A novel AI model can use information collected during routine sleep studies to identify patients' long-term health risks, including heart disease and cognitive decline. The findings also suggest that routine medical tests may contain substantially more physiologic information than current clinical practice extracts.
Researchers developed a quantum machine learning framework to predict which tumor mutations will trigger an immune response. The Q-CHIPP model outperformed classical computing methods and achieved a significant technical milestone by scaling to full-length peptide modeling on quantum hardware.
A study led by Robert Koeth found a connection between elevated blood levels of TMAO, a gut bacteria byproduct, and an increased risk of atrial fibrillation. The research team discovered that TMAO changes the heart's electrical environment, making it more susceptible to abnormal rhythms.
A new global report highlights opportunities to strengthen diagnosis, treatment, and education for women and girls with hematological conditions. The report calls for earlier diagnosis, more consistent treatment, and stronger research and education to improve outcomes globally.
Researchers created a new quantum computing paradigm, QHDC, that works 500 times faster than existing methods. It uses hyperdimensional vectors and leverages quantum properties to efficiently encode and process complex data.
The Cleveland Discovery and Innovation Forum showcased the impact of AI and quantum computing on biomedical research, from prevention to treatment. The partnership between Cleveland Clinic and IBM's Discovery Accelerator has supported over 50 projects, contributing to multiple publications and education curriculum development.
A new study found significant regional differences in access to donor lungs for lung transplants in the US, with western states having lower availability. The revised lung allocation policy may exacerbate these disparities, prioritizing proximity to donors over patient needs.
Researchers developed an AI system called CMR-CLIP that can interpret complex heart scans without manual labels, outperforming existing models by up to 35%. The system learned from over a million images and hundreds of thousands of motion sequences collected from Cleveland Clinic.
A new study finds that testosterone slows the growth of glioblastoma in men, contrary to its usual effect on tumors. Blocking testosterone makes tumors grow faster in both male and female patients.
A gene-edited treatment has shown remarkable success against severe sickle cell disease, with 27 out of 28 patients achieving a functional cure and no painful crises. The therapy uses CRISPR/Cas12a technology to modify stem cells and increase levels of fetal hemoglobin.
A Cleveland Clinic analysis of nearly 8,000 patients found that discontinuing semaglutide and tirzepatide does not lead to significant weight regain in clinical practice. Many patients successfully stabilized their weight after one year through alternative treatments and therapeutic lifestyle interventions.
A new study by Cleveland Clinic and Dyania Health demonstrates the potential of large language models in accurately identifying patients who could benefit from clinical research. The AI system reviewed 1,476 patients and identified 46 as potential matches, resulting in a more diverse patient population.
Two studies found that elevated bacteria levels in tumors weaken immune response, driving resistance to immunotherapy. Researchers are now exploring how to identify patients most likely to benefit from immunotherapy and develop targeted interventions to restore its effectiveness.
The study found that the investigational vaccine produced an immune response in 74% of participants and was safe and well-tolerated. A Phase 2 study is planned to evaluate the vaccine's efficacy, offering new hope for triple-negative breast cancer treatment.
Researchers at Cleveland Clinic and IBM developed a hybrid quantum-classical model to simulate molecular interactions. The study accurately simulated two supramolecular systems, water dimer and methane dimer, for the first time using quantum computers.
Up to 17 million people in the US, approximately 5%, carry genetic mutations associated with cancer risk. The study highlights the importance of routine cancer screenings and suggests expanding genetic testing beyond high-risk groups.
Researchers identified a previously unknown gene, SMARCAL1, that increases the risk of developing osteosarcoma in children and young adults. The study found that approximately 2.6% of children with osteosarcoma carry inherited mutations in SMARCAL1, which may weaken DNA repair and promote tumor growth.
Researchers developed a genomic model to tailor radiation doses to individual patients with HPV-positive throat cancer. The study found that higher scores on the Genomic Adjusted Radiation Dose (GARD) model were associated with improved survival outcomes, even when patients received the same radiation dose.
A Cleveland Clinic study found that bariatric surgery offers greater long-term benefits compared to GLP-1 medicines, including lower risks of death, heart disease, and kidney failure. Patients who underwent weight-loss surgery experienced better blood sugar control and relied less on diabetes medications over 10 years.
Researchers found a connection between high TMAO levels and faster rates of aneurysm expansion, as well as greater risk for needing surgery. Targeting TMAO levels may help prevent and treat aneurysmal disease beyond surgery.
A new study identified neurobeachin as a genetic predictor of weight loss response to GLP-1RAs. The findings have the potential to advance obesity care and provide more effective, personalized treatment options.
Researchers combined quantum computing with supercomputing to simulate large molecule stability and behavior, overcoming current barriers. The hybrid approach used a quantum computer for complex calculations and a supercomputer for error correction, enabling accurate predictions of molecule stability.
A Cleveland Clinic study found that patients taking injectable GLP-1 medications for obesity lost an average of 3.6% body weight, significantly lower than the 11.9% seen in non-discontinuers. Treatment discontinuation negatively impacted blood sugar control in those with prediabetes.
A team led by Kenneth Merz used IBM Quantum System One to run Sample-Based Quantum Diagonalization, a new method for simulating molecules in solvent. The approach achieved high chemical accuracy and demonstrated the ability to predict molecular energies and solvation free energy in aqueous solutions.
The Cleveland Clinic has been awarded a $5 million grant from the Cystic Fibrosis Foundation to continue its role as the Biorepository Coordinating Center for the Cystic Fibrosis Lung Transplant Consortium until 2030. The center will support research to improve understanding of factors affecting lung transplant outcomes and advance kno...
