A Stanford Medicine-led study develops an AI tool that predicts prematurity complications by analyzing blood samples collected at birth. The algorithm correlates molecular patterns with health outcomes, offering a new understanding of prematurity as multiple distinct conditions.
A new diet option has been shown to improve both physical symptoms and biological indicators of mild-to-moderate Crohn's disease. Participants in the fasting mimicking group experienced significant declines in fecal calprotectin, a protein indicating gut inflammation, and showed clinical benefits even after just one cycle.
A new AI model, SleepFM, uses large-scale sleep data to predict over 100 health conditions. The model analyzes various physiological signals and identifies patterns that can forecast disease onset with reasonable accuracy.
Researchers identified CXCL10 and IFN-gamma as the major drivers of myocarditis in mRNA-vaccine recipients. The two proteins trigger an inflammatory response that damages heart muscle cells, leading to hospitalizations and deaths in severe cases. Most cases recover swiftly with full heart function retained.
A Stanford Medicine-led study reveals that a signaling pathway controls the immune response, allowing researchers to potentially treat various diseases. The research focuses on peripheral immune tolerance, which prevents inappropriate attacks on healthy tissue.
Researchers found that those who received the shingles vaccine were 20% less likely to develop dementia over seven years compared to those who did not receive it. The vaccine was also shown to slow disease progression in those already diagnosed with dementia.
A Stanford Medicine-led study discovers an oral treatment that regenerates joint cartilage in old mice, reversing naturally occurring cartilage loss and preventing arthritis. The treatment targets the cause of osteoarthritis, a degenerative joint disease affecting millions worldwide.
Researchers at Stanford Medicine have successfully transplanted a hybrid immune system into mice with Type 1 diabetes, preventing the disease from progressing. The approach involves adding a drug to the pre-transplant regimen, which resulted in all mice being cured or prevented from developing the disease.
A new machine learning model predicts the time of death for organ donors, enabling more efficient liver transplants. The model outperformed surgeon judgment and reduced futile procurements by 60%, making the transplant process more efficient and potentially allowing more candidates to receive a transplant.
Researchers at Stanford University found that very old mice are less prone to cancer, with significantly fewer lung tumors than younger animals. This contradicts the long-held assumption that cancer risk increases with age, suggesting a deeper biological cause.
Researchers found that the Epstein-Barr virus (EBV) is directly responsible for triggering lupus, a chronic autoimmune condition. Most Americans carry EBV, which resides silently inside their bodies and can activate autoreactive B cells to attack healthy tissues.
A new study by Stanford Medicine researchers finds that a personalized prehab coaching program can motivate patients, enhance their immune system, and result in fewer complications. The study suggests that one-on-one help is crucial for successful prehabilitation, leading to better adherence and improved clinical outcomes.
Researchers have developed a low-cost approach, called ComSLI, that can visualize the orientation and organization of tissue fibers at micrometer resolution. This enables detailed mapping of neural pathways and fiber appearances in various tissues, including brain samples from patients with neurological disorders like Alzheimer's disease.
Researchers used smartphones to track patients with neuromuscular diseases, achieving results comparable to traditional movement tests. The system detected disease-specific movement patterns, allowing for early diagnosis and treatment.
Researchers at Stanford Medicine have created a new cell-sorting device that uses electromagnetic levitation to separate different types of cells, including cancer cells and live cells from dead cells. The device can precisely direct the movement of cells without attaching fluorescent labels or exposing them to harsh chemicals.
The PRIMA device partially restored vision to 27 out of 32 participants in a clinical trial, allowing them to read with acuity equivalent to 20/42 vision. The device works by projecting images onto the retina via infrared light and converting them into electrical stimulation, enabling form vision.
A new study led by Stanford Medicine found that premature babies who heard recordings of their mothers reading to them showed improved language pathways in their brains. The researchers played the recordings for a total of 2 hours and 40 minutes a day, and saw measurable differences in brain development.
