University of Michigan researchers propose a technique called Dynamic Sensor Selection to identify disease biomarkers. The approach, which applies control theory and observability principles to biological systems, has been shown to pinpoint biomarkers at each time point and reduce data complexity.
Poor blood sugar control in adolescence increases the risk of painful future complications for people with type 1 diabetes. Children diagnosed with type 1 diabetes at a young age have trouble controlling their blood sugar as teens and are more likely to develop neuropathy in adulthood.
Researchers analyzed 659 posts on Reddit to better understand the role of social media in managing inflammatory bowel disease. The study found that patients use social media to track symptoms, manage medications, and cope with stress.
A new study shows that a multi-step effort to reduce unneeded pre-operative testing, using a tailored program for each hospital, can lead to significant reductions in wasteful tests. The findings have already spurred an expansion of the program to 16 more Michigan hospitals.
A study published in PLOS Biology finds no evidence of subcortical processing for selective attention, suggesting the auditory cortex 'turns up the volume' on focused sound. Researchers used novel experimental techniques to test this hypothesis using audiobooks and diotic and dichotic listening tasks.
A phase 3 clinical trial found that sotatercept significantly reduces the likelihood of worsening disease in patients with severe pulmonary hypertension when added to standard treatment within the first year after diagnosis. The medication reduced the risk of deterioration by 76% and hospitalizations by nearly half.
A study found that 21% of Gen X women and 10% of men meet criteria for ultra-processed food addiction, with a higher prevalence in older women. The study highlights the link between ultra-processed foods and risk of chronic disease and premature death, particularly among those who perceive themselves as overweight.
Researchers evaluated over 3,000 ischemic stroke patients and found that telestroke patients were 1.6 times more likely to receive clot-busting drugs, but took nearly seven minutes longer to receive treatment after arriving at the hospital. The study highlights clear gaps in timely treatment for these patients.
Researchers discovered that sperm mark centromeres with less CENPA, leading to unequal strength between maternal and paternal chromosomes. To compensate, a second protein, CENPC, recruits extra CENPA to the father's chromosomes, equalizing centromeric strength before cell division.
Using embryoid models made of stem cells, researchers uncovered important processes mimicking the first moments of human development. The team applied AI neural networks to thousands of images collected with confocal fluorescent microscopy to detect features and protein marker expression data.
A new study suggests that children with chronic medical conditions are more likely to experience food insecurity, which can have negative health consequences. The prevalence of food insecurity remained high in this group, even after accounting for key family and household characteristics.
A new poll finds that 38% of people over 50 have had a spouse or other adult at their health care appointment, and 34% have accompanied another person. The vast majority said having someone was helpful, with 92% reporting it made them feel comfortable sharing information and helped them follow through on instructions.
Researchers found that fish oil supplements were ineffective in preventing colorectal tumors in mice lacking the enzyme ALOX15. The team also discovered that different forms of omega-3 fatty acids, such as EPA and DHA, varied in their ability to inhibit tumor growth.
Researchers used adult stem cells to improve vision in patients with advanced dry age-related macular degeneration. The treatment was safe and showed significant vision gain, particularly in severely affected patients.
A new national poll reveals that parents of children with health conditions are less confident about their child's ability to have a positive school year. The poll found that these parents are more likely to be concerned about their child adjusting to a new school or teacher, dealing with conflict, staying healthy, and fitting in.
As states prepare to implement work requirements for Medicaid expansion, a University of Michigan health care researcher emphasizes the need for key actions to protect enrollees with chronic conditions. Ayanian's guidance includes steps for healthcare providers and organizations to ensure individuals do not lose coverage if they qualify.
Scientists have solved a mystery vexing biological chemists for over 30 years by determining 3D structures of blood clotting proteins using cryo-electron microscopy. The discovery sheds light on how the cascade of events that leads to blood clotting is triggered, with potential implications for anticoagulant drugs like Warfarin.
A new study suggests that contingency management, which uses cash or gift certificate prizes as incentives, can reduce the risk of death among veterans with stimulant use disorder. The study found a 41% lower risk of death in veterans who received contingency management care compared to those who didn't.
A study published in Circulation found that abnormal cell growth in blood vessels leads to organ deterioration and failure in patients with APS. The researchers identified CCN1 and CCN2 proteins as key players in the process, raising hope for new treatment strategies.
Researchers discovered that glioblastoma cells differ from normal cells in how they consume certain nutrients, which can be targeted to slow tumor growth and improve treatment responses. Amino acid-restricted diets may also enhance treatment outcomes by limiting the availability of building blocks for cancer cell growth.
Researchers discovered a specific cell that responds to environmental toxins found in cigarettes, leading to aggressive tumor growth in mice with pancreatic cancer. The study also identified a type of immune cell that fuels this response while stopping the immune system from fighting tumor growth.
A recent study by Michigan Medicine researchers has found that CRISPR-Cas9 forms immune memories in bacteria by boosting spacer acquisition when RNA levels are low. This discovery expands our understanding of how bacteria safeguard their immune memory and may inspire new ways to design CRISPR-based molecular recording tools.
A new study found that fewer than half of children with sickle cell disease and Medicaid in Michigan received dental services. Dental health is crucial for these children due to the reciprocal relationship between the disease and oral infections.
A new U-M study found that xylazine does not amplify the decrease in breathing rate caused by fentanyl use, but reduces heart rate more than fentanyl. This reduction in heart rate may be a more important driver of increased overdose risk, highlighting the need for further research into polysubstance use involving opioids.
A new study published in PNAS reveals how prostate tumors respond to treatment by identifying key cellular features. The researchers created a comprehensive cellular atlas of mouse prostates using single-cell RNA sequencing, multiomics, and spatial transcriptomics, which provided insights into the progression of human disease.
