Research from Michigan Medicine found that combining online resources and phone-based coaching increased genetic testing rates by 5% after six months and 10% after a year. The interventions aimed to overcome barriers to testing, including lack of knowledge and fear, and tailored approaches for individual needs.
Researchers enhanced cancer sequencing with long-read nanopore sequencing, detecting genetic alterations missed by conventional sequencing. The study found 32 tumors with unexplained causes resolved by long-read sequencing, and identified inherited cancer risk and gene therapy complications.
Researchers found that RPT04402 can stabilize protein phosphatase 2A to suppress growth of cancer cells. The compound showed promise in treating non-small cell lung cancers with KRAS mutations and uterine cancer, with tumors shrinking in mouse models.
Researchers will enroll 1,500 children, ages 0-24 months, and study biological and environmental factors linked to recovery, severe illness, and long-term lung health. The goal is to identify patterns that explain why children follow different paths after an early viral infection.
Gene therapies can already change clinical care, but their use in common conditions raises concerns about permanent harm and competition with existing treatments. Cardiologists propose strategies for determining when genomic therapy is justified, including considering the benefits, risks, and long-term safety monitoring.
A national poll found that four in five parents struggle financially to raise young children, with many supporting policies like paid leave, formula subsidies, and free childcare to alleviate these burdens. Parents are finding creative ways to make ends meet, but many want to help but are unsure where to start.
A new study found significant disparities in access to anti-amyloid Alzheimer's treatments, with Black adults and Hispanic adults having lower odds of receiving the medication. However, once treatment began, patients were equally likely to take the medication as prescribed, regardless of their race or ethnicity.
According to a new poll, 60% of older adults spend less than an hour choosing their Medicare coverage during Open Enrollment, with 27% not reviewing their options at all. 80% stick with their current coverage, and 25% consult Medicare's plan-finding tool or hotline as their most important source of information.
A study of 1,600 recent medical school graduates reveals that 1/3 of OB-GYN residents develop clinical depression in their first year of training, with only 1/3 seeking help. The findings highlight a need for increased support during residency, particularly in a field dominated by women.
Researchers found tens of thousands of e/sQTL signals with high resolution in large-scale studies, revealing more control switches for genes and increasing the understanding of genetic variation and disease connections. The study highlights the importance of collecting tissue samples for larger sample sizes, particularly for non-Europe...
A recent study found that 57% of girls who started their periods at age 9-10 reported painful periods, with those experiencing more physical puberty symptoms more likely to report pain. Sleep disturbances were associated with the amount of pain that interfered with daily life, but were not predictive of future period pain.
A new study shows that hospitals still have far to go in implementing strategies to prevent catheter-associated urinary tract infections (CAUTIs), despite 20 years of effort. The study found that only 49% of general hospitals and 32% of VA hospitals have a system in place to remind doctors of a patient's catheter status, and that highe...
Researchers found that well-designed digital alerts can assist clinicians in high-pressure situations, prompting them to make recommended treatment decisions and recognize when patients are deteriorating. The studies demonstrated the effectiveness of electronic health record alerts in the emergency department and cardiac intensive care...
The Michigan ADRC will support studies on basic science, clinical trials, caregiver interventions, and longitudinal research to advance Alzheimer's disease prevention, treatment, and care. The center aims to fast-track clinical trials and improve the health and well-being of caregivers.
Researchers discovered a new pathway that sensitizes mIDH1 gliomas to radiation, inhibiting autophagy and delivering small RNAs to kill cancer cells. In mouse models, 60% of animals were cured of their tumors and survived long-term without developing tumors.
A new study reveals that workers with variable hours and incomes are more likely to rely on Medicaid or ACA Marketplace plans, which may be affected by 2027 changes. Millions of low- and middle-income workers with irregular schedules will be particularly susceptible to Medicaid disenrollment due to fluctuating work hours.