Researchers found that older mice showed less stable spatial memory and difficulty navigating between familiar and unfamiliar environments. In contrast, younger mice developed distinct firing patterns for each track, allowing them to remember hidden reward locations on alternating tracks with ease.
Researchers developed a collection of blood tests that assess genetic activity patterns in immune cells to reveal patient immune states. These tests could help physicians determine diagnosis and care protocols for patients with suspected infections or critical conditions, providing more accurate diagnoses and treatment guidance.
A study by Stanford Medicine researchers reveals that creeping fat, a type of abnormal adipose tissue, forms scars in the intestines of people with Crohn's disease. This triggers debilitating scarring, which worsens symptoms and treatment options for patients.
Researchers at Stanford Medicine have created an AI-powered CRISPR tool called CRISPR-GPT, which helps scientists design and analyze gene-editing experiments. The technology aims to produce lifesaving drugs faster and expand access to gene editing for a wider range of scientists, including those with limited experience.
A study by Stanford Medicine researchers finds that permanent standard time would be healthier than seasonal shifting, with benefits including reduced cases of stroke and obesity. Permanent daylight saving time would achieve about two-thirds of the same effect.
Lucy Shapiro, a pioneering biologist and advocate, is awarded the Lasker-Koshland Award for her life-changing trajectory in chemistry and biology. Her work on bacterial compartmentalization has overturned prevailing ideas and paved the way for new discoveries.
Researchers discover lung cancer cells in the brain form synapses with neurons, promoting tumor growth. This finding highlights the importance of neural signaling in cancer growth and suggests novel therapies to interrupt this signaling.
A Stanford Medicine-led study found that many young children with ADHD are prescribed medication just after diagnosis, contradicting treatment guidelines. The study highlights a gap in medical care for 4- and 5-year-olds with ADHD, who should try six months of behavior therapy before starting medication.
Researchers have found that hyperactivity in a specific brain region can drive behaviors associated with autism spectrum disorder. They reversed symptoms such as seizures, sensory hypersensitivity and repetitive behaviors by suppressing this area of the brain using epilepsy drugs.
Researchers at Stanford Medicine developed a non-invasive system that delivers drugs to specific regions of the body, reducing unwanted side effects. The system uses nanoparticles encapsulated in a sugar solution that responds to ultrasound stimulation, allowing for precise delivery of medication.
Researchers developed a device and platform to measure Parkinson's disease symptoms quantitatively and reproducibly. The technology allows clinicians to guide treatments remotely and has been shown to be easy to use by patients.
Researchers at Stanford Medicine developed a way to replace more than half of the most severely affected brain cells with non-genetically matched precursor cells in mice. The approach helped animals live longer and reduced behavioral symptoms of the disease, offering hope for families of children with these rare diseases.
A Stanford Medicine-led report found that children with rare flu complications like influenza-associated acute necrotizing encephalopathy (ANE) need prompt treatment to survive. The condition causes brain swelling and a runaway immune response, leading to fatal outcomes if left untreated.
Researchers at Stanford Medicine have developed a virtual lab powered by AI, allowing them to tackle complex biological problems and devise innovative solutions. The virtual lab has been successfully tested in devising a new basis for a vaccine against recent COVID-19 variants using nanobodies.
Researchers found that ibogaine significantly improves cognitive function and reduces PTSD symptoms in veterans with TBI. The study suggests that stronger theta rhythms may promote neuroplasticity, while reduced cortical activity may alleviate PTSD symptoms.
Researchers at Stanford Medicine have developed an antibody treatment that eliminates the need for toxic busulfan chemotherapy or radiation in stem cell transplants, making it possible to treat patients with Fanconi anemia and other genetic diseases. The new approach has shown exceptional outcomes, enabling patients to complete two yea...
Researchers developed a new method to generate CAR-T cells in laboratory mice with mRNA-based vaccines, which proved effective and safe. The approach eradicated tumors in 75% of mice with B cell lymphoma after several doses.
