A study published in Nature Communications found that developing countries get more nutrition per dollar in seafood imports than developed countries. They receive more protein, fatty acids, iron, and vitamin B12 per dollar, largely because they pay less for non-nutritional attributes like convenience.
A new AI framework called MetaGIN delivers fast and accurate predictions of molecular properties without relying on complex 3D structural data. This innovation promises to accelerate early-stage drug discovery and bring new therapies closer to patients by reducing computational bottlenecks and resource requirements.
Researchers at Iowa State University developed a new internal barrel design for the 'gene gun' technology, improving its efficiency by up to 50 times. The Flow Guiding Barrel reduces particle loss and uneven distribution, enabling more consistent and reliable genetic material delivery into plant cells.
Research using cardiac MRI found that long-term exposure to air pollution is associated with early signs of heart damage, including diffuse myocardial fibrosis. The study suggests that fine particulate matter in the air may contribute to changes in the heart structure, potentially setting the stage for future cardiovascular disease.
The Society for Cardiovascular Angiography and Interventions (SCAI) has published evidence-based clinical practice guidelines for the management of chronic venous disease. The guidelines provide patient-centered recommendations on therapeutic options, including compression therapy, wound care, and minimally invasive procedures. Key fin...
The American Thoracic Society has launched an initiative to provide paid time-off for employees participating in clinical trials. This effort aims to reduce barriers to participation, particularly among underserved communities, and promote diversity in medical research.
The Brain & Behavior Research Foundation invites a free webinar on transforming OCD treatment outcomes. Dr. Helen Blair Simpson will discuss the most effective first-line treatments and neuroimaging research seeking to uncover brain mechanisms underlying OCD.
A new study maps the geographical distribution of shallow-water marine mollusks, showing how temperature, ocean currents, and paleogeographic development shape their habitats. The research highlights the impact of rapid climate change on marine ecosystems, threatening biodiversity.
A study found a significant increase in adolescent vaping of THC, CBD, and synthetic cannabinoids from 2021 to 2023. The prevalence of THC vaping peaked in 2022, while SCs continued to rise, with females having a higher rate of vaping these substances.
A new study led by Stanford Medicine suggests that inhibiting the LRRK2 enzyme could stabilize brain cell signaling and potentially halt cell death in Parkinson's disease. The researchers found that a kinase inhibitor, MLi-2, restored primary cilia on brain cells, enabling them to receive crucial signals and survive.
Researchers developed Variant-aware Cas-OFFinder, a web-based tool that improves CRISPR accuracy by identifying off-target effects across genetic variations. The tool offers a significant step forward in personalized genome editing by incorporating genetic diversity directly into off-target predictions.
Hideyuki Okano has been elected President of the International Society for Stem Cell Research (ISSCR), an organization dedicated to promoting excellence in stem cell science. He will champion inclusive excellence, advance discovery, and ensure that the transformative promise of stem cell science benefits the world.
A study by Brown University researchers found that people tend to gossip less with friends of the subject and more with popular yet distantly connected individuals. The researchers used a computational model to simulate how brains predict gossip movement through social networks, revealing the sophistication of human gossiping abilities.
A large observational study found that women over 65 are at higher risk of cervical cancer due to HPV, contradicting current guidelines. The study suggests that these women should be re screened for cervical cancer as the risk is significantly higher than previously thought
Researchers at Huazhong University of Science and Technology have developed a new approach to help artificial intelligence work more reliably with messy or misleading data. The Soft-GNN method selectively uses cleaner data during training, achieving lower error rates and more stable performance, particularly under high-noise conditions.
Researchers built a digital model of a bee's brain, discovering how movement facilitates accurate learning and recognition of complex visual patterns. This breakthrough could lead to more efficient AI and robots that use movement to gather information.
A study by Georgia State University researchers found that a novel mucosal adjuvant enhances protection against various influenza virus challenges. The adjuvant, derived from mature bone marrow-derived dendritic cells, elicited significant and cross-reactive immune responses in mice.
Mitochondria are responsible for producing cellular energy and maintaining homeostasis, but dysfunction has been implicated in neurodegenerative disorders, cardiovascular diseases, metabolic disorders, cancer, and aging. Targeted therapies are being explored to restore mitochondrial function and reduce oxidative stress.
Researchers have confirmed the presence of Barbonymus schwanefeldii (tinfoil barb) in Laguna de Bay, Philippines' largest freshwater lake. The invasive species can outcompete native fish for food and breeding grounds, posing long-term ecological consequences.
A new study by Mass General Brigham found that hospitals that implemented improved recovery protocols saw a significant decrease in patients' long-term opioid use. The research suggests that minimizing opioid exposure during and after surgery can help reduce the risk of addiction.
