C.S. Mott Children's Hospital is the first hospital in the US to implant an expandable heart valve, the Autus Valve, during the FDA review phase. The device is designed to grow with children and can potentially reduce the need for replacement surgeries.
Researchers developed an oral drug that can increase the ability of T cells to attack tumors, improving the efficacy of cancer immunotherapy. The gut-borne compound 3,4-dihydroxybenzoic acid trains T cells to become memory T cells, which drive anti-tumor immune responses.
According to a national poll, many parents face challenges getting their kids to eat a healthy breakfast before school. Common barriers include picky eating, time constraints, and morning moods. Parents can make a difference by offering nutritious options and letting their child decide, even with busy school mornings.
Researchers at Michigan Medicine identified two pathways that can be targeted to treat transdifferentiated prostate tumors. Using a combination of BET bromodomain and DNMT inhibitors, the growth of prostate cancer cell lines and tumors in mice was suppressed, reversing gene expression changes and reducing tumor growth.
A new study found that 23% of emergency department boarding patients wait at least 4 hours before receiving inpatient-quality care, with some patients waiting 12 or 24 hours. The study highlights the importance of efficient handoffs from emergency to inpatient care, particularly for vulnerable populations.
Researchers have found that Prevotella melaninogenica can survive in the presence of oxygen, challenging a long-held assumption about its obligate anaerobic nature. The study also reveals new insights into the bacteria's ability to consume oxygen and deal with oxidative stress.
A study found a sharp increase in leucovorin dispensing to children aged 0-17 after a press conference touting its autism benefits, despite limited evidence supporting the claim. The spike in prescriptions rose 700% between 2024 and 2025, with the largest increases seen among children ages 6-11 and in the southern US.
A new study examines the KEYNOTE-689 trial cohort to determine whether anticipated survival benefits outweigh the costs based on a standard threshold. Patients with higher combined positive scores saw significant quality-adjusted life years gains with perioperative pembrolizumab.
A national poll reveals that nearly one in six parents say their young adult child doesn't handle basic healthcare tasks independently. Parents attribute the gap to a lack of knowledge and experience, with most reporting they've done enough to prepare their child for health responsibility.
Researchers found that CRISPR-Cas systems regulate the expression of innate immunity genes to defend against bacteriophages. This layered regulatory hierarchy provides a layer of protection, making it challenging for phages to evade the defense mechanisms.
A study published in Nature Medicine found that a single daily dose of a polypill significantly enhances cardiac function and reduces hospitalizations for patients with heart failure. The treatment, which combines three types of medications, shows promise as a simplified approach to optimal therapy.
A new University of Michigan poll reveals that 31% of people aged 50 and over have never heard of any mental health crisis line, while 69% are unfamiliar with 988. Despite this, most participants expressed willingness to use these services in a mental health emergency, highlighting the need for increased awareness-raising efforts.
Researchers identified a specific pocket within ERG and developed a small molecule probe, PBITE-1, that can bind to it. This breakthrough allows for the targeting of ERG in prostate cancer cells, potentially leading to personalized therapy.
Researchers discovered a potential drug developed at Michigan Medicine reverses metabolic dysfunction-associated steatohepatitis (MASH) in animal models by disrupting the disease-driving pathway that links the gut and liver. DT-109 improved gut health, reducing inflammation in livers of nonhuman primates.
A new poll shows nearly all Michiganders age 50 and over value keeping their brains healthy, but less than half know daily habits can reduce dementia risk. Only half practice key brain-protecting habits.
Researchers at University of Michigan Health have implanted the first wireless brain-computer interface (BCI) to restore communication in a patient with motor neuron disease. The study, called Connect-One Early Feasibility Study, aims to assess the device's long-term safety and effectiveness in synthesizing text and speech.
Colorectal cancer cells exploit a specific mitochondrial complex, complex II, to buffer iron toxicity and prevent cell death. By knocking out this complex, researchers found that cancer cells were more susceptible to cell death, suggesting it as a promising target for drug development.
The University of Michigan has successfully implanted the first-in-human Paradromics wireless brain-computer interface, designed to restore communication for patients with difficulty speaking. The clinical trial will focus on the device's long-term safety and assess its ability to restore communication through synthesized text and speech.
Half of parents track their adult kids' locations occasionally, with 1 in 4 saying it increases anxiety. While tracking provides reassurance, constant access to information can also fuel anxiety and blur the lines between safety and privacy.
Researchers have developed an algorithmic tool called CytoSignal that can analyze spatial transcriptomic data to infer cell-cell communication. The method can identify defective signaling interactions underlying diseases and potentially lead to new treatments by targeting specific receptor proteins.
Research on deer mice reveals a unique gene family, Phf8y, that acquired from the X chromosome and duplicated itself on the Y chromosome. This discovery provides insights into how the Y chromosome defends against decay and maintains fertility in males.
LGBTQ+ adults over 50 face disparities in health care, mental health, and social connections compared to non-LGBTQ+ peers. They are more likely to experience discrimination and feel isolated from others.
Researchers have announced promising results of the B-Well clinical trials, showing that 20% and 19% of patients achieved a functional cure for their chronic hepatitis B infections after 24 weeks of bepirovirsen treatment. This represents a significant step towards developing a curative treatment for the disease.
Researchers have discovered that precursor lesions in the pancreas, often considered a step towards cancer, do not undergo malignant transformation if they lack a specific microenvironment. The team used advanced technologies to isolate and analyze single cells from over 150 donated pancreases, finding that the microenvironment surroun...
A national poll reveals that most parents value private conversations between teens and healthcare providers during checkups, but few actually provide such opportunities. Experts suggest that these barriers can hinder young people from seeking care for sensitive issues like mental health and reproductive health.
