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Science News for December 15, 2025


On the energy loss maximization in gas-liquid two-phase flows driven by rotors

The study reveals that torque maximization arises from both direct collisions and pressure imbalances in gas-liquid interface waves. This phenomenon is significant for energy savings and optimal design in complex industrial equipment, such as power transmission devices, cooling systems, and chemical agitators.

SourceThe University of Osaka·JournalMultiphase Science and Technology·TypeComputational simulation/modeling·DateDec 15, 2025

Hospitality sector edges closer to delivering on diversity promise

A new study by Flinders University researcher Ashokkumar Manoharan finds that despite widespread acceptance of DEI regulations, applicants may still encounter barriers to securing roles due to automated processes on job sites. The research highlights the importance of transparency and adequate resources in meaningful DEI initiatives.

SourceFlinders University·JournalInternational Journal of Hospitality Management·TypeData/statistical analysis·DateDec 15, 2025

HKUST-led study warns of climate “whiplash” threatening global stability by 2064

A new climate study reveals that extreme weather events starting in 2064 will have catastrophic impacts on food production, water management, and clean energy systems. The research predicts a significant increase in 'subseasonal whiplash' events characterized by extreme downpours and dry spells in Asia and broader tropical regions.

SourceHong Kong University of Science and Technology·JournalScience Advances·TypeMeta-analysis·DateDec 15, 2025

New framework reveals where transport emissions concentrate in Singapore

A new framework reveals that compact, mixed-use districts like One-North are designed to generate cleaner travel patterns, but the reality is more complex. Emissions hotspots were identified at major arterial roads, weaker transit-accessible edges of districts, and busy corridors like North Buona Vista Road.

SourceSingapore University of Technology and Design·JournalInternational Journal on Smart and Sustainable Cities·DateDec 15, 2025

Dual-function biomaterials for postoperative osteosarcoma: Tumor suppression and bone regeneration

Researchers have developed dual-function biomaterials that can suppress tumors and regenerate bone, offering a promising strategy to address the challenges of postoperative osteosarcoma. The materials are designed to enhance antitumor efficacy while minimizing systemic toxicity, and also provide structural support for bone regeneration.

SourceResearch·JournalResearch·TypeNews article·DateDec 15, 2025

Synergistic interface engineering in Cu-Zn-Ce catalysts for efficient CO2 hydrogenation to methanol

Researchers developed a Cu-Zn-Ce ternary catalyst using an innovative urea-assisted grinding strategy, overcoming interfacial limitations and achieving high CH3OH selectivity. The active site is identified as a composite structure consisting of Cu0-Zn2+-Ov-Ce3+, where Zn species donate electrons to Cu, enhancing CO2 activation.

Scalable and healable gradient textiles for multi‑scenario radiative cooling via bicomponent blow spinning

Researchers have developed ultra-flexible self-healing micro-fibre textiles engineered with dual-built-in gradients that reflect and absorb radiation, providing efficient radiative cooling for various scenarios. These gradient-textiles offer a sustainable route to beat the heat anywhere under the Sun.

SourceShanghai Jiao Tong University Journal Center·JournalNano-Micro Letters·TypeNews article·DateDec 15, 2025

Development of the Japanese version of WHO indicators to assess inclusive social participation of persons with disabilities

The University of Tsukuba developed a Japanese version of WHO indicators to assess inclusive social participation of persons with disabilities. The indicators were validated through an online survey among persons with and without disabilities, demonstrating strong internal consistency and construct validity.

SourceUniversity of Tsukuba·JournalDisability and Rehabilitation·DateDec 15, 2025

COVID-19 leaves a lasting mark on the human brain

Researchers found altered brain tissue microstructure and neurochemical profiles in Long COVID and recovered COVID-19 individuals through advanced MRI techniques. This study provides vital insights into how COVID-19 affects the central nervous system, potentially explaining cognitive problems reported after infection.

SourceGriffith University·TypeCase study·DateDec 15, 2025

The number of abortions decreased by nearly a quarter in Spain during the two months of strict lockdown due to COVID-19

The study found that abortions in Spain fell by around 24% during the two months of strict lockdown due to COVID-19, mainly due to a decrease in unwanted pregnancies among single women. The number of abortions remained low even after the lockdown ended and did not differ between cohabiting and single women.