A new study reveals that turbulence-induced disturbances can trigger compressor stall precursors, and a large-eddy simulation method captures these dynamics. The researchers propose several indicators for assessing stability limits and emphasize the need for scale-resolving numerical methods to simulate complex flows.
Researchers developed a novel passive control method inspired by bird feathers, achieving minimal additional losses while maintaining induced vortex strength. The bio-inspired herringbone groove array delays airfoil stall by strengthening mixing between mainstream and boundary layer, enhancing energy resistance.
A recent study published in Genes & Diseases reveals the relationship between immune cell characteristics, blood metabolites, and urolithiasis. The research highlights how genetically predicted blood metabolites mediate the association between specific immune cell profiles and urinary stone formation.
Research reveals common patterns between ice shelf, sea ice, and ocean swell conditions prior to three large-scale iceberg calving events. Long periods of sea ice loss surrounding the ice shelves were found in the months leading up to the events.
A clinical trial found that vitamin D3 nanoemulsion significantly improved core symptoms of autism spectrum disorder in children, including language development and adaptive behavior. The nanoemulsion form was shown to be more effective than conventional oral supplementation.
A new study published in PLOS Biology found that non-invasive brain stimulation can improve maths learning outcomes for individuals with weaker brain connectivity between the dorsolateral prefrontal cortex and the posterior parietal cortex. The treatment also showed positive effects on GABA levels, a brain chemical involved in learning.
Scientists have developed a new multiscale modeling approach that can simulate how microscopic changes affect macroscale brain activity. The framework successfully predicted the effects of anesthesia on synaptic receptors, bridging the gap between molecular and whole-brain levels.
Researchers at Stanford Medicine discovered that a common signaling pathway protects airways from damage caused by toxins like wildfire smoke or respiratory viruses. The drug, which activates the pathway, protected mice with influenza or COVID-19 infections, while blocking it caused severe damage to their airways.
The project aims to improve propellant and life-support compound production in lunar and Martian environments. The researchers will evaluate the performance of a patent-pending electrolyzer developed with NASA support, testing its ability to produce fuel and oxygen.
The University of Miami and Frontiers have partnered on a flat fee open access agreement, allowing affiliated researchers to publish in high-impact journals without APCs. This partnership enhances the visibility of research outputs across various fields, providing a reputable platform for scholars to share their work globally.
Researchers found that prebiotics such as FOS increased brain GABA levels in mice, while also raising homocarnosine levels, which may enhance brain health. The study suggests a potential link between gut microbiota and brain GABA levels.
A study found that CEOs with Machiavellian personalities, characterized by self-interest and manipulation, earn significantly more than their counterparts. These leaders often secure higher pay through negotiation skills, benefiting both the company and themselves.
Scientists have developed a miniature device that mimics human bone marrow and immune environment, enabling predictive testing of cancer immunotherapy success in patients. The device recreates three regions of bone marrow where leukemia develops and retains the complex immune environment of the tissue.
A new method of separating rare earth elements from used neodymium magnets has been developed, allowing for environmentally friendly purification without organic solvents or toxic substances. The process is adaptable for other rare earths found in neodymium magnets and has the potential to influence various industrial sectors.
Researchers at the University of Illinois Urbana-Champaign have developed a new non-invasive MRI approach that visualizes brain metabolism and detects metabolic alterations associated with brain diseases. The technique uses magnetic resonance spectroscopic imaging to provide insights into brain function and disease processes.
A new study by Michigan State University found that people's personality perceptions of tattooed individuals are often inaccurate. Researchers discovered that those with quirky or wacky tattoos were accurately judged as open-minded and open to new experiences, despite not aligning with other traits.
A new study found that Black emergency department patients are less likely to be treated with opioids, but when their preferences are not met, they are at a higher risk of misusing opioids three months later. Patients who were satisfied with their pain care had lower rates of opioid misuse.
A new study found that amylin administration exacerbates tauopathy by impairing lysosomal mechanisms in a hybrid diabetes model. The research highlights the intricate relationship between diabetes and Alzheimer's disease, suggesting that amylin plays a key role in the pancreas-brain axis.
A new study published in Epilepsy & Behavior found that a self-management program for people with epilepsy can reduce health complications, improve mood, and enhance quality of life. The program, called SMART, features remote training sessions and written resource materials to help participants manage their condition.
Climate anxiety is growing, especially amongst young people, due to the polarized debate around climate change. Professor Beattie's book offers psychological tips on how to handle climate anxiety, including writing personal narratives about difficult emotional experiences. Strategies focus on improving mental well-being and empowering ...
A new executive order aims to deregulate the US seafood sector, but experts argue it will weaken scientific authority and environmental protections. The policy threatens the sustainability of wild fisheries and aquaculture development, which is crucial for food security.
Residential segregation contributes to lung cancer development in African Americans, highlighting the need for policymakers to address disparities. Structural racism in neighborhoods affects health outcomes, emphasizing the importance of reducing racial gaps in healthcare.
