The complexity of the tumor microenvironment hinders therapeutic intervention; nanomedicine emerges as a promising tool to modulate it. Researchers have systematically reviewed four primary mechanisms by which nanomaterials enhance antitumor therapy, including modulation of complex components within the TME.
Researchers have discovered how a compound called naringenin chalcone 'reprograms' a light-sensing protein in plants, activating it to send growth-regulating signals even without UV light. This unexpected interaction could lead to crops with improved tolerance to harsh environments and more efficient use of light energy.
A new study finds that a 2°C warming intensifies the Arctic's ability to absorb greenhouse gases, but reduces its capacity in alpine regions. This imbalance has significant implications for global carbon budgets and climate projections.
A team of researchers developed a new manufacturing process using bio-based solvents to reduce the production cost of perovskite solar cells by half and decrease climate impact by over 80%. AI-based reverse engineering technology was used to identify optimal conditions for efficiency and sustainability.
The project aims to strengthen community involvement in water management, improve child health and reduce under-age mortality in Ecuador, Peru, Chile, Morocco and Tunisia amid global climate change. The research team will gather socioeconomic data and information on water governance, health risks and infant mortality.
Scientists at Linköping University develop artificial neurons made of conductive plastics that perform advanced functions like biological nerve cells. They simplify the basic structure to make it compact and biologically relevant.
Researchers have developed new eDNA tools to quantify kelp-derived biomass in sediments below commercial kelp farms. The study confirms that kelp aquaculture has little impact on the seafloor community and provides evidence for using eDNA to examine 'blue carbon' accounting efforts.
Researchers at Boston University School of Medicine will create a detailed postmortem cardiac and blood vessel tissue repository to study the relation between cardiovascular risk factors and structure. The project aims to identify new biomarker signatures for cardiovascular disease, advancing our understanding of CVD risk.
Researchers at Salk Institute and UC San Diego have identified a unique sugar called HSAT as a potential therapeutic target for slowing tumor progression and metastasis in pancreatic ductal adenocarcinoma. Boosting HSAT levels may slow the formation and spread of pancreatic cancer, leading to improved survival rates among patients.
Researchers identify basal stem-like cells as the origin of small cell lung cancer, providing a major shift in understanding this deadly disease. The study's findings allow for exploration of strategies to prevent the disease before it evades the immune system and spreads.
A new study found that people with three or more symptoms of physical frailty were nearly three times more likely to develop dementia than those without frailty. The researchers also discovered changes in brain structure and biomarkers in people with frailty, which may be a mechanism underlying the pathway from frailty to dementia.
A new study uses three wearable sensors to track eating behavior and identifies five distinct patterns, including late-night snacking and stress binging. The findings lay the groundwork for personalized interventions to help individuals overcome unconscious habits that drive overeating.
Researchers from St. Jude Children's Research Hospital have made a breakthrough in treating neuroblastoma by combining immunotherapy with the drug indisulam, achieving complete therapeutic responses in laboratory models regardless of cell state.
The PANORAMA microscope overcomes challenges of traditional microscopes by capturing submicron details across an area roughly the size of a U.S. dime without moving the sample. It produces gigapixel-scale images with high resolution, ideal for medical pathology and industrial inspection.
Researchers have identified a secreted form of a protein called Clever-1 that systemically suppresses T cells essential for fighting cancer. The investigational anti-Clever-1 antibody, bexmarilimab, directly inhibits the release of sClever-1, potentially predicting treatment resistance and paving the way for new combination treatments.
Researchers have developed a novel approach to control Dirac plasmon polaritons in topological insulator metaelements, enabling tunable terahertz optical devices with lower energy loss and enhanced performance.
Researchers Josh Frieman and Anowar Shajib found that physics-based models for evolving dark energy better explain current data than the standard model. The data suggests that dark energy density has decreased by about 10% over the last several billion years, changing the cosmic expansion history.
Researchers predict EU will need to meet 250 TWh annually for local battery cell production by 2050, offsetting 90 TWh of upstream fossil fuel energy. Maximizing recycling rates could reduce import dependency and future energy demand.
A recent UMass Amherst study led by Daniel Corkran uncovers the physical mechanisms governing sustainable water usage in salares, overturning commonly held assumptions. The research suggests that companies should pump water from briniest patches, not freshwater portions, to minimize impact on wetlands and shores.
A study found that older adults with Parkinson's disease have a higher rate of brain amyloid positivity compared to younger patients, even without dementia. The researchers suggest this may indicate an accelerated transition from healthy cognition to dementia in PD patients.
A Swedish study of over 1.2 million children found no significant association between prenatal exposure to opioids and increased risk of autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD). The researchers attributed the observed differences in ASD rates among exposed versus unexposed children to other pre...