SourceUniversitat Pompeu Fabra - Barcelona·JournalPopulation and Development Review·TypeData/statistical analysis·DateDec 15, 2025

Hidden viruses in wastewater treatment may shape public health risks, study finds

Researchers discovered complex viral communities in wastewater treatment plants, interacting with bacteria to influence treatment efficiency and health risks. The study found that viruses can act as reliable biological indicators of treatment performance, while also potentially promoting the spread of antibiotic resistance genes.

Who is more likely to get long COVID?

Researchers have identified 32 causal genes that increase the likelihood of developing long COVID, including 13 new genes not previously associated with the disease. The study's findings could lead to more precise diagnoses and treatment options for the condition, which affects an estimated 400 million people worldwide.

SourceUniversity of South Australia·JournalPLOS Computational Biology·TypeData/statistical analysis·DateDec 15, 2025

Alcohol causes cancer. A study from IOCB Prague confirms damage to DNA and shows how cells defend against it

Researchers found that alcohol causes DNA damage, which can lead to cancer, and discovered a repair mechanism using the SXE enzyme complex. Individuals with genetic mutations affecting DNA repair may be more susceptible to alcohol-related cancers.

Seeing farther: A new camera-based technique detects distant vehicles for safer roads

A new method analyzes nearby vehicle motion to estimate road's trajectory and vanishing point, capturing distant road areas and enhancing safety. The system outperformed conventional and deep learning-based techniques in tests under day and night conditions, reducing intersection-related accidents.

SourceShibaura Institute of Technology·JournalIEEE Open Journal of Intelligent Transportation Systems·TypeComputational simulation/modeling·DateDec 15, 2025

Saving lives, not raising birthrates, is Eastern Europe’s best hope against population decline

A new study reveals that reducing mortality through large-scale investment in public health is a more effective and ethically sound strategy than encouraging people to have more children. By focusing on lowering mortality rates, countries can slow population decline and maximize the return on investment in their existing population.

SourceInternational Institute for Applied Systems Analysis·JournalBulletin of the World Health Organization·DateDec 15, 2025

Fossil fuel industry’s “climate false solutions” reinforce its power and aggravate environmental injustice

A study by Universitat Autonoma de Barcelona finds that fossil fuel companies' promoted low-carbon projects are ineffective in reducing emissions and prolonging the lifespan of fossil fuel infrastructures. These projects reinforce the industry's power and aggravate environmental injustice, while delaying a rapid phase-out of fossil fuels.

SourceUniversitat Autonoma de Barcelona·JournalEnergy Research & Social Science·TypeCase study·DateDec 15, 2025

An ‘illuminating’ design sheds light on cholesterol

A team of researchers at the University of Pennsylvania has designed a new light-controlled cholesterol molecule that selectively targets two poorly understood sterol transport proteins, ORP1 and ORP2. This breakthrough enables precise spatiotemporal control over cholesterol's biological activity, paving the way for advanced therapeutics.

SourceUniversity of Pennsylvania·JournalJournal of the American Chemical Society·TypeExperimental study·DateDec 15, 2025

Reducing saturated fat intake shows mortality benefit, but only in high-risk individuals

A systematic review of 17 randomized trials found that reducing saturated fat intake lowered all-cause mortality and cardiovascular deaths among high-cardiovascular risk individuals. For people at low to intermediate risk, cutting or replacing saturated fat intake offered little benefit over 5 years. The study suggests that saturated f...

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeNews article·DateDec 15, 2025

Machine learning offers growers a new tool for predicting crop water use

A new study demonstrates strong performance in predicting daily crop transpiration using machine-learning models and high-resolution lysimeter data. Machine learning can reliably predict daily transpiration from environmental conditions and plant characteristics, highlighting an important conceptual step toward plant-driven prediction ...

SourceThe Hebrew University of Jerusalem·JournalPlant Cell & Environment·TypeObservational study·DateDec 15, 2025

Surfing on the waves of the microcosm

Researchers use model calculations to optimize work extraction from fluctuating environments, enabling the development of nanomachines that can efficiently transport nutrients and other molecules within cells. The study's findings have significant implications for understanding thermodynamics in the microscopic world.