Researchers create a potential treatment for glioblastoma, called MT-125, that makes malignant cells responsive to radiation and chemotherapy. The compound also blocks the cancer's ability to invade other tissue and has shown promise in animal studies.
The European Centre for Disease Prevention and Control (ECDC) has launched new weekly surveillance updates and public health guidance on mosquito-borne diseases, covering chikungunya, dengue, Zika, and West Nile viruses. The reports provide a comprehensive view of the evolving situation across European countries.
This study investigates the cyclic bond behavior of FRP bars in concrete, analyzing key factors such as bar diameter and embedment length. A unified bond stress–slip constitutive model is developed to capture interfacial degradation mechanisms under cyclic loads.
Aortic aneurysms are potentially lethal dilatations of the aorta with limited treatment options. Researchers seek to understand molecular mechanisms and develop targeted therapies to prevent AA morbidity and deaths. Dr. Francesca Seta aims to create experimental tools for novel therapies.
A landmark 30-year study of over four million women in England found that women with endometriosis-associated infertility had a four times higher chance of conception compared to those with infertility from other causes. The study also showed that women with endometriosis may retain good reproductive potential, especially if diagnosed ...
A national study found children aged 2-4 years in the US are exposed to a wide range of hazardous chemicals, including phthalates and pesticides, which can interfere with hormone development and immune function. The research emphasizes the need for expanded biomonitoring and stronger regulations to protect children from harmful exposures.
A new research paper introduces DoliClock, a biological aging clock based on lipid profiles in the human brain, showing accelerated brain aging in individuals with autism, schizophrenia, and Down syndrome. The study found that dolichol levels serve as reliable biomarkers of aging.
Researchers have discovered that the down-regulation of YWHAB in ovarian cancer peritoneal metastasis cells promotes YAP signaling, enhancing chemotherapy resistance and maintaining stem-like characteristics. Targeting the YWHAB-YAP pathway may lead to innovative therapeutic strategies.
A study published in the Journal of Epidemiology & Community Health found that a pro-inflammatory diet during pregnancy may raise a child's risk of developing type 1 diabetes. The research, which followed pregnant women from Denmark, found a 16% increase in risk for each unit increase in dietary measure of inflammatory food intake.
A research team has proposed a novel algorithmic framework that leverages multi-frame spatio-temporal features to track swarm UAVs in air-to-air scenarios. The method achieves state-of-the-art performance across several datasets and demonstrates its suitability for real-world drone swarms.
A new software tool called VR-Omics has the potential to further our understanding of other childhood diseases. The technology can identify previously undetected cell activities of cardiac rhabdomyoma, a type of benign heart tumour that can cause respiratory distress and irregular heartbeat.
Researchers at the University of Illinois developed cryosoret nanoassemblies that enhance fluorescence signals, reducing detection limits for biomarkers. The new platform offers dual-mode interaction between electric and magnetic components of light, promising highly sensitive and tunable biosensing systems.
The new AIFS ENS model outperforms state-of-the-art physics-based models, with gains of up to 20%, and generates forecasts over 10 times faster while reducing energy consumption by approximately 1,000 times. This complements ECMWF's portfolio by leveraging machine learning and artificial intelligence.
Professor Eran Meshorer's groundbreaking research in epigenetics and stem cell biology has uncovered critical insights into chromatin structure and gene expression. His work has broad implications for regenerative medicine, developmental biology, and understanding neurological disorders.
A survey of over 2,200 US adults found that majority incorrectly believe plant-based diets are more expensive, with baby boomers being the most likely to think so. A diet centered on whole, minimally processed plant foods can be affordable and nourishing.
Researchers at University of Liège developed a safer, more environmentally friendly polymer called PHOx, which outperforms traditional polyurethane in critical medical applications. PHOx reduces blood clotting risks, inhibits bacterial adhesion, and is biocompatible, making it suitable for custom-made implants.
Research from Ann & Robert H. Lurie Children's Hospital of Chicago found that neurological crises, psychiatric conditions, and substance abuse were the most common reasons for school-based medical emergencies. The study highlights the need for schools to prioritize staff training and availability of key medications.
A new route for the efficient production of aromatics has been developed via the coupling of CO2 and propane over H-ZSM-5. The introduction of CO2 significantly improves aromatic selectivity, and carbon atoms in CO2 directly participate in product formation.
A novel dimethylpiperidine-based cross-linker, DPST, enables one-step enrichment and quantitative analysis of protein complexes in limited samples. Using DPST, researchers successfully mapped the protein interaction network in primary neurons and detected transient and weak interactions.
The Social Probing project uses indirect surveys to estimate public opinion, requiring smaller samples and preserving privacy. The methodology has been successfully applied to track COVID-19, estimate voting intentions, and analyze domestic chores distribution.
