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Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign


High resolution x-ray analysis reveals the inner life of leaves while advancing engineering efforts to reduce crop sweat

Researchers used high-resolution three-dimensional imaging to study the internal anatomy of sorghum leaves, revealing a complex ventilation system. The study found that reducing stomata size can increase air spaces beneath the leaf, improving CO2 distribution without compromising photosynthesis.

AirPods-sized fluorescence analytical device holds the promise for timely home molecular testing

A portable, airpod-size fluorescence analytical device has been designed to provide timely home molecular testing. The VPodDuo can measure fluorescent signals generated by various detection chemistry formats and detect quantities of genetic material from several pathogens and human cancer markers.

Researchers call on conservation genomics efforts to better engage with Indigenous communities and knowledge

A team of researchers is calling for more ethical consideration in using genomic technologies to influence the environment and species. They recommend respecting Indigenous data sovereignty and ensuring access and benefit sharing.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalConservation Biology·TypeCommentary/editorial·DateJul 2, 2026

New fluorescence-based method for identifying gene editing targets

Researchers developed a novel fluorescent-based method to analyze upstream open reading frames (uORFs) in plant genomes, enabling rapid analysis of gene regulation. The technique simplifies current methods by using intact leaf tissue and fluorescent proteins, reducing sample preparation and consumable materials.

Rethinking plant photoprotection: New insights into antenna protein CP26

Researchers investigated the function of antenna protein CP26 and found that it affects the structural organization of the photosynthetic system instead of directly participating in non-photochemical quenching. Plants lacking CP26 showed moderate modifications to NPQ rates and photosynthetic efficiency.

A new ecological model highlights how fluctuating environments push microbes to work together

Researchers develop mathematical model to capture microbial cooperation and community stability, predicting the outcome of experiments with E. coli strains. The model's results show that auxotrophs contribute to stable communities by trading essential nutrients and limiting growth.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalCell Systems·TypeComputational simulation/modeling·DateFeb 24, 2026

Renewable biological catalyst carries the potential to transform wastewater into phosphorus resource

Researchers developed a process to convert phytate into bioavailable phosphate using a biocatalyst, improving phosphorus recycling efficiency. The method uses engineered yeast cells displaying the enzyme phytase, which can efficiently and stably convert organic phosphorus into usable phosphate.

Novel approach to a key biofuel production step captures an elusive energy source

Researchers at the University of Illinois have developed a novel approach to recover native lignin structure in plants, enabling higher yields of valuable materials with lower energy inputs. This breakthrough advances biofuel production by providing a key component for conversion to other valuable products.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalChemical Engineering Journal Advances·TypeExperimental study·DateFeb 2, 2026

Bigger is not always better: Smaller leaves optimize light use in soybeans

Researchers found that narrower soybean leaves can improve how efficiently plants use available light. By altering leaf shape through a single gene, they reduced total leaf area by 13% without affecting yield, resulting in more efficient sunlight conversion into seed.

Researchers enable microorganisms to build molecules with light

A team from the University of Illinois developed a photobiocatalytic platform that enables Escherichia coli to produce complex molecules through light-driven enzymatic reactions. This breakthrough broadens the capabilities of biomanufacturing, offering a promising avenue for sustainable production of chemicals and materials.

Tracing a path through photosynthesis to food security

A new review evaluates biological strategies to improve the efficiency of photosynthesis, highlighting promising solutions such as engineering Rubisco enzyme and developing cooperative crops. The research aims to address global challenges in agriculture and ensure food security for the world's population.

Learning the language of lasso peptides to improve peptide engineering

A new large language model, LassoESM, has been developed to predict lasso peptide properties, enabling the acceleration of rational design for biomedical applications. The model was trained on thousands of lasso peptide sequences and demonstrated accurate prediction of various properties.

Illinois team to lead up to $28M initiative to build a precision phage platform for promoting public health

Researchers are developing a precision phage platform to restore microbiome balance and combat antibiotic-resistant diseases. The MIGHTY project aims to harness phages as targeted antimicrobials, leveraging AI and machine learning methods to identify effective phage combinations.

Manipulation of light at the nanoscale helps advance biosensing

Researchers at the University of Illinois developed cryosoret nanoassemblies that enhance fluorescence signals, reducing detection limits for biomarkers. The new platform offers dual-mode interaction between electric and magnetic components of light, promising highly sensitive and tunable biosensing systems.

Fruit fly study reveals a gene’s hidden ability to keep regrowth on the right track

A recent study has identified a gene, Zelda, that plays a crucial role in regulating the end of regrowth in fruit fly larvae. The researchers found that Zelda helps control the activity of genes involved in tissue development, revealing a new understanding of the regenerative process.

Two-step method to prevent biofilm regrowth is a SLAM dunk

A new study presents a two-step method to effectively dismantle bacterial biofilms and prevent regrowth. By using self-locomotive antibacterial microbubblers (SLAM) followed by a mixture of hydrogen peroxide and peroxyacetic acid, researchers were able to prevent the regrowth of biofilms on surfaces, including medical instruments.

Harnessing generative AI to expand the mitochondrial targeting toolkit

Researchers used generative AI to design diverse mitochondrial targeting sequences, achieving a 50-100% success rate in yeast, plant cells, and mammalian cells. The AI-generated sequences showed improved targeting abilities compared to existing ones, with potential applications in metabolic engineering and therapeutics.

