Researchers identified two common drugs, aspirin and lansoprazole, that may prevent early labor when given together during pregnancy. The study used a digital twin system to simulate the immune system of individual pregnant women and found that the combination had a large effect on delaying labor.
A new genetic study reveals that Native Hawaiians originated from Easter Island, with a 7,000km journey in the Middle Ages. The study identifies strong genetic bottlenecks among Native Hawaiians, which can have significant implications for precision medicine and disease risks.
A new study reveals that the Hadza and Tsimane populations, with lifestyles differing by only industrialization, share over 1,200 bacterial species, many with ancient roots. This suggests that these microbes may have co-evolved with humans over millennia, potentially impacting health in industrialized populations.
A new urine test devised by researchers at Stanford Medicine can diagnose bladder cancer more accurately than current methods, capturing a tumor's behavior in addition to its presence. The test, called uRARE-seq, correctly identified 95% of people with localized bladder cancer and gave a clean bill of health to 90% of those who did not.
A recent clinical trial led by Stanford Medicine shows that a new oral medication, acebilustat, effectively alleviated many symptoms of lymphedema, a condition characterized by excess lymph fluid accumulation. The study involved 23 participants with lymphedema, who took acebilustat for a year and experienced significant symptom relief.
A new California law aims to eliminate ultra-processed foods from school menus, but researchers warn of fiscal and logistical challenges, including budget constraints and difficulty with food procurement. The study's findings highlight the need for increased funding to support healthier school menus and improve student nutrition.
Researchers found that the human brain consists of two ancient nervous systems, one regulating vital functions and the other enabling human distinctiveness. This discovery opens new avenues for studying devastating brain diseases and could help grow brain cells in the laboratory.
A virtual biotech company powered by AI agents has made groundbreaking discoveries in drug discovery, including a biological signal that predicts which drug candidates are more likely to succeed. The company has also designed a cancer therapy that was later independently built by a major pharmaceutical company.
Researchers successfully transplanted human brain cells into mice, allowing for the study of brain disorders such as schizophrenia, epilepsy, and autism. The new model provides a unique opportunity to study the causes and mechanisms of these conditions, potentially leading to the development of new treatments.
A Stanford Medicine team has developed an AI program called Paper2Agent that turns scientific manuscripts into interactive agents, enabling chat and collaboration between agents. This innovation has the potential to accelerate research and discoveries, particularly in areas like genetic mutations and ADHD risk.
Researchers at Stanford Medicine have developed AI cell models, called universal cell embedding and TranscriptFormer, to compare cells among species and gain insights into diseases. These models can identify cell types, evolutionary relationships, and even distinguish between healthy and diseased cells.
A Stanford Medicine study found that pop-up messages warning of social media harms, such as mental health consequences, can reduce young people's use and boost their knowledge of risks. The study, which tested 14 warnings, found that messages on overall mental health harms, depression, and anxiety resonated most with young people.
Researchers have developed an ultracompact gene activation tool called TIGRa, which can target multiple genes simultaneously and is smaller than CRISPR-based tools. TIGRa was tested in a mouse model and showed promising results in treating retinal degenerative conditions, including glaucoma.
A Stanford Medicine study found that estrogen-only menopausal hormone therapy may reduce the risk of Alzheimer's disease in women. The study, which analyzed brain autopsies and cerebrospinal fluid samples, found a 35% reduction in Alzheimer's-related pathological deposits in women who used estrogen-only MHT.
Researchers create two-headed molecule that physically links a cancer-causing protein with another molecule that switches on cell death mechanisms. In mice, treatment with the molecule eliminated aggressive lymphoma tumors within 11 days, with no obvious signs of toxicity.
A study by Stanford Medicine scientists reveals that wayward tau molecules can gum up mitochondria's internal energy-production lines, initiating a vicious cycle of pathological events. This discovery provides a new mechanism driving tauopathies and renders these disorders amenable to new therapeutic interventions.