In a recent study, researchers found that loudness is a strong indicator of the speaker's facing direction, but also rely on spectral cues. The findings have implications for designing more realistic virtual interactions, particularly those involving human speech, and can enhance user experience in immersive media.
Researchers at King's College London used cryo-electron microscopy to study the flagellum in unprecedented detail, revealing its architecture and identifying potential drug targets. This breakthrough could lead to the development of new treatments for bacterial infections without driving resistance.
A new study from Michigan State University explores the economic shock of the largest series of U.S. tariff hikes since 1930, reshaping global supply chains. The framework helps researchers and policymakers understand the chaos and make sense of future disruptions.
A recent Norwegian University of Science and Technology study found that children born late in the year are more frequently diagnosed with mental health disorders, including ADHD. The researchers identified an increase in incidence of 20-80% for the youngest class members, regardless of birth weight or premature birth status.
A new protocol has been developed to enhance quantum metrology by leveraging quantum resonance dynamics in periodically driven spin systems. This approach eliminates the need for highly entangled states and achieves Heisenberg-limited measurement precision. The protocol starts with a robust and easily prepared SU(2) spin coherent state...
Researchers from Illinois Grainger College of Engineering have developed a simple method to realize asymmetric couplings in integrated photonics. They successfully demonstrated giant optical isolation and discovered photonic gyration, which could lead to new insights into topological physics.
A University of Adelaide study has revealed clear patterns in the flow of shark products between Australia and Aotearoa/New Zealand. The research highlights Asia as the primary source of origin for seized products, particularly fin products, which are used in shark fin soup.
The American College of Chest Physicians launches a new initiative to aid in reducing time to diagnosis for complex lung conditions like NTM disease and bronchiectasis. The Bridging Specialties program aims to provide clinicians with essential tools for earlier detection, accurate diagnosis, and effective management.
The University of Illinois team created a user-friendly process to improve enzyme performance using AI and automated robotics. By predicting sequence changes and testing variants, they increased the activity of two key industrial enzymes by up to 26 times and 90 times.
A new study by NERC finds that long-term funding has driven the UK's offshore wind industry, providing 17% of total UK electricity and supporting 32,000 jobs. The investment is expected to grow to 100,000 by 2030.
Researchers created a machine vision sensor that adapts to extreme changes in light faster than the human eye, using quantum dots to mimic key behaviors. The device can respond dynamically to bright and dim lighting, outperforming existing systems by reducing redundant data and computational burden.
A recent study published in Nature Metabolism found that electrical activity in synapses can lead to the use of lipid droplets as an energy source in the brain. Researchers discovered that neurons can break down fat into fatty acids and produce ATP, even when glucose is not present.
A new imaging technique developed by MIT researchers leverages reflections from wireless signals like Wi-Fi to create accurate 3D reconstructions of objects blocked from view. This approach achieved 96 percent reconstruction accuracy on everyday objects with complex shapes.
Research on record-low years of Antarctic sea ice reveals warming of the Southern Ocean, increased ice-shelf calving, and stronger phytoplankton blooms. Low sea-ice area negatively affects krill and fish populations, ultimately impacting their predators and humans operating in Antarctica.
A recent study utilizes genomic data and environmental factors to predict key apple traits, improving the selection process for climate-resilient cultivars. Deep learning models outperform traditional methods for traits with complex genetic architectures.
Dr. Salil Bidaye has received a $450,000 Klingenstein fellowship award to investigate the mechanisms behind postural instability, a hallmark of many neurological disorders that decreases quality of life. His research aims to advance motor control research across other model systems and inform brain-computer interface prosthetics.
Researchers have discovered that blocking NK cell checkpoints could significantly enhance cancer immunotherapy, providing new avenues for treating solid tumors and blood cancers. Emerging precision approaches using gene editing and engineered cell therapies promise specific recognition of cancer cells with potentially fewer side effects.
Laura Cancedda, head of IIT's Brain Development and Disease Research Unit, has been elected to EMBO for her research excellence. She joins two Italian researchers among the new 60 members from 18 countries, who will contribute to life sciences globally.
Researchers explored clinical implications of loss-of-function IKBKG/NEMO mutations in the NF-κB signaling pathway. The study revealed diverse clinical manifestations associated with these mutations, including skin abnormalities, dental anomalies, and infections.
Researchers analyzed immune cell transcriptomes to understand JIA's pathogenesis. Monocytes, monocyte-derived dendritic cells, and platelets are increased in JIA patients, while B-cell responses differ between sJIA and non-sJIA subtypes.
Researchers used herbarium specimens to estimate when plants germinated and grew in areas with varying climate conditions. The study found that plants adapt to hotter, drier times and microclimates, rather than changing their environments.
A large study found that a healthy diet rich in fibre and low in red meat, regular exercise, and not smoking significantly lowers diverticulitis risk. Lifestyle factors offset the effects of inherited genes, with a score of 5 being associated with a 50% lower risk.
