A new study by Stanford Medicine researchers finds that a personalized prehab coaching program can motivate patients, enhance their immune system, and result in fewer complications. The study suggests that one-on-one help is crucial for successful prehabilitation, leading to better adherence and improved clinical outcomes.
Researchers have developed a low-cost approach, called ComSLI, that can visualize the orientation and organization of tissue fibers at micrometer resolution. This enables detailed mapping of neural pathways and fiber appearances in various tissues, including brain samples from patients with neurological disorders like Alzheimer's disease.
Researchers used smartphones to track patients with neuromuscular diseases, achieving results comparable to traditional movement tests. The system detected disease-specific movement patterns, allowing for early diagnosis and treatment.
Researchers at Stanford Medicine have created a new cell-sorting device that uses electromagnetic levitation to separate different types of cells, including cancer cells and live cells from dead cells. The device can precisely direct the movement of cells without attaching fluorescent labels or exposing them to harsh chemicals.
The PRIMA device partially restored vision to 27 out of 32 participants in a clinical trial, allowing them to read with acuity equivalent to 20/42 vision. The device works by projecting images onto the retina via infrared light and converting them into electrical stimulation, enabling form vision.
A new study led by Stanford Medicine found that premature babies who heard recordings of their mothers reading to them showed improved language pathways in their brains. The researchers played the recordings for a total of 2 hours and 40 minutes a day, and saw measurable differences in brain development.
Researchers found that older mice showed less stable spatial memory and difficulty navigating between familiar and unfamiliar environments. In contrast, younger mice developed distinct firing patterns for each track, allowing them to remember hidden reward locations on alternating tracks with ease.
Researchers developed a collection of blood tests that assess genetic activity patterns in immune cells to reveal patient immune states. These tests could help physicians determine diagnosis and care protocols for patients with suspected infections or critical conditions, providing more accurate diagnoses and treatment guidance.
A study by Stanford Medicine researchers reveals that creeping fat, a type of abnormal adipose tissue, forms scars in the intestines of people with Crohn's disease. This triggers debilitating scarring, which worsens symptoms and treatment options for patients.
Researchers at Stanford Medicine have created an AI-powered CRISPR tool called CRISPR-GPT, which helps scientists design and analyze gene-editing experiments. The technology aims to produce lifesaving drugs faster and expand access to gene editing for a wider range of scientists, including those with limited experience.
A study by Stanford Medicine researchers finds that permanent standard time would be healthier than seasonal shifting, with benefits including reduced cases of stroke and obesity. Permanent daylight saving time would achieve about two-thirds of the same effect.
Lucy Shapiro, a pioneering biologist and advocate, is awarded the Lasker-Koshland Award for her life-changing trajectory in chemistry and biology. Her work on bacterial compartmentalization has overturned prevailing ideas and paved the way for new discoveries.
Researchers discover lung cancer cells in the brain form synapses with neurons, promoting tumor growth. This finding highlights the importance of neural signaling in cancer growth and suggests novel therapies to interrupt this signaling.
A Stanford Medicine-led study found that many young children with ADHD are prescribed medication just after diagnosis, contradicting treatment guidelines. The study highlights a gap in medical care for 4- and 5-year-olds with ADHD, who should try six months of behavior therapy before starting medication.
Researchers have found that hyperactivity in a specific brain region can drive behaviors associated with autism spectrum disorder. They reversed symptoms such as seizures, sensory hypersensitivity and repetitive behaviors by suppressing this area of the brain using epilepsy drugs.
Researchers at Stanford Medicine developed a non-invasive system that delivers drugs to specific regions of the body, reducing unwanted side effects. The system uses nanoparticles encapsulated in a sugar solution that responds to ultrasound stimulation, allowing for precise delivery of medication.
Researchers developed a device and platform to measure Parkinson's disease symptoms quantitatively and reproducibly. The technology allows clinicians to guide treatments remotely and has been shown to be easy to use by patients.