In a new clinical trial, about one-third of children with multiple food allergies gained the ability to safely eat full servings of their allergy-triggering foods. The trial, led by Stanford Medicine, tested omalizumab and oral immunotherapy as treatments for life-threatening food allergies.
Researchers found that tissue-resident macrophages, responsible for clearing senescent cells, become dysfunctional with age, leading to chronic inflammation and organ damage. Blocking a specific receptor on these cells preserved youthfulness of multiple organs in mice.
A Stanford Medicine-led study found that teenagers with autism are less responsive to unfamiliar voices as they mature. Unlike neurotypical teens, the reward centers in autistic teens' brains don't become increasingly responsive to strangers' voices during adolescence, which may impact social connections and friendships.
A new study suggests that a gradual approach to tapering opioid doses, putting the patient in control, can help them reduce their opioid use long-term without increasing pain. After 12 months, about half of patients achieved a successful response, defined as cutting their opioid dose by at least 50%.
Researchers developed an AI platform, CANVAS, to predict cellular neighborhoods and their relationships in tumor tissues. The platform identified 10 discrete neighborhoods, including those rich in immune cells and associated with poorer outcomes and reduced responsiveness to immunotherapy.
Researchers at Stanford Medicine have developed a new technique that enables the precise location of cancer-fighting antibodies in human tumors. The technique, known as single-cell spatial pharmacobiology, allows for detailed imaging of antibody binding to specific cells within the tumor microenvironment.
The study, conducted by Stanford Medicine scientists, found that family-based therapy and psychoeducational motivational therapy can effectively treat ARFID in children. Family-based therapy empowers parents to manage their child's food and nutrition, while psychoeducational motivational therapy puts the child in charge.
Researchers discovered a molecular seesaw that regulates healthy skin development. Modulating this balance with topical drugs could aid wound healing and slow skin cancer growth. The study found ubiquitin-like proteins trigger progenitor cells to mature or self-renew, leading to changes in immune cell populations.
A Stanford Medicine study found that pregnant women with severe hyperemesis gravidarum face higher risks for preterm birth, anemia, smaller babies, preeclampsia, and placental abruption. The study also showed that hospitalization for HG can flag a pregnancy as being at higher risk for serious complications.
A new study by Stanford Medicine investigators found that biological age of organs can predict disease risk and longevity. The researchers used a blood-based indicator to assess the age of 11 organ systems, including brain, heart, and lungs, and found strong associations between these ages and various diseases.
Researchers discovered a way to supercharge natural killer cells into specialized form that can reside inside tissues and kill tumor cells. The therapy slowed the growth of various solid tumors when tested in mice, offering potential new approach for cancer treatment.
Researchers found that obexelimab significantly reduces the risk of relapse in patients with IgG4-related disease, a rare chronic immune condition. The study showed that patients treated with obexelimab were nearly twice as likely to be in complete remission after one year and needed less emergency steroid treatment.
Researchers found that a compound already in clinical trials for age-related muscle loss may mitigate the negative effects of GLP-1 on muscle health. In young adult mice treated with semaglutide, PGDHi enhanced muscle regeneration and recovery after injury, restoring strength without undermining fat loss.
Researchers found that combining formoterol and methacholine speeds up mucociliary clearance, reducing chronic lung infections. The combination is safe and well-tolerated, offering a new approach to managing the disease.
Researchers developed a wearable ultrasound patch to monitor high-risk pregnancies, providing continuous, real-time information about blood flow in the fetus and umbilical cord. The device holds promise for helping doctors detect conditions like intrauterine growth restriction, which affects 10% of all pregnancies.
Neutrophils have been found to manufacture a protein called C4A, which has been linked to schizophrenia. This discovery ties together various observations about the disorder and could lead to better treatments and diagnostics.
Researchers found that combining ketamine with low-dose buprenorphine treatment can prolong its antisuicidal effects for at least a month. Patients who received this combination treatment showed greater and longer-lasting reductions in suicidality compared to those given a placebo.
