's results suggest that this more aggressive treatment approach may be considered for eligible patients.
A controlled clinical trial has shown that the new drug leriglitazone can prevent neurodegeneration and brain inflammation in patients with X-linked adrenoleukodystrophy. The study found improvements in neurological conditions such as balance disorders, which had a positive impact on quality of life.
Scientists used multi-isotope imaging mass spectrometry to identify key contributors to blood vessel obstruction in PAH. The study reveals proline and glucose play a crucial role in forming excess scar tissue, which obstructs blood flow.
Researchers at Aston University have created the world's first computer reconstruction of a virus, including its complete native genome. This breakthrough could lead to the development of targeted treatments to kill bacteria that are dangerous to humans, reducing the threat of antibiotic resistance.
The implementation of the Affordable Care Act led to a significant reduction in uninsured adults under 65 with schizophrenia, from 8.4% to 4%. Medicaid coverage increased by 70%, while Medicare and private insurance coverage also rose.
A new study found that red sea urchin populations in Northern and Southern California have different levels of vulnerability to climate change. The researchers grew juvenile sea urchins in outdoor tanks and exposed them to changing conditions, showing that the Southern California population is more sensitive to environmental changes.
A new study led by Mayo Clinic researchers found that women carrying specific genetic changes, such as BRCA1 and BRCA2, have a twofold increased risk of developing contralateral breast cancer. Premenopausal women with these mutations are more likely to develop cancer in both breasts.
A research team led by Dr. Eddie Ma Chi-him identified a therapeutic small molecule M1 that increases mitochondrial dynamics and sustains long-distance axon regeneration, restoring visual functions in mice. Regenerated axons elicited neural activities and survived for four weeks after optic nerve injury.
A new genetic disorder causing immunodeficiency and susceptibility to opportunistic infections, including life-threatening fungal pneumonia, has been identified. The mutation affects the IRF4 gene and alters the protein's normal gene expression profile.
A study by researchers at the University of Göttingen investigated the effect of mixing wheat and faba beans on pollinating insects. They found that areas with mixed crops were visited equally often by foraging bees as those with single crops. The findings suggest that this mixture may counteract pollinator decline.
Researchers analyzed how immunological memory gets generated and maintained to understand its role in cancer and inflammatory diseases. They found that increased inflammation can actually reduce immunological memory, highlighting the need for regulation.
A novel KRAS mutation promotes tumor evasion from innate immune surveillance by activating CD47, leading to decreased phagocytosis of cancer cells. Disruption of the KRAS-CD47 signaling axis with siRNA or inhibitors restores innate immune surveillance and enhances macrophage phagocytic capacity.
A new 'whipping jet' aerosol sprayer can precisely control how aerosols move, a crucial aspect of various industries. The technology has potential applications in pharmaceutical sciences, climate research, automotive, food processing, and carbon capture.
Researchers from UCalgary and the World Health Organization found that people with hybrid immunity have the highest level of protection against severe illness and reinfection, offering a key finding for public policy makers. The study suggests vaccination should be prioritized even among those who have had COVID-19.
A recent study reveals that high-severity wildfires are increasing in Sierra Nevada and Southern Cascade forests, with the average annual area burned at high severity nearly quintupled since before Euro-American settlement. This trend is concerning as most affected forest types are adapted to low-to-moderate severity burning.
A new study published in JAMA Network Open suggests that an early return to school after a concussion can lead to better outcomes. The study found that returning to school sooner was linked to lower symptom burdens in youth aged 8-12 and 13-18, potentially due to therapeutic benefits from normal activities.
A team of researchers observed magnetically mediated hole pairing in a synthetic crystal, confirming theories that magnetic fluctuations give rise to pairing. The experiments suggest significant mobility of bound hole pairs, which could be efficient carriers of currents.
Researchers at University of Galway have created a digital microbe database, AGORA2, which enables computer simulations of how drug treatments work and how patients respond. The resource offers personalized predictions of differences in metabolism between individuals for diseases such as Parkinson’s and colorectal cancer.
A new study suggests that producing the same amount of steel with zero emissions is unlikely, and that reducing demand through material efficiency and upcycling could be key. The research highlights the need for a more strategic approach to decarbonization, rather than relying on technological innovations alone.
Researchers at MUSC Hollings Cancer Center discovered the cellular origin of normal pancreatic fibroblasts and cancer-associated fibroblasts, which play a key role in tumor progression. The findings suggest that targeting cancer-associated fibroblasts holds exciting potential for therapeutic benefits.
