A newly developed tool called the DILI-Inpt prognostic score can predict which hospitalized patients with severe idiosyncratic drug-induced liver injury are unlikely to recover on their own. The scoring system outperformed existing systems in identifying patients at high risk of death and liver transplant need.
Leading experts urge universal hepatitis B vaccination for all newborns in the US, citing a 95% decline in infant infections since 1991. The policy has prevented an estimated one million hospitalizations and 90,000 deaths.
A two-stage, 24-week controlled trial found that patients who received lactulose therapy followed by tai-chi experienced fewer falls compared to a control group. The rate of injurious and non-injurious falls was significantly improved for those receiving both treatments.
A new poll found large gaps in knowledge about palliative care and hospice among older adults, with many unaware of the options despite interest expressed once explained. The poll highlights racial and demographic differences in understanding and interest, with some groups more likely to know about these types of care.
Research from Michigan Medicine uncovers connections between a longevity gene, behavior, and environment, suggesting that manipulating stress responses could extend life without downsides. Touch activates a circuit modulating signals to reduce the longevity effect of dietary restriction.
Two new studies found that 75% of adults prefer non-colonoscopy screening options like stool tests, while physicians prefer colonoscopy. Additionally, follow-up colonoscopies rose 41% after a policy change eliminated patient cost sharing for abnormal home-based stool tests.
Cardiac rehabilitation significantly improves short and long-term recovery for heart surgery patients, but women participate less than men due to barriers such as lower referral rates, clinician bias, and caregiving responsibilities. The American Heart Association scientific statement calls for targeted interventions to improve enrollm...
Researchers discovered that brains and economies follow similar rules in crisis, using physics principles to predict collapse and recovery. The study found that networks closer to first-order transition show faster collapse and slower recovery after a crisis.
A University of Michigan study found that Medicaid coverage is linked to employment gains among low-income adults with serious health problems. Employment nearly doubled among enrollees who experienced improved health, from 26% to 47%. This suggests that Medicaid expansion may actually help individuals participate in the workforce.
A study found that further testing in renal cell carcinoma with an overexpression of gene TRIM63 could uncover a mutation otherwise undetected, leading to more treatment options. In cases where tumors were positive for TRIM63 on a biomarker level but FISH negative, 70% ended up having MiTF gene rearrangement.
Researchers found that RNA modifications regulated Six3 RNA stability and inhibited stem cells-to-retina formation. The study also discovered a surprising effect of METTL3 on DNA without affecting its shape.
Rates of medications for opioid use disorder (MOUD) use increased among surgical patients from 2016 to 2022, with buprenorphine being the primary driver. MOUD use was highest in debridement and orthopedic procedures, highlighting the need for clinical practice guidelines to coordinate care and pain management.
A new poll reveals that 19% of people age 50 and over identify as a person with a disability, while half may be entitled to protections and accommodations due to physical or mental conditions. Despite this, only 18% receive accommodations for healthcare visits.
Researchers have discovered a novel compound that degrades key proteins found in prostate cancer cells, blocking oncogenic androgen receptor signaling. The study found that levels of H2BNTac, p300 and CBP are elevated in prostate cancer compared to normal tissue.
A national poll found that 1 in 10 young children play outdoors as infrequently as once a week, while nearly all engage in screen time daily. Parents are encouraged to create space for active, imaginative, and social play to support healthy development.
Physician Organization of Michigan ACO (POM ACO) has achieved significant savings for Medicare by reducing unnecessary spending and focusing on preventive care. The organization's efforts saved Medicare nearly $35 million in 2024, with members sharing in the $17 million incentive.
A recent study by the University of Michigan highlights the issue of limited language accessibility in patient portals, which can prevent vulnerable patients from accessing vital healthcare services. The study found that 29% of hospitals only offer access to their patient portal in English, and fewer than 5% offer it in the most common...
A new study finds that benzodiazepines and antipsychotics prescribed to patients with dementia receiving hospice care may carry major unintended risks, including increased mortality. The study highlights two policy issues: lack of oversight of medication use in hospice and a mismatch between hospice policy and dementia care.
University of Michigan researchers propose a technique called Dynamic Sensor Selection to identify disease biomarkers. The approach, which applies control theory and observability principles to biological systems, has been shown to pinpoint biomarkers at each time point and reduce data complexity.
Poor blood sugar control in adolescence increases the risk of painful future complications for people with type 1 diabetes. Children diagnosed with type 1 diabetes at a young age have trouble controlling their blood sugar as teens and are more likely to develop neuropathy in adulthood.
Researchers analyzed 659 posts on Reddit to better understand the role of social media in managing inflammatory bowel disease. The study found that patients use social media to track symptoms, manage medications, and cope with stress.
A new study shows that a multi-step effort to reduce unneeded pre-operative testing, using a tailored program for each hospital, can lead to significant reductions in wasteful tests. The findings have already spurred an expansion of the program to 16 more Michigan hospitals.
A study published in PLOS Biology finds no evidence of subcortical processing for selective attention, suggesting the auditory cortex 'turns up the volume' on focused sound. Researchers used novel experimental techniques to test this hypothesis using audiobooks and diotic and dichotic listening tasks.
A phase 3 clinical trial found that sotatercept significantly reduces the likelihood of worsening disease in patients with severe pulmonary hypertension when added to standard treatment within the first year after diagnosis. The medication reduced the risk of deterioration by 76% and hospitalizations by nearly half.
A study found that 21% of Gen X women and 10% of men meet criteria for ultra-processed food addiction, with a higher prevalence in older women. The study highlights the link between ultra-processed foods and risk of chronic disease and premature death, particularly among those who perceive themselves as overweight.