SourceHeinrich-Heine University Duesseldorf·JournalNature Communications·DateDec 15, 2025

Illinois Grainger Engineers develop reconfigurable slow-light platform for on-chip photonic engineering

The Illinois Grainger Engineers have developed a reconfigurable slow-light platform for on-chip photonic engineering, which enables high spectral resolution features. This technology has the potential to be used for classical and quantum applications such as quantum memory, single photon storage, and exotic structures.

Mapping the future: AI method to transform alloy properties prediction and design

Researchers at the University of Illinois developed a machine learning approach to analyze diffraction patterns and capture an alloy's microstructure in unprecedented detail. This method accelerates alloy property prediction by orders of magnitude, enabling rapid fundamental understanding of structure properties in metals.

SourceUniversity of Illinois Grainger College of Engineering·Journalnpj Computational Materials·DateDec 15, 2025

An atlas of personality profiles created by Estonian researchers reveals patterns between personality and life events

The study pooled data from 90 previously published research papers, standardizing 162 different phenotypes, including life events, traits, or choices. The researchers found five large groups of personality profiles, each characterized by distinct patterns of neuroticism, extraversion, and sociability.

SourceEstonian Research Council·JournalPersonality Science·TypeMeta-analysis·DateDec 15, 2025

Moss and symbionts offer a promising solution for removing metals from mining and forestry-impacted waters

Mosses have been found to remove metals from water by utilizing the help of their microbial symbionts. The key to this process is the cooperation between the moss and its endophytes, which enhance metal tolerance. Mosses from polluted environments were found to host more beneficial microbes that facilitate metal removal.

SourceUniversity of Oulu, Finland·JournaliMetaOmics·DateDec 15, 2025

Raw materials from CO

Researchers have created a novel synthetic enzyme that efficiently converts CO2 into formic acid, opening up new possibilities for biotechnological production of valuable chemicals and fuels. The enzyme, FAR, tolerates high concentrations of formate and is stable in both living cells and cell-free systems.

SourceMax-Planck-Gesellschaft·JournalACS Catalysis·DateDec 15, 2025

Climate shapes arms race between ants and their social parasites

Two new studies show how climate shapes the behavior, communication, and genome evolution of ants and their social parasites, leading to adaptation in this long-standing conflict. Climate influences aggression, chemical profiles, and genetic strategies in both hosts and parasites, with varying responses across different climates.

SourceJohannes Gutenberg Universitaet Mainz·JournalJournal of Evolutionary Biology·TypeObservational study·DateDec 15, 2025

Buffalo's deadly blizzard revealed when travel bans lose their power over time

A new framework uses weather indicators to estimate how quickly a travel ban may start to lose effectiveness. The approach could inform targeted interventions before storms hit and preserve emergency measures' legitimacy while keeping people safer. It was developed after analyzing two Buffalo storms in late 2022.

SourceNYU Tandon School of Engineering·JournalTransport Policy·TypeData/statistical analysis·DateDec 15, 2025

Groundbreaking University of Limerick, Ireland research reveals personality traits are powerful predictors of risk of death

A major new study from University of Limerick analysing almost six million person-years of data has revealed that personality traits are linked to longevity and risk of death. The research highlights that personality is likely associated with risk of death through an influence on a range of health behaviours and biological processes.

SourceUniversity of Limerick·JournalJournal of Personality and Social Psychology·TypeMeta-analysis·DateDec 15, 2025

Study: Mixed results in using lipoic acid to treat progressive multiple sclerosis

A randomized controlled trial found that lipoic acid had a small beneficial effect on slowing brain atrophy in people with progressive multiple sclerosis. However, it did not improve walking speed as the primary clinical outcome. The study suggests that lipoic acid may be worth further investigation for its potential benefits.

SourceOregon Health & Science University·JournalNeurology·TypeRandomized controlled/clinical trial·DateDec 15, 2025

Dual-UAV system boosts color accuracy in crop remote sensing

A dual-UAV color correction method improves crop remote sensing accuracy by over 70%, aligning image color with ground-truth measurements and enabling more precise phenotyping and agricultural decision-making. The technology offers a scalable pathway for reliable high-throughput applications in precision agriculture.

SourceNanjing Agricultural University The Academy of Science·JournalPlant Phenomics·TypeExperimental study·DateDec 15, 2025

Contaminated bathing water easier to detect

A new method uses machine learning and flow cytometry to detect contaminated bathing water, providing faster and more complete answers on water safety. The method has several advantages, including being open-source and able to detect changes in entire bacterial communities.