A new study by Michigan Medicine found that heart surgery infection rates vary significantly across U.S. hospitals, with some experiencing nearly double the risk of others. By reducing infections, hospitals could prevent 2,600 infections and reduce Medicare spending by $441 million annually.
A new study reveals that psychedelics and anesthetics create 'mirror image' patterns in brain organization, with opposite network features. Researchers found that psychedelics increase functional connectivity, while sleep and anesthesia reduce it.
A study found that probiotic supplement use increased 287% among adults and 786% among young people, while fiber intake remained unchanged, between 2009 and 2023. Probiotic users consumed more high-microbial foods and fiber content than non-users, but these beneficial diet habits may be decreasing due to supplement use.
C.S. Mott Children's Hospital is the first hospital in the US to implant an expandable heart valve, the Autus Valve, during the FDA review phase. The device is designed to grow with children and can potentially reduce the need for replacement surgeries.
Researchers developed an oral drug that can increase the ability of T cells to attack tumors, improving the efficacy of cancer immunotherapy. The gut-borne compound 3,4-dihydroxybenzoic acid trains T cells to become memory T cells, which drive anti-tumor immune responses.
According to a national poll, many parents face challenges getting their kids to eat a healthy breakfast before school. Common barriers include picky eating, time constraints, and morning moods. Parents can make a difference by offering nutritious options and letting their child decide, even with busy school mornings.
Researchers at Michigan Medicine identified two pathways that can be targeted to treat transdifferentiated prostate tumors. Using a combination of BET bromodomain and DNMT inhibitors, the growth of prostate cancer cell lines and tumors in mice was suppressed, reversing gene expression changes and reducing tumor growth.
A new study found that 23% of emergency department boarding patients wait at least 4 hours before receiving inpatient-quality care, with some patients waiting 12 or 24 hours. The study highlights the importance of efficient handoffs from emergency to inpatient care, particularly for vulnerable populations.
Researchers have found that Prevotella melaninogenica can survive in the presence of oxygen, challenging a long-held assumption about its obligate anaerobic nature. The study also reveals new insights into the bacteria's ability to consume oxygen and deal with oxidative stress.
A study found a sharp increase in leucovorin dispensing to children aged 0-17 after a press conference touting its autism benefits, despite limited evidence supporting the claim. The spike in prescriptions rose 700% between 2024 and 2025, with the largest increases seen among children ages 6-11 and in the southern US.
A new study examines the KEYNOTE-689 trial cohort to determine whether anticipated survival benefits outweigh the costs based on a standard threshold. Patients with higher combined positive scores saw significant quality-adjusted life years gains with perioperative pembrolizumab.
A national poll reveals that nearly one in six parents say their young adult child doesn't handle basic healthcare tasks independently. Parents attribute the gap to a lack of knowledge and experience, with most reporting they've done enough to prepare their child for health responsibility.
Researchers found that CRISPR-Cas systems regulate the expression of innate immunity genes to defend against bacteriophages. This layered regulatory hierarchy provides a layer of protection, making it challenging for phages to evade the defense mechanisms.
A study published in Nature Medicine found that a single daily dose of a polypill significantly enhances cardiac function and reduces hospitalizations for patients with heart failure. The treatment, which combines three types of medications, shows promise as a simplified approach to optimal therapy.
A new University of Michigan poll reveals that 31% of people aged 50 and over have never heard of any mental health crisis line, while 69% are unfamiliar with 988. Despite this, most participants expressed willingness to use these services in a mental health emergency, highlighting the need for increased awareness-raising efforts.
Researchers identified a specific pocket within ERG and developed a small molecule probe, PBITE-1, that can bind to it. This breakthrough allows for the targeting of ERG in prostate cancer cells, potentially leading to personalized therapy.
Researchers discovered a potential drug developed at Michigan Medicine reverses metabolic dysfunction-associated steatohepatitis (MASH) in animal models by disrupting the disease-driving pathway that links the gut and liver. DT-109 improved gut health, reducing inflammation in livers of nonhuman primates.