Traditional breeding falls short in boosting soybean photosynthesis

A team from the University of Illinois found that traditional breeding methods are unlikely to improve soybean light-harvesting efficiency. Gene editing is likely needed to unlock soybean potential. The researchers gathered detailed measurements throughout an entire growing season to understand photoprotection relaxation in soybeans.

Researchers develop enhanced method for wastewater surveillance of antibiotic resistance

A new method for detecting antibiotic resistance genes (ARGs) in wastewater has been developed by researchers, which uses CRISPR-Cas9 technology to enrich ARG fragments and increase detection sensitivity. This enhanced method was found to detect 1189 more ARGs and 61 more ARG families compared to standard metagenomics methods.

Rubisco's role in food and energy security

Increasing Rubisco, the plant enzyme responsible for capturing atmospheric CO2, can complement existing efforts to enhance yields while research on complex innovations progresses. This approach may offer benefits sooner than other strategies, particularly in conditions with decreased CO2 concentration, such as drought or heat stress.

Climate-ready crop

A team from the University of Illinois has engineered a potato crop that can thrive in elevated temperatures, resulting in a 30% increase in tuber mass under heatwave conditions. This adaptation aims to improve food security for families dependent on potatoes, which are often affected by changing climate conditions.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalGlobal Change Biology·TypeExperimental study·DateDec 4, 2024

NSF to invest $5 million to the Reliable and Scalable Biofoundries for Biomanufacturing and Global Bioeconomy

The NSF has invested $5 million in the Reliable and Scalable Biofoundries for Biomanufacturing and Global Bioeconomy to advance bioeconomy research and solve global challenges. The project aims to establish standards and metrics for biofoundry applications, promote industry partnerships, and develop workforce development programs.

Researchers discover how enzymes ‘tie the knot’

Scientists used artificial intelligence and molecular dynamics simulations to understand how enzymes fold lasso peptides into a unique structure. They identified key residues important for interaction with the substrate, enabling the design of new cyclase variants that can produce potent lasso peptides.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalNature Chemical Biology·TypeExperimental study·DateSep 20, 2024

Researchers investigate parent perceptions of virtual learning

The study found that parents experienced significant stress due to the transition to virtual learning, with many reporting difficulties in monitoring their children's work and managing their own schedules. However, some parents reported positive experiences with virtual learning, particularly for students with special needs, highlighti...

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalSocial Education Research·TypeObservational study·DateAug 16, 2024

Coinfecting viruses impede each other’s ability to enter cells

Researchers used advanced techniques to study phage infection at the level of individual bacterial cells. They found that coinfecting phages impede each other's entry, perturbing the cell's electrophysiology and affecting the outcome of infection. This discovery opens a new avenue for research in bacterial electrophysiology.

Rising antimicrobial resistance in certain Salmonella serovars isolated from retail chicken meat

Emerging antimicrobial resistance in Salmonella isolates found in retail chicken meat poses a significant threat to public health. The study found a dramatic increase in multidrug-resistant S. Infantis, which has been linked to high levels of antimicrobial resistance and virulence genes.

Researchers find genetic stability in a long-term Panamanian hybrid zone of manakins

Hybrids between two manakin species in Panama have remained relatively stable over the past 30 years, with minimal changes in genomic markers. The phenotypic transition zone also shows stability, with only one trait having shifted location, suggesting a potential selection for green bellies.

Changes Upstream: RIPE team uses CRISPR/Cas9 to alter photosynthesis for the first time

Researchers from the University of Illinois have used CRISPR/Cas9 to alter the upstream regulatory DNA of a food crop, increasing gene expression and improving downstream photosynthesis. This approach, which does not require adding foreign DNA, has shown promising results in increasing photosynthetic activity in rice.

Researchers find unique adaptations of fungus associated with bee bread

A new study reveals that fungi associated with bee bread have unique adaptations that allow them to thrive in the acidic environment. The researchers found that one strain of Aspergillus flavus can withstand extreme pH levels and propolis, which has fungicidal properties.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalEcology and Evolution·TypeExperimental study·DateMay 21, 2024

Engineered increase in mesophyll conductance improves photosynthetic efficiency in field trial

Researchers engineered increased mesophyll conductance in a model crop, improving CO2 diffusion and uptake. The study showed an 8% increase in photosynthesis in the field, demonstrating potential for improved crop production and sustainable water use.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalPlant Biotechnology Journal·TypeExperimental study·DateApr 30, 2024

Tibetan plateau had broader social dimensions than previously thought

Researchers discovered stone artifacts on the Tibetan plateau that suggest long-distance cultural exchanges between residents and those living on its perimeter. The findings, published in Quaternary Science Reviews, reveal a more complex social dimension than previously thought.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalQuaternary Science Reviews·TypeExperimental study·DateApr 29, 2024

Researchers identify key regulators underlying regeneration in Drosophila

The study reveals Brat's role in regulating wing imaginal discs regeneration by modulating downstream growth factors. Flies with reduced Brat demonstrated improved wing regeneration but also exhibited deficiencies in cell-fate specification, highlighting the delicate balance required for proper regeneration.

Researchers design new open-source technology for interfacing with living neurons

Researchers developed a new open-source system to interface with living neurons, offering enhanced control and precision in measuring neural processes. The system boasts over 500 electrodes, allowing for more data collection and customization, while being 10 times cheaper than commercial systems.