Researchers analyzed blood cell genomes from 23 patients treated with various chemotherapies, discovering new patterns of DNA damage and mutational signatures associated with specific drugs. The study suggests using genomic data to choose chemotherapies that minimize premature ageing and potential secondary cancer risks.
Researchers have developed a knowledge graph-based approach to searching ROS packages, achieving at least 21% higher accuracy than existing methods. This tool helps developers find the right components in seconds, reducing bugs and improving robot performance.
Researchers have demonstrated a new technique, RisingAttacK, to manipulate all widely used AI computer vision systems, allowing them to control what the AI 'sees'. The attack is effective at influencing the AI's ability to detect top targets, such as cars, pedestrians, or stop signs.
The CNOP-DL method extends classical CNOP for deep learning methods, breaking deterministic causality and attributing forecast errors to all input slices. This new structure identifies critical time steps and locations where additional observations can significantly improve forecasts.
A custom CNN trained on synthetic datasets decomposes modes in multimode fiber, eliminating coherent detection. This approach achieves high frame rates and low power consumption with FPGA acceleration.
Recent studies show chlorpyrifos exposure impairs spermatogenesis by compromising blood-testis barrier integrity, disrupting Sertoli cell junctional function and inducing ferroptosis. Chlorpyrifos primarily metabolite TCP triggers clockophagy-mediated ferroptosis in Sertoli cells.
A new study reveals that thunderstorms are a major cause of tree death in tropical forests, explaining patterns of mortality and carbon storage. The research highlights the growing threat of storms to trees and the planet's carbon stores.
Researchers found significant differences in gut microbiota composition between pregnant women with and without gestational diabetes. A diagnostic model based on genus-level markers showed high precision for early detection of the condition, offering new opportunities for prevention and personalized management.
A new study found that acquiring a dog during the COVID-19 lockdown had a short-lived boost in cheerfulness but no long-term positive effects on human well-being. Losing a pet also did not leave a lasting impact on its former owners' well-being.
The study projects a significant increase in uterine cancer incidence and mortality rates in the US by 2050, with incidence-based mortality nearly three times higher in Black women compared to white women. The model also shows that obesity and hysterectomy rates will contribute to increased risks.
The latest APA journal issues feature research on high-potency cannabis use, adolescent suicidal behavior, and problematic internet usage. Highlights include a systematic review of cannabis health effects in adolescents and trends in prescription stimulant and opioid use among US teens.
A study published in PLOS Biology found that mild electrically stimulating certain neural networks can improve math learning in individuals with weaker connections. The researchers used brain stimulation and magnetic resonance spectroscopy to measure connection strength between brain regions associated with math learning.
A research team developed an AI tool that created 7,245 new proteins, which can be used in medicines, lab tests, and scientific research. The AI design process helps cut months of lab work down to weeks, making it faster and more efficient.
Researchers detected microplastics in 69% of women's follicular fluid and 55% of men's seminal fluid, with PTFE being the most prevalent polymer. The study highlights the need to explore possible implications for human reproductive health and fertility.
Researchers used daily high-resolution images to create 3D elevation models of three glaciers: La Perouse Glacier in Alaska, Viedma Glacier in Argentina, and Skamri Glacier in Central Asia. The analysis revealed consistent thinning in the Viedma and La Perouse Glaciers but a small net gain of ice in the Skamri Glacier.
A new study found that providing housing and supportive services without requiring drug treatment is a surprisingly cost-effective approach to helping unhoused people with opioid use disorder. The 'housing first' model output showed that people with stable housing are more likely to enter treatment for opioid use and have a higher like...
A new article by University of Bath academics highlights the urgent need to address conflicts of interest with industries causing harm, such as tobacco and ultra-processed food. The authors argue that excluding these industries from policy-making is essential to restore trust in public institutions and prevent ill health.
A study by KIOST finds rising sea temperatures causing Turbo sazae to expand its habitat 37 degrees north, indicating climate-driven shifts in marine ecosystems. The research analyzed genetic connectivity and physiological responses of the mollusk to warmer waters.
Researchers developed Clustered Reinforcement Learning (CRL), a plug-and-play framework that sorts similar situations into clusters, rewarding AI for trying new things and building on past successes. This approach achieves top performance across multiple benchmarks, including robotic control tasks and difficult Atari games.
A study explores how Arab men interpret and internalize their experiences of living in violent environments. Key findings reveal four central themes: the association of crime with power, emotional struggles, concerns for the future, and a desire for transformation. The research highlights an urgent need for culturally tailored therapeu...
A cross-sectional study revealed racial disparities in COVID-19 treatment, with targeted interventions like expanding rapid test access and virtual care potentially improving equity. The findings suggest that encounter-level factors, such as differences in diagnostic test type and site of care, contribute to these inequities.