Researchers have found that a specific protein modification to the immune protein MDA5 can block viral replication and reduce heart inflammation. The study's findings could lead to the development of broad-spectrum antiviral treatments that target multiple viruses.
A phase 3 trial demonstrated a 31% delay in confirmed disability progression in patients with non-relapsing secondary progressive multiple sclerosis. Tolebrutinib, an oral Bruton's tyrosine kinase inhibitor, showed promise as a potential treatment option for this form of the disease.
The collaboration aims to advance research on brain health with a focus on Alzheimer's disease. Initial projects will use CAS Content Collection and advanced technologies, including AI models and quantum computing to build and train disease-specific models.
Cleveland Clinic researchers successfully tested quantum computing's ability to simulate proton affinity, a fundamental chemical process critical to life. The study used machine learning applications on quantum hardware, achieving higher accuracy than classical computing in predicting proton affinity.
The study of 19,000 patients shows immune checkpoint inhibitors greatly improved survival rates for those living with MSI-H colorectal cancer. Researchers found factors that may improve therapy's effectiveness against MSS tumors under certain conditions.
Researchers developed a risk-prediction model based on four factors: family history, body mass index, sex, and smoking. A score equal to or greater than 9 indicates an above 14% likelihood of developing cancer or advanced precancerous lesions in adults under 45.
Researchers from Cleveland Clinic’s Genome Center linked human herpesviruses to Alzheimer's disease via transposable elements. They identified TEs activated in HSV-1 infected brains and found that commercially available drugs can reverse this pathway.
Researchers used AI to identify genetic factors in Parkinson's disease progression and FDA-approved drugs that can be repurposed for treatment. The study found potential risk genes like SNCA and LRRK2, which are known to cause inflammation, and identified candidate drugs such as simvastatin.
A Cleveland Clinic study shows that bariatric surgery significantly lowers the risk of developing serious liver complications in patients with obesity and fatty liver-related cirrhosis. The study found a 72% lower risk of liver disease complications and an 80% lower risk of progression to decompensated stage among surgical patients.
The partnership establishes Ohio's first specialized degree programs and research experiences in quantum computing, cultivating scientific and entrepreneurial talent. Miami University and Cleveland Clinic will accelerate the leading-edge power of quantum computing to shape the future of healthcare and technology.
Researchers have identified a link between bacteria and kidney stone formation, finding that low levels of E. coli and Lactobacillus promote or prevent kidney stone development. The study suggests that the urinary tract is not sterile and that antibiotic misuse can skew the microbiome towards stone-promoting bacteria.
Researchers have developed a network-based approach to understand how immune cells called microglia transform and drive harmful processes like neuroinflammation in Alzheimer's disease. The study identified three unique subtypes of harmful microglia that promote disease progression, with genetic signatures driving their behaviors.
Researchers at Cleveland Clinic have made significant progress in their novel vaccine aimed at preventing triple-negative breast cancer. The study found that the investigational vaccine was generally well-tolerated and produced an immune response in most patients, with the highest tolerated dose to date identified.
Researchers found that a 12-week virtual yoga program can reduce back pain intensity and improve back-related function in participants with chronic low back pain. Additionally, participants who practiced virtual yoga reported better sleep quality and reduced use of pain medications.
A new AI tool called PIONEER has been developed to predict protein-protein interaction mutations in hundreds of diseases, including dozens of cancers. The tool allows researchers to navigate the interactome for over 10,500 diseases and identify potential drug targets.
New research confirms that young adults are at risk for large vessel occlusion acute ischemic strokes, which were previously thought to occur mainly in older adults. The study found that nearly 20% of a cohort of 1,200 young adult patients had these strokes, highlighting the need for regular check-ups and prompt treatment.
A new study reveals that mild and asymptomatic SARS-CoV-2 infections can trigger immune responses in pregnant individuals, causing serious inflammatory responses in the developing fetus. The study also found that even without full infection, a pregnant individual's immunological response to infection may impact the fetus.
A history of COVID-19 can double the risk of heart attack, stroke or death for up to three years after diagnosis. Genetic analysis revealed individuals with non-O blood types were twice as likely to experience cardiovascular events.
Researchers used AI to repurpose FDA-approved drugs for chronic pain treatment. The LISA-CPI framework identified compounds that can bind to specific pain receptors and modulate signaling effects. Studies are underway to validate these compounds in the lab, offering a promising approach to advanced pain management.
Researchers created the largest atlas of how tumor architecture changes in response to immune checkpoint therapy. The study found that multiple T cells recognize different neoantigens, altering the tumor ecosystem, and challenged prevailing theories on immunotherapy.
Researchers identified T. immunophila as a key player in breaking down the gut's protective immune barrier, leading to increased susceptibility to pathogens and delayed repair of the gut barrier. The discovery provides a promising new avenue for treatment of inflammatory bowel disease, Crohn's, and ulcerative colitis.
A Cleveland Clinic study found bariatric surgery to be more effective in protecting kidney function and reducing the risk of kidney failure compared to GLP-1 medications. The study showed a 60% lower risk of progression of kidney disease and a 44% lower risk of developing kidney failure or death.
Researchers found pomalidomide to be safe and effective in reducing nosebleed severity, improving quality of life, and decreasing the need for blood transfusions in adults with hereditary hemorrhagic telangiectasia. The trial stopped early due to successful findings, offering a promising treatment option for this rare bleeding disorder.
A study found that every 1% decrease in BMI leads to a 4% reduction in cardiovascular risk. Blood sugar control also lowers the risk of chronic kidney disease independently of weight change.
A Cleveland Clinic study identified key factors that can impact the long-term weight loss of patients with obesity who were prescribed injectable semaglutide or liraglutide. The study found that medication's active agent, dosage, treatment indication, and persistence with the medication were associated with weight change.