A recent study published in Cell reveals that ethnicity and geography significantly influence human molecular diversity, including metabolism, immunity, and gut microbiota. The research found distinct molecular signatures associated with each ethnic group, highlighting the complex interplay between genetics and environment.
Researchers identified two biological subtypes of migraines using brain imaging, which could lead to better treatments and predictions for chronic migraine. The study found that patients in one subtype had more severe symptoms but were no more likely to develop chronic migraine, highlighting the need for improved diagnosis and treatment.
Researchers developed a blood test that identifies nine cellular neighborhoods surrounding tumors, correlating with tumor response to immunotherapy and patient prognosis. The test provides real-time access to information about successful therapies.
A new Stanford Medicine study shows that brain-scan averages obscure individual brain dynamics, particularly in children with attention-deficit/hyperactivity disorder. By analyzing data from over 4,000 children, researchers found distinct patterns of brain activity when data is analyzed individually versus as a group.
A recent study published in Nature Medicine found that AI-powered chatbots can effectively answer nuanced clinical questions, even when paired with human doctors. The research suggests that successful collaboration depends on integrating AI tools into medical workflow, where they can provide initial takes or second opinions.
Researchers at Stanford Medicine successfully cured Type 1 diabetes in mice by combining a blood stem cell and pancreatic islet cell transplant with a gentler pre-transplant treatment. The approach resulted in an immune system made up of cells from both the donor and recipient, preventing disease progression and cure.
A new study published in The New England Journal of Medicine found that infants whose mothers received buprenorphine during pregnancy had better health outcomes than those exposed to methadone. Another follow-up study by Stanford Medicine and Harvard University teams discovered similar rates of neurodevelopmental disorders among childr...
A new study by Stanford Medicine scientists has identified a genetic variant that causes resistance to GLP-1 diabetes drugs in up to 10% of the population. The variant affects an enzyme called PAM, which handicaps the hormone's biological activity, leading to increased levels but reduced effectiveness.
A new study offers a powerful approach to personalized bladder cancer care using a non-invasive urine test. The test can detect minimal residual disease while accounting for mutations present in normal urothelium, allowing clinicians to distinguish between patients who benefit from additional therapy and those who don't.
Researchers equipped immune cells with proteins to recognize cancer cell metabolism, enhancing their ability to infiltrate and control tumor growth. The new therapy approach shows promise in treating solid tumors, overcoming a key limitation of existing immunotherapies.
Researchers discovered a metabolite called pTOS in pythons that increases appetite suppression in obese mice, leading to significant weight loss. The study sheds light on the power of studying extremes in the animal kingdom and may lead to new weight-loss treatments.
Aging gut affects memory formation, new study reveals gut microbiome plays a critical role in cognitive decline, but altering gut-brain communication can reverse effects in mice
A Stanford Medicine-led study reveals that the US method for ranking children on heart transplant waitlists does not consistently prioritize the sickest patients. The current system fails to capture medical urgency, leading to higher waitlist mortality rates and potential unfair treatment of some patients.
Researchers developed a universal vaccine formula that provides broad protection against respiratory viruses, bacteria and even allergens. The vaccine is delivered intranasally and works for a wide spectrum of respiratory threats, including SARS-CoV-2 and common hospital-acquired infections.
Researchers discovered that animals across species exhibit sunk cost bias, valuing items more if they've invested time and effort into acquiring them. This phenomenon is linked to dopamine release in the brain, influencing behavior and decision-making.
A study by Stanford Medicine researchers found that people with colorblindness have a 52% higher mortality rate over 20 years compared to those with normal vision due to delayed diagnosis. The study suggests that missing the early sign of blood in urine can lead to worse outcomes.
Researchers found that activating specific healing pathways in fibroblasts from facial tissues can lead to regenerative wound healing with reduced scarring. This study could lead to new treatments for scar formation and its associated complications, including chronic pain and disease.