A randomized clinical trial found that SMART training significantly improved cognitive gains in active-duty service members with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). The top-down approach of SMART brain training showed faster cognitive gains compared to a bottom-up approach.
A new study explores how cousin marriage traditions shape informal businesses in Africa, finding that firms operating in areas with a historical tradition of cousin marriage prioritize hiring relatives and experience greater employment increases but smaller gains in revenue.
Scientists have discovered that certain species of gut bacteria can absorb PFAS, potentially protecting against its harmful effects. The researchers plan to develop probiotic dietary supplements to boost the levels of these helpful microbes in our gut.
A new study from the University of Kansas has identified a small protein domain called Mac1 as a critical target for inhibiting coronavirus replication. The research team developed molecules that bind to Mac1 and inhibit viral activity in cell cultures, providing potential antiviral therapies for future pandemics.
A new study from the University of Bath found that inappropriate polypharmacy is a major driver of emergency hospital admissions among adults aged 65 and over. The researchers developed a digital tool to proactively identify older adults at risk of medication-related harm, which could reduce preventable emergency hospitalisations.
Researchers at George Mason University conducted impact testing on utility poles made of different materials to determine acceleration and behavior during impact. The study, funded by the Electric Power Research Institute, aims to compare performance across various material types.
A new neural network improves overall fact-checking accuracy and exact-match accuracy on standard benchmarks, highlighting the precise text that supports an event's truth. The model achieves a factual-accuracy score of 66.9% and exact matches rose to 42.9%, demonstrating its ability to adapt across languages.
A new IIASA-led study finds that Earth's carbon-climate system may be more fragile than thought, with quantified 'stress power' reaching between 12.8 and 15.5 pascals per year. The researchers also identified a turning point in the planet's response to stress around 1925-1945.
The Danforth Plant Science Center welcomes Dr. Justin Conover and Dr. Erin Sparks as new faculty members, expanding their expertise in polyploidy and plant biomechanics. These additions strengthen partnerships with the University of Missouri, elevating research on crop genetics and resilience.
A Nagoya University group created a sandwich ELISA technique to accurately measure polysialic acid levels in the blood of patients with psychiatric disorders. The technique uses antibodies that minimize non-specific binding, resulting in increased accuracy.
A report from the BMJ Commission on the Future of the NHS highlights alarming normalization of racism and sexism in the NHS. Discrimination and inequities lead to poor health outcomes, staff wellbeing issues, and significant financial consequences.
Researchers at Mass General Brigham found a novel strategy to help patients control their disease, increasing eligibility for stem cell transplants. The combination of duvelisib and romidepsin was effective, tolerable, and safe for patients with relapsed/refractory peripheral and cutaneous T-cell lymphomas.
Scientists at Duke University have developed a freely available tool that can estimate an individual's rate of aging and predict their risk for chronic diseases like dementia. The tool, called DunedinPACNI, analyzes brain scans to identify those who are aging faster, which may lead to cognitive decline and age-related health problems.
Researchers have identified a gene signature indicative of hepatic ferroptosis using an iron overload-induced mouse model and validated it in human liver injury systems. The study highlights the role of ferroptosis in liver injuries and offers potential therapeutic targets.
A new blue fluorescent molecule, TGlu, has been discovered that reaches record-breaking brightness and efficiency in both solid and liquid states. The molecule's design could cut down development time and cost for future applications.
Researchers developed a non-invasive method combining 3D laser scanning and sensor data analysis to detect subsurface structural defects in water treatment filters. This breakthrough significantly reduces inspection time and labor costs, ensuring safer and more efficient water processing.
A newly developed microfluidic point-of-care device has been tested on a small cohort of patients, demonstrating strong correlation with laboratory measurements and high diagnostic performance. The device offers a promising alternative for bilirubin testing in resource-limited settings.
A new study found that safe brain stimulation could help people aged 18 to 30 solve maths problems more efficiently by strengthening connectivity between the dorsolateral prefrontal cortex and posterior parietal cortex.
A new review recommends combining enfortumab vedotin with pembrolizumab as the first-line therapy for advanced urothelial cancer, offering a more effective and better-tolerated alternative to traditional chemotherapy.
A team of researchers has made significant strides in solving one of hypersonic aerodynamics' most persistent puzzles - the unpredictable transition from smooth to turbulent airflow. They discovered two competing instability patterns that provide a possible explanation for the long-debated transition reversal phenomenon.
Researchers investigated the link between HIV treatment regimens and osteoarthritis development, revealing that certain medications like lopinavir can exacerbate OA in the knee. The study's findings have important implications for people living with HIV, highlighting the need to carefully consider treatment options.
Researchers developed an energy-efficient strategy to tackle digital traffic jams during peak hours, ensuring seamless services like navigation updates and pollution alerts. The approach, powered by Lyapunov optimization and the Kuhn–Munkres algorithm, reduces processing delays and power use while maintaining system reliability.