A new poll shows nearly all Michiganders age 50 and over value keeping their brains healthy, but less than half know daily habits can reduce dementia risk. Only half practice key brain-protecting habits.
Researchers at University of Michigan Health have implanted the first wireless brain-computer interface (BCI) to restore communication in a patient with motor neuron disease. The study, called Connect-One Early Feasibility Study, aims to assess the device's long-term safety and effectiveness in synthesizing text and speech.
Colorectal cancer cells exploit a specific mitochondrial complex, complex II, to buffer iron toxicity and prevent cell death. By knocking out this complex, researchers found that cancer cells were more susceptible to cell death, suggesting it as a promising target for drug development.
The University of Michigan has successfully implanted the first-in-human Paradromics wireless brain-computer interface, designed to restore communication for patients with difficulty speaking. The clinical trial will focus on the device's long-term safety and assess its ability to restore communication through synthesized text and speech.
Half of parents track their adult kids' locations occasionally, with 1 in 4 saying it increases anxiety. While tracking provides reassurance, constant access to information can also fuel anxiety and blur the lines between safety and privacy.
Researchers have developed an algorithmic tool called CytoSignal that can analyze spatial transcriptomic data to infer cell-cell communication. The method can identify defective signaling interactions underlying diseases and potentially lead to new treatments by targeting specific receptor proteins.
Research on deer mice reveals a unique gene family, Phf8y, that acquired from the X chromosome and duplicated itself on the Y chromosome. This discovery provides insights into how the Y chromosome defends against decay and maintains fertility in males.
LGBTQ+ adults over 50 face disparities in health care, mental health, and social connections compared to non-LGBTQ+ peers. They are more likely to experience discrimination and feel isolated from others.
Researchers have announced promising results of the B-Well clinical trials, showing that 20% and 19% of patients achieved a functional cure for their chronic hepatitis B infections after 24 weeks of bepirovirsen treatment. This represents a significant step towards developing a curative treatment for the disease.
Researchers have discovered that precursor lesions in the pancreas, often considered a step towards cancer, do not undergo malignant transformation if they lack a specific microenvironment. The team used advanced technologies to isolate and analyze single cells from over 150 donated pancreases, finding that the microenvironment surroun...
A national poll reveals that most parents value private conversations between teens and healthcare providers during checkups, but few actually provide such opportunities. Experts suggest that these barriers can hinder young people from seeking care for sensitive issues like mental health and reproductive health.
A new peer-reviewed study found that Michigan State University's Rx Kids program is associated with substantial reductions in child maltreatment investigations among infants. The program provided early economic support to families, leading to a 7-percentage-point decline or 32% relative reduction in maltreatment investigations.
Elective MRI screenings may lead to false positives, unnecessary surgery, and emotional harm. Experts argue that detecting certain cancers early is not always beneficial, and the scans can exacerbate anxiety rather than improve quality of life.
Research suggests that tailoring weight loss strategies to individual patients can help preserve lean mass and reduce the risk of regaining weight. The study found that a specific gut hormone, FGF15, plays a key role in this process.
A new dual-targeting compound, SH-273, has been developed to improve immunotherapy treatments for pancreatic cancer. The drug simultaneously activates STING and inhibits PI3Kγ, increasing the survival of pancreatic cancer mouse models to 201 days.
A new study published in the American Journal of Obstetrics and Gynecology finds that approximately 11.8% of reproductive-age Latina women have fibroids, lower than previously estimated rates. The study, led by Michigan Medicine researchers, used ultrasound-confirmed diagnoses to confirm fibroid cases.
A new study found that Michigan Medicaid expansion helped enrollees significantly reduce their medical debt in collections by up to 75% within seven years of enrollment. Additionally, the study shows substantial drops in sub-prime credit scores, improving financial stability and long-term health outcomes.