Brief medication visits can incorporate psychotherapy to improve patient outcomes and psychiatrist job satisfaction. Practical approaches involve building elements of supportive, psychodynamic, and cognitive-behavioral therapies into abbreviated visits.
ESMT Berlin has appointed Henry Sauermann as its new TEAM GLOBAL Chair for Disruptive Innovation, with support from technology holding TEAM GLOBAL. The chair will focus on translating fundamental research into teaching and practical support for innovators, aiming to elevate civilization to the next level.
Researchers at KIMS have developed a composite catalyst using MXene that suppresses chloride ions in seawater, leading to improved durability and current density. The material's performance was validated in an actual electrolysis unit cell, paving the way for large-scale production and sustainable hydrogen infrastructure.
A new study published in Pharmaceutics found that semaglutide provides powerful protection against diabetic retinopathy, a condition that can lead to sight loss. The study suggests that GLP-1 receptor agonists enhance retinal cells' defences against damage in diabetes-like conditions.
A randomized trial shows that implanting a brain shunt in older patients with normal pressure hydrocephalus significantly improves symptoms, including gait speed, cognition, and bladder control. The study resolves controversy surrounding the condition's existence and treatment effectiveness.
This cohort study found that receiving encounters with behavioral health clinicians and psychotropic prescriptions was associated with reduced psychosocial symptoms. The results suggest that expanding integrated pediatric behavioral health care could improve outcomes among vulnerable child populations.
The Blavatnik Regional Awards recognize exceptional postdoctoral researchers in Life Sciences, Physical Sciences & Engineering, and Chemical Sciences. Veena Padmanaban, Valentin Crépel, and Xiao Xie are this year's winners, honored for groundbreaking discoveries in cancer cell biology, condensed matter physics, and chemical biology tools.
A new study reveals that adults with atopic eczema are more likely to experience suicidal thoughts, with factors such as age of onset, obesity, and clinical features strongly associated with increased risk. The study highlights the need for healthcare professionals to better recognize and address these challenges.
Researchers developed new methods to accurately target the centromedian nucleus for deep brain stimulation in patients with drug-resistant epilepsy. Advanced imaging techniques, such as high-resolution MRI and DTI tractography, improve targeting accuracy by identifying specific brain pathways and neural firing patterns.
Researchers found that having more older brothers close in age reduces the chances of survival for girls, whereas having more older sisters close in age has a positive effect on both girls and boys. This study highlights the importance of considering sex-specific effects when studying the impact of siblings on human survival.
The EWRR Congress will become an integral part of EULAR's meeting portfolio from 2027 onwards. The event aims to attract young scientists and provide opportunities for networking and collaboration.
Researchers have developed an emulator called Effort.jl that mimics the behavior of large-scale structure models, allowing for fast analysis on standard laptops. The new model delivers similar accuracy as the original, enabling scientists to analyze upcoming data releases from experiments like DESI and Euclid.
A large-scale U.S-based randomized trial shows that intensive lifestyle changes can significantly improve global cognition in older adults at high risk of cognitive decline. The intervention emphasized regular physical activity, healthy diet, cognitive stimulation, and social engagement, leading to clinically meaningful improvements. T...
Researchers developed a new tool that combines electronic structure theories and machine learning to simulate transition metal catalytic dynamics. The Weighted Active Space Protocol (WASP) delivers dramatic speedups, enabling simulations of catalysts under realistic conditions.
Researchers developed DF-FPDT to address low-frequency loss from non-matched illumination in live-cell imaging, enabling high-resolution and high-contrast 3D reconstructions. This breakthrough technique leverages non-matched illumination to enhance structural details without additional hardware or post-processing.
Researchers have discovered how lymphatic vessels, the 'plumbing system' of the kidney, undergo dramatic changes during chronic transplant rejection. The vessels become structurally disorganized and spread to unusual parts of the kidney, disrupting immune balance and fuelling inflammation.
A team of researchers at Rice University has developed a faster and cleaner method for recovering aluminum from bauxite residue, or red mud, by using a brief electrical pulse and chlorine gas. The process, called flash Joule heating, selectively vaporizes toxic metals while retaining almost all the aluminum.
The WZB Berlin Social Science Center honored economist Penny Goldberg for her research on global trade linkages and their impact on global inequality with the A_SK Social Science Award 2025. The award recognizes her work on how protectionism affects income distribution, particularly in strongly Republican districts.
A new study conducted at the University of Hawaiʻi has shown that the loss of a key male fertility gene leads to infertility and changes in the expression of hundreds of other important genes. The researchers found that sperm precursor cells are dying prematurely, and sperm have DNA that is not properly condensed.