SourceLund University·JournalWater Research X·DateDec 15, 2025

UT Health Sciences researchers demonstrate breakthroughs in cancer treatment quality through AI-enhanced data analytics

Researchers at UT Health Sciences Center have developed an AI-enhanced platform called ENRICH, which leverages advanced analytics with community-based human support to reduce treatment interruptions and improve cancer outcomes. The program identifies patients at highest risk for interruption and deploys targeted support resources.

SourceUniversity of Tennessee Health Science Center·TypeData/statistical analysis·DateDec 15, 2025

Biologists discover neurons use physical signals — not electricity — to stabilize communication

Researchers at USC Dornsife College of Letters, Arts and Sciences discovered that neurons can rapidly adjust their signaling using a fast, physical mechanism. This system relies on structural cues rather than electrical signals to maintain balance between neurons, which is essential for muscle control, learning, and overall brain health.

SourceUniversity of Southern California·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateDec 15, 2025

New research finds Zillow’s Zestimate reduces uncertainty and improves outcomes for both buyers and sellers

New research found that Zestimate boosts efficiency in the residential real estate sector while benefiting lower-income neighborhoods. The algorithm helps alleviate uncertainty about property values, leading to increased buyer surplus and seller profit by an average of 5.94% and 4.36%, respectively.

New phenotyping platform identifies key drought-tolerance genes in soybean

A novel phenotyping platform has identified a major QTL and candidate gene GmWRKY58 linked to drought resilience in soybean. The low-cost platform uses automated load-cell weighing devices to record pot weight, estimating transpiration rates and detecting key traits such as stress recognition time point and decrease under stress.

SourceNanjing Agricultural University The Academy of Science·JournalPlant Phenomics·TypeExperimental study·DateDec 15, 2025

Icahn School of Medicine at Mount Sinai named member of the Milken Institute’s Women’s Health Network

The Icahn School of Medicine at Mount Sinai is advancing women's health through cutting-edge research and compassionate care, with a focus on addressing knowledge gaps and promoting seamless treatment journeys. The institution joins the Milken Institute's Women's Health Network to bring its expertise in clinical excellence, research in...

UTHealth Houston, in collaboration with UTMB Health, awarded $50 million by the state of Texas to lead ibogaine clinical trials

UTHealth Houston, in collaboration with UTMB Health, will lead a $50 million two-year ibogaine clinical trial to evaluate its effect on patients suffering from addiction, traumatic brain injury, and behavioral health conditions. The trial aims to advance ibogaine research for improving behavioral health outcomes across Texas.

Households using more of the most popular WIC food benefits stay in the program longer, UW study finds

A new study by the University of Washington found that households redeeming higher amounts of popular WIC food categories are less likely to drop out of the program. The research identified a link between increased redemption rates and lower risk of discontinuation, with fruits, vegetables, eggs, and whole milk being key categories.

SourceUniversity of Washington·JournalJAMA Network Open·TypeData/statistical analysis·DateDec 15, 2025

Familial patterns in criminal conviction risk observed among individuals with ADHD

A large-scale study found that individuals with ADHD are at higher risk of being convicted of crimes compared to those without ADHD. Relatives of individuals with ADHD also show increased risk, even if they themselves do not have ADHD. Early identification and treatment of ADHD in high-risk families may help mitigate these risks.

SourceElsevier·JournalBiological Psychiatry·TypeData/statistical analysis·DateDec 15, 2025

A testing paradox for sexually transmitted infections

A new modeling study suggests that regular testing for sexually transmitted infections (STIs) can successfully reduce their spread, even if individuals on PrEP engage in riskier behavior. The paradoxical findings highlight the importance of careful surveillance data interpretation when evaluating public health interventions.

SourceMax Planck Institute for Dynamics and Self-Organization·JournalProceedings of the National Academy of Sciences·TypeComputational simulation/modeling·DateDec 15, 2025

Blood test may help identify which colon cancer patients benefit from NSAIDs

A blood test may help doctors identify which patients with colon cancer can benefit from anti-inflammatory medication and chemotherapy after surgery. The test measures circulating tumor DNA levels, and high-risk patients who test positive see improved survival rates when taking celecoxib with chemotherapy.