Researchers at Stanford Medicine developed a way to replace more than half of the most severely affected brain cells with non-genetically matched precursor cells in mice. The approach helped animals live longer and reduced behavioral symptoms of the disease, offering hope for families of children with these rare diseases.
A Stanford Medicine-led report found that children with rare flu complications like influenza-associated acute necrotizing encephalopathy (ANE) need prompt treatment to survive. The condition causes brain swelling and a runaway immune response, leading to fatal outcomes if left untreated.
Researchers at Stanford Medicine have developed a virtual lab powered by AI, allowing them to tackle complex biological problems and devise innovative solutions. The virtual lab has been successfully tested in devising a new basis for a vaccine against recent COVID-19 variants using nanobodies.
Researchers found that ibogaine significantly improves cognitive function and reduces PTSD symptoms in veterans with TBI. The study suggests that stronger theta rhythms may promote neuroplasticity, while reduced cortical activity may alleviate PTSD symptoms.
Researchers at Stanford Medicine have developed an antibody treatment that eliminates the need for toxic busulfan chemotherapy or radiation in stem cell transplants, making it possible to treat patients with Fanconi anemia and other genetic diseases. The new approach has shown exceptional outcomes, enabling patients to complete two yea...
Researchers developed a new method to generate CAR-T cells in laboratory mice with mRNA-based vaccines, which proved effective and safe. The approach eradicated tumors in 75% of mice with B cell lymphoma after several doses.
Researchers developed a blood-based indicator of organ age and found that individuals with young brains have a lower risk of developing diseases associated with their brain. The study also showed that organs' biological ages can predict health outcomes, such as increased risk of Alzheimer's disease for those with an old brain.
A new study led by Stanford Medicine suggests that inhibiting the LRRK2 enzyme could stabilize brain cell signaling and potentially halt cell death in Parkinson's disease. The researchers found that a kinase inhibitor, MLi-2, restored primary cilia on brain cells, enabling them to receive crucial signals and survive.
Researchers at Stanford Medicine discovered that a common signaling pathway protects airways from damage caused by toxins like wildfire smoke or respiratory viruses. The drug, which activates the pathway, protected mice with influenza or COVID-19 infections, while blocking it caused severe damage to their airways.
A decrease in acute myocardial infarction deaths has led to an increase in deaths from other types of chronic heart conditions. The researchers attribute this shift to improved management and prevention of heart attacks, resulting in more patients living beyond these events and developing other heart conditions.
A phase 3 clinical trial shows that genetically engineered skin grafts treat severe dystrophic epidermolysis bullosa, reducing pain and healing time. The treatment is part of a larger effort to improve EB patients' treatment options.
Researchers at Stanford Medicine successfully grew heart and liver organoids with integrated blood vessels, allowing them to overcome the current size limit. These vascularized organoids can grow larger and reach a more mature state, making them more useful as biological models for research and potential treatment of various diseases.
A new study published in Nature Medicine suggests that individual differences in blood sugar responses to various carbohydrates can indicate specific metabolic health subtypes. These subtypes are associated with different levels of insulin resistance or beta-cell dysfunction, which can contribute to prediabetes and Type 2 diabetes.
Researchers at Stanford Medicine have mapped brain activity underlying emotional responses to mild unpleasant sensory experiences. Shared features between human and mouse brains may help understand driving forces behind neuropsychiatric disorders. The study's findings could unveil new insights into the mechanisms of emotional regulation.
Researchers at Stanford Medicine have discovered the long-sought genetic mutation responsible for orange cat coloration, which occurs exclusively in males. The study reveals how subtle genetic changes give rise to new traits and sheds light on molecular evolution.
A new Stanford Medicine-led study reveals that CAR-T cell therapy causes mild cognitive impairments in cancer patients, independent of other treatments. Researchers identified the cellular mechanism behind this effect and found strategies to reverse it.
