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Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign


New study investigates the microbiomes of dogs across the world

Researchers sampled fecal microbiomes from dogs across diverse populations in South Africa, India, and Laos, revealing similar metabolic functions. The study suggests that industrialization may affect the human microbiome diversity in non-industrialized settings.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalProceedings of the Royal Society B Biological Sciences·TypeObservational study·DateJun 28, 2022

Bioengineering team develops a remote lab to teach enzyme kinetics

Researchers from the University of Illinois at Urbana-Champaign created a remote laboratory activity to teach undergraduate students about enzyme kinetics. The at-home kit included basic equipment and protocols that allowed students to conduct experiments and collect data, providing an alternative to traditional lab techniques.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalJournal of Microbiology and Biology Education·TypeExperimental study·DateJun 13, 2022

No photosynthetic improvement in ictB transformants in field-grown model crop

Researchers tested ictB transformants in field-grown tobacco and found no significant improvement in photosynthesis or biomass production. Despite previous studies suggesting potential benefits, the current study suggests that ictB overexpression may only be beneficial in controlled environments.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalJournal of Experimental Botany·TypeExperimental study·DateMay 27, 2022

Understanding the genomic modifications in transgenic papaya

A new study has identified genomic modifications in the transgenic papaya 'SunUp', which was developed to resist the papaya ringspot virus. The researchers used advanced sequencing technologies to read long stretches of DNA and found that the insertion did not cause any change in gene expression.

Decoding the molecular clock that controls neurogenesis in the visual center of Drosophila

In a study published in Nature Communications, researchers uncovered the molecular players involved and how timing is controlled for creating neural diversity. Single-cell RNA sequencing technology revealed a temporal patterning gene network in Drosophila medulla neuroblasts, including nine new transcription factors.

Collaborative RIPE team prove leaf width-biomass correlations in cowpea

Researchers found a correlation between leaf width and above-ground biomass across diverse germplasm and environmental conditions. The study's findings have the potential to improve breeding programs for cowpea biomass in Nigerian fields, enhancing grain and fodder production.

Illinois team significantly improves BioCro software for growing virtual crops

Researchers from the University of Illinois have revamped the popular crop growth simulation software BioCro, allowing modelers to use the technology more easily. The updated version includes faster and more accurate algorithms, enabling researchers to try new simulations more easily and link to other models.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·Journalin silico Plants·TypeComputational simulation/modeling·DateFeb 28, 2022

Acceleration of cancer biomarker detection for point of care diagnostics

Researchers at the University of Illinois have developed a new approach to detect cancer biomarkers in human serum, reducing the detection time from hours to just one minute. This method uses magnetic-plasmonic nanoparticles and photonic resonator absorption microscopy to achieve high selectivity and rapid sample-to-answer analysis.

Fickle sunshine slows down Rubisco and limits photosynthetic productivity of crops

Researchers discovered that Rubisco's activity drops more rapidly in cowpea leaves when they go into the shade, resulting in missed opportunities to convert sunlight into sugars. This imperfection could be shared with other crops and may lead to targeted breeding for improved productivity.

Prenatal exposure to phthalates damages reproductive tissue in female mice

A new study found that prenatal exposure to phthalates affects ovarian steroidogenesis and folliculogenesis in female mice offspring, leading to lower hormone levels and impaired fertility. The researchers discovered that phthalate mixtures can inhibit the expression of genes involved in hormone production.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalReproductive Toxicology·TypeExperimental study·DateDec 15, 2021

Stronger drought resistance of urban vegetation due to higher temperature, CO2 and reduced O3

A recent study found that urban vegetation has a stronger ability to withstand drought compared to rural areas. The researchers attribute this enhanced drought resistance to increased temperature and CO2 concentration, as well as reduced ozone levels in urban environments.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalEnvironmental Research Letters·TypeData/statistical analysis·DateDec 15, 2021

The heat is on: RIPE researchers show ability to future-proof crops for changing climate

Researchers at the University of Illinois and US Department of Agriculture's Agricultural Research Service have developed a way to future-proof crops for changing climate conditions. By bypassing a common photosynthetic glitch, crops can withstand heat stress, reducing yield losses estimated at up to 40-50% in regions around the equator.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalPlant Biotechnology Journal·TypeExperimental study·DateDec 15, 2021