A new study published in Clinical Gastroenterology and Hepatology shows that AI analysis can accurately identify mucosal ulceration as well as human reviewers, providing a more objective and reproducible assessment of Crohn's disease. The findings have potential implications for education, drug development, and automated care.
A new University of Michigan study found that critically ill patients without health insurance are less likely to receive inter-hospital transfers for treatment, leading to higher mortality rates. Patients with commercial insurance have a significantly lower risk of death compared to those without insurance or with Medicare/Medicaid.
A study published in Molecular Metabolism found that specific brain neurons in the hypothalamus play a crucial role in maintaining blood glucose levels during day-to-day activities. These neurons help regulate lipolysis, breaking down fat to produce glycerol and sugar.
A recent University of Michigan-led study found that almost 10% of patients with sepsis who were previously healthy died within 90 days. These patients tended to have less organ failure and more COVID-19 related sepsis than those with underlying health conditions.
Researchers developed PathoPlex to map over 140 proteins across 40 tissue samples, identifying kidney stress-related groups of proteins in individuals with type 2 diabetes. The technology revealed protein patterns that can link organ dysfunction and disease progression.
A study in mice found that high triglyceride levels directly cause abdominal aortic aneurysms, challenging the notion that they are merely biomarkers of vascular disease. Researchers identified specific proteins and lipoproteins as causal drivers of aneurysm development and growth.
A new study by Michigan Medicine University of Michigan researchers concludes that broad COVID-19 vaccination in adults saves the US more money than it spends, with significant economic benefits for those over 65 and middle-aged adults. The model focuses on preventing deaths, hospitalizations, and lost productivity.
Key findings show a decline in childhood and adolescent immunization rates in Michigan, with completion rates dropping sharply during the COVID-19 pandemic. The study highlights the need for targeted efforts to increase immunization rates in counties with lower income and higher uninsurance rates.
A recent study found that human gut evolution is closely tied to the recent surge in gastrointestinal disorders globally. The research team created human and chimpanzee intestinal organoids using stem cells, identifying key genetic differences that may have primed the human intestine for better nutrient absorption.
Targeting CDK12/13 strongly activates STING signaling pathway, enhancing effectiveness of immunotherapies. Inactivation of both CDK12 and CDK13 is associated with higher T cell activity and better treatment outcomes in various cancers.
Researchers from Michigan Medicine found that glutamine is essential for photoreceptor survival, and its imbalance can lead to rapid vision loss. Maintaining glutamine levels may help prevent vision loss and blindness by supporting amino acid biosynthesis and suppressing the integrated stress response.
A national study finds that the percentage of patients who wait four or more hours for a hospital bed has increased significantly, with even lower rates during non-peak months. The issue, known as 'boarding,' has become a major concern, putting patient safety at risk and straining emergency departments.
A new study published in JAMA Health Forum suggests that Medicare could save $3.6 billion annually by eliminating or reducing low-value tests and procedures for patients who do not benefit from them. This reduction in unnecessary care could also result in $800 million less in out-of-pocket costs for older adults.
Researchers uncover more clues about the risk conferred by variants in the MUTYH gene, which can cause abnormal growths and increase colon cancer risk. The study's high-throughput functional analysis method accurately sorts variants into functional and non-functional categories.
Research from Michigan Medicine found that one in three patients remain connected to a breathing tube after passing a spontaneous breathing trial, increasing the risk of ventilator-associated complications. The study highlights the importance of close communication between healthcare teams to determine the safest time for extubation.
A low FODMAP diet has been shown to improve colonic barrier function and reduce mast cell activation in patients with IBS-D. The study found that the diet reduced symptoms of diarrhea and abdominal pain, and improved intestinal permeability.
Two studies from University of Michigan researchers suggest many older adults and people with disabilities need more impartial help picking the best Medicare plan. Only about 13% of enrollees switch plans annually, and even fewer use the internet to research options.
A study of 22 million urgent care visits found 12.4% of patients received antibiotics, 9.1% glucocorticoids, and 1.3% opioids for generally inappropriate diagnoses. The trends highlight the need for improved clinician knowledge, patient demand, and decision support.
A recent study published in Nature Metabolism found that patients with type 2 diabetes have accumulated misfolded proteins in their mitochondria, which can lead to cell death. The researchers hope that targeting the protein-folding mechanism could be a new avenue for therapy.
A new report reveals that one in five parents experience potty anxiety during toilet training, while another one in five finds the process harder than expected. Parents cite various reasons for starting potty training, including readiness signs, daycare or preschool requirements, and cost pressures.
A new poll suggests that older adults are divided on the use of artificial intelligence (AI), with some expressing curiosity and others skepticism. The study found that nearly all participants wanted clear labeling of AI-generated information, while also acknowledging its potential benefits for independent living. However, many express...
A study suggests that more than half of newborns diagnosed with HIV by age one did not receive preventative medicine after birth, indicating undetected maternal infections. The study highlights racial disparities in HIV exposure, infection, and treatment, with the majority of infants who had not been treated being Black.
A new study from the University of Michigan Rogel Cancer Center identifies a cellular signature that explains why about one-third of prostate cancers respond especially poorly to treatment. The researchers found that docetaxel could be a good option earlier on in patients whose tumor harbors a specific gene program linked to extreme no...
A study of over 2,500 adults aged 50-80 found that nearly 1 in 6 take aspirin for cardiovascular protection without a history of heart disease. Despite revised guidelines reducing aspirin use for primary prevention after age 70, many patients are unaware of the increased risk of bleeding.
Researchers discovered two distinct ways mutation of the FOXA1 gene alters tumor formation and therapy resistance in prostate cancer in mouse models. The findings provide insight into how different classes of FOXA1 mutations operate, shedding light on the complex mechanisms driving prostate cancer progression.