A new computational biology pipeline has identified 13,312 highly conserved 'universal' groups of grass genes, present across all studied grasses and responsible for vital functions. The study used a Hidden Markov Model, which outperformed a simpler approach, to distinguish between lineage-specific and non-specific genes.
Researchers developed a magnetic resonance technique to detect fentanyl hydrochloride in sealed packages, offering a non-invasive solution. The technique uses Nuclear Quadrupole Resonance (NQR) spectroscopy, which can identify key target nuclei in the drug, allowing for effective detection and potential diversion of large quantities.
Researchers found that a single synonymous mutation in a gene drives cucumber elongation by altering RNA structure and function. This breakthrough has significant implications for crop breeding programs and may lead to the development of precision-crop improvement techniques.
Combinative and transformative creativity are recognized by Julio M. Ottino as essential components of creative breakthroughs. Historical figures such as Filippo Brunelleschi and Niels Bohr demonstrate creative fluidity, while AI's limitations in transformationally creative tasks are discussed.
New research from Aston University suggests that parents can help promote healthy eating in their children by creating structure and independence around mealtime. The study recommends prioritizing health, maintaining a calm atmosphere during meals, and setting regular meal times to encourage supportive feeding practices.
Dysregulation of phosphatases modulates various signaling pathways, including RAS/MAPK, PI3K, HIPPO, and JAK/STAT. This review highlights the tumour suppressive, tumour promoting, and context-dependent activities of phosphatases, as well as their roles in reshaping the tumour microenvironment through exosomal miRNA secretion.
A new study by the Complexity Science Hub questions Rotterdam's 'balanced neighborhoods' policy, finding little evidence of stronger community ties despite efforts to mix income groups. The research highlights the risks of gentrification and displacement of low-income communities.
Researchers developed a puzzle game called AI Puzzlers that teaches kids to spot errors in AI responses and think creatively. By comparing their solutions to those from various AI chatbots, kids learn to use AI as a tool that needs guidance rather than an answer machine.
A recent study by Prof. Dr. Detlef Pollack reveals a dramatic decline in religious ties across the world, with secularization being a major factor. The study examines various factors contributing to this decline, including growing prosperity and individualization.
This study found that NKAPL downregulation in NSCLC is associated with poor prognosis and hypermethylation of its promoter. High NKAPL expression inhibits NSCLC cell proliferation, migration, and invasion. NKAPL enhances TRIM21 protein stability, leading to suppression of the NF-κB signaling pathway.
A new study found that slower arm movements in older adults increase the risk of falls, which can lead to hip fractures. The research team discovered that faster arm corrections can limit whole-body movement during a slip, highlighting the importance of strengthening targeted muscles.
Researchers discovered high-velocity clouds in the nearby spiral galaxy M83, which moved at speeds significantly different from the galaxy's overall speed of rotation. The findings suggest that these clouds originated outside the galaxy, providing new insights into how galaxies acquire fresh gas and sustain star formation over billions...
Agroecological methods improve biodiversity, pollination, natural pest control, and crop yields, but new subsidies are needed to support farms' transition. The study found that incorporating nature-friendly practices increases benefits for nature and farmers, with higher soil carbon and overall increased crop yields.
New research reveals that plants rely on multiple heat-sensing systems and a sugar-based mechanism to detect temperature changes. Sugar produced in sunlight helps plants grow taller even when thermosensors like phytochrome B are less effective. This discovery could lead to breeding crops more resiliently under stress.
Researchers have made a breakthrough in understanding malaria parasite proteins that could lead to targeted therapies. Two key proteins, PfRAP03 and PfRAP08, regulate gene expression in the apicoplast, a unique organelle found in P. falciparum. The loss of either protein led to parasite death, confirming their essential roles.
Researchers developed a miniature 'leukemia-on-a-chip' device that recreates human bone marrow and immune system to predict cancer immunotherapy success. The device enables real-time observation of how immunotherapy drugs interact with cancer cells in an environment closely mimicking the human body.
Researchers assess ligament maturation and movement impact on scoliotic conditions, providing new insights into the structural hallmarks of embryonic spinal ligaments. The study aims to identify potential connections between embryonic movement and spinal deformities in adolescent idiopathic scoliosis.
A new study synthesized over 70 publications on the 2021 heat wave, attributing it to a rare high-pressure ridge and increasing temperatures. The researchers predict that such events will become more frequent as the climate warms.
Researchers have deciphered a key mechanism for RNA therapeutics, explaining why certain modified RNAs evade the innate immune response. Pseudouridine modifications can avoid detection by pattern recognition receptors, such as TLR7 and TLR8, through impaired endolysosomal processing.
