Researchers at Karolinska Institutet used AI to analyze brain images from 70-year-olds and found that factors like inflammation and high glucose levels are associated with an older-looking brain. A healthy lifestyle, on the other hand, was linked to brains with a younger appearance.
A study investigated the effects of N-(1,3,4-thiadiazol-2-yl)-3-pyridinecarboxamide (TGN-020), a selective AQP4 inhibitor, on glymphatic function. The results showed that acute inhibition of AQP4 significantly impaired glymphatic function without inducing short-term behavioral abnormalities in mice.
Gozetotide offers an added benefit for patients with metastatic, castration-resistant prostate cancer who receive abiraterone or enzalutamide treatment. The study shows improved overall survival and reduced need for radiotherapy. However, side effects such as myelosuppression are also present.
The DFG is investing €30 million in eight new research units tackling pressing issues such as quantum materials, macrophage biology and language convergence. The new units will focus on innovative directions in their respective fields.
MIT researchers developed a biosensing technique that eliminates the need for wires, using tiny wireless antennas with light detection to measure electrical signals from cells. The devices can capture scattered light with an optical microscope and measure signals with micrometer spatial resolution.
A new study reveals that targeted preventative measures can significantly reduce the economic burden of tooth decay, particularly in deprived groups. The research estimates that implementing upstream and downstream interventions could save £14,000 per person in the most deprived group.
Researchers have identified a new pathway for ergosterol biosynthesis in Leishmania parasites, paving the way for more effective antiparasitic drugs. The discovery reveals that azole antifungals targeting a specific enzyme can be highly effective against leishmaniasis.
A new photosensitizer, Ce6-GFFY, is synthesized and demonstrates enhanced anti-tumor immune responses in mouse models. Effective against primary and metastatic tumors, Ce6-GFFY offers a promising therapeutic strategy for colorectal cancer treatment.
A new AI-driven approach identifies potentially harmful chemical substances in rivers by monitoring their effects on tiny water fleas, providing insights into complex mixtures and aquatic life. The study enables more comprehensive environmental monitoring and supports better-informed regulations for chemical discharge into waterways.
Researchers at Osaka Metropolitan University identified clogging in a geothermal well due to accidental venting, highlighting the need for regular inspection and monitoring of water quality. The study emphasizes the importance of geochemical analysis of groundwater for stable and widespread use of aquifer thermal energy storage systems.
A new study analyzing 192 years of alliances, hostilities, and neutrality found that neutral ties were more prevalent than previously thought, playing a crucial role in global stability. The research introduces a new measure of relational structure called 'balance correlations,' which has profound implications for policymakers.
Researchers have developed a new sodium-ion battery material that improves performance by 15% and increases energy density to 458 Wh/kg. The material, Na x V2(PO4)3, allows for stable operation and continuous voltage change, making it a promising alternative to lithium-ion batteries.
Assistant Professor Yvonne Su argues that inclusivity in academia is often superficial and conditional, rather than transformational. She advocates for institutional changes to create space and autonomy for women of colour academics to do their work.
Environmental heterogeneity consistently increases pathogen virulence and infectivity. Modest variations in local conditions can lead to up to 40% higher evolved virulence compared to homogeneous metapopulations.
Current energy-hungry transformer-based systems contrast with Turing's idea of machines that develop intelligence naturally, like human children. AI systems can now perform tasks exclusive to human intellect, such as generating coherent text and discussing abstract ideas, but with limitations on sustainability and societal impact
A Stanford Medicine study found that AI can help researchers quickly evaluate large amounts of medical data, identifying trends and patterns. The tool was trained on notes from 1,201 children with ADHD, allowing researchers to pinpoint gaps in follow-up care and identify tactics to improve ADHD management.
Researchers at Texas A&M University have discovered that chronic alcohol use alters brain signaling pathways, specifically targeting cholinergic interneurons. This impairment affects learning and adaptability, critical components of cognitive flexibility.
A UC Riverside-led team, funded by the NIH, aims to uncover molecular factors governing gene regulation and chromatin organization in P. falciparum. The project focuses on long non-coding RNAs, which play a crucial role in regulating gene expression and influencing disease progression.
A French research team has developed a method to manage animal-vehicle collisions by deploying camera trap networks and leveraging artificial intelligence and ecological modeling. The approach simulates animal movements, identifies collision hotspots, and estimates species abundance, providing a map of collision risk.
Quantum walks utilize quantum phenomena to design algorithms for applications such as database search, network analysis, and navigation. These models offer unique features and computational advantages, including faster diffusion and improved sampling efficiency.
Researchers used time-delayed laser pulses to capture electric and magnetic field vectors of surface plasmon polaritons, revealing a meron pair's spin texture. The study demonstrates stable spin structures despite fast field rotations.
A new study published in Science Advances reveals that right whales can survive for over 130 years, with some individuals possibly reaching 150 years. This discovery highlights the impact of human activities on whale lifespans, particularly entanglement in fishing gear and ship strikes.
Scientists have used data from CryoSat-2 and ICESat-2 to track changes in the Greenland Ice Sheet's thickness, revealing an average thinning of 1.2 meters between 2010 and 2023. The study confirms that combining satellite measurements can produce a more reliable estimate of ice loss.
New research led by Penn State scientists reveals flies are increasingly at risk due to rising global temperatures, compromising their role as prolific pollinators. The study found that bees can tolerate higher temperatures than flies, highlighting the vulnerability of fly populations to climate change.
A research team led by a physician-scientist found that artificial heart patients can regenerate heart muscle cells, which may lead to new ways to treat and potentially cure heart failure. The study showed that these patients' hearts regenerate muscle cells at more than six times the rate of healthy hearts.
A systematic review of data on 2.4 million adults from 69 countries established international norms for handgrip strength, ranking strength into five categories: low, somewhat low, moderate, somewhat high, and high. The new framework enables clinicians to identify people at risk of poor health and track changes in strength over time.
Researchers have made significant breakthroughs in synthesizing innovative materials for all-solid-state batteries (ASSBs), improving their performance and safety. The review highlights the challenges that remain, such as limited compatibility between electrolytes and electrodes.
A recent study by UPF and UOC found that over half of young Spaniards spend more than an hour a day on TikTok, with girls exceeding the risk threshold for mental health problems. The app's passive consumption features and traditional gender roles in content preferences contribute to this issue.
Researchers reveal that human eyelashes have a unique structure that enables rapid and directional water expulsion to maintain visual clarity. The hydrophobic, curved, flexible fiber array features surface micro-ratchets and macro-curvature approximating the Brachistochrone curve.
Early adoption of Tobacco 21 policies maximizes potential mortality reductions, but enforcement varies widely across states. The federal law's enforcement is crucial in states without state-level T21 policies.
A recent study found that socioeconomic inequalities trap local governments in a cycle of limited resources, rising inequality, and declining capacity to meet citizens' needs. Strategic, targeted interventions are necessary to break the cycle of inequality and enhance public satisfaction with local governance.
Scientists at the Institute of Physical Chemistry Polish Academy of Sciences created a method to measure molecular brightness and eliminate background light. This technique allows for counting individual photons emitted by molecules, enabling precise measurement of molecule concentrations. The researchers applied this approach to study...
Researchers developed a prediction model for infected pancreatic necrosis (IPN) in acute pancreatitis patients, identifying high-risk individuals within 24 hours of hospital admission. The model achieved an area under the receiver operating characteristic curve (AUC) of 0.85, outperforming widely used scoring systems.
A new test, SMC-Kids, has been developed to evaluate the motor competence of preschoolers without requiring specialized equipment or large spaces. The tool showed strong associations with established assessment tools and demonstrated excellent reliability.
Researchers have identified two new deubiquitinases, USP53 and USP54, which play a crucial role in removing polyubiquitin tags from proteins. This study suggests that mutations in the USP53 gene are associated with paediatric cholestasis, highlighting the potential for targeted treatment.
The University of Tennessee Institute of Agriculture's annual report highlights the challenges faced by Tennessee's farmers and foresters in 2024, including drought, agricultural land loss, and decreasing foreign market demand. The outlook for 2025 is clouded due to trade policy uncertainty, low crop prices, and high input costs.
A systematic review of 1500 research papers found that pregnant women who contract bird flu have a high risk of death and birth defects. The study stresses the importance of early inclusion of pregnant women in public health vaccination programs during pandemics.
Researchers found a link between chronic gut infection with cytomegalovirus and the development of Alzheimer's disease, suggesting that the virus may contribute to immune system changes and brain inflammation. The study suggests that existing antiviral drugs could potentially treat or prevent this form of Alzheimer's.
D-Glue, an eco-friendly adhesive designed to break apart at lower temperatures, will partner with Plug and Play Japan's Deeptech Program. The debondable glue aims to reduce landfill waste and energy consumption, with the potential to expand production on a mass scale.
A new study from Oregon Health & Science University found that people who receive physical therapy earlier after a concussion tend to have better balance control and reduced reaction times. This can lead to improved outcomes and reduced risk of re-injury. Early intervention may enable the brain to return to a more normal state, compens...
The National Institute of Neurological Disorders and Stroke has awarded researchers at the University of Tennessee Health Science Center $2.18 million to investigate a new small molecule that activates SERCA2, aiming to correct calcium imbalances caused by diabetes after a stroke.
Randomized controlled trials on non-pharmacological therapies in Chinese medicine have suboptimal reporting quality, with gaps in treatment regimens and practitioner background. The review calls for strengthened journal endorsement of guidelines to improve study accuracy and reliability.
Researchers developed a laser-based artificial neuron that emulates biological graded neuron functions, achieving a signal processing speed of 10 GBaud. This enables fast AI decision-making in time-critical applications with high accuracy.
A recent UC Riverside study found that raking dead grass can boost California's native wildflower diversity, reducing fire danger and increasing plant community changes. The simple, low-cost method of removing invasive grass layers allows native seeds to germinate and grow.
A new study found that climate warming will increase evaporation of ocean waters and alter atmospheric rivers in Southern California, while warmer temperatures in the ocean and atmosphere will affect those in the Pacific Northwest. This could lead to increased flooding risks and more powerful storms.
The Biden-Harris administration has awarded the Enrico Fermi Presidential Award to three US Department of Energy scientists for their groundbreaking contributions to nanoscience, electroanalytical chemistry, and fusion. Their work is expected to have a lasting impact on energy transformation and creation.
A new study finds that disease-causing bacteria can infect a wide range of plant species, including non-flowering plants, using a common set of pathogenicity factors. The research suggests that the toxin syringomycin interferes with cell membranes across diverse plant species.
Narcissists can be charming early on, but subtle signs indicate a need to get out of the relationship. Brunell discusses how researchers have learned to understand and cope with narcissists in various settings, including workplaces. Strategies for setting clear boundaries and managing situations are also shared.
Researchers have discovered that AHCC suppresses liver fibrosis by inhibiting the activation of hepatic stellate cells through two channels. Early administration of AHCC may hold the key to preventing the onset of cirrhosis, a potentially fatal condition.
Researchers at UMass Amherst have identified Hsc70 as a vital chaperone protein that ensures SNAP-25's proper functioning in neurotransmission. The study sheds new light on the underlying mechanics of neurodegenerative diseases like Alzheimer's and Parkinson's.
Research from University of Texas at Austin finds that having Democratic lawmakers as shareholders can deter activist investors who target companies for cost cuts and environmental, social, and governance (ESG) programs. The study found no effect from Republican politicians as shareholders.
A randomized clinical trial found that a brief outpatient rehabilitation program improved physical function in patients with post-COVID condition. The intervention showed sustained benefits over time, with negligible adverse effects.
Kobe University researchers discovered three gene regulation design principles to improve yeast promoter performance, reducing leakiness and increasing productivity. The study's findings have potential applications in hospitals and can be used to produce multiple biologics with a single yeast strain.
A first-of-its-kind study from the University of Minnesota Twin Cities utilizes remote sensing technology to monitor plastic debris in freshwater environments like the Mississippi River. The research helps increase understanding of plastic debris behavior in these systems, shedding light on a growing environmental issue.
A team from the University of Cambridge has developed a model to predict desert locust swarms, enabling national agencies to respond quickly. The model uses weather forecast data and computational models to forecast locust swarm movements both short and long-term.
Researchers propose TailRec, a framework that leverages contextual information to improve tail item representation quality in sequential recommender systems. The approach demonstrates improved recommendation performances and training efficiency, making it a promising solution for enhancing SRS models.
Researchers have developed a way to make the seasonal influenza vaccine more effective by targeting all four subtypes of the flu virus. The method works by tricking the immune system into producing antibodies that can bind to multiple types of viruses, reducing the risk of severe illness.
Grocers can reduce food waste by using digital labels that allow for speedy price changes. This technology benefits both consumers and stores, as prices are adjusted to move older stock off shelves. By implementing dynamic pricing, grocers can save time and money while reducing emissions from food waste.
Researchers at Sanford Burnham Prebys used two sequencing methods to reveal new mRNAs associated with Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease. The study found vast mRNA isoform diversity in genes related to neurodegenerative diseases.
Researchers at VUB have developed a nanobody tracer to identify patients who will respond best to immunotherapy. The technology helps predict treatment outcomes by measuring the quantity of tumor-associated macrophages within tumors.