A Stanford Medicine study found that VR-guided meditation reduced parental anxiety by 30% and was more effective for Spanish-speaking families. The six-minute guided meditation helps build healthy coping skills, allowing parents to manage stress in the hospital setting.
Researchers found that blocking the activity of a protein called erythropoietin (EPO) turns formerly 'cold' liver tumors into 'hot' tumors teeming with cancer-fighting immune cells. The treatment led to complete regression of existing liver tumors in most mice, outperforming immunotherapy alone.
A recent study by Stanford Medicine researchers warns that measles and other diseases may make a comeback in the US if immunization rates drop. The study found that even at current levels, measles may become endemic within two decades, leading to an estimated 851,300 cases over 25 years.
Researchers developed a blood test analyzing messenger RNA to detect cancers, track treatment resistance, and monitor tissue injury. The test increased cancer detection by over a factor of 50 and provides useful information for non-cancer applications, such as COVID-19 severity and lung health.
Scientists have built a digital twin of the mouse brain's visual cortex using AI, predicting neural activity and anatomical features. The model can generalize to new visual inputs and data, speeding up brain research and understanding intelligence.
Researchers successfully assembled a miniaturized human nervous system to reconstitute the ascending sensory pathway, which transmits sensations from the skin to the brain. The new construct promises to accelerate understanding and treatment of chronic pain by allowing for non-invasive modeling and manipulation of the pain pathway.
Physician burnout rates have dropped slightly since the last study in 2021, but still remain a concern, affecting quality of patient care and work-life integration. Women physicians are more likely to experience burnout than men, while doctors in certain specialties like emergency medicine face heightened risk.
A new study published in Nature found that the shingles vaccine may lower dementia risk by 20%, with researchers analyzing health records of over 280,000 older adults in Wales. The vaccine was shown to reduce the occurrence of shingles by 37% and is considered a promising preventive intervention for dementia.
A Stanford Medicine study reveals glucose plays a crucial role in tissue regeneration by binding to proteins that control gene expression. Researchers found that glucose levels increase significantly as cells differentiate, supporting the growth of specialized cells in various tissues.
A Stanford Medicine study demonstrates how an AI algorithm can enable doctors to make better clinical decisions for sick newborns. The algorithm predicts which nutrients preemies need and in what quantities, reducing medical errors and saving time.
A new gel impregnated with molecule T-5224 blocks key signaling pathway in scar tissue formation, reducing adhesions by nearly 300% in mice and minipigs. The gel is easy to apply and release the molecule over a period of two weeks.
Researchers develop a 'colocatome' to study the interactions between cancer cells and their surrounding non-cancerous cells, revealing how these interactions impact tumor growth and treatment resistance. The study aims to provide insights into universal rules of tumor behavior and guide the design of more effective treatments.
A newly discovered peptide called BRP has been found to rival semaglutide (Ozempic) in suppressing appetite and reducing body weight. Unlike Ozempic, BRP acts through a separate metabolic pathway, activating different neurons in the brain, which may offer a more targeted approach to body weight reduction.
Researchers at Stanford Medicine have devised a way to mine the immune system's internal database to diagnose diseases such as diabetes and COVID-19. The machine-learning based technique, called Mal-ID, uses B and T cell receptor sequences and structures to identify individuals with specific diseases.
A large-scale screen of single nucleotide variants has identified 380 variants controlling cancer-associated genes. These variants regulate biological pathways such as DNA repair, energy production, and cell microenvironment interaction. The findings suggest new therapeutic targets for preventing or stopping cancer growth.
A new Stanford Medicine-led study found that 59% of kids who die in mass shootings were at the hands of a family member. The research highlights the need to protect children from firearm injuries and domestic violence, emphasizing that homes may be more dangerous than schools.
A new blood test developed at Stanford Medicine has shown to accurately diagnose invasive mold disease in most cases, replacing invasive procedures. The test detects genetic material from mold in the bloodstream, allowing for faster diagnosis and treatment, which has been linked to improved patient outcomes.