A new peer-reviewed study found that Michigan State University's Rx Kids program is associated with substantial reductions in child maltreatment investigations among infants. The program provided early economic support to families, leading to a 7-percentage-point decline or 32% relative reduction in maltreatment investigations.
Elective MRI screenings may lead to false positives, unnecessary surgery, and emotional harm. Experts argue that detecting certain cancers early is not always beneficial, and the scans can exacerbate anxiety rather than improve quality of life.
Research suggests that tailoring weight loss strategies to individual patients can help preserve lean mass and reduce the risk of regaining weight. The study found that a specific gut hormone, FGF15, plays a key role in this process.
A new dual-targeting compound, SH-273, has been developed to improve immunotherapy treatments for pancreatic cancer. The drug simultaneously activates STING and inhibits PI3Kγ, increasing the survival of pancreatic cancer mouse models to 201 days.
A new study published in the American Journal of Obstetrics and Gynecology finds that approximately 11.8% of reproductive-age Latina women have fibroids, lower than previously estimated rates. The study, led by Michigan Medicine researchers, used ultrasound-confirmed diagnoses to confirm fibroid cases.
A new study found that Michigan Medicaid expansion helped enrollees significantly reduce their medical debt in collections by up to 75% within seven years of enrollment. Additionally, the study shows substantial drops in sub-prime credit scores, improving financial stability and long-term health outcomes.
A new study shows that while dental opioid prescription fills in the US have dropped by 27% since 2021, the rate remains higher than in other developed countries and the US territory of Puerto Rico. The study suggests that some US dentists are still overprescribing opioids.
A national study found that people with severe strokes have a five times higher odds of developing dementia. Stroke severity also affects thinking and memory after stroke, highlighting the need for close monitoring and treatment of dementia risk factors.
Researchers found distinct gut microbiome characteristics that predicted treatment response to the low FODMAP diet and rifaximin. Patients who responded to these treatments had different microbial signatures, with increases in diversity for those on the low FODMAP diet and resilience against antibiotics for those on rifaximin.
A national poll suggests that one in three parents report their young adult children are minimally active or inactive, with lack of interest and screen time being major barriers. Parents often try to encourage physical activity through verbal encouragement, activities, and exercising together, but many efforts are not successful.
A new study found that pregnancy-related deaths increased sharply during the pandemic, particularly among Black women, but rates have since returned to pre-pandemic levels for most groups. However, disparities persist, especially in later postpartum deaths, which remain elevated for non-Hispanic Black mothers.
A new University of Michigan-led research has identified a connection between keratin 16 and type 1 interferon in the molecular pathways of pachyonychia congenita. The study found that losing or altering K16 causes amplification of the inflammatory response, but also helps pump the brakes on that response.
People aged 50 and over who serve as unpaid family caregivers are more likely to support government-funded care, while non-caregivers prefer family or older adult payment. Concerns about long-term care costs and access persist among caregivers versus non-caregivers.
A new study identified PIKfyve as a promising therapeutic target for gastroenteropancreatic neuroendocrine tumors (GEP-NETs), leading to longer survival in mouse models. By targeting two separate pathways that control lipid synthesis, the researchers found that inhibiting PIKfyve reduced tumor volume and weight compared to controls.
A new study identified two enzymes, glucose-6-phosphate dehydrogenase and malic enzyme 1, that can influence metabolic changes in pancreatic cells. Decreased activity of these enzymes results in increased reactive oxygen species, leading to precancerous lesion formation.
Researchers have developed copper-loaded starch nanoparticles that can be broken down by specific bacteria to release antibacterial copper molecules. These nanoparticles were effective against Staphylococcus aureus and Bacillus subtilis, with improved targeting capabilities compared to previous studies.
A web-based platform, GIFT, educates people with cancer about the impact of genetic variants on their family. The tool allows patients to invite relatives and provides information, decision support, and access to genetic testing.
A new poll finds that nearly a third of Americans over 50 provide regular care to an adult relative or friend with a health issue or disability, highlighting the need for increased awareness of existing programs such as adult day programs and respite care. Many caregivers face financial stress and don't know about or use these resource...
A new study from Michigan Medicine found that over 7% of Americans have thought about shooting someone, while 8.7 million adults considered it in the last year. Firearm owners were no more likely to have these thoughts than non-owners, but 21% of those who had thoughts said they would consider giving their gun to someone for safekeeping.
A new pediatric mental health care model, P2C3, combines primary care and psychiatry to improve access and training for future pediatricians. The model, which has completed over 1,500 visits and cared for over 400 patients, has shown durable and scalable results, reducing fragmentation and providing timely access to mental health care.
A national poll finds 1 in 3 parents worry their teen or young adult driver could cause an accident, with most witnessing unsafe driving behaviors. Despite concerns, most parents rate their child's driving as average or better, and relatively few impose consequences for risky behaviors.
Researchers found that fedratinib inhibits BRD4, activating a transcriptional pathway that induces ERMCS formation and causes structural changes in organelles. The study provides a potential therapeutic avenue for diseases like neurodegeneration, obesity, and cancer.
Researchers from Michigan Medicine discovered that photoreceptor cell death is reversible and can be rescued by removing damaged mitochondria. The study found that mitophagy, a process that removes dysfunctional mitochondria, plays a crucial role in this recovery process.
Researchers discovered that 53% of newborns with myelomeningocele had sleep-disordered breathing, highlighting the need for routine screening and early intervention to prevent long-term complications. The study's findings suggest that addressing sleep disorders in high-risk infants could meaningfully improve their neurodevelopment.
Researchers found that glucose levels sustain increased STAT3 activation in colorectal cancer cells. Targeting glucose metabolism could inhibit STAT3 and lead to novel therapeutic strategies.