Researchers evaluated over 3,000 ischemic stroke patients and found that telestroke patients were 1.6 times more likely to receive clot-busting drugs, but took nearly seven minutes longer to receive treatment after arriving at the hospital. The study highlights clear gaps in timely treatment for these patients.
Researchers discovered that sperm mark centromeres with less CENPA, leading to unequal strength between maternal and paternal chromosomes. To compensate, a second protein, CENPC, recruits extra CENPA to the father's chromosomes, equalizing centromeric strength before cell division.
Using embryoid models made of stem cells, researchers uncovered important processes mimicking the first moments of human development. The team applied AI neural networks to thousands of images collected with confocal fluorescent microscopy to detect features and protein marker expression data.
A new study suggests that children with chronic medical conditions are more likely to experience food insecurity, which can have negative health consequences. The prevalence of food insecurity remained high in this group, even after accounting for key family and household characteristics.
A new poll finds that 38% of people over 50 have had a spouse or other adult at their health care appointment, and 34% have accompanied another person. The vast majority said having someone was helpful, with 92% reporting it made them feel comfortable sharing information and helped them follow through on instructions.
Researchers found that fish oil supplements were ineffective in preventing colorectal tumors in mice lacking the enzyme ALOX15. The team also discovered that different forms of omega-3 fatty acids, such as EPA and DHA, varied in their ability to inhibit tumor growth.
Researchers used adult stem cells to improve vision in patients with advanced dry age-related macular degeneration. The treatment was safe and showed significant vision gain, particularly in severely affected patients.
A new national poll reveals that parents of children with health conditions are less confident about their child's ability to have a positive school year. The poll found that these parents are more likely to be concerned about their child adjusting to a new school or teacher, dealing with conflict, staying healthy, and fitting in.
As states prepare to implement work requirements for Medicaid expansion, a University of Michigan health care researcher emphasizes the need for key actions to protect enrollees with chronic conditions. Ayanian's guidance includes steps for healthcare providers and organizations to ensure individuals do not lose coverage if they qualify.
Scientists have solved a mystery vexing biological chemists for over 30 years by determining 3D structures of blood clotting proteins using cryo-electron microscopy. The discovery sheds light on how the cascade of events that leads to blood clotting is triggered, with potential implications for anticoagulant drugs like Warfarin.
A new study suggests that contingency management, which uses cash or gift certificate prizes as incentives, can reduce the risk of death among veterans with stimulant use disorder. The study found a 41% lower risk of death in veterans who received contingency management care compared to those who didn't.
A study published in Circulation found that abnormal cell growth in blood vessels leads to organ deterioration and failure in patients with APS. The researchers identified CCN1 and CCN2 proteins as key players in the process, raising hope for new treatment strategies.
Researchers discovered that glioblastoma cells differ from normal cells in how they consume certain nutrients, which can be targeted to slow tumor growth and improve treatment responses. Amino acid-restricted diets may also enhance treatment outcomes by limiting the availability of building blocks for cancer cell growth.
Researchers discovered a specific cell that responds to environmental toxins found in cigarettes, leading to aggressive tumor growth in mice with pancreatic cancer. The study also identified a type of immune cell that fuels this response while stopping the immune system from fighting tumor growth.
A recent study by Michigan Medicine researchers has found that CRISPR-Cas9 forms immune memories in bacteria by boosting spacer acquisition when RNA levels are low. This discovery expands our understanding of how bacteria safeguard their immune memory and may inspire new ways to design CRISPR-based molecular recording tools.
A new study found that fewer than half of children with sickle cell disease and Medicaid in Michigan received dental services. Dental health is crucial for these children due to the reciprocal relationship between the disease and oral infections.
A new U-M study found that xylazine does not amplify the decrease in breathing rate caused by fentanyl use, but reduces heart rate more than fentanyl. This reduction in heart rate may be a more important driver of increased overdose risk, highlighting the need for further research into polysubstance use involving opioids.
A new study published in PNAS reveals how prostate tumors respond to treatment by identifying key cellular features. The researchers created a comprehensive cellular atlas of mouse prostates using single-cell RNA sequencing, multiomics, and spatial transcriptomics, which provided insights into the progression of human disease.
A new study published in Clinical Gastroenterology and Hepatology shows that AI analysis can accurately identify mucosal ulceration as well as human reviewers, providing a more objective and reproducible assessment of Crohn's disease. The findings have potential implications for education, drug development, and automated care.
A new University of Michigan study found that critically ill patients without health insurance are less likely to receive inter-hospital transfers for treatment, leading to higher mortality rates. Patients with commercial insurance have a significantly lower risk of death compared to those without insurance or with Medicare/Medicaid.
A study published in Molecular Metabolism found that specific brain neurons in the hypothalamus play a crucial role in maintaining blood glucose levels during day-to-day activities. These neurons help regulate lipolysis, breaking down fat to produce glycerol and sugar.
A recent University of Michigan-led study found that almost 10% of patients with sepsis who were previously healthy died within 90 days. These patients tended to have less organ failure and more COVID-19 related sepsis than those with underlying health conditions.
Researchers developed PathoPlex to map over 140 proteins across 40 tissue samples, identifying kidney stress-related groups of proteins in individuals with type 2 diabetes. The technology revealed protein patterns that can link organ dysfunction and disease progression.
A study in mice found that high triglyceride levels directly cause abdominal aortic aneurysms, challenging the notion that they are merely biomarkers of vascular disease. Researchers identified specific proteins and lipoproteins as causal drivers of aneurysm development and growth.
A new study by Michigan Medicine University of Michigan researchers concludes that broad COVID-19 vaccination in adults saves the US more money than it spends, with significant economic benefits for those over 65 and middle-aged adults. The model focuses on preventing deaths, hospitalizations, and lost productivity.