These rare tumors often present with aggressive behavior, early metastasis, and resistance to chemotherapy and radiotherapy. Early detection and disease staging are key factors associated with improved survival.
A phase 3 trial of once-daily orforglipron found substantial weight loss in people with obesity but not type 2 diabetes. The medication improved cardiometabolic levels and was associated with significant reductions in body weight, waist circumference, systolic blood pressure, triglyceride levels, and non-HDL cholesterol.
A new AI-powered deep learning model has been shown to accurately estimate the malignancy risk of lung nodules, achieving high detection rates while reducing false-positive results. The model outperformed existing probability-based tools in a retrospective study, with a relative reduction of 39.4% in false positives.
A new open-source AI tool, ProRNA3D-single, has significantly increased accuracy in predicting and visualizing protein-RNA complex structures. This method can generate finely detailed images of molecules in 3D, enabling drug developers to design treatments by analyzing where viruses attach to human proteins.
Researchers developed a custom speech recognition system trained on Supreme Court hearings, reducing transcription errors by up to 9% compared to leading commercial tools. The AI tool semantically matches paragraphs with timestamps, allowing users to scroll through judgements and instantly watch relevant exchanges from the hearing.
A new study highlights the devastating impact of the fentanyl epidemic on certain regions, with some states experiencing a 31-fold increase in overdose deaths. The research estimates that the nationwide toll in 2022 was at least 2 million years of life lost, corresponding to an economic loss of $57 billion to $67 billion.
A recent study found that cybersecurity training programs do little to prevent employees from falling for phishing scams. Researchers sent 10 different phishing email campaigns to over 19,500 employees at UC San Diego Health and found that embedded phishing training only reduced the likelihood of clicking on a phishing link by 2%. As t...
A new way to produce ammonia more efficiently has been discovered by boosting its production using low-temperature plasma. This method could create ammonia in smaller facilities closer to where it is needed, making it safer and easier to transport, and potentially leading to a transformative change in energy storage and transportation.
Researchers developed a data-driven macroscopic mobility model that relies on simple observations from city planners' routine data collection. The D3M model can accurately represent diverse traffic conditions and simulate complex system-level dynamics.
A research team led by Dr. Marina Lusic identified RNA:DNA hybrids as molecular signposts for the virus, providing new therapeutic approaches for controlling HIV reservoirs. Removing Aquarius enzyme significantly decreases integration rate and shifts to R-loop-poor regions.
A new white paper urges placing biodiversity at the heart of the UN Pact for the Future, highlighting its essential role in food security, public health, and climate stability. The authors propose a global alliance to integrate biodiversity conservation into the core priorities of the UN Summit of the Future.
New research from the University of Bristol found that problem gamblers face triple the suicide risk one year later and quadruple the risk four years on. The study analyzed data from over 2,800 participants, aged 18-30, and found a strong link between gambling harms and suicidal behavior.
A new biotechnical vector, VIBV, combines viral mimicry with synthetic nanotechnology to deliver targeted RNA therapies for cancer treatment. The vector uses a spindle-shaped nanostructure and polyethylene glycolylated liposomal coat to evade immunity and extend circulation.
A study by University of New Hampshire reports a significant increase in childless women, with 5.7 million more women of prime child-bearing age than expected in 2024. This shift has contributed to 11.8 million fewer births than expected over the past 17 years.
A $1.7M Department of Defense grant funds the Convergent Science Virtual Cancer Center, strengthening expertise in cancer risks faced by military personnel and their families. The center provides personalized mentorship, immersive workshops, and non-traditional educational opportunities to improve patient outcomes across various cancers.
Xinting Yu, an assistant professor at UT San Antonio, has been awarded the 2025 Harold C. Urey Prize for her contributions to planetary science. Her research focuses on understanding how planetary surfaces and atmospheres interact and evolve, with applications in exoplanet characterization and habitability studies.
The JAMA Network has selected 13 early-career researchers from around the world to participate in the 2025–2026 Peer Review Academy. The program aims to cultivate excellence in peer reviewing and deepen understanding of editorial decision-making.
Pharmaceutical scientists at NUS developed DOMEK method to characterise enzyme-substrate interactions, enabling analysis of thousands of potential substrates. The technique combines mRNA display and next-generation sequencing to calculate specificity constant for each substrate.
Kennesaw State University has received two National Science Foundation grants to unite educators from across the country in defining how students should learn to use artificial intelligence responsibly. The project aims to create a shared resource network, foster collaboration and lay the groundwork for common guidelines in AI education.
Scientists have discovered a rare cosmic pattern known as an Einstein Cross with a fifth image, which reveals hidden dark matter. The team used computer modeling and analysis to infer the presence of a massive, invisible mass surrounding the foreground galaxies.