SourceAlliance for Clinical Trials in Oncology·JournalJAMA Oncology·TypeRandomized controlled/clinical trial·DateDec 15, 2025

Refining the uncharted landscape of human transcription factors: a strategic framework for future prioritization

A study analyzed large-scale human ChIP-seq data to identify unmeasured transcription factor-tissue/cell type pairs, revealing significant gaps in current knowledge. These findings indicate that essential regulatory mechanisms may have been overlooked, emphasizing the need for strategic prioritization of measurement targets.

SourceUniversity of Tsukuba·JournalBriefings in Functional Genomics·DateDec 15, 2025

Breakthrough on gene therapy for hereditary spastic paraplegia

Researchers at Drexel University and UMass Chan Medical School have developed a gene therapy approach that silences and replaces disease-causing genes in mice with hereditary spastic paraplegia. The treatment prevents nerve breakdown and symptoms, offering a potential cure for the rare disease. Studies suggest that the therapy could be...

SourceDrexel University·JournalMolecular Therapy·TypeExperimental study·DateDec 15, 2025

Researchers show visual training dramatically improves cognitive function after concussion

A new study published in Frontiers in Human Neuroscience reveals that a visual training program called Perceptual Attention Therapy (PATH) produces rapid improvements in reading, attention, memory, and executive function after concussion. PATH addresses underlying visual timing deficits before strengthening specific cognitive skills.

SourceUniversity of California - San Diego·JournalFrontiers in Human Neuroscience·TypeRandomized controlled/clinical trial·DateDec 15, 2025

Researchers identify Tapt1 gene as essential maintainer of protein synthesis and brain development

Researchers have identified Tapt1 as a key gene in maintaining the balance between protein synthesis and degradation, crucial for normal brain development. The study reveals that Tapt1, along with its partner Suco, ensures proper neural stem cell proliferation and differentiation.

SourceChinese Academy of Sciences Headquarters·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateDec 15, 2025

Streptococcus suis serotype 2 collagenase-like protease promotes meningitis by increasing blood-brain barrier permeability

A study found that Streptococcus suis serotype 2 collagenase-like protease enhances virulence and tissue colonization, promoting BBB destruction and increased permeability. The protein also induced apoptosis in brain microvascular endothelial cells and infiltrated immune cells into the brain after infection.

SourceKeAi Communications Co., Ltd.·JournalJournal of Integrative Agriculture·TypeExperimental study·DateDec 15, 2025

Scientists create stable, switchable vortex knots inside liquid crystals

Researchers created particle-like vortex knots in chiral nematic liquid crystals and discovered they can be reversibly switched between different knotted forms using electric pulses. The study provides a physical testbed for mathematical ideas, opening possible new routes toward knot-based electro-optic and photonic technologies.

Review article | Towards a Global Ground-Based Earth Observatory (GGBEO): Leveraging existing systems and networks

The study presents a comprehensive roadmap for building an integrated GGBEO to meet the United Nations' Sustainable Development Goals and advance climate science. The system would integrate regional and global ground-based in situ and remote sensing systems, marine, and airborne observational data.

SourceBig Earth Data·JournalBig Earth Data·TypeLiterature review·DateDec 15, 2025

Penn and UMich create world’s smallest programmable, autonomous robots

Researchers at Penn and UMich created microscopic swimming machines that can independently sense and respond to their surroundings, operate for months, and cost just a penny each. The robots are powered by light and can be programmed to move in complex patterns, sense local temperatures, and adjust their paths accordingly.

SourceUniversity of Pennsylvania School of Engineering and Applied Science·JournalScience Robotics·TypeExperimental study·DateDec 15, 2025

New international study reveals major survival gaps among children with cancer

A major international study reveals significant disparities in childhood cancer survival rates worldwide. The global average is just 37% survival rate, while high-income countries boast an 80% rate. Better monitoring and investment in healthcare are critical to achieve the WHO's goal of at least 60% survival by 2030.

