A Cleveland Clinic study found that only 42% of deaths after angioplasty were caused by the procedure itself, highlighting the need for a more accurate reporting system. The researchers argue that alternative outcome reporting mechanisms should be considered to better reflect quality and performance.
The Cleveland Clinic study found that an Internet-based stress management program reduced stress for a sustainable period, comparable to face-to-face programs. Participants showed a significant decrease in perceived stress and improved emotional wellbeing after completing the eight-week online relaxation practice materials and meditati...
A clinical study in over 4,000 subjects found a correlation between high blood levels of trimethylamine N-oxide (TMAO) and increased future risks of death, nonfatal heart attack, or stroke. TMAO is produced when intestinal bacteria digest phosphatidylcholine, commonly found in animal products.
A new study by Cleveland Clinic Children's Hospital suggests that respiratory syncytial virus (RSV) can be transferred from mother to fetus during pregnancy, leading to lifelong consequences. RSV is found in the lungs after birth and throughout development, contributing to asthma development.
Cleveland Clinic researchers find that patients with prior chest radiation are nearly twice as likely to die in the years following their heart surgery compared to similar patients who did not undergo radiation treatment. Radiation heart disease can cause coronary artery disease, valve disease, cardiomyopathy, and other cardiac problems.
A new study by Cleveland Clinic researchers reveals a connection between red meat consumption and an increased risk of heart disease. The research found that a diet high in carnitine promotes the growth of bacteria that metabolize the compound, leading to the production of TMAO, which is associated with atherosclerosis.
A Phase 3 clinical trial by Cleveland Clinic and Sahlgrenska University Hospital found that darbepoetin alfa does not reduce the risk of death from any cause or hospitalization for worsening heart failure in anemic patients. Despite increasing hemoglobin levels, treatment did not provide improved health outcomes.
Researchers found that frequent head hits in football players can lead to long-term brain changes, even without concussions. Elevated levels of S100B protein in blood tests correlated with brain tissue damage and autoimmune responses.
A two-year study found that gastric bypass surgery reverses diabetes by uniquely restoring pancreatic function, particularly in reducing belly fat. The study showed a remarkable 5.8-fold increase in overall pancreatic cell function in patients who underwent gastric bypass.
Researchers will use a novel model and emerging technology to study astrocytes in autism spectrum disorders, providing a framework for future strategies. The grant supports Trapp's work on mechanisms of neurodegeneration and repair in multiple sclerosis and related conditions.
The Cleveland Clinic has developed a clinical screening program for Lynch syndrome, the most common genetic cause of colon cancer in adults. The program uses universal screening for colorectal cancers surgically removed at the clinic and successfully referred individuals whose tumors screen positive to genetics professionals.
Researchers discovered two new genes, PIK3CA and AKT1, linked to Cowden syndrome, a condition carrying high cancer risks. The findings promote diagnosis, clinical management, and genetic counseling, aiding predictive testing.
Researchers at Cleveland Clinic have found that vitamin E may reduce cancer risk in individuals with Cowden Syndrome, a genetic disorder that increases the risk of breast and thyroid cancers. Vitamin E's antioxidant properties may help prevent cellular damage caused by mutations in succinate dehydrogenase genes.
Researchers at Cleveland Clinic's Lerner Research Institute and Anesthesiology Institute have discovered a potential new treatment for Alzheimer's disease. The compound MDA7 has been shown to induce beneficial immune responses that limit the development of the disease, restoring cognition, memory, and synaptic plasticity in animal models.
The National Heart, Lung, and Blood Institute has awarded a $4.78 million grant to Cleveland Clinic researchers to discover new pathways linked to cardiovascular diseases through metabolomics. The study aims to improve diagnostics and treatments for cardiovascular disease by analyzing the role of gut flora in heart disease.
A naturally occurring molecule, Akt3, regulates lipid entry into macrophages and prevents cholesterol storage, potentially leading to new plaque-fighting drugs. The discovery could also aid doctors in developing screening tests for patient risk levels of atherosclerosis.
The Cleveland Clinic will participate in a six-institution MDS Clinical Research Consortium, supported by the Aplastic Anemia & MDS International Foundation. The five-year initiative aims to improve outcomes for patients with myelodysplastic syndrome through clinical trials and research.
A Cleveland Clinic study has detected significant changes in brain activity patterns of patients receiving chemotherapy, supporting the existence of 'chemobrain'. Women showed higher amplitude brain activity after physical and cognitive tasks during treatment.
A landmark study found that bevacizumab (Avastin) is equivalent to ranibizumab (Lucentis) in treating wet age-related macular degeneration through two years, with monthly dosing producing slightly more vision gain. The study showed similar visual results regardless of dosing frequency, with 60% of patients achieving driving vision.
Consuming sugar-sweetened and low-calorie sodas is associated with a higher risk of stroke, while decaffeinated coffee may reduce the risk. Higher soda consumption also leads to high blood pressure, high cholesterol, and lower physical activity rates.
A study published by Cleveland Clinic found that bariatric surgery significantly improved blood sugar control, with 42.6% of gastric bypass patients achieving normal levels without medication. Sleeve gastrectomy also showed promising results, with 36.7% of patients reaching normal blood sugar levels.
Researchers at Cleveland Clinic discovered that corin enzyme deficiency in the uterus may be an underlying cause of pre-eclampsia. The study found that many patients with pre-eclampsia had low levels of corin and identified corin gene mutations.
The study aims to confirm the predictive value of established genetic markers and enroll 600 children over two years. If successful, a genetic test could help identify children with autism earlier, providing beneficial treatment and improved outcomes.
A new study found that overweight and obese adults with chronic kidney disease who attempt to lose weight through diets and diet pills may cause further kidney damage. The study highlights the need for safe weight loss strategies that protect kidney function.
Dr. Richard Ransohoff receives the 2012 John Dystel Prize for his groundbreaking work on understanding and treating multiple sclerosis. His research has led to a deeper understanding of MS progression and the development of novel therapeutic targets.
Research from Cleveland Clinic found that padded headgear and gloves can reduce linear impact forces but not rotational forces. The study suggests that young fighters should wear protective headgear whenever possible to minimize head and neck injuries.
Researchers found three genes linked to an increased risk of thyroid cancer, including PTEN, which is a tumor suppressor gene. The study recommends increased surveillance for children with PTEN mutation-causing Cowden syndrome-related disease.
A new study published in the New England Journal of Medicine found that multiple sclerosis begins in the cerebral cortex, contrary to previous theories. The research involved analyzing 563 brain biopsies and revealed distinct differences in lesions, providing clues for better disease management.
A one-time injection of fibronectin immediately after spinal cord injury can limit pain for an extended period, according to Cleveland Clinic research. The treatment suppresses inflammatory response and maintains blood-spinal cord barrier integrity.
A Cleveland Clinic study reveals that maximum doses of Crestor and Lipitor are equally effective in reversing atherosclerosis after 24 months of treatment. The trial showed no significant differences between the two drugs in reducing plaque burden, but rosuvastatin was found to lower LDL cholesterol and increase HDL levels.
Evacetrapib, a new CETP inhibitor drug, shows striking increases in HDL (good) cholesterol and significant reductions in LDL (bad) cholesterol. The study found that evacetrapib increased HDL levels by 53.6-128.8 percent and lowered LDL by 13.6-35.9 percent.
A three-year grant will fund clinical trials testing patient navigator models and electronic health record enhancements for chronic kidney disease care. The study aims to improve treatment adherence and patient outcomes.
Researchers discovered a gene has opposite effects in prostate and breast cancers, promoting growth when 'on' or 'off'. This finding suggests treating prostate and breast cancers requires distinct strategies, with blocking AR effective for prostate cancer but supporting AR production for breast cancer.
A large national study has found that men taking a daily vitamin E supplement face an increased risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) tracked over 35,000 men and found a 17 percent higher incidence of prostate cancer in those taking the supplement.
Researchers at Cleveland Clinic discovered that medicated stents reduce heart attacks and new blockages in vessels beyond the stent. Patients receiving drug-coated stents have a lower likelihood of suffering heart attacks or developing new blockages.
Researchers are developing a blood test that can identify concussions in athletes by measuring biomarkers such as S100B. The test aims to provide faster and more efficient diagnosis of concussions, which are the leading cause of brain damage in sports.