Researchers propose a paradigm shift toward an educational model built on human interdependence, urging a re-examination of success and purpose. The new approach emphasizes uniquely human capacities, creativity, emotional intelligence, and collaboration with AI.
Researchers uncover evidence of monumental structures built by hunter-gatherer groups at Kaillachuro, a collection of burial mounds in the Titicaca Basin. Burial activity evolved over time into stone masonry burial boxes covered by mounds of debris from ongoing rituals and remembrances of ancestors.
Researchers decoded the complex history of ancient Arles' aqueduct system by analyzing limescale deposits and building materials. The study confirmed that the basin functioned as a header basin upstream of an aqueduct arcade bridge, and revealed the role of large lead pipes in supplying water to different parts of the city.
Researchers used machine learning to simulate galaxy evolution and supernova explosions, achieving speeds four times faster than supercomputers. This breakthrough enables the study of galaxy origins, including the creation of the Milky Way's elements essential for life.
Scientists have found a way to track protein structures directly inside cells using natural proteins as tiny sensors, providing a more accurate and non-invasive approach. This method could help study disease mechanisms such as cancer and neurodegeneration.
A study of over 1,000 students found a strong association between lactose intolerance and nightmares, suggesting that changing eating habits could alleviate poor sleep. The researchers also discovered that people with food sensitivities were more likely to report negative dreams and poor sleep quality.
Paulina DeVito, a Ph.D. candidate in computer science at Florida Atlantic University, has been awarded the NSF Graduate Research Fellowship to pursue research on developing large language model-based approaches for analyzing public discourse on social media. Her work aims to understand how people discuss emerging technologies and infor...
Researchers at Beihang University derived capture zones of pulsed and continuous guidance laws for both pursuer and evader, highlighting their differences and influence factors. The study provides a theoretical guideline for guidance law selection in various pursuit-evasion games.
Researchers have discovered an oral drug called MA-5 that can improve both heart and muscle problems in patients with Barth syndrome, a rare genetic disorder. The drug boosts cellular energy production by up to 50% and protects cells from oxidative stress-induced death, addressing the underlying cause of the disease.
A new study led by RMIT University found that restoring southern Australian reefs from urchin barrens is feasible and beneficial for improved water quality, fisheries, and carbon sequestration. Economic modelling showed an AU$50 million investment would return up to AU$92 million in economic benefits.
The American Heart Association has appointed two new volunteer leaders: Lee Shapiro, a financial expert in health technology, as chairperson, and Stacey Rosen, a cardiologist, as president. Both experts have extensive experience supporting women's cardiovascular health and aim to accelerate innovation and strategic collaborations.
Jingyan Han has received a three-year, $300,000 AHA Transformational Project Award to study artificial blood vessels using 3D printing. Her research aims to improve understanding of vascular biology and disease resistance by investigating the role of cell alignment in vascular function.
A new approach to intersectional learning prioritizes individual diversity and promotes collective emergence. By understanding the degree of relatedness between individuals and issues, stakeholders can be involved in a wider range of themes, leading to increased community engagement and learner transformations.
A research team discovered a counter-ion competition mechanism that explains the superiority of negatively charged nanofiltration membranes in separating lithium and magnesium ions. This finding provides critical insights for designing next-generation NF membranes with tailored ion selectivity.
A computational study found amygdalin to be a promising therapeutic agent for HER2-positive breast cancer. The compound shows favorable binding energies and induces structural changes in the HER2 protein, suggesting its potential to suppress cancer-promoting activity.
A new AI-driven model accurately predicts interactions between microRNAs and drugs, expanding the target pool for novel therapeutic targets. The model showed higher accuracy than previous methods across three public datasets, with performance scores reaching up to 96%.
Kilonova Seekers, a public participation project, has announced its first major discovery - a bright exploding star named GOTO0650. The team collected highly complete dataset on the star through fast response from volunteers, suggesting it's a period bouncer and rare object to find in wide-field imaging surveys.
Pyruvate alleviates ulcerative colitis symptoms by targeting cPLA2, suppressing TNFα/NFκB signaling and reducing inflammation. Pyruvate preserves intestinal mucosal barrier integrity and normalizes tight junction proteins.
Dr. Danielle Beckman's research uses animal models to understand how viruses like COVID-19 trigger neurological damage and accelerate Alzheimer's disease. Her work has established critical connections between viral infections and neurodegenerative processes.
A new dual diffusion framework, Para2Mesh, has been proposed to achieve direct prediction from design parameters to adaptive meshes aligned with the flow field. This approach overcomes the limitation of previous methods requiring posteriori solution information, enabling more efficient and accurate computational fluid dynamics simulati...
The study found that HIV testing rates were higher among men, younger individuals, and migrants, while women, older adults, and those living in rural areas were underdiagnosed. The results also reveal significant differences by socioeconomic level and geographical area, highlighting the need for targeted interventions to improve adhere...