Researchers developed a blood-based indicator of organ age and found that individuals with young brains have a lower risk of developing diseases associated with their brain. The study also showed that organs' biological ages can predict health outcomes, such as increased risk of Alzheimer's disease for those with an old brain.
A new study led by Stanford Medicine suggests that inhibiting the LRRK2 enzyme could stabilize brain cell signaling and potentially halt cell death in Parkinson's disease. The researchers found that a kinase inhibitor, MLi-2, restored primary cilia on brain cells, enabling them to receive crucial signals and survive.
Researchers at Stanford Medicine discovered that a common signaling pathway protects airways from damage caused by toxins like wildfire smoke or respiratory viruses. The drug, which activates the pathway, protected mice with influenza or COVID-19 infections, while blocking it caused severe damage to their airways.
A decrease in acute myocardial infarction deaths has led to an increase in deaths from other types of chronic heart conditions. The researchers attribute this shift to improved management and prevention of heart attacks, resulting in more patients living beyond these events and developing other heart conditions.
A phase 3 clinical trial shows that genetically engineered skin grafts treat severe dystrophic epidermolysis bullosa, reducing pain and healing time. The treatment is part of a larger effort to improve EB patients' treatment options.
Researchers at Stanford Medicine successfully grew heart and liver organoids with integrated blood vessels, allowing them to overcome the current size limit. These vascularized organoids can grow larger and reach a more mature state, making them more useful as biological models for research and potential treatment of various diseases.
A new study published in Nature Medicine suggests that individual differences in blood sugar responses to various carbohydrates can indicate specific metabolic health subtypes. These subtypes are associated with different levels of insulin resistance or beta-cell dysfunction, which can contribute to prediabetes and Type 2 diabetes.
Researchers at Stanford Medicine have mapped brain activity underlying emotional responses to mild unpleasant sensory experiences. Shared features between human and mouse brains may help understand driving forces behind neuropsychiatric disorders. The study's findings could unveil new insights into the mechanisms of emotional regulation.
Researchers at Stanford Medicine have discovered the long-sought genetic mutation responsible for orange cat coloration, which occurs exclusively in males. The study reveals how subtle genetic changes give rise to new traits and sheds light on molecular evolution.
A new Stanford Medicine-led study reveals that CAR-T cell therapy causes mild cognitive impairments in cancer patients, independent of other treatments. Researchers identified the cellular mechanism behind this effect and found strategies to reverse it.
A Stanford Medicine study found that VR-guided meditation reduced parental anxiety by 30% and was more effective for Spanish-speaking families. The six-minute guided meditation helps build healthy coping skills, allowing parents to manage stress in the hospital setting.
Researchers found that blocking the activity of a protein called erythropoietin (EPO) turns formerly 'cold' liver tumors into 'hot' tumors teeming with cancer-fighting immune cells. The treatment led to complete regression of existing liver tumors in most mice, outperforming immunotherapy alone.
A recent study by Stanford Medicine researchers warns that measles and other diseases may make a comeback in the US if immunization rates drop. The study found that even at current levels, measles may become endemic within two decades, leading to an estimated 851,300 cases over 25 years.
Researchers developed a blood test analyzing messenger RNA to detect cancers, track treatment resistance, and monitor tissue injury. The test increased cancer detection by over a factor of 50 and provides useful information for non-cancer applications, such as COVID-19 severity and lung health.
Scientists have built a digital twin of the mouse brain's visual cortex using AI, predicting neural activity and anatomical features. The model can generalize to new visual inputs and data, speeding up brain research and understanding intelligence.
Researchers successfully assembled a miniaturized human nervous system to reconstitute the ascending sensory pathway, which transmits sensations from the skin to the brain. The new construct promises to accelerate understanding and treatment of chronic pain by allowing for non-invasive modeling and manipulation of the pain pathway.