Researchers discovered that interfacial water promotes non-thermal C-H activation by abstracting hydrogen from methane, improving conversion rates dramatically. This work provides a fundamental basis for designing non-thermal catalytic systems for sustainable methane utilization under ambient conditions.
Citizen science project EEE enables students to collect and analyze data on cosmic rays, producing secondary particles that can be detected on Earth. The network of 60 detectors across Italy allows for correlations between events hundreds of kilometers apart.
Biomedical engineers at the University of Cincinnati are investigating the potential of interstitial fluid for early disease diagnosis and long-term health monitoring. The study proposes sampling interstitial fluid just under the skin using tiny microneedles, offering a more accessible and less painful alternative to blood testing.
A new study published in JAMA Network Open suggests that an early return to school is associated with better outcomes for children who have suffered a concussion. The study found that children who returned to school within two days of their injury had lower symptom burdens and faster recoveries compared to those who stayed home longer.
A recent study by CSIC reveals that soil biodiversity is essential for the maintenance of urban greenspaces, supporting various ecosystem functions such as carbon sequestration and water regulation. The study highlights the importance of invertebrates and microbes in these ecosystems, emphasizing their role in maintaining soil health.
A new method has been developed to calibrate the activity-based travel demand model, taking into account bounded rationality and interdependencies between activities. The study uses a simultaneous perturbation stochastic approximation method to solve the calibration problem.
A recent study found that college students reporting high levels of loneliness were more likely to have altered diet quality and engage in sedentary behavior. The research suggests that interventions targeting loneliness may also promote health improvement among this population.
Researchers have used a technique called QCM-D to observe the interplay between hydration structures and ion configurations in layered materials. The study found that the hydration structure plays a crucial role in determining the material's ion-storage capacity, with flexible layers helping to stabilize the structure.
A nationwide study using Google Street View images found that predominantly White neighborhoods had better neighborhood conditions associated with good health, such as fewer neglected buildings and more greenery. In contrast, neighborhoods with residents who were primarily Black or of other minority races had fewer green spaces and mor...
Researchers found that orienteering can improve spatial navigation and memory in healthy adults, suggesting it could be a useful intervention to prevent cognitive decline. The sport's unique combination of physical exercise and navigational skills may stimulate parts of the brain that are no longer needed due to modern conveniences.
Researchers discover piperlongumine (PL), extracted from long pepper, as a potent antiviral treatment for SARS-CoV-2. PL delays disease progression and reduces lung inflammation in mice infected with alpha, delta, and omicron variants, offering a potential solution to combat upcoming outbreaks.
The full parallel programme for WCSJ 2023 has been published, featuring 24 sessions across five tracks on biodiversity, climate change and more. The conference takes place from March 27-31 in Medellín, offering pre-conference workshops and post-conference tours.
The study reveals that repeated mutations in the sarZ gene lead to increased severity of MRSA blood stream infections, and that surface protein ClfB plays a critical role in pathogenesis. The findings provide insights into the factors contributing to MRSA virulence and may help uncover new treatment approaches.
The article highlights that forests are not just threatened by agricultural expansion, but also by the consumption of non-agricultural products and international trade. Intact forests play a crucial role in regulating climate and biodiversity, and their loss can have significant indirect impacts on carbon emissions and biodiversity loss.
Researchers identified structural changes in the thalamus and strengthened connections with the temporal cortex, enabling visual cortex activation through non-visual stimuli.
Measurements taken by University of Copenhagen researchers show high air pollution levels in the Copenhagen metro, with ultra-small particles 10-20 times higher than on heavily trafficked streets. The pollution comes mainly from trains' brakes and rails, posing a health risk to frequent users.
A recent study of over 42,000 patients found low adherence to COVID-19 booster dose recommendations among immunocompromised individuals. This vulnerable population faces increased risk of severe COVID-19, underscoring the importance of tailored efforts to ensure they remain up-to-date with booster doses.
Researchers used museum collections to measure ecological response to climate change in central Norway, finding clear regional connections and impacts on species life cycles. Small temperature changes can have significant effects on species distribution and biodiversity.
A study found that wind turbines in forests cause common noctules, a threatened bat species, to collide with blades and lose foraging space. The researchers recommend building turbines at least 500 meters away from roosts and compensating for lost habitats elsewhere.