SourceThe University of Bergen·JournalJNCI Journal of the National Cancer Institute·DateDec 15, 2025

The Lundquist Institute and its start-up company Vitalex Biosciences Announces Strategic Advancement of Second-Generation fungal Vaccine VXV-01 through Phase 1 Trials under $40 Million Competitive Contract from NIH/NIAID

The Lundquist Institute's second-generation fungal vaccine candidate, VXV-01, is moving forward in development after securing a $40 million NIH/NIAID contract. The vaccine aims to elicit robust immunity against opportunistic and hospital-associated pathogens.

Scientists develop a smarter mRNA therapy that knows which cells to target

Researchers have created an mRNA system that activates therapeutic genes in specific cell populations, potentially leading to safer and more precise cancer treatments. The system uses microRNAs to recognize cancer cells and shuts off the treatment if it's not needed, reducing toxicity and expanding mRNA therapy's reach.

SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalMolecular Therapy·TypeExperimental study·DateDec 15, 2025

Jeonbuk National University researchers explore the impact of different seasonings on the flavor perception of Doenjang soup

Jeonbuk National University researchers examine how different seasonings shape kokumi perception in doenjang soup, influencing consumer acceptance. They found that umami is a major sensory driver of kokumi perception and can be enhanced to improve the flavor quality of fermented foods.

World-first discovery uncovers how glioblastoma tumours dodge chemotherapy, potentially opening the door to new treatments

Researchers discovered glioblastoma cells use PRDM9 to survive chemotherapy and regrow tumors. By blocking PRDM9 or cutting off cholesterol supply, persister cells can be wiped out, improving survival in mice. This breakthrough offers new strategies for treating the deadliest brain cancer.

SourceUniversity of Sydney·JournalNature Communications·TypeExperimental study·DateDec 15, 2025

Immune system keeps mucosal fungi in check

A study by University of Zurich researchers has shed light on the mechanisms that maintain homeostasis with mucosal fungi. The team discovered that the fungus Candida albicans uses a toxin called candidalysin to survive in the mouth, and that interleukin 17-mediated immunity prevents it from growing out of control.

SourceUniversity of Zurich·JournalNature Microbiology·TypeExperimental study·DateDec 15, 2025

Combination pills for high blood pressure may simplify treatment, improve long-term health

A new American Heart Association scientific statement suggests that combination pills combining two or more medications may help adults with high blood pressure achieve optimal blood pressure goals more quickly, reduce their risk of heart attack and stroke, and improve long-term health. Currently, most people need two or more medicatio...

SourceAmerican Heart Association·JournalHypertension·DateDec 15, 2025

Electrodes created using light

Researchers at Linköping University have successfully created electrodes from conductive plastics using visible light, eliminating the need for toxic chemicals. The technology allows for the creation of flexible electronics and biocompatible sensors on various surfaces, including skin.

SourceLinköping University·JournalAngewandte Chemie·DateDec 15, 2025

How human interaction drove evolution to make bears less aggressive

A new study found that Italian bears living in areas with many villages have evolved to become smaller and less aggressive. The researchers attributed this change to the removal of more aggressive bears by humans, which led to a selection for behavior-related genetic variants associated with reduced aggressiveness.

SourceOxford University Press USA·JournalMolecular Biology and Evolution·TypeExperimental study·DateDec 15, 2025

Clues to the origin of hot Jupiters hidden in their orbits

A team of researchers has discovered a distinct group of hot Jupiters whose circular orbits contradict the expected timescale for tidal migration. These planets exhibit characteristics consistent with disk migration, such as primordial alignment and planet multiplicity, suggesting they formed smoothly within the protoplanetary disk.

Canada’s reduced pledge to Global Fund will impact domestic health

A reduced pledge by Canada to the Global Fund could lead to decreased success in controlling tuberculosis and HIV/AIDS in the country. The authors of an editorial urge Canada's government to invest in improving social determinants of health and implement disease-specific suggestions to address these pressing global health issues.

SourceCanadian Medical Association Journal·JournalCanadian Medical Association Journal·TypeCommentary/editorial·DateDec 15, 2025

1 in 4 children with major traumatic injuries not cared for in pediatric trauma centres

Research shows that 77% of severely injured children are transported or transferred to pediatric trauma centers, highlighting the need for improved access and evidence-based strategies. Variability in access exists across Canadian provinces, with some areas having higher access than others.

SourceCanadian Medical Association Journal·JournalCanadian Medical Association Journal·TypeObservational study·DateDec 15, 2025