Katherine A. High, MD, receives the 2013 E. Donnall Thomas Lecture and Prize for her pioneering research on gene therapy for hemophilia and inherited retinal degenerative diseases. Her work has led to sustained clinical improvements using adeno-associated virus vectors.
A study by the NIH found that deleting a protein called Olfm4 improves white blood cells' ability to fight bacteria in mice with chronic granulomatous disease (CGD). This suggests a novel strategy for developing new treatments against common and deadly infections.
Researchers used mathematical models and lab-based synthetic biology to predict bacterial investment crashes and boom-bust cycles. The study reveals how the diversity of life is maintained and demonstrates that investment decisions can be precisely defined.
A new computer model developed by a UCI-led team accurately accounts for bacteria and fungi's impact on soil carbon, leading to more reliable forecasts. The model suggests two novel scenarios: soil accumulating or releasing carbon due to microbial growth changes with temperature.
HudsonAlpha and UAB researchers aim to identify optimal treatments for ER+ breast cancer using tumor genomics. By analyzing genetic data from patients who responded or didn't respond to treatment, they hope to develop targeted therapies.