Study reveals how bacterial pathogen adapts to nutritional stress

Researchers at Illinois provided insight into the signal transduction mechanism utilized by Staphylococcus aureus's TCS ArlRS in response to host-imposed manganese and glucose starvation. The study found that histidine kinase ArlS is necessary for activation of response regulator ArlR under both manganese and glucose-limited conditions.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalJournal of Bacteriology·TypeExperimental study·DateDec 6, 2021

Chemical pollutants disrupt reproduction in anemonefish, study finds

Researchers found that fish exposed to BPA exhibited feminizing effects on gonads, brain genes, and hormone levels, leading to changes in aggression and sex determination. In contrast, EE2 had less pronounced effects, with decreased aggression despite feminization of gonads.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalHormones and Behavior·TypeExperimental study·DateDec 3, 2021

What doesn’t kill you makes you stronger: Illinois research shows crops have drought ‘memory’ to help reduce yield loss

Crops that survive early-season drought conditions are better able to deal with those same conditions later in their growth cycle, a phenomenon known as 'drought memory'. This adaptation allows crops to mitigate losses from late-season droughts up to seven percent.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalFood and Energy Security·TypeExperimental study·DateNov 8, 2021

C4 bioenergy grass: Working towards higher productivity under fluctuating light

A recent study found that C4 bioenergy grass species outperform C3 species in assimilating carbon during fluctuating light conditions. This discovery could lead to increased productivity and reduced dependence on fossil fuels through targeted plant breeding programs.

Compact biosensor microscope built for point of care diagnostics

Researchers developed a compact photonic resonator absorption microscope for point-of-care diagnostics, using photonic crystal biosensors to detect proteins or other biomarkers linked to gold nanoparticles. The portable instrument costs $7,000 and has potential applications in detecting various cancers.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalBiomedical Optics Express·TypeExperimental study·DateOct 18, 2021

Can parental care influence sperm-mediated effects in threespine sticklebacks?

A new study found that parental care does not seem to affect sperm-mediated effects in threespine sticklebacks, contrary to previous expectations. The researchers tested the behavior and stress responses of offspring from predator-exposed fathers with or without parental care.

Referential alarm calls increase vigilance in brood parasite hosts

Researchers found that female yellow warblers who heard referential 'seet' calls the previous day would sit on their nest for a longer period and be less active, suggesting they recalled past events and engaged in mental time travel to boost vigilance. This behavior may indicate a heightened state of alert or cognitive processing.

Deep-learning algorithm aims to accelerate protein engineering

A new deep-learning algorithm, ECNet, has been developed to accelerate protein engineering by predicting the fitness of all possible sequences. By incorporating evolutionary history, ECNet outperforms current methods on several datasets and identifies novel mutants with improved fitness.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalNature Communications·TypeComputational simulation/modeling·DateOct 7, 2021

New markers for coronary microvascular disease identified

Researchers have identified stearic acid and ornithine as indicators of coronary microvascular disease (CMD), a condition that damages blood vessels and causes decreased blood flow to the heart muscle. The study suggests that estrogen may also play a role in CMD development, particularly in postmenopausal women.

COVID-19 peaks reflect time-dependent social activity, not herd immunity

Scientists developed a model showing that collective immunity emerged during the early COVID-19 epidemic but was destroyed as people changed their social behaviors over time. The model suggests that subsequent waves of infection will appear due to variations in imposed mitigations and pandemic fatigue.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalProceedings of the National Academy of Sciences·DateApr 21, 2021

New computational models to understand colon cancer

The study identified several cellular pathways that change when a tumor becomes aggressive, and developed a simple system to model their effect. The model integrated different types of experimental data, including transcription factors, to predict which targets are important for colorectal cancer aggressiveness.

Researchers hunt for drugs that keep HIV latent

A team of researchers from the University of Illinois at Urbana-Champaign has identified five new chemicals that can promote latency in HIV, providing a potential solution to the disease. By screening over 1800 compounds, they discovered compounds that can suppress viral reactivation and reduce the risk of disease progression.

SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalProceedings of the National Academy of Sciences·DateMar 23, 2021

Deciphering the impacts of small RNA interactions in individual bacterial cells

Researchers deciphered the impacts of sRNA interactions on individual bacterial cells, revealing minor effects from base-pairing interactions and significant effects from disruptions in Hfq binding. The study used high-throughput sequencing and quantitative super-resolution imaging